LOCUS       NM_008599               2905 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C-X-C motif chemokine ligand 9 (Cxcl9), mRNA.
ACCESSION   NM_008599
VERSION     NM_008599.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2905)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2905)
  AUTHORS   Peng,L., Lu,Y., Gu,Y., Liang,B., Li,Y., Li,H., Ke,Y., Zhu,H. and
            Li,Z.
  TITLE     Mechanisms of action of Lycium barbarum polysaccharide in
            protecting against vitiligo mice through modulation of the
            STAT3-Hsp70-CXCL9/CXCL10 pathway
  JOURNAL   Pharm Biol 61 (1), 281-287 (2023)
   PUBMED   36655287
  REMARK    GeneRIF: Mechanisms of action of Lycium barbarum polysaccharide in
            protecting against vitiligo mice through modulation of the
            STAT3-Hsp70-CXCL9/CXCL10 pathway.
REFERENCE   3  (bases 1 to 2905)
  AUTHORS   Diamond,T., Lau,M., Morrissette,J., Chu,N. and Behrens,E.M.
  TITLE     CXCL9 inhibition does not ameliorate disease in murine models of
            both primary and secondary hemophagocytic lymphohistiocytosis
  JOURNAL   Sci Rep 13 (1), 12298 (2023)
   PUBMED   37516815
  REMARK    GeneRIF: CXCL9 inhibition does not ameliorate disease in murine
            models of both primary and secondary hemophagocytic
            lymphohistiocytosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2905)
  AUTHORS   Richmond,J.M., Patel,D., Watanabe,T., Chen,H.W., Martyanov,V.,
            Werner,G., Garg,M., Haddadi,N.S., Refat,M.A., Mahmoud,B.H.,
            Wong,L.D., Dresser,K., Deng,A., Zhu,J.L., McAlpine,W., Hosler,G.A.,
            Feghali-Bostwick,C.A., Whitfield,M.L., Harris,J.E., Torok,K.S. and
            Jacobe,H.T.
  TITLE     CXCL9 Links Skin Inflammation and Fibrosis through CXCR3-Dependent
            Upregulation of Col1a1 in Fibroblasts
  JOURNAL   J Invest Dermatol 143 (7), 1138-1146 (2023)
   PUBMED   36708947
  REMARK    GeneRIF: CXCL9 Links Skin Inflammation and Fibrosis through
            CXCR3-Dependent Upregulation of Col1a1 in Fibroblasts.
REFERENCE   5  (bases 1 to 2905)
  AUTHORS   Seitz,S., Dreyer,T.F., Stange,C., Steiger,K., Brauer,R.,
            Scheutz,L., Multhoff,G., Weichert,W., Kiechle,M., Magdolen,V. and
            Bronger,H.
  TITLE     CXCL9 inhibits tumour growth and drives anti-PD-L1 therapy in
            ovarian cancer
  JOURNAL   Br J Cancer 126 (10), 1470-1480 (2022)
   PUBMED   35314795
  REMARK    GeneRIF: CXCL9 inhibits tumour growth and drives anti-PD-L1 therapy
            in ovarian cancer.
REFERENCE   6  (bases 1 to 2905)
  AUTHORS   Setsuda,J., Teruya-Feldstein,J., Harris,N.L., Ferry,J.A.,
            Sorbara,L., Gupta,G., Jaffe,E.S. and Tosato,G.
  TITLE     Interleukin-18, interferon-gamma, IP-10, and Mig expression in
            Epstein-Barr virus-induced infectious mononucleosis and
            posttransplant lymphoproliferative disease
  JOURNAL   Am J Pathol 155 (1), 257-265 (1999)
   PUBMED   10393857
  REMARK    GeneRIF: PTLD (posttransplant lymphoproliferative disease) tissues
            express significantly lower levels of Mig compared to lymphoid
            tissues diagnosed with acute EBV-induced infectious mononucleosis,
            as assessed by semiquantitative RT-PCR analysis.
REFERENCE   7  (bases 1 to 2905)
  AUTHORS   Sun,H., Jackson,M.J., Kundu,N. and Fulton,A.M.
  TITLE     Interleukin-10 gene transfer activates interferon-gamma and the
            interferon-gamma-inducible genes Gbp-1/Mag-1 and Mig-1 in mammary
            tumors
  JOURNAL   Int J Cancer 80 (4), 624-629 (1999)
   PUBMED   9935167
REFERENCE   8  (bases 1 to 2905)
  AUTHORS   Horton,M.R., McKee,C.M., Bao,C., Liao,F., Farber,J.M.,
            Hodge-DuFour,J., Pure,E., Oliver,B.L., Wright,T.M. and Noble,P.W.
  TITLE     Hyaluronan fragments synergize with interferon-gamma to induce the
            C-X-C chemokines mig and interferon-inducible protein-10 in mouse
            macrophages
  JOURNAL   J Biol Chem 273 (52), 35088-35094 (1998)
   PUBMED   9857043
REFERENCE   9  (bases 1 to 2905)
  AUTHORS   Modi,W.S., Amarante,M.R., Hanson,M., Womack,J.E. and Chidambaram,A.
  TITLE     Assignment of the mouse and cow CXC chemokine genes
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 213-216 (1998)
   PUBMED   9730606
REFERENCE   10 (bases 1 to 2905)
  AUTHORS   Farber,J.M.
  TITLE     A macrophage mRNA selectively induced by gamma-interferon encodes a
            member of the platelet factor 4 family of cytokines
  JOURNAL   Proc Natl Acad Sci U S A 87 (14), 5238-5242 (1990)
   PUBMED   2115167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK042017.1 and AC122365.4.
            
            On Dec 11, 2007 this sequence version replaced NM_008599.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference assembly was not available for all regions of the
            RefSeq transcript. The extent of this transcript is supported by
            transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156029.1, AK157118.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1251              AK042017.1         3-1253
            1252-2905           AC122365.4         69402-71055         c
FEATURES             Location/Qualifiers
     source          1..2905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 46.51 cM"
     gene            1..2905
                     /gene="Cxcl9"
                     /gene_synonym="CMK; crg-10; Mig; MuMIG; Scyb9"
                     /note="C-X-C motif chemokine ligand 9"
                     /db_xref="GeneID:17329"
                     /db_xref="MGI:MGI:1352449"
     exon            1..117
                     /gene="Cxcl9"
                     /gene_synonym="CMK; crg-10; Mig; MuMIG; Scyb9"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..437
                     /gene="Cxcl9"
                     /gene_synonym="CMK; crg-10; Mig; MuMIG; Scyb9"
                     /note="C-X-C motif chemokine 9; gamma interferon-induced
                     monokine; protein m119; monokine induced by
                     interferon-gamma; M119; small-inducible cytokine B9; small
                     inducible cytokine B subfamily (Cys-X-Cys), member 9;
                     monokine induced by gamma interferon; chemokine (C-X-C
                     motif) ligand 9"
                     /codon_start=1
                     /product="C-X-C motif chemokine 9 precursor"
                     /protein_id="NP_032625.2"
                     /db_xref="CCDS:CCDS39152.1"
                     /db_xref="GeneID:17329"
                     /db_xref="MGI:MGI:1352449"
                     /translation="MKSAVLFLLGIIFLEQCGVRGTLVIRNARCSCISTSRGTIHYKS
                     LKDLKQFAPSPNCNKTEIIATLKNGDQTCLDPDSANVKKLMKEWEKKISQKKKQKRGK
                     KHQKNMKNRKPKTPQSRRRSRKTT"
     exon            118..244
                     /gene="Cxcl9"
                     /gene_synonym="CMK; crg-10; Mig; MuMIG; Scyb9"
                     /inference="alignment:Splign:2.1.0"
     exon            245..329
                     /gene="Cxcl9"
                     /gene_synonym="CMK; crg-10; Mig; MuMIG; Scyb9"
                     /inference="alignment:Splign:2.1.0"
     exon            330..2905
                     /gene="Cxcl9"
                     /gene_synonym="CMK; crg-10; Mig; MuMIG; Scyb9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1225..1230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl9"
                     /gene_synonym="CMK; crg-10; Mig; MuMIG; Scyb9"
                     /note="hexamer: AGTAAA"
     polyA_site      1248
                     /gene="Cxcl9"
                     /gene_synonym="CMK; crg-10; Mig; MuMIG; Scyb9"
                     /note="major polyA site"
     regulatory      2884..2889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl9"
                     /gene_synonym="CMK; crg-10; Mig; MuMIG; Scyb9"
                     /note="hexamer: AATAAA"
     polyA_site      2905
                     /gene="Cxcl9"
                     /gene_synonym="CMK; crg-10; Mig; MuMIG; Scyb9"
ORIGIN      
        1 aaagacattc tcggacttca ctccaacaca gtgactcaat agaactcagc tctgccatga
       61 agtccgctgt tcttttcctc ttgggcatca tcttcctgga gcagtgtgga gttcgaggaa
      121 ccctagtgat aaggaatgca cgatgctcct gcatcagcac cagccgaggc acgatccact
      181 acaaatccct caaagacctc aaacagtttg ccccaagccc caattgcaac aaaactgaaa
      241 tcattgctac actgaagaac ggagatcaaa cctgcctaga tccggactcg gcaaatgtga
      301 agaagctgat gaaagaatgg gaaaagaaga tcagccaaaa gaaaaagcaa aagaggggga
      361 aaaaacatca aaagaacatg aaaaacagaa aacccaaaac accccaaagt cgtcgtcgtt
      421 caaggaagac tacataagag accattactt taccaacaag caccctgaat cttaatgggt
      481 tttagattgt actgaaaagc cttccctggc agagcagcct ttaatacata ggcttttaat
      541 acattaactc aactacaaaa cataaagtgt taatttgaaa ttataactaa ctttaggaag
      601 ttaattgcaa aactccaata gtaacaattg ctagaggcaa aaactctgtg ttctacacag
      661 ccaacaaaat ttcatcacgc ccttgagcct agtcgtgata acatcagatc tgggcaagtg
      721 tccctttcct tcatagctat ccaatgcaca acagctgtct ggcttccaga gccacacatt
      781 tggcagcctc cgaagacttc tgaggctcac gtcaccaaat cccaggcctg tctgtttgct
      841 ggtgagctag atagacctca ccaagctgga gaggccctcg gcagctgcat ttgggtcagc
      901 ctagagcccc tgcacacatt gtgtctcaga gatggtgcta atggttttgg ggttctacag
      961 tggagaccac cagagttggc cttcagaacc tcccacgtag ctttcgagac catgggattt
     1021 cattattaac ttgatcccat cttcagagct tattctaagt ttgcctcttc aataaaactc
     1081 tcctagaagg ttgtggctgt agcttagtgg cagaacactt ggtgttgcag ggaccaggtc
     1141 cttcactaac agtgcaaaaa cttaaccaat ttaaagaaca ttttctggct actcaaattc
     1201 tcttaaattt attcctgttt cacaagtaaa cacttcgctg ctatctaatt ggatttgttt
     1261 gtttgtttgt tttacttttt ccaacgagac gggtttttaa gagtagggac cacagactat
     1321 tcccctaaat cttccacagt gcctacaaaa acttggtttt gaataatttc ctaattgtat
     1381 gtgtgagagg tagaaaggct gttacacacc aggcattggc caatccccgg ctgctccaaa
     1441 ttgcctaact aacctttggc ctccttgctt gcttaccact tttttttttt ttttttaaag
     1501 aaagttttat atctggctgt cctaaaactc tcaaagtaga caaggctggt ctcaaattca
     1561 tacatatctg tattctactg cctcctgaat gctggggtta aaggtgtgtg ctactacacc
     1621 tgattgcctg ccttccttcc tttctccctc cctcccttcc ttccttcctt ccttccttcc
     1681 ttccttcctt ccttccttcc ttccttcctt aaattatcta gctttcttat tatcttcaga
     1741 catcttcagc gcacagagcc agacagggtg aaaaagagcc ttaccttgtg acaggaggct
     1801 cgtgtcttta acaaacagga atcacatgtt caagacattt gcggatattt gggactgctc
     1861 aggaaaaatt acacaggcca tctagaaaca taagcttaca tggaagacag gtttgactga
     1921 ttggcaaata ctagatcttt cctcactcaa aacaaaattc ctctaatatc attcttgatc
     1981 aggacaagct ccctaggagt caacaaaaga gctgccaaat cctttagcaa gtttatctta
     2041 ggtgaatatg aatttccttg ccaccttccc tccctcattg cagaaatccc agtgtatgat
     2101 tgtatggatt gccacatcag gctaggagtg gtgaaatgga aagatcaggg ctggagaggg
     2161 agccagagtt ccattcccag cacccacccc cacgtgtgcg tgagccttgt ggccacctgt
     2221 gactccagct ccagggaacc catttctctc ttctggcctc tgcaagcatt gcacaggtgt
     2281 acacaggccc ccatgacata cacccataat ctcagacggc aaataaaaat ctttacagag
     2341 atatttttaa aggaattaag agctacagga agcagtaaat tctgcgagtg gaagtgtgga
     2401 cagggccaag ttagcctgtg tgggagctgg aaactgctct agagaggagg tctgatgaat
     2461 tagatagaaa agaatgtctc tgggcagaag ttccgtcttg agcatgcttt ttctcaaata
     2521 ctgccattcc tggcgctgca tgcaggtggt ttttgtgctg ctggtgggac tcccatccaa
     2581 acaacattgc acagtcaaaa cgttgtccac ctcccttcgg taatttactt tggaaaaaaa
     2641 aaaaaaaagt ctaaaattgt ttcctaacta gttagctacc cttgcatctg acagctgggt
     2701 agtatgcata acgactagcc aaagcctgtg taatttttac taaatagtta tgttggatgc
     2761 atatgcctac agtatgactt catatgtgta ctctaatttt taattcaaag caaattagca
     2821 tatgtgctct gaagctattt cgtgaaagcg tagtgatatc agtaaaagtg cactaaattc
     2881 caaaataaac atgtttttca atgtc
//
