LOCUS       NM_009141               1656 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C-X-C motif chemokine ligand 5 (Cxcl5), mRNA.
ACCESSION   NM_009141
VERSION     NM_009141.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1656)
  AUTHORS   Yin,C., Liu,B., Dong,Z., Shi,S., Peng,C., Pan,Y., Bi,X., Nie,H.,
            Zhang,Y., Tai,Y., Hu,Q., Wang,X., Shao,X., An,H., Fang,J., Wang,C.
            and Liu,B.
  TITLE     CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint
            pain and inflammation in experimental gouty arthritis
  JOURNAL   Nat Commun 15 (1), 3263 (2024)
   PUBMED   38627393
  REMARK    GeneRIF: CXCL5 activates CXCR2 in nociceptive sensory neurons to
            drive joint pain and inflammation in experimental gouty arthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1656)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1656)
  AUTHORS   Li,S., Yu,M., Wang,X. and Fei,B.
  TITLE     MiR-597-5p inhibits carcinogenesis and macrophage recruitment in
            colitis-related colorectal cancer via reducing the expression of
            CXCL5
  JOURNAL   Cancer Biol Ther 24 (1), 2274122 (2023)
   PUBMED   37942533
  REMARK    GeneRIF: MiR-597-5p inhibits carcinogenesis and macrophage
            recruitment in colitis-related colorectal cancer via reducing the
            expression of CXCL5.
REFERENCE   4  (bases 1 to 1656)
  AUTHORS   Jin,F., Li,Y., Gao,X., Yang,X., Li,T., Liu,S., Wei,Z., Li,S.,
            Mao,N., Liu,H., Cai,W., Xu,H. and Zhang,H.
  TITLE     Exercise training inhibits macrophage-derived IL-17A-CXCL5-CXCR2
            inflammatory axis to attenuate pulmonary fibrosis in mice exposed
            to silica
  JOURNAL   Sci Total Environ 902, 166443 (2023)
   PUBMED   37611700
  REMARK    GeneRIF: Exercise training inhibits macrophage-derived
            IL-17A-CXCL5-CXCR2 inflammatory axis to attenuate pulmonary
            fibrosis in mice exposed to silica.
REFERENCE   5  (bases 1 to 1656)
  AUTHORS   Mei,J., Liu,Y., Dai,N., Favara,M., Greene,T., Jeyaseelan,S.,
            Poncz,M., Lee,J.S. and Worthen,G.S.
  TITLE     CXCL5 regulates chemokine scavenging and pulmonary host defense to
            bacterial infection
  JOURNAL   Immunity 33 (1), 106-117 (2010)
   PUBMED   20643340
  REMARK    GeneRIF: regulates chemokine scavenging and pulmonary host defense
            to bacterial infection
REFERENCE   6  (bases 1 to 1656)
  AUTHORS   Wuyts,A., D'Haese,A., Cremers,V., Menten,P., Lenaerts,J.P., De
            Loof,A., Heremans,H., Proost,P. and Van Damme,J.
  TITLE     NH2- and COOH-terminal truncations of murine granulocyte
            chemotactic protein-2 augment the in vitro and in vivo neutrophil
            chemotactic potency
  JOURNAL   J Immunol 163 (11), 6155-6163 (1999)
   PUBMED   10570306
REFERENCE   7  (bases 1 to 1656)
  AUTHORS   Pan,Y., Decker,W.K., Huq,A.H. and Craigen,W.J.
  TITLE     Retrotransposition of glycerol kinase-related genes from the X
            chromosome to autosomes: functional and evolutionary aspects
  JOURNAL   Genomics 59 (3), 282-290 (1999)
   PUBMED   10444329
REFERENCE   8  (bases 1 to 1656)
  AUTHORS   Modi,W.S., Amarante,M.R., Hanson,M., Womack,J.E. and Chidambaram,A.
  TITLE     Assignment of the mouse and cow CXC chemokine genes
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 213-216 (1998)
   PUBMED   9730606
REFERENCE   9  (bases 1 to 1656)
  AUTHORS   Wuyts,A., Haelens,A., Proost,P., Lenaerts,J.P., Conings,R.,
            Opdenakker,G. and Van Damme,J.
  TITLE     Identification of mouse granulocyte chemotactic protein-2 from
            fibroblasts and epithelial cells. Functional comparison with
            natural KC and macrophage inflammatory protein-2
  JOURNAL   J Immunol 157 (4), 1736-1743 (1996)
   PUBMED   8759763
REFERENCE   10 (bases 1 to 1656)
  AUTHORS   Smith,J.B. and Herschman,H.R.
  TITLE     Glucocorticoid-attenuated response genes encode intercellular
            mediators, including a new C-X-C chemokine
  JOURNAL   J Biol Chem 270 (28), 16756-16765 (1995)
   PUBMED   7622488
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105995.9 and BQ829929.1.
            
            On May 2, 2013 this sequence version replaced NM_009141.2.
            
            Summary: This gene encodes a protein that is a member of the CXC
            subfamily of chemokines. Chemokines, which recruit and activate
            leukocytes, are classified by function (inflammatory or
            homeostatic) or by structure. This protein is proposed to bind the
            G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to
            recruit neutrophils and to have homeostatic and inflammatory
            functions. In mouse, deficiency of this gene is associated with
            increased lung inflammation that is neutrophil-dependent. [provided
            by RefSeq, May 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ830198.1, BQ900714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC105995.9         81124-81296
            174-607             BQ829929.1         92-525
            608-1656            AC105995.9         82403-83451
FEATURES             Location/Qualifiers
     source          1..1656
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.78 cM"
     gene            1..1656
                     /gene="Cxcl5"
                     /gene_synonym="AMCF-II; Cxcl6; ENA-78; GCP-2; LIX; Scyb5;
                     Scyb6"
                     /note="C-X-C motif chemokine ligand 5"
                     /db_xref="GeneID:20311"
                     /db_xref="MGI:MGI:1096868"
     exon            1..263
                     /gene="Cxcl5"
                     /gene_synonym="AMCF-II; Cxcl6; ENA-78; GCP-2; LIX; Scyb5;
                     Scyb6"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..544
                     /gene="Cxcl5"
                     /gene_synonym="AMCF-II; Cxcl6; ENA-78; GCP-2; LIX; Scyb5;
                     Scyb6"
                     /note="C-X-C motif chemokine 5; cytokine LIX;
                     small-inducible cytokine B5; small inducible cytokine B
                     subfamily, member 5; granulocyte chemotactic protein-2;
                     small inducible cytokine subfamily B, member 15; chemokine
                     (C-X-C motif) ligand 5"
                     /codon_start=1
                     /product="C-X-C motif chemokine 5 precursor"
                     /protein_id="NP_033167.2"
                     /db_xref="CCDS:CCDS19414.1"
                     /db_xref="GeneID:20311"
                     /db_xref="MGI:MGI:1096868"
                     /translation="MSLQLRSSARIPSGSISPFMRMAPLAFLLLFTLPQHLAEAAPSS
                     VIAATELRCVCLTVTPKINPKLIANLEVIPAGPQCPTVEVIAKLKNQKEVCLDPEAPV
                     IKKIIQKILGSDKKKAKRNALAVERTASVQ"
     exon            264..399
                     /gene="Cxcl5"
                     /gene_synonym="AMCF-II; Cxcl6; ENA-78; GCP-2; LIX; Scyb5;
                     Scyb6"
                     /inference="alignment:Splign:2.1.0"
     exon            400..483
                     /gene="Cxcl5"
                     /gene_synonym="AMCF-II; Cxcl6; ENA-78; GCP-2; LIX; Scyb5;
                     Scyb6"
                     /inference="alignment:Splign:2.1.0"
     exon            484..1656
                     /gene="Cxcl5"
                     /gene_synonym="AMCF-II; Cxcl6; ENA-78; GCP-2; LIX; Scyb5;
                     Scyb6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1635..1640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl5"
                     /gene_synonym="AMCF-II; Cxcl6; ENA-78; GCP-2; LIX; Scyb5;
                     Scyb6"
                     /note="hexamer: AATAAA"
     polyA_site      1656
                     /gene="Cxcl5"
                     /gene_synonym="AMCF-II; Cxcl6; ENA-78; GCP-2; LIX; Scyb5;
                     Scyb6"
                     /note="major polyA site"
ORIGIN      
        1 agtttcctgc ctgaaggaag agagagaaca gataaaaggg gtgcagtggg tttgagaaca
       61 ccatagtgct ctgtagagcc ccaatctcca cacctcctcc agcatatccc gagctggtgc
      121 tccctggtcc gggatcttgt ccacaatgag cctccagctc cgcagctccg cccgcatccc
      181 cagcggttcc atctcgccat tcatgcggat ggcgccgctg gcatttctgt tgctgttcac
      241 gctgccgcag catctagctg aagctgcccc ttcctcagtc atagccgcaa cggagctgcg
      301 ttgtgtttgc ttaaccgtaa ctccaaaaat taatcccaaa ttgatcgcta atttggaggt
      361 gatccctgca ggtccacagt gccctacggt ggaagtcata gctaaactga aaaaccagaa
      421 ggaggtctgt ctggatccag aagctcctgt gataaagaaa atcattcaga aaatattggg
      481 cagtgacaaa aagaaagcta agcggaatgc actcgcagtg gaaagaacgg ccagtgttca
      541 atagaaagat ttctgaggac tctgacccca gtgaagataa gaagaaaggg ctgattctct
      601 ccacccacgg attttcttta tgaactccct gctttgatga gaaaagggaa accattgtcc
      661 ctgaagcttc ctgctcatct cacaagtgta tttagcaaaa atatttccta ttctttccta
      721 tctgtcacac tatcggaaat tgtgatactt tagtgtgtaa gtcaagaatc attggttgtt
      781 aacctttcaa aatgtcttga actgaaggtg actattgcat tgtctccgga atatgtatat
      841 gtatatgtat atgtatatgt atatgtatat gtatatgtat atgtatatgt atatgtatat
      901 gtatatgtat atgtatatga tgtatatgta tatgtatatg tgtgtgtata tatatatata
      961 tatcctttgt aatgttcatg agaaggcaat gctgtcatac tctctctcat aaaatgggga
     1021 cctcttttac tgttgtttct tgggtgtgtt aagagtgttc ttacgtctga gcctgggctg
     1081 gcatataact tttatggttt tagaaagctg ctgtgtcatg cagaaaccta tgtagaacac
     1141 agttccttat ttagaatttc taaatgtgta agttctagaa ggatcaatgt gttctcatct
     1201 tataatttta gacatttgat gtcttcgtag tatggcataa tgtcatgact tactcaacaa
     1261 actgtatact atttattaat tattaactag tttattagta ttactatttg ggccactaac
     1321 tatatatttt agatagtata tattttagat aggtgaagaa ggtaagaagc aaggaaattc
     1381 cttacctagt tttcataaaa aacatttaaa agttatttct agggagagaa actttagcaa
     1441 atatctatac tcttagagtt ttgaaaacat acttaacatg tttgaatatg gattgctgag
     1501 atatttagat gtctgtagtg tgtcttttaa agagtgtgct ttgttataag gagattaatg
     1561 aattcatcac atccattatt ttaagcctgt acatcttata gtgtctcact tctttatatt
     1621 actcttttga ggaaaataaa gtagctctag attcca
//
