LOCUS       NM_203320               1018 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C-X-C motif chemokine ligand 3 (Cxcl3), mRNA.
ACCESSION   NM_203320 XM_284097
VERSION     NM_203320.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1018)
  AUTHORS   Fang,C., Zhong,R., Lu,S., Yu,G., Liu,Z., Yan,C., Gao,J., Tang,Y.,
            Wang,Y., Zhao,Q. and Feng,X.
  TITLE     TREM2 promotes macrophage polarization from M1 to M2 and suppresses
            osteoarthritis through the NF-kappaB/CXCL3 axis
  JOURNAL   Int J Biol Sci 20 (6), 1992-2007 (2024)
   PUBMED   38617547
  REMARK    GeneRIF: TREM2 promotes macrophage polarization from M1 to M2 and
            suppresses osteoarthritis through the NF-kappaB/CXCL3 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1018)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1018)
  AUTHORS   Yan,W., Chen,S., Wang,Y., You,Y., Lu,Y., Wang,W., Wu,B., Du,J.,
            Peng,S., Cai,W. and Xiao,Y.
  TITLE     Loss of Mptx2 alters bacteria composition and intestinal
            homeostasis potentially by impairing autophagy
  JOURNAL   Commun Biol 7 (1), 94 (2024)
   PUBMED   38218976
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1018)
  AUTHORS   He,X., Wang,L., Li,H., Liu,Y., Tong,C., Xie,C., Yan,X., Luo,D. and
            Xiong,X.
  TITLE     CSF2 upregulates CXCL3 expression in adipocytes to promote
            metastasis of breast cancer via the FAK signaling pathway
  JOURNAL   J Mol Cell Biol 15 (4) (2023)
   PUBMED   37073091
  REMARK    GeneRIF: CSF2 upregulates CXCL3 expression in adipocytes to promote
            metastasis of breast cancer via the FAK signaling pathway.
REFERENCE   5  (bases 1 to 1018)
  AUTHORS   Sokulsky,L.A., Garcia-Netto,K., Nguyen,T.H., Girkin,J.L.N.,
            Collison,A., Mattes,J., Kaiko,G., Liu,C., Bartlett,N.W., Yang,M.
            and Foster,P.S.
  TITLE     A Critical Role for the CXCL3/CXCL5/CXCR2 Neutrophilic Chemotactic
            Axis in the Regulation of Type 2 Responses in a Model of
            Rhinoviral-Induced Asthma Exacerbation
  JOURNAL   J Immunol 205 (9), 2468-2478 (2020)
   PUBMED   32948685
  REMARK    GeneRIF: A Critical Role for the CXCL3/CXCL5/CXCR2 Neutrophilic
            Chemotactic Axis in the Regulation of Type 2 Responses in a Model
            of Rhinoviral-Induced Asthma Exacerbation.
REFERENCE   6  (bases 1 to 1018)
  AUTHORS   Krausgruber,T., Schiering,C., Adelmann,K., Harrison,O.J.,
            Chomka,A., Pearson,C., Ahern,P.P., Shale,M., Oukka,M. and Powrie,F.
  TITLE     T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell
            responses in the intestine
  JOURNAL   Nat Commun 7, 11627 (2016)
   PUBMED   27193261
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1018)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1018)
  AUTHORS   Farioli-Vecchioli,S., Cina,I., Ceccarelli,M., Micheli,L.,
            Leonardi,L., Ciotti,M.T., De Bardi,M., Di Rocco,C., Pallini,R.,
            Cavallaro,S. and Tirone,F.
  TITLE     Tis21 knock-out enhances the frequency of medulloblastoma in
            Patched1 heterozygous mice by inhibiting the Cxcl3-dependent
            migration of cerebellar neurons
  JOURNAL   J Neurosci 32 (44), 15547-15564 (2012)
   PUBMED   23115191
  REMARK    GeneRIF: Tis21 induces migration of cerebellar granule neuron
            precursor cells through Cxcl3, which may represent a novel target
            for medulloblastoma therapy
REFERENCE   9  (bases 1 to 1018)
  AUTHORS   Zlotnik,A., Yoshie,O. and Nomiyama,H.
  TITLE     The chemokine and chemokine receptor superfamilies and their
            molecular evolution
  JOURNAL   Genome Biol 7 (12), 243 (2006)
   PUBMED   17201934
  REMARK    Review article
REFERENCE   10 (bases 1 to 1018)
  AUTHORS   Nolan,K.F., Strong,V., Soler,D., Fairchild,P.J., Cobbold,S.P.,
            Croxton,R., Gonzalo,J.A., Rubio,A., Wells,M. and Waldmann,H.
  TITLE     IL-10-conditioned dendritic cells, decommissioned for recruitment
            of adaptive immunity, elicit innate inflammatory gene products in
            response to danger signals
  JOURNAL   J Immunol 172 (4), 2201-2209 (2004)
   PUBMED   14764687
  REMARK    GeneRIF: DCIP-1 interacts with chemokine CXCR2 and mediates human
            neutrophil chemotaxis, consistent with its role during the early
            proinflammatory phase of dendritic cell maturation.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105995.9 and AK150314.1.
            
            On May 3, 2013 this sequence version replaced NM_203320.2.
            
            Summary: This gene encodes a protein that is a member of the CXC
            subfamily of chemokines. Chemokines, which recruit and activate
            leukocytes, are classified by function (inflammatory or
            homeostatic) or by structure. This secretory protein is proposed to
            bind the G-protein coupled receptor chemokine (C-X-C motif)
            receptor 2 to recruit neutrophils. [provided by RefSeq, May 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144158.1, AY311403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC105995.9         107927-107928
            3-958               AK150314.1         2-957
            959-1018            AC105995.9         109860-109919
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.78 cM"
     gene            1..1018
                     /gene="Cxcl3"
                     /gene_synonym="Dcip1; Gm1960"
                     /note="C-X-C motif chemokine ligand 3"
                     /db_xref="GeneID:330122"
                     /db_xref="MGI:MGI:3037818"
     exon            1..149
                     /gene="Cxcl3"
                     /gene_synonym="Dcip1; Gm1960"
                     /inference="alignment:Splign:2.1.0"
     exon            150..273
                     /gene="Cxcl3"
                     /gene_synonym="Dcip1; Gm1960"
                     /inference="alignment:Splign:2.1.0"
     exon            274..357
                     /gene="Cxcl3"
                     /gene_synonym="Dcip1; Gm1960"
                     /inference="alignment:Splign:2.1.0"
     exon            358..1018
                     /gene="Cxcl3"
                     /gene_synonym="Dcip1; Gm1960"
                     /inference="alignment:Splign:2.1.0"
     regulatory      999..1004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl3"
                     /gene_synonym="Dcip1; Gm1960"
                     /note="hexamer: AATAAA"
     polyA_site      1018
                     /gene="Cxcl3"
                     /gene_synonym="Dcip1; Gm1960"
                     /note="major polyA site"
ORIGIN      
        1 ccagatctca ccacagccct tcgcaccagc tcccgcgctc cagactccag ccacactcca
       61 gcctagcgcc atggcccctc ccacctgccg gctcctcagt gctgcactgg tcctgctgct
      121 gctgctggcc accaaccacc aggctacagg ggctgttgtg gccagtgagc tgcgctgtca
      181 gtgcctgaac accctaccaa gggttgattt tgagaccatc cagagcttga cggtgacgcc
      241 cccaggaccc cactgcaccc agacagaagt catagccact ctcaaggatg gtcaagaagt
      301 ttgcctcaac ccccaaggcc ccaggcttca gataatcatc aagaagatac tgaagagcgg
      361 caagtccagc tgagccggga aaggaggaag cccctcacca tgatgaagga cctgcattct
      421 aaatcagaga aaagcgatcc atcccaacgg tgtctggatg tgtctttacc tgcttgtttt
      481 taacaactcc tgagagttca tacctatttt atttcacatg taaaataact acgggtataa
      541 ttgcatctac ttgcaagatg gcatcttatt taatgtttat ttaatatcaa gtctaagttt
      601 aaccaagcct attcttaact tgaaggttag agattttcag attctgttag ggagttatat
      661 tgctatttct gaggcagtat tccttggctg gccattttgg tggcagctgt gatagtcaaa
      721 aaacagacaa acaaggtcat gccggtgtag gaagaatgca tgtgcacatc tagttttgta
      781 actatacaag attatcagtt gttatttatt gaaatggtct tacggtgtca catgaaatat
      841 caactttgtg ttaaagcttt aagaattata atgcattata tatttcttag acattttaag
      901 tgatttttta aaaataaggc acagtgacta tttaatgcct ttatgtctta gaatggagaa
      961 gtttaaatat ttattggtat ttttacaaat aatttgaaaa taaaatattt taaaataa
//
