LOCUS       NM_009140               1083 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus C-X-C motif chemokine ligand 2 (Cxcl2), mRNA.
ACCESSION   NM_009140
VERSION     NM_009140.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1083)
  AUTHORS   Huang,T., Guo,Y., Xie,W., Yin,J., Zhang,Y., Chen,W., Huang,D. and
            Li,P.
  TITLE     Brain border-derived CXCL2+ neutrophils drive NET formation and
            impair vascular reperfusion following ischemic stroke
  JOURNAL   CNS Neurosci Ther 30 (8), e14916 (2024)
   PUBMED   39135337
  REMARK    GeneRIF: Brain border-derived CXCL2[+] neutrophils drive NET
            formation and impair vascular reperfusion following ischemic
            stroke.
REFERENCE   2  (bases 1 to 1083)
  AUTHORS   Lin,W., Li,Q., Liu,L., Wang,Q., Zhang,D., Wang,F., Xu,R., Fan,Y.,
            Xing,M., Zhou,C. and Yuan,Q.
  TITLE     Early infiltrating NKT lymphocytes attenuate bone regeneration
            through secretion of CXCL2
  JOURNAL   Sci Adv 10 (20), eadl6343 (2024)
   PUBMED   38758783
  REMARK    GeneRIF: Early infiltrating NKT lymphocytes attenuate bone
            regeneration through secretion of CXCL2.
REFERENCE   3  (bases 1 to 1083)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1083)
  AUTHORS   Yan,W., Chen,S., Wang,Y., You,Y., Lu,Y., Wang,W., Wu,B., Du,J.,
            Peng,S., Cai,W. and Xiao,Y.
  TITLE     Loss of Mptx2 alters bacteria composition and intestinal
            homeostasis potentially by impairing autophagy
  JOURNAL   Commun Biol 7 (1), 94 (2024)
   PUBMED   38218976
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1083)
  AUTHORS   Coburn,P.S., Parrott,A.C., Miller,F.C., LaGrow,A.L., Mursalin,M.H.
            and Callegan,M.C.
  TITLE     The Role of C-X-C Chemokines in Staphylococcus aureus
            Endophthalmitis
  JOURNAL   Invest Ophthalmol Vis Sci 64 (3), 10 (2023)
   PUBMED   36867134
REFERENCE   6  (bases 1 to 1083)
  AUTHORS   Bozic,C.R., Gerard,N.P., von Uexkull-Guldenband,C., Kolakowski,L.F.
            Jr., Conklyn,M.J., Breslow,R., Showell,H.J. and Gerard,C.
  TITLE     The murine interleukin 8 type B receptor homologue and its ligands.
            Expression and biological characterization
  JOURNAL   J Biol Chem 269 (47), 29355-29358 (1994)
   PUBMED   7961909
REFERENCE   7  (bases 1 to 1083)
  AUTHORS   Widmer,U., Manogue,K.R., Cerami,A. and Sherry,B.
  TITLE     Genomic cloning and promoter analysis of macrophage inflammatory
            protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the
            chemokine superfamily of proinflammatory cytokines
  JOURNAL   J Immunol 150 (11), 4996-5012 (1993)
   PUBMED   8496601
REFERENCE   8  (bases 1 to 1083)
  AUTHORS   Heufler,C., Topar,G., Koch,F., Trockenbacher,B., Kampgen,E.,
            Romani,N. and Schuler,G.
  TITLE     Cytokine gene expression in murine epidermal cell suspensions:
            interleukin 1 beta and macrophage inflammatory protein 1 alpha are
            selectively expressed in Langerhans cells but are differentially
            regulated in culture
  JOURNAL   J Exp Med 176 (4), 1221-1226 (1992)
   PUBMED   1402664
REFERENCE   9  (bases 1 to 1083)
  AUTHORS   Tekamp-Olson,P., Gallegos,C., Bauer,D., McClain,J., Sherry,B.,
            Fabre,M., van Deventer,S. and Cerami,A.
  TITLE     Cloning and characterization of cDNAs for murine macrophage
            inflammatory protein 2 and its human homologues
  JOURNAL   J Exp Med 172 (3), 911-919 (1990)
   PUBMED   2201751
REFERENCE   10 (bases 1 to 1083)
  AUTHORS   Wolpe,S.D., Sherry,B., Juers,D., Davatelis,G., Yurt,R.W. and
            Cerami,A.
  TITLE     Identification and characterization of macrophage inflammatory
            protein 2
  JOURNAL   Proc Natl Acad Sci U S A 86 (2), 612-616 (1989)
   PUBMED   2643119
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC157938.9.
            
            On Nov 17, 2006 this sequence version replaced NM_009140.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X53798.1, AK155916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC157938.9         123306-123430
            126-249             AC157938.9         123523-123646
            250-333             AC157938.9         123764-123847
            334-1083            AC157938.9         124596-125345
FEATURES             Location/Qualifiers
     source          1..1083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.78 cM"
     gene            1..1083
                     /gene="Cxcl2"
                     /gene_synonym="CINC-2a; Gro2; GROb; Mgsa-b; MIP-2; MIP-2a;
                     Mip2; Scyb; Scyb2"
                     /note="C-X-C motif chemokine ligand 2"
                     /db_xref="GeneID:20310"
                     /db_xref="MGI:MGI:1340094"
     exon            1..125
                     /gene="Cxcl2"
                     /gene_synonym="CINC-2a; Gro2; GROb; Mgsa-b; MIP-2; MIP-2a;
                     Mip2; Scyb; Scyb2"
                     /inference="alignment:Splign:2.1.0"
     exon            126..249
                     /gene="Cxcl2"
                     /gene_synonym="CINC-2a; Gro2; GROb; Mgsa-b; MIP-2; MIP-2a;
                     Mip2; Scyb; Scyb2"
                     /inference="alignment:Splign:2.1.0"
     exon            250..333
                     /gene="Cxcl2"
                     /gene_synonym="CINC-2a; Gro2; GROb; Mgsa-b; MIP-2; MIP-2a;
                     Mip2; Scyb; Scyb2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..1083
                     /gene="Cxcl2"
                     /gene_synonym="CINC-2a; Gro2; GROb; Mgsa-b; MIP-2; MIP-2a;
                     Mip2; Scyb; Scyb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttcctcgg gcactccaga ctccagccac acttcagcct agcgccatgg cccctcccac
       61 ctgccggctc ctcagtgctg cactggtcct gctgctgctg ctggccacca accaccaggc
      121 tacaggggct gttgtggcca gtgaactgcg ctgtcaatgc ctgaagaccc tgccaagggt
      181 tgacttcaag aacatccaga gcttgagtgt gacgccccca ggaccccact gcgcccagac
      241 agaagtcata gccactctca agggcggtca aaaagtttgc cttgaccctg aagcccccct
      301 ggttcagaaa atcatccaaa agatactgaa caaaggcaag gctaactgac ctggaaagga
      361 ggagcctggg ctgctgtccc tcaacggaag aaccaaagag aaagaaaaaa acaaacagca
      421 cccgggaagc ctggatcgta cctgatgtgc ctcgctgtct gagagttcac ttatttattt
      481 atctatgtat ttatttattt attaattcca ttgcccagat gttgttatgt ttattttgat
      541 atttaaagat atgcattcgc taattcactg taatatctta aaaggtcatt ttaatatgtt
      601 aaagtttatt ttaataatgt ttaatgtgtt caattaaagt tatttaactt atatagttgg
      661 aaggtgataa atttttaaac ctatttattc attagtttct ggggagaggg tgagttggga
      721 actagctaca tcccacccac acagtgaaag agactgggga taaggggtgg gggtggggac
      781 aaatagatgc agtcggatgg ctttcatgga aggagtgtgc atgttcacat catttttttg
      841 taagcaccga ggagagtaga acagctgtta tttaggtttc agtgtttgta aactgtatgt
      901 acaacatttt tgatgctgga tttcaatgta atgttgtgag taacccttgg acattttatg
      961 tcttcctcgt aaggcacagt gccttgctta gcaattgttt tgtcatgcct tttcgtgtct
     1021 tgaagtggac acatttattt attcatgtat ttttacaaat aacaaaaaat aaaaacgtct
     1081 gtt
//
