LOCUS       NP_033166                100 aa            linear   ROD 24-SEP-2024
DEFINITION  C-X-C motif chemokine 2 precursor [Mus musculus].
ACCESSION   NP_033166
VERSION     NP_033166.1
DBSOURCE    REFSEQ: accession NM_009140.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 100)
  AUTHORS   Huang,T., Guo,Y., Xie,W., Yin,J., Zhang,Y., Chen,W., Huang,D. and
            Li,P.
  TITLE     Brain border-derived CXCL2+ neutrophils drive NET formation and
            impair vascular reperfusion following ischemic stroke
  JOURNAL   CNS Neurosci Ther 30 (8), e14916 (2024)
   PUBMED   39135337
  REMARK    GeneRIF: Brain border-derived CXCL2[+] neutrophils drive NET
            formation and impair vascular reperfusion following ischemic
            stroke.
REFERENCE   2  (residues 1 to 100)
  AUTHORS   Lin,W., Li,Q., Liu,L., Wang,Q., Zhang,D., Wang,F., Xu,R., Fan,Y.,
            Xing,M., Zhou,C. and Yuan,Q.
  TITLE     Early infiltrating NKT lymphocytes attenuate bone regeneration
            through secretion of CXCL2
  JOURNAL   Sci Adv 10 (20), eadl6343 (2024)
   PUBMED   38758783
  REMARK    GeneRIF: Early infiltrating NKT lymphocytes attenuate bone
            regeneration through secretion of CXCL2.
REFERENCE   3  (residues 1 to 100)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 100)
  AUTHORS   Yan,W., Chen,S., Wang,Y., You,Y., Lu,Y., Wang,W., Wu,B., Du,J.,
            Peng,S., Cai,W. and Xiao,Y.
  TITLE     Loss of Mptx2 alters bacteria composition and intestinal
            homeostasis potentially by impairing autophagy
  JOURNAL   Commun Biol 7 (1), 94 (2024)
   PUBMED   38218976
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 100)
  AUTHORS   Coburn,P.S., Parrott,A.C., Miller,F.C., LaGrow,A.L., Mursalin,M.H.
            and Callegan,M.C.
  TITLE     The Role of C-X-C Chemokines in Staphylococcus aureus
            Endophthalmitis
  JOURNAL   Invest Ophthalmol Vis Sci 64 (3), 10 (2023)
   PUBMED   36867134
REFERENCE   6  (residues 1 to 100)
  AUTHORS   Bozic,C.R., Gerard,N.P., von Uexkull-Guldenband,C., Kolakowski,L.F.
            Jr., Conklyn,M.J., Breslow,R., Showell,H.J. and Gerard,C.
  TITLE     The murine interleukin 8 type B receptor homologue and its ligands.
            Expression and biological characterization
  JOURNAL   J Biol Chem 269 (47), 29355-29358 (1994)
   PUBMED   7961909
REFERENCE   7  (residues 1 to 100)
  AUTHORS   Widmer,U., Manogue,K.R., Cerami,A. and Sherry,B.
  TITLE     Genomic cloning and promoter analysis of macrophage inflammatory
            protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the
            chemokine superfamily of proinflammatory cytokines
  JOURNAL   J Immunol 150 (11), 4996-5012 (1993)
   PUBMED   8496601
REFERENCE   8  (residues 1 to 100)
  AUTHORS   Heufler,C., Topar,G., Koch,F., Trockenbacher,B., Kampgen,E.,
            Romani,N. and Schuler,G.
  TITLE     Cytokine gene expression in murine epidermal cell suspensions:
            interleukin 1 beta and macrophage inflammatory protein 1 alpha are
            selectively expressed in Langerhans cells but are differentially
            regulated in culture
  JOURNAL   J Exp Med 176 (4), 1221-1226 (1992)
   PUBMED   1402664
REFERENCE   9  (residues 1 to 100)
  AUTHORS   Tekamp-Olson,P., Gallegos,C., Bauer,D., McClain,J., Sherry,B.,
            Fabre,M., van Deventer,S. and Cerami,A.
  TITLE     Cloning and characterization of cDNAs for murine macrophage
            inflammatory protein 2 and its human homologues
  JOURNAL   J Exp Med 172 (3), 911-919 (1990)
   PUBMED   2201751
REFERENCE   10 (residues 1 to 100)
  AUTHORS   Wolpe,S.D., Sherry,B., Juers,D., Davatelis,G., Yurt,R.W. and
            Cerami,A.
  TITLE     Identification and characterization of macrophage inflammatory
            protein 2
  JOURNAL   Proc Natl Acad Sci U S A 86 (2), 612-616 (1989)
   PUBMED   2643119
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC157938.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X53798.1, AK155916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..100
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.78 cM"
     Protein         1..100
                     /product="C-X-C motif chemokine 2 precursor"
                     /note="C-X-C motif chemokine 2; macrophage inflammatory
                     protein 2; small inducible cytokine subfamily, member 2;
                     chemokine (C-X-C motif) ligand 2"
                     /calculated_mol_wt=7849
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2789
     mat_peptide     28..100
                     /product="C-X-C motif chemokine 2. /id=PRO_0000005061"
                     /note="propagated from UniProtKB/Swiss-Prot (P10889.2)"
                     /calculated_mol_wt=7849
     Region          33..95
                     /region_name="Chemokine_CXC"
                     /note="1 of 4 subgroup designations based on the
                     arrangement of the two N-terminal cysteine residues;
                     includes a number of secreted growth factors and
                     interferons involved in mitogenic, chemotactic, and
                     inflammatory activity; many members contain an RCxC
                     motif...; cd00273"
                     /db_xref="CDD:238171"
     Site            order(33..35,41,45..50,59..61,71..72,75..77,83,88)
                     /site_type="active"
                     /note="receptor binding site [active]"
                     /db_xref="CDD:238171"
     Site            33..35
                     /site_type="active"
                     /note="ELR motif [active]"
                     /db_xref="CDD:238171"
     Site            order(34,37,50..51,54..56,66..69,71,75..76,79,86,90,
                     93..94)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:238171"
     Site            order(34,37,54,56,66,68,71,75..76)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238171"
     Site            order(35..36,38)
                     /site_type="active"
                     /note="RCXC motif [active]"
                     /db_xref="CDD:238171"
     Site            order(37..43,45..50)
                     /site_type="active"
                     /note="N-loop [active]"
                     /db_xref="CDD:238171"
     Site            order(39..40,42,45,49,68,71,75,77)
                     /site_type="active"
                     /note="receptor binding cleft [active]"
                     /db_xref="CDD:238171"
     Site            order(46,48,82,85,87..90,92,95)
                     /site_type="other"
                     /note="glycosaminoglycan (GAG) binding site [chemical
                     binding]"
                     /db_xref="CDD:238171"
     Site            order(48,51,70,72,75..76)
                     /site_type="other"
                     /note="putative glycosaminoglycan (GAG) binding site
                     [chemical binding]"
                     /db_xref="CDD:238171"
     Site            order(50..51,55,67,69,79,86,90,93..94)
                     /site_type="other"
                     /note="dimer interface (I form) [polypeptide binding]"
                     /db_xref="CDD:238171"
     Site            59..61
                     /site_type="other"
                     /note="30s-loop"
                     /db_xref="CDD:238171"
     Site            59..61
                     /site_type="other"
                     /note="GPH motif"
                     /db_xref="CDD:238171"
     Site            72..74
                     /site_type="other"
                     /note="40s-loop"
                     /db_xref="CDD:238171"
     CDS             1..100
                     /gene="Cxcl2"
                     /gene_synonym="CINC-2a; Gro2; GROb; Mgsa-b; MIP-2; MIP-2a;
                     Mip2; Scyb; Scyb2"
                     /coded_by="NM_009140.2:47..349"
                     /db_xref="CCDS:CCDS39144.1"
                     /db_xref="GeneID:20310"
                     /db_xref="MGI:MGI:1340094"
ORIGIN      
        1 mapptcrlls aalvllllla tnhqatgavv aselrcqclk tlprvdfkni qslsvtppgp
       61 hcaqteviat lkggqkvcld peaplvqkii qkilnkgkan
//
