LOCUS       NM_153576                760 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus C-X-C motif chemokine ligand 17 (Cxcl17), mRNA.
ACCESSION   NM_153576
VERSION     NM_153576.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 760)
  AUTHORS   Ocon,B., Xiang,M., Bi,Y., Tan,S., Brulois,K., Ayesha,A., Kunte,M.,
            Zhou,C., LaJevic,M., Lazarus,N., Mengoni,F., Sharma,T.,
            Montgomery,S., Hooper,J.E., Huang,M., Handel,T., Dawson,J.R.D.,
            Kufareva,I., Zabel,B.A., Pan,J. and Butcher,E.C.
  TITLE     A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae
            and CNS
  JOURNAL   Nature 635 (8039), 736-745 (2024)
   PUBMED   39293486
REFERENCE   2  (bases 1 to 760)
  AUTHORS   Silver,S.V., Tucker,K.J., Vickman,R.E., Lanman,N.A., Semmes,O.J.,
            Alvarez,N.S. and Popovics,P.
  TITLE     Characterization of prostate macrophage heterogeneity, foam cell
            markers, and CXCL17 upregulation in a mouse model of steroid
            hormone imbalance
  JOURNAL   Sci Rep 14 (1), 21029 (2024)
   PUBMED   39251671
  REMARK    GeneRIF: Characterization of prostate macrophage heterogeneity,
            foam cell markers, and CXCL17 upregulation in a mouse model of
            steroid hormone imbalance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 760)
  AUTHORS   Lowry,E., Chellappa,R.C., Penaranda,B., Sawant,K.V., Wakamiya,M.,
            Garofalo,R.P. and Rajarathnam,K.
  TITLE     CXCL17 is a proinflammatory chemokine and promotes neutrophil
            trafficking
  JOURNAL   J Leukoc Biol 115 (6), 1177-1182 (2024)
   PUBMED   38298146
  REMARK    GeneRIF: CXCL17 is a proinflammatory chemokine and promotes
            neutrophil trafficking.
REFERENCE   4  (bases 1 to 760)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 760)
  AUTHORS   Giblin,S.P. and Pease,J.E.
  TITLE     What defines a chemokine? - The curious case of CXCL17
  JOURNAL   Cytokine 168, 156224 (2023)
   PUBMED   37210967
  REMARK    GeneRIF: What defines a chemokine? - The curious case of CXCL17.
            Review article
REFERENCE   6  (bases 1 to 760)
  AUTHORS   Burkhardt,A.M., Maravillas-Montero,J.L., Carnevale,C.D.,
            Vilches-Cisneros,N., Flores,J.P., Hevezi,P.A. and Zlotnik,A.
  TITLE     CXCL17 is a major chemotactic factor for lung macrophages
  JOURNAL   J Immunol 193 (3), 1468-1474 (2014)
   PUBMED   24973458
  REMARK    GeneRIF: CXCL17 is a novel macrophage chemoattractant that operates
            in mucosal tissues as a major regulator of inflammatory responses.
REFERENCE   7  (bases 1 to 760)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 760)
  AUTHORS   Matsui,A., Yokoo,H., Negishi,Y., Endo-Takahashi,Y., Chun,N.A.,
            Kadouchi,I., Suzuki,R., Maruyama,K., Aramaki,Y., Semba,K.,
            Kobayashi,E., Takahashi,M. and Murakami,T.
  TITLE     CXCL17 expression by tumor cells recruits CD11b+Gr1 high F4/80-
            cells and promotes tumor progression
  JOURNAL   PLoS One 7 (8), e44080 (2012)
   PUBMED   22952881
  REMARK    GeneRIF: These results suggest that aberrant expression of CXCL17
            in tumor cells recruits immature myeloid-derived cells and promotes
            tumor progression through angiogenesis.
REFERENCE   9  (bases 1 to 760)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   10 (bases 1 to 760)
  AUTHORS   Weinstein,E.J., Head,R., Griggs,D.W., Sun,D., Evans,R.J.,
            Swearingen,M.L., Westlin,M.M. and Mazzarella,R.
  TITLE     VCC-1, a novel chemokine, promotes tumor growth
  JOURNAL   Biochem Biophys Res Commun 350 (1), 74-81 (2006)
   PUBMED   16989774
  REMARK    GeneRIF: VCC-1 plays a role in angiogenesis and possibly in the
            development of tumors in some tissue types[VCC-1]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY598463.1 and AC162443.3.
            
            On Mar 21, 2007 this sequence version replaced NM_153576.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024561.1, DV047460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AY598463.1         1-61
            62-546              AY598463.1         63-547
            547-760             AC162443.3         154207-154420
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.8 cM"
     gene            1..760
                     /gene="Cxcl17"
                     /gene_synonym="VCC-1; Vcc1"
                     /note="C-X-C motif chemokine ligand 17"
                     /db_xref="GeneID:232983"
                     /db_xref="MGI:MGI:2387642"
     exon            1..185
                     /gene="Cxcl17"
                     /gene_synonym="VCC-1; Vcc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..466
                     /gene="Cxcl17"
                     /gene_synonym="VCC-1; Vcc1"
                     /note="VEGF co-regulated chemokine 1; 13.6-kDa protein;
                     6-Cys CXCL17; C-X-C motif chemokine 17; VEGF coregulated
                     chemokine 1; chemokine (C-X-C motif) ligand 17"
                     /codon_start=1
                     /product="C-X-C motif chemokine 17 precursor"
                     /protein_id="NP_705804.2"
                     /db_xref="CCDS:CCDS80680.1"
                     /db_xref="GeneID:232983"
                     /db_xref="MGI:MGI:2387642"
                     /translation="MKLLASPFLLLLPVMLMSMVFSSPNPGVARSHGDQHLAPRRWLL
                     EGGQECECKDWFLQAPKRKATAVLGPPRKQCPCDHVKGREKKNRHQKHHRKSQRPSRA
                     CQQFLKRCHLASFALPL"
     exon            186..266
                     /gene="Cxcl17"
                     /gene_synonym="VCC-1; Vcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..368
                     /gene="Cxcl17"
                     /gene_synonym="VCC-1; Vcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..760
                     /gene="Cxcl17"
                     /gene_synonym="VCC-1; Vcc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      738..743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl17"
                     /gene_synonym="VCC-1; Vcc1"
                     /note="hexamer: ATTAAA"
     polyA_site      756
                     /gene="Cxcl17"
                     /gene_synonym="VCC-1; Vcc1"
                     /note="major polyA site"
ORIGIN      
        1 gtaggattaa attgtagaca ctactccacc tgagcagtta caagaaatca gaagcctcta
       61 actggtgaca atccacacag cctttaagaa ccaacagaca gccacaatga agcttctagc
      121 ctctcccttc cttctgttgc ttccagtgat gctcatgtcc atggtcttca gcagcccgaa
      181 cccaggggtc gccagaagcc acggggacca acacctggct cctaggaggt ggctcttgga
      241 aggtggccaa gaatgtgaat gcaaagattg gttcctgcaa gccccaaaga gaaaagccac
      301 agcagtgctg gggccaccaa ggaagcagtg tccctgtgat cacgtcaagg gcagggagaa
      361 aaaaaacaga caccaaaagc accacaggaa gtcgcaaaga ccctccagag cctgccagca
      421 atttctcaaa cgatgtcacc tggcaagctt tgcgctgccc ttatagtact gagactctgc
      481 tcctctagtt agactctctc agtggaaagg aggtgaccag ccctagcacg gttcttattc
      541 tccccacccc catcctcacc aagagcaccc cagtgctctc tgaaggcact gcctcacagt
      601 gtatctatga ctgtgcccct agtgccggct gcacttgcca ctcttgtctt atgccttctg
      661 tttaccctac aagaatgcag gacacctcgg cctcctgttg gcctcacatt gcaatcagaa
      721 aacttgcaat gaaaataatt aaatacatag tgcatacgtg
//
