LOCUS       NM_023158               1509 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus C-X-C motif chemokine ligand 16 (Cxcl16), transcript
            variant 1, mRNA.
ACCESSION   NM_023158
VERSION     NM_023158.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1509)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 1509)
  AUTHORS   Koya,J., Tanigawa,T., Mizuno,K., Kim,H., Ito,Y., Yuasa,M.,
            Yamaguchi,K., Kogure,Y., Saito,Y., Shingaki,S., Tabata,M.,
            Murakami,K., Chiba,K., Okada,A., Shiraishi,Y., Marouf,A.,
            Lievin,R., Chaubard,S., Jaccard,A., Hermine,O., de Leval,L.,
            Tournilhac,O., Damaj,G., Gaulard,P., Couronne,L., Yasui,T.,
            Nakashima,K., Miyoshi,H., Ohshima,K. and Kataoka,K.
  TITLE     Modeling NK-cell lymphoma in mice reveals its cell-of-origin and
            microenvironmental changes and identifies therapeutic targets
  JOURNAL   Nat Commun 15 (1), 9106 (2024)
   PUBMED   39438472
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1509)
  AUTHORS   Dingyi,L., Libin,H., Jifeng,P., Ding,Z., Yulong,L., Zhangyi,W.,
            Yunong,Y., Qinghua,W. and Feng,L.
  TITLE     Silencing CXCL16 alleviate neuroinflammation and M1 microglial
            polarization in mouse brain hemorrhage model and BV2 cell model
            through PI3K/AKT pathway
  JOURNAL   Exp Brain Res 242 (8), 1917-1932 (2024)
   PUBMED   38896294
  REMARK    GeneRIF: Silencing CXCL16 alleviate neuroinflammation and M1
            microglial polarization in mouse brain hemorrhage model and BV2
            cell model through PI3K/AKT pathway.
REFERENCE   4  (bases 1 to 1509)
  AUTHORS   Srivastava,N., Hu,H., Peterson,O.J., Vomund,A.N., Stremska,M.,
            Zaman,M., Giri,S., Li,T., Lichti,C.F., Zakharov,P.N., Zhang,B.,
            Abumrad,N.A., Chen,Y.G., Ravichandran,K.S., Unanue,E.R. and Wan,X.
  TITLE     CXCL16-dependent scavenging of oxidized lipids by islet macrophages
            promotes differentiation of pathogenic CD8+ T cells in diabetic
            autoimmunity
  JOURNAL   Immunity 57 (7), 1629-1647 (2024)
   PUBMED   38754432
  REMARK    GeneRIF: CXCL16-dependent scavenging of oxidized lipids by islet
            macrophages promotes differentiation of pathogenic CD8[+] T cells
            in diabetic autoimmunity.
REFERENCE   5  (bases 1 to 1509)
  AUTHORS   Cardarelli,S., Biglietto,M., Orsini,T., Fustaino,V., Monaco,L., de
            Oliveira do Rego,A.G., Liccardo,F., Masciarelli,S., Fazi,F.,
            Naro,F., De Angelis,L. and Pellegrini,M.
  TITLE     Modulation of cAMP/cGMP signaling as prevention of congenital heart
            defects in Pde2A deficient embryos: a matter of oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 169 (2024)
   PUBMED   38395995
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1509)
  AUTHORS   Gough,P.J., Garton,K.J., Wille,P.T., Rychlewski,M., Dempsey,P.J.
            and Raines,E.W.
  TITLE     A disintegrin and metalloproteinase 10-mediated cleavage and
            shedding regulates the cell surface expression of CXC chemokine
            ligand 16
  JOURNAL   J Immunol 172 (6), 3678-3685 (2004)
   PUBMED   15004171
REFERENCE   7  (bases 1 to 1509)
  AUTHORS   Yamauchi,R., Tanaka,M., Kume,N., Minami,M., Kawamoto,T., Togi,K.,
            Shimaoka,T., Takahashi,S., Yamaguchi,J., Nishina,T., Kitaichi,M.,
            Komeda,M., Manabe,T., Yonehara,S. and Kita,T.
  TITLE     Upregulation of SR-PSOX/CXCL16 and recruitment of CD8+ T cells in
            cardiac valves during inflammatory valvular heart disease
  JOURNAL   Arterioscler Thromb Vasc Biol 24 (2), 282-287 (2004)
   PUBMED   14699018
  REMARK    GeneRIF: SR-PSOX/CXCL16 may be involved in CD8+ T cell recruitment
            through VLA-4 activation and stimulation of IFN-[gamma] production
            by CD8+ T cells during inflammatory valvular heart disease.
REFERENCE   8  (bases 1 to 1509)
  AUTHORS   Shimaoka,T., Nakayama,T., Fukumoto,N., Kume,N., Takahashi,S.,
            Yamaguchi,J., Minami,M., Hayashida,K., Kita,T., Ohsumi,J.,
            Yoshie,O. and Yonehara,S.
  TITLE     Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm
            adhesion of CXC chemokine receptor 6-expressing cells
  JOURNAL   J Leukoc Biol 75 (2), 267-274 (2004)
   PUBMED   14634054
REFERENCE   9  (bases 1 to 1509)
  AUTHORS   Shimaoka,T., Kume,N., Minami,M., Hayashida,K., Kataoka,H., Kita,T.
            and Yonehara,S.
  TITLE     Molecular cloning of a novel scavenger receptor for oxidized low
            density lipoprotein, SR-PSOX, on macrophages
  JOURNAL   J Biol Chem 275 (52), 40663-40666 (2000)
   PUBMED   11060282
REFERENCE   10 (bases 1 to 1509)
  AUTHORS   Matloubian,M., David,A., Engel,S., Ryan,J.E. and Cyster,J.G.
  TITLE     A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo
  JOURNAL   Nat Immunol 1 (4), 298-304 (2000)
   PUBMED   11017100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028875.1 and BE956848.1.
            
            On Oct 6, 2017 this sequence version replaced NM_023158.6.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028875.1, AK152547.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1492              AK028875.1         3-1494
            1493-1509           BE956848.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     gene            1..1509
                     /gene="Cxcl16"
                     /gene_synonym="0910001K24Rik; b2b498Clo; CXCL16v1;
                     CXCL16v2; SR-PSOX; Zmynd15"
                     /note="C-X-C motif chemokine ligand 16"
                     /db_xref="GeneID:66102"
                     /db_xref="MGI:MGI:1932682"
     exon            1..607
                     /gene="Cxcl16"
                     /gene_synonym="0910001K24Rik; b2b498Clo; CXCL16v1;
                     CXCL16v2; SR-PSOX; Zmynd15"
                     /inference="alignment:Splign:2.1.0"
     CDS             538..1278
                     /gene="Cxcl16"
                     /gene_synonym="0910001K24Rik; b2b498Clo; CXCL16v1;
                     CXCL16v2; SR-PSOX; Zmynd15"
                     /note="C-X-C motif chemokine 16; zinc finger, MYND-type
                     containing 15; chemokine (C-X-C motif) ligand 16;
                     small-inducible cytokine B16; transmembrane chemokine
                     CXCL16; scavenger receptor for phosphatidylserine and
                     oxidized low density lipoprotein; SR-PSOX/CXCL16; Cxc
                     chemokine ligand 16"
                     /codon_start=1
                     /product="C-X-C motif chemokine 16 precursor"
                     /protein_id="NP_075647.3"
                     /db_xref="CCDS:CCDS24948.1"
                     /db_xref="GeneID:66102"
                     /db_xref="MGI:MGI:1932682"
                     /translation="MRRGFGPLSLAFFLFLLALLTLPGDGNQGSVAGSCSCDRTISSG
                     TQIPQGTLDHIRKYLKAFHRCPFFIRFQLQSKSVCGGSQDQWVRELVDCFERKECGTG
                     HGKSFHHQKHLPQASTQTPEAAEGTPSDTSTPAHSQSTQHSTLPSGALSLNKEHTQPW
                     EMTTLPSGYGLEARPEAEANEKQQDDRQQEAPGAGASTPAWVPVLSLLAIVFFLTAAM
                     AYVLCNRRATQQNSAGLQLWYTPVEPRP"
     exon            608..746
                     /gene="Cxcl16"
                     /gene_synonym="0910001K24Rik; b2b498Clo; CXCL16v1;
                     CXCL16v2; SR-PSOX; Zmynd15"
                     /inference="alignment:Splign:2.1.0"
     exon            747..829
                     /gene="Cxcl16"
                     /gene_synonym="0910001K24Rik; b2b498Clo; CXCL16v1;
                     CXCL16v2; SR-PSOX; Zmynd15"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1237
                     /gene="Cxcl16"
                     /gene_synonym="0910001K24Rik; b2b498Clo; CXCL16v1;
                     CXCL16v2; SR-PSOX; Zmynd15"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1493
                     /gene="Cxcl16"
                     /gene_synonym="0910001K24Rik; b2b498Clo; CXCL16v1;
                     CXCL16v2; SR-PSOX; Zmynd15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1474..1479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl16"
                     /gene_synonym="0910001K24Rik; b2b498Clo; CXCL16v1;
                     CXCL16v2; SR-PSOX; Zmynd15"
                     /note="hexamer: ATTAAA"
     polyA_site      1493
                     /gene="Cxcl16"
                     /gene_synonym="0910001K24Rik; b2b498Clo; CXCL16v1;
                     CXCL16v2; SR-PSOX; Zmynd15"
                     /note="major polyA site"
ORIGIN      
        1 catgtgactg gatcctactg agacccagcg gtccagggaa gtgaaagcat cttggagcca
       61 gaggaaggat ctagagggtc acccacttta caaaccagca gacagacaga tgacttctca
      121 agagggctga aatccccgaa cccaaccgag tcattcttcg ggaaccacag cttgctcact
      181 cggattcctc tggttctaca gcccaaattt tctttcggtt ttgtcggata gtcttggctg
      241 accctacggc tggccggccg gagactggag ctccgccttc ggggcagggg tgtgtgtgtc
      301 ccccgactgg gagctgggcg caaagcgggc tccccggtac cgaccagacg gtcggttccg
      361 gacagcgcgc gccgggggac agaaggcgcc accacctcgc gccccctccc ctcctgagct
      421 tggcacggat cagcgccttc gcaaaacatc agtcagggtg aagaagagaa agctttagag
      481 aattggctgg atgtcggcta ggtgacctcg tcccaacaag ctccgcagaa gccggagatg
      541 aggcggggct ttggaccctt gtctcttgcg ttcttccttt tcttgttggc gctgctgacc
      601 ctgccaggcg atggcaacca gggcagtgtc gctggaagtt gttcttgtga tcgtaccatt
      661 tcttctggca cccagatacc gcagggtact ttggatcaca tccgaaaata cctgaaagca
      721 tttcatcgtt gtccattctt tatcaggttc cagttgcagt ccaaaagcgt gtgtggggga
      781 agccaagacc agtgggtccg tgaactagtg gactgctttg agcgcaaaga gtgtggaact
      841 ggtcatggga agagttttca ccaccaaaaa catttgcctc aagccagtac ccagacccct
      901 gaggccgcag aggggacacc ttcggacacg agcacccctg cacatagtca gagcactcag
      961 cactccactc ttccatcagg agcactgtcc ttaaacaaag agcacaccca accctgggag
     1021 atgaccactc tcccttcagg ctatggtctg gaagctaggc ctgaggctga ggcaaatgag
     1081 aaacagcaag atgacagaca gcaagaagca ccaggagctg gagctagcac accagcttgg
     1141 gtaccggtgc tgtccctcct ggccattgtc ttcttcctca ctgcagccat ggcctatgtg
     1201 ctgtgcaaca ggagagcgac acagcagaac tctgcaggtt tgcagctctg gtacactcct
     1261 gttgaaccaa gaccctagcg cctacagcaa gagtggaagc tcatgagaga tggatgatga
     1321 catgggagag gtggtagggc agcaggctcg tctccatcag tgaatggaac ctgagctcac
     1381 tgtttctcat gctgtcttga gacaaagtat ccatatggaa cctaggttag ctttgacctg
     1441 ctgacccttt gcctctacct cctagattct gcgattaaag acatatgcta ccaaaaaaaa
     1501 aaaaaaaaa
//
