LOCUS       NM_011339               2127 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus C-X-C motif chemokine ligand 15 (Cxcl15), mRNA.
ACCESSION   NM_011339
VERSION     NM_011339.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2127)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2127)
  AUTHORS   Shao,Y., Lan,Y., Song,B., Sun,J. and Yang,T.
  TITLE     [CXCL8 generates an immunosuppressive microenvironment in
            colorectal cancer through induction of M2 macrophage infiltration
            and inhibition of CD8+ T cell infiltration]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 40 (10), 880-886 (2024)
   PUBMED   39442986
  REMARK    GeneRIF: [CXCL8 generates an immunosuppressive microenvironment in
            colorectal cancer through induction of M2 macrophage infiltration
            and inhibition of CD8[+] T cell infiltration].
REFERENCE   3  (bases 1 to 2127)
  AUTHORS   Wu,J., Zhang,Q., Wu,J., Yang,Z., Liu,X., Lou,C., Wang,X., Peng,J.,
            Zhang,J., Shang,Z., Xiao,J., Wang,N., Zhang,R., Zhou,J., Wang,Y.,
            Hu,Z., Zhang,R., Zhang,J. and Zeng,Z.
  TITLE     IL-8 from CD248-expressing cancer-associated fibroblasts generates
            cisplatin resistance in non-small cell lung cancer
  JOURNAL   J Cell Mol Med 28 (4), e18185 (2024)
   PUBMED   38396325
  REMARK    GeneRIF: IL-8 from CD248-expressing cancer-associated fibroblasts
            generates cisplatin resistance in non-small cell lung cancer.
REFERENCE   4  (bases 1 to 2127)
  AUTHORS   Cho,Y.E., Kim,Y., Kim,S.J., Lee,H. and Hwang,S.
  TITLE     Overexpression of Interleukin-8 Promotes the Progression of Fatty
            Liver to Nonalcoholic Steatohepatitis in Mice
  JOURNAL   Int J Mol Sci 24 (20), 15489 (2023)
   PUBMED   37895168
  REMARK    GeneRIF: Overexpression of Interleukin-8 Promotes the Progression
            of Fatty Liver to Nonalcoholic Steatohepatitis in Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2127)
  AUTHORS   Shu,Q., Zhang,N., Liu,Y., Wang,X., Chen,J., Xie,H., Pan,F.,
            Zhao,L., Ding,X., Wen,Y., Wang,L., Xie,W., Lu,J., Su,G., Peng,H.
            and Yang,P.
  TITLE     IL-8 Triggers Neutrophil Extracellular Trap Formation Through an
            Nicotinamide Adenine Dinucleotide Phosphate Oxidase- and
            Mitogen-Activated Protein Kinase Pathway-Dependent Mechanism in
            Uveitis
  JOURNAL   Invest Ophthalmol Vis Sci 64 (13), 19 (2023)
   PUBMED   37824136
  REMARK    GeneRIF: IL-8 Triggers Neutrophil Extracellular Trap Formation
            Through an Nicotinamide Adenine Dinucleotide Phosphate Oxidase- and
            Mitogen-Activated Protein Kinase Pathway-Dependent Mechanism in
            Uveitis.
REFERENCE   6  (bases 1 to 2127)
  AUTHORS   Zhiguang,X., Wei,C., Steven,R., Wei,D., Wei,Z., Rong,M., Zhanguo,L.
            and Lianfeng,Z.
  TITLE     Over-expression of IL-33 leads to spontaneous pulmonary
            inflammation in mIL-33 transgenic mice
  JOURNAL   Immunol Lett 131 (2), 159-165 (2010)
   PUBMED   20412815
REFERENCE   7  (bases 1 to 2127)
  CONSRTM   IUIS/WHO Subcommittee on Chemokine Nomenclature
  TITLE     Chemokine/chemokine receptor nomenclature
  JOURNAL   J Immunol Methods 262 (1-2), 1-3 (2002)
   PUBMED   12080938
REFERENCE   8  (bases 1 to 2127)
  AUTHORS   Chen,S.C., Mehrad,B., Deng,J.C., Vassileva,G., Manfra,D.J.,
            Cook,D.N., Wiekowski,M.T., Zlotnik,A., Standiford,T.J. and
            Lira,S.A.
  TITLE     Impaired pulmonary host defense in mice lacking expression of the
            CXC chemokine lungkine
  JOURNAL   J Immunol 166 (5), 3362-3368 (2001)
   PUBMED   11207292
REFERENCE   9  (bases 1 to 2127)
  AUTHORS   Ohneda,O., Ohneda,K., Nomiyama,H., Zheng,Z., Gold,S.A., Arai,F.,
            Miyamoto,T., Taillon,B.E., McIndoe,R.A., Shimkets,R.A., Lewin,D.A.,
            Suda,T. and Lasky,L.A.
  TITLE     WECHE: a novel hematopoietic regulatory factor
  JOURNAL   Immunity 12 (2), 141-150 (2000)
   PUBMED   10714680
REFERENCE   10 (bases 1 to 2127)
  AUTHORS   Rossi,D.L., Hurst,S.D., Xu,Y., Wang,W., Menon,S., Coffman,R.L. and
            Zlotnik,A.
  TITLE     Lungkine, a novel CXC chemokine, specifically expressed by lung
            bronchoepithelial cells
  JOURNAL   J Immunol 162 (9), 5490-5497 (1999)
   PUBMED   10228029
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142955.1.
            
            On Aug 29, 2006 this sequence version replaced NM_011339.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142955.1, BC061138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2127              AK142955.1         3-2129
FEATURES             Location/Qualifiers
     source          1..2127
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.78 cM"
     gene            1..2127
                     /gene="Cxcl15"
                     /gene_synonym="Il8; lungkine; Scyb15; weche"
                     /note="C-X-C motif chemokine ligand 15"
                     /db_xref="GeneID:20309"
                     /db_xref="MGI:MGI:1339941"
     exon            1..95
                     /gene="Cxcl15"
                     /gene_synonym="Il8; lungkine; Scyb15; weche"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..541
                     /gene="Cxcl15"
                     /gene_synonym="Il8; lungkine; Scyb15; weche"
                     /note="chemokine (C-X-C motif) ligand 15 (MGD|MGI:1339941
                     GB|BC061138, evidence: BLASTN, 100%, match=954); putative;
                     C-X-C motif chemokine 15; small-inducible cytokine B15;
                     small inducible cytokine subfamily B, member 15;
                     interleukin 8"
                     /codon_start=1
                     /product="C-X-C motif chemokine 15 precursor"
                     /protein_id="NP_035469.1"
                     /db_xref="CCDS:CCDS19418.1"
                     /db_xref="GeneID:20309"
                     /db_xref="MGI:MGI:1339941"
                     /translation="MAAQGWSMLLLAVLNLGIFVRPCDTQELRCLCIQEHSEFIPLKL
                     IKNIMVIFETIYCNRKEVIAVPKNGSMICLDPDAPWVKATVGPITNRFLPEDLKQKEF
                     PPAMKLLYSVEHEKPLYLSFGRPENKRIFPFPIRETSRHFADLAHNSDRNFLRDSSEV
                     SLTGSDA"
     exon            96..225
                     /gene="Cxcl15"
                     /gene_synonym="Il8; lungkine; Scyb15; weche"
                     /inference="alignment:Splign:2.1.0"
     exon            226..309
                     /gene="Cxcl15"
                     /gene_synonym="Il8; lungkine; Scyb15; weche"
                     /inference="alignment:Splign:2.1.0"
     exon            310..2127
                     /gene="Cxcl15"
                     /gene_synonym="Il8; lungkine; Scyb15; weche"
                     /inference="alignment:Splign:2.1.0"
     regulatory      940..945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl15"
                     /gene_synonym="Il8; lungkine; Scyb15; weche"
                     /note="hexamer: AATAAA"
     polyA_site      963
                     /gene="Cxcl15"
                     /gene_synonym="Il8; lungkine; Scyb15; weche"
                     /note="major polyA site"
     regulatory      1738..1743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl15"
                     /gene_synonym="Il8; lungkine; Scyb15; weche"
                     /note="hexamer: AATAAA"
     polyA_site      1758
                     /gene="Cxcl15"
                     /gene_synonym="Il8; lungkine; Scyb15; weche"
                     /note="major polyA site"
     regulatory      2104..2109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl15"
                     /gene_synonym="Il8; lungkine; Scyb15; weche"
                     /note="hexamer: AATAAA"
     polyA_site      2126
                     /gene="Cxcl15"
                     /gene_synonym="Il8; lungkine; Scyb15; weche"
ORIGIN      
        1 ttttaccatc cagaccagag tcaggccaca gacggacatg gctgctcaag gctggtccat
       61 gctcctgctg gctgtcctta acctaggcat cttcgtccgt ccctgtgaca ctcaagagct
      121 acgatgtctg tgtattcagg aacactctga attcattcct ctcaaactca ttaaaaatat
      181 aatggtgata ttcgagacca tttactgcaa cagaaaggaa gtgatagcag tcccaaaaaa
      241 tgggagtatg atttgtttgg atcctgatgc tccatgggtg aaggctactg ttggcccaat
      301 tactaacagg ttcctacctg aggacctcaa acaaaaggaa tttccaccgg caatgaagct
      361 tctgtatagt gttgagcatg aaaagcctct atatctttca tttgggagac ctgagaacaa
      421 gagaatattt ccctttccaa ttcgggagac ctctagacac tttgctgatt tagctcacaa
      481 cagtgatagg aattttctac gggactccag tgaagtcagc ttgacaggca gtgatgccta
      541 aaagccactc atgaggcaaa gagtttcaag gaagctctcc tcctggagtt ttggcgttct
      601 cattcttata ctctattccc gcgttagtct ggtgtatgga tctatgagct ctcttttaat
      661 attttattat aaatgtttta tttacttaac ttcctagtga atgttcacag gtgactgctc
      721 ccccatcccc atttcttgat attacatata atggcatcat ataccccttt attgactgac
      781 aaactactca gattgcttaa cattttgtgc ttcaaagtct tatcccactc cactatgggc
      841 tgttacagag tgcatctcgg tgtagagcaa ggctccttgt cttcagtgcc ccagggtgaa
      901 atacttcttt gaaaaatttt cattcatcag aaaatctgaa ataaaaatat gtcttaattg
      961 agactcagtg ggatatgcat gtaataccag cacttgggaa gttaacgcaa gaagatcatg
     1021 aattcaaggc tagcctggag tacatagtca gttacagact aacttgggct atagggacac
     1081 tgtgcttcaa acacacacac acacacacac acacacacac acacacacac acacacacac
     1141 acaccagtgg tggatgggta gatgaggtga tatcaattgt atagcataaa tattttaaaa
     1201 tttaaaatgt acttttcagg tttttagttt gcatttgtgt gtgtatgtgt gtctgtttgt
     1261 gtgtgtgaat atgtatgtgc aaaacttcag gtgtcagttc tcaattccca ccttgaggca
     1321 agatccctct gttgttttta caccaagaat gtcaggctag gtggccatga catctcaggg
     1381 agcctcctgt cactgtagga acactggggt tacagatata tttgcttttg gctttgcgtt
     1441 gattctggga actcaaacct tggtcttcct gcttgaatgg cttgaatact agtcatattt
     1501 ccaaaccaat cactttttag taaattttta attgagaaaa ccttgtagat aacatttgtc
     1561 aagattatag gcaaacgaaa atgtggatgg gaacaacgat aggaaatcaa ggctttccac
     1621 atttgaggac gataatcagg acaccgctgc agacaagtga ggtgcagaga gacagagata
     1681 ccgccacgtt ctgaccactt agcttcttcc tgacagaaat ttggcatata taacaccaat
     1741 aaatattaaa taaccaaaca tccactttct gcttgtcatt tcagatgaaa gagtgtgtta
     1801 caagatgaat gatattacct tggagccaag gcaagaacac tgtgtccaaa gaggactgtg
     1861 tgtaggcttt ctctagccaa ctcttttgtg tttgcctttt tctgtgaacc ggatgcctct
     1921 ccatttcctg cttagtcttt ctgctttgct gttctgcatg gacagtcatc cacccatttt
     1981 tagttttgaa agaggtgtta ctgatcatgt tgctttgttt gtacacattg gttcaactac
     2041 ctatagctca gagcctcttt ccccatggct caagtgaggc cgttctgtgg tctgtcattg
     2101 cagaataaag aaatagatta tagtgat
//
