LOCUS       NM_021704               1878 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus C-X-C motif chemokine ligand 12 (Cxcl12), transcript
            variant 1, mRNA.
ACCESSION   NM_021704
VERSION     NM_021704.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   Do,L.N.H., Delgado,E., Lim,C.G., Bkhache,M., Peluzzo,A.M., Hua,Y.,
            Oza,M., Mohsin,S., Chen,H., Autieri,M.V., Kim,S. and Liu,X.
  TITLE     A neuro-lymphatic communication guides lymphatic development by
            CXCL12 and CXCR4 signaling
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39470100
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Zhao,Y., Liang,W., Liu,Z., Chen,X. and Lin,C.
  TITLE     Impact of SDF-1 and AMD3100 on Hair Follicle Dynamics in a Chronic
            Stress Model
  JOURNAL   Biomolecules 14 (10), 1206 (2024)
   PUBMED   39456139
  REMARK    GeneRIF: Impact of SDF-1 and AMD3100 on Hair Follicle Dynamics in a
            Chronic Stress Model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Thierry,G.R., Baudon,E.M., Bijnen,M., Bellomo,A., Lagueyrie,M.,
            Mondor,I., Simonnet,L., Carrette,F., Fenouil,R., Keshvari,S.,
            Hume,D.A., Dombrowicz,D. and Bajenoff,M.
  TITLE     Non-classical monocytes scavenge the growth factor CSF1 from
            endothelial cells in the peripheral vascular tree to ensure
            survival and homeostasis
  JOURNAL   Immunity 57 (9), 2108-2121 (2024)
   PUBMED   39089257
REFERENCE   4  (bases 1 to 1878)
  AUTHORS   Grammer,C., Komorowska,J.A. and Swann,J.B.
  TITLE     Vhl safeguards thymic epithelial cell identity and thymopoietic
            capacity by constraining Hif1a activity during development
  JOURNAL   iScience 27 (7), 110258 (2024)
   PUBMED   39040069
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1878)
  AUTHORS   Karin,N.
  TITLE     The multiple faces of CXCL12 (SDF-1alpha) in the regulation of
            immunity during health and disease
  JOURNAL   J Leukoc Biol 88 (3), 463-473 (2010)
   PUBMED   20501749
  REMARK    Review article
REFERENCE   6  (bases 1 to 1878)
  AUTHORS   Shirozu,M., Nakano,T., Inazawa,J., Tashiro,K., Tada,H.,
            Shinohara,T. and Honjo,T.
  TITLE     Structure and chromosomal localization of the human stromal
            cell-derived factor 1 (SDF1) gene
  JOURNAL   Genomics 28 (3), 495-500 (1995)
   PUBMED   7490086
REFERENCE   7  (bases 1 to 1878)
  AUTHORS   Jiang,W., Zhou,P., Kahn,S.M., Tomita,N., Johnson,M.D. and
            Weinstein,I.B.
  TITLE     Molecular cloning of TPAR1, a gene whose expression is repressed by
            the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)
  JOURNAL   Exp Cell Res 215 (2), 284-293 (1994)
   PUBMED   7982471
REFERENCE   8  (bases 1 to 1878)
  AUTHORS   Nagasawa,T., Kikutani,H. and Kishimoto,T.
  TITLE     Molecular cloning and structure of a pre-B-cell growth-stimulating
            factor
  JOURNAL   Proc Natl Acad Sci U S A 91 (6), 2305-2309 (1994)
   PUBMED   8134392
REFERENCE   9  (bases 1 to 1878)
  AUTHORS   Tashiro,K., Tada,H., Heilker,R., Shirozu,M., Nakano,T. and Honjo,T.
  TITLE     Signal sequence trap: a cloning strategy for secreted proteins and
            type I membrane proteins
  JOURNAL   Science 261 (5121), 600-603 (1993)
   PUBMED   8342023
REFERENCE   10 (bases 1 to 1878)
  AUTHORS   Botey,J., Cozzo,M., Eseverri,J.L. and Marin,A.
  TITLE     Sulfites and skin pathology in children
  JOURNAL   Allergol Immunopathol (Madr) 15 (6), 365-367 (1987)
   PUBMED   3445877
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC155646.4 and AK045092.1.
            
            On Dec 8, 2009 this sequence version replaced NM_021704.2.
            
            Summary: This gene encodes a member of the alpha chemokine protein
            family. The encoded protein is secreted and functions as the ligand
            for the G-protein coupled receptor, chemokine (C-X-C motif)
            receptor 4. The encoded protein plays a role in many diverse
            cellular functions, including embryogenesis, immune surveillance,
            inflammation response, tissue homeostasis, and tumor growth and
            metastasis. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) differs in the 3' UTR and 3'
            coding region compared to variant 3. The resulting isoform (alpha)
            is shorter at the C-terminus, compared to isoform gamma.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D43804.1, BC029335.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC155646.4         113302-113343
            43-1878             AK045092.1         2-1837
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 54.81 cM"
     gene            1..1878
                     /gene="Cxcl12"
                     /gene_synonym="Pbsf; Scyb12; Sdf1; Tlsf; Tpar1"
                     /note="C-X-C motif chemokine ligand 12"
                     /db_xref="GeneID:20315"
                     /db_xref="MGI:MGI:103556"
     exon            1..182
                     /gene="Cxcl12"
                     /gene_synonym="Pbsf; Scyb12; Sdf1; Tlsf; Tpar1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..391
                     /gene="Cxcl12"
                     /gene_synonym="Pbsf; Scyb12; Sdf1; Tlsf; Tpar1"
                     /note="isoform alpha precursor is encoded by transcript
                     variant 1; pre-B-cell growth-stimulating factor; stromal
                     cell-derived factor 1; 12-O-tetradecanoylphorbol
                     13-acetate repressed protein 1; thymic lymphoma
                     cell-stimulating factor; chemokine (C-X-C motif) ligand
                     12"
                     /codon_start=1
                     /product="stromal cell-derived factor 1 isoform alpha
                     precursor"
                     /protein_id="NP_068350.1"
                     /db_xref="CCDS:CCDS39606.1"
                     /db_xref="GeneID:20315"
                     /db_xref="MGI:MGI:103556"
                     /translation="MDAKVVAVLALVLAALCISDGKPVSLSYRCPCRFFESHIARANV
                     KHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK"
     exon            183..300
                     /gene="Cxcl12"
                     /gene_synonym="Pbsf; Scyb12; Sdf1; Tlsf; Tpar1"
                     /inference="alignment:Splign:2.1.0"
     exon            301..1878
                     /gene="Cxcl12"
                     /gene_synonym="Pbsf; Scyb12; Sdf1; Tlsf; Tpar1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1795..1800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl12"
                     /gene_synonym="Pbsf; Scyb12; Sdf1; Tlsf; Tpar1"
                     /note="hexamer: AATAAA"
     polyA_site      1824
                     /gene="Cxcl12"
                     /gene_synonym="Pbsf; Scyb12; Sdf1; Tlsf; Tpar1"
                     /note="major polyA site"
     regulatory      1858..1863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl12"
                     /gene_synonym="Pbsf; Scyb12; Sdf1; Tlsf; Tpar1"
                     /note="hexamer: AATAAA"
     polyA_site      1878
                     /gene="Cxcl12"
                     /gene_synonym="Pbsf; Scyb12; Sdf1; Tlsf; Tpar1"
ORIGIN      
        1 ggttttcgcc tctaaagcgc ccagcgctcg cctcccgctg ccgcactttc actctcggtc
       61 cacctcggtg tcctcttgct gtccagctct gcagcctccg gcgcgccctc ccgcccacgc
      121 catggacgcc aaggtcgtcg ccgtgctggc cctggtgctg gccgcgctct gcatcagtga
      181 cggtaaacca gtcagcctga gctaccgatg cccctgccgg ttcttcgaga gccacatcgc
      241 cagagccaac gtcaagcatc tgaaaatcct caacactcca aactgtgccc ttcagattgt
      301 tgcacggctg aagaacaaca acagacaagt gtgcattgac ccgaaattaa agtggatcca
      361 agagtacctg gagaaagctt taaacaagta agcacaacag cccaaaggac tttccagtag
      421 acccccgagg aaggctgaca tccgtgggag atgcaagggc agtggtgggg aggagggcct
      481 gaaccctggc caggatggcc ggcgggacag cactgactgg ggtcatgcta aggtttgcca
      541 gcataaagac actccgccat agcatatggt acgatattgc agcttatatt catccctgcc
      601 ctcgcccgtg cacaatggag cttttataac tggggttttt ctaaggaatt gtattaccct
      661 aaccagttag cttcatcccc attctcctca tcctcatctt cattttaaaa agcagtgatt
      721 acttcaaggg ctgtattcag tttgctttgg agcttctctt tgccctgggg cctctgggca
      781 cagttataga cggtggcttt gcagggagcc ctagagagaa accttccacc agagcagagt
      841 ccgaggaacg ctgcagggct tgtcctgcag ggggcgctcc tcgacagatg ccttgtcctg
      901 agtcaacaca agatccggca gagggaggct cctttatcca gttcagtgcc agggtcggga
      961 agcttccttt agaagtgatc cctgaagctg tgctcagaga ccctttccta gccgttcctg
     1021 ctctctgctt gcctccaaac gcatgcttca tctgacttcc gcttctcacc tctgtagcct
     1081 gacggaccaa tgctgcaatg gaagggagga gagtgatgtg gggtgccccc tccctctctt
     1141 ccctttgctt tcctctcact tgggcccttt gtgagatttt tctttggcct cctgtagaat
     1201 ggagccagac catcctggat aatgtgagaa catgcctaga tttacccaca aaacacaagt
     1261 ctgagaatta atcataaacg gaagtttaaa tgaggatttg gactttggta attgtccctg
     1321 agtcctatat atttcaacag tggctctatg ggctctgatc gaatatcagt gatgaaaata
     1381 ataataataa taataataac gaataagcca gaatcttgcc atgaagccac agtggggatt
     1441 ctgggttcca atcagaaatg gagacaagat aaaacttgca tacattctta tgatcacaga
     1501 cggccctggt ggtttttggt aactatttac aaggcatttt tttacatata tttttgtgca
     1561 ctttttatgt ttctttggaa gacaaatgta tttcagaata tatttgtagt caattcatat
     1621 atttgaagtg gagccatagt aatgccagta gatatctcta tgatcttgag ctactggcaa
     1681 cttgtaaaga aatatatatg acatataaat gtattgtagc tttccggtgt cagccacggt
     1741 gtatttttcc acttggaatg aaattgtatc aactgtgaca ttatatgcac tagcaataaa
     1801 atgctaattg tttcatgctg taaacctcct accgtatgtg ggaatttatt tacctgaaat
     1861 aaaatctact agttgtta
//
