LOCUS       NM_021274               1120 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus C-X-C motif chemokine ligand 10 (Cxcl10), mRNA.
ACCESSION   NM_021274 XM_906256 XM_919730 XM_919737
VERSION     NM_021274.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1120)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1120)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1120)
  AUTHORS   Wang,Y., Du,J., Hu,Y. and Zhang,S.
  TITLE     CXCL10 impairs synaptic plasticity and was modulated by cGAS-STING
            pathway after stroke in mice
  JOURNAL   J Neurophysiol 132 (3), 722-732 (2024)
   PUBMED   38919986
  REMARK    GeneRIF: CXCL10 impairs synaptic plasticity and was modulated by
            cGAS-STING pathway after stroke in mice.
REFERENCE   4  (bases 1 to 1120)
  AUTHORS   Liu,F., Sun,X., Deng,S., Wu,Y., Liu,X., Wu,C., Huang,K., Li,Y.,
            Dong,Z., Xiao,W., Li,M., Chen,Z., Ju,Z., Xiao,J., Du,J. and Zeng,H.
  TITLE     Cxcl10 and Cxcr3 regulate self-renewal and differentiation of
            hematopoietic stem cells
  JOURNAL   Stem Cell Res Ther 15 (1), 248 (2024)
   PUBMED   39113086
  REMARK    GeneRIF: Cxcl10 and Cxcr3 regulate self-renewal and differentiation
            of hematopoietic stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1120)
  AUTHORS   Yang,J., Zhang,Y.N., Wang,R.X., Hao,C.Z., Qiu,Y., Chi,H.,
            Luan,W.S., Tang,H., Zhang,X.J., Sun,X., Sheps,J.A., Ling,V., Cao,M.
            and Wang,J.S.
  TITLE     ZFYVE19 deficiency: a ciliopathy involving failure of cell
            division, with cell death
  JOURNAL   J Med Genet 61 (8), 750-758 (2024)
   PUBMED   38816193
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1120)
  AUTHORS   Smith,J.B. and Herschman,H.R.
  TITLE     Glucocorticoid-attenuated response genes encode intercellular
            mediators, including a new C-X-C chemokine
  JOURNAL   J Biol Chem 270 (28), 16756-16765 (1995)
   PUBMED   7622488
REFERENCE   7  (bases 1 to 1120)
  AUTHORS   Gattass,C.R., King,L.B., Luster,A.D. and Ashwell,J.D.
  TITLE     Constitutive expression of interferon gamma-inducible protein 10 in
            lymphoid organs and inducible expression in T cells and thymocytes
  JOURNAL   J Exp Med 179 (4), 1373-1378 (1994)
   PUBMED   8145049
REFERENCE   8  (bases 1 to 1120)
  AUTHORS   Narumi,S., Wyner,L.M., Stoler,M.H., Tannenbaum,C.S. and
            Hamilton,T.A.
  TITLE     Tissue-specific expression of murine IP-10 mRNA following systemic
            treatment with interferon gamma
  JOURNAL   J Leukoc Biol 52 (1), 27-33 (1992)
   PUBMED   1640172
REFERENCE   9  (bases 1 to 1120)
  AUTHORS   Vanguri,P. and Farber,J.M.
  TITLE     Identification of CRG-2. An interferon-inducible mRNA predicted to
            encode a murine monokine
  JOURNAL   J Biol Chem 265 (25), 15049-15057 (1990)
   PUBMED   2118520
REFERENCE   10 (bases 1 to 1120)
  AUTHORS   Ohmori,Y. and Hamilton,T.A.
  TITLE     A macrophage LPS-inducible early gene encodes the murine homologue
            of IP-10
  JOURNAL   Biochem Biophys Res Commun 168 (3), 1261-1267 (1990)
   PUBMED   2189406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY165450.1 and BC030067.1.
            
            On Jan 12, 2012 this sequence version replaced NM_021274.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030067.1, AK146144.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BY165450.1         2-34
            34-1120             BC030067.1         1-1087
FEATURES             Location/Qualifiers
     source          1..1120
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 46.57 cM"
     gene            1..1120
                     /gene="Cxcl10"
                     /gene_synonym="C7; CRG-2; gIP-10; Ifi10; INP10; IP-10;
                     IP10; mob-1; Scyb10"
                     /note="C-X-C motif chemokine ligand 10"
                     /db_xref="GeneID:15945"
                     /db_xref="MGI:MGI:1352450"
     exon            1..136
                     /gene="Cxcl10"
                     /gene_synonym="C7; CRG-2; gIP-10; Ifi10; INP10; IP-10;
                     IP10; mob-1; Scyb10"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..372
                     /gene="Cxcl10"
                     /gene_synonym="C7; CRG-2; gIP-10; Ifi10; INP10; IP-10;
                     IP10; mob-1; Scyb10"
                     /note="C-X-C motif chemokine 10; gamma-IP10;
                     small-inducible cytokine B10; interferon-gamma induced
                     protein CRG-2; 10 kDa interferon gamma-induced protein;
                     small inducible cytokine B subfamily (Cys-X-Cys), member
                     10; chemokine (C-X-C motif) ligand 10; interferon
                     activated gene 10"
                     /codon_start=1
                     /product="C-X-C motif chemokine 10 precursor"
                     /protein_id="NP_067249.1"
                     /db_xref="CCDS:CCDS39153.1"
                     /db_xref="GeneID:15945"
                     /db_xref="MGI:MGI:1352450"
                     /translation="MNPSAAVIFCLILLGLSGTQGIPLARTVRCNCIHIDDGPVRMRA
                     IGKLEIIPASLSCPRVEIIATMKKNDEQRCLNPESKTIKNLMKAFSQKRSKRAP"
     exon            137..263
                     /gene="Cxcl10"
                     /gene_synonym="C7; CRG-2; gIP-10; Ifi10; INP10; IP-10;
                     IP10; mob-1; Scyb10"
                     /inference="alignment:Splign:2.1.0"
     exon            264..353
                     /gene="Cxcl10"
                     /gene_synonym="C7; CRG-2; gIP-10; Ifi10; INP10; IP-10;
                     IP10; mob-1; Scyb10"
                     /inference="alignment:Splign:2.1.0"
     exon            354..1101
                     /gene="Cxcl10"
                     /gene_synonym="C7; CRG-2; gIP-10; Ifi10; INP10; IP-10;
                     IP10; mob-1; Scyb10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1075..1080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl10"
                     /gene_synonym="C7; CRG-2; gIP-10; Ifi10; INP10; IP-10;
                     IP10; mob-1; Scyb10"
                     /note="hexamer: AATAAA"
     regulatory      1083..1088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl10"
                     /gene_synonym="C7; CRG-2; gIP-10; Ifi10; INP10; IP-10;
                     IP10; mob-1; Scyb10"
                     /note="hexamer: AATAAT"
     polyA_site      1096
                     /gene="Cxcl10"
                     /gene_synonym="C7; CRG-2; gIP-10; Ifi10; INP10; IP-10;
                     IP10; mob-1; Scyb10"
     polyA_site      1101
                     /gene="Cxcl10"
                     /gene_synonym="C7; CRG-2; gIP-10; Ifi10; INP10; IP-10;
                     IP10; mob-1; Scyb10"
                     /note="major polyA site"
ORIGIN      
        1 ggcactcgag aagcgcttca tccaccgctg agagacatcc cgagccaacc ttccggaagc
       61 ctccccatca gcaccatgaa cccaagtgct gccgtcattt tctgcctcat cctgctgggt
      121 ctgagtggga ctcaagggat ccctctcgca aggacggtcc gctgcaactg catccatatc
      181 gatgacgggc cagtgagaat gagggccata gggaagcttg aaatcatccc tgcgagccta
      241 tcctgcccac gtgttgagat cattgccacg atgaaaaaga atgatgagca gagatgtctg
      301 aatccggaat ctaagaccat caagaattta atgaaagcgt ttagccaaaa aaggtctaaa
      361 agggctcctt aactggagtg aagccacgca cacaccccgg tgctgcgatg gatggacagc
      421 agagagcctc tctccatcac tcccctttac ccagtggatg gctagtccta attgcccttg
      481 gtcttctgaa aggtgaccag ccgtggtcac atcagctgct actcctcctg caggatgatg
      541 gtcaagccat ggtcctgaga caaaagtaac tgccgaagca agaattcttt aagggctggt
      601 ctgagtcctc gctcaagtgg ctgggatggc tgtcctagct ctgtactgta agctatgtgg
      661 aggtgcgacg cccttcacca tgtgccatgc ccaggctgct ccccacaccc tccttgtcct
      721 ccctagctca ggctcgtcag ttctaagttt acctgagctc ttttatttca gatgtaagac
      781 tacaaattta agtttgtaag gacgaactta accaccatct tcccaagggg ttatcaagat
      841 actcagagga acctgaaaat gtatgtgtaa atactattta atgaacgact gtacaaagta
      901 gaattcctaa tgtatttttt gtatgctttg cattgtatat ggaagaactt gtgtcatcaa
      961 gtatgtatca atgggtagtt aaagtttatt tttaaaaccg tccaatacct tttgtattat
     1021 gtaacattca aaagacaatg tactgtattg aaagtagtaa gagacccaaa atgtaataaa
     1081 gtaataataa ctgacatgaa aaaaaaaaaa aaaaaaaaaa
//
