LOCUS       NM_008176                964 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus C-X-C motif chemokine ligand 1 (Cxcl1), mRNA.
ACCESSION   NM_008176
VERSION     NM_008176.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 964)
  AUTHORS   Ross,J.L., Puigdelloses-Vallcorba,M., Pinero,G., Soni,N.,
            Thomason,W., DeSisto,J., Angione,A., Tsankova,N.M., Castro,M.G.,
            Schniederjan,M., Wadhwani,N.R., Raju,G.P., Morgenstern,P.,
            Becher,O.J., Green,A.L., Tsankov,A.M. and Hambardzumyan,D.
  TITLE     Microglia and monocyte-derived macrophages drive progression of
            pediatric high-grade gliomas and are transcriptionally shaped by
            histone mutations
  JOURNAL   Immunity 57 (11), 2669-2687 (2024)
   PUBMED   39395421
REFERENCE   2  (bases 1 to 964)
  AUTHORS   Yang,J., Zhang,Y.N., Wang,R.X., Hao,C.Z., Qiu,Y., Chi,H.,
            Luan,W.S., Tang,H., Zhang,X.J., Sun,X., Sheps,J.A., Ling,V., Cao,M.
            and Wang,J.S.
  TITLE     ZFYVE19 deficiency: a ciliopathy involving failure of cell
            division, with cell death
  JOURNAL   J Med Genet 61 (8), 750-758 (2024)
   PUBMED   38816193
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 964)
  AUTHORS   Batra,S., Cai,S., Balamayooran,G. and Jeyaseelan,S.
  TITLE     Intrapulmonary administration of leukotriene B(4) augments
            neutrophil accumulation and responses in the lung to Klebsiella
            infection in CXCL1 knockout mice
  JOURNAL   J Immunol 188 (7), 3458-3468 (2012)
   PUBMED   22379035
  REMARK    GeneRIF: CXCL1 controls neutrophil recruitment and regulates the
            expression of NADPH oxidase, iNOS & LTB4 in the lungs after K.
            pneumoniae infection.
REFERENCE   4  (bases 1 to 964)
  AUTHORS   King,A.G., Johanson,K., Frey,C.L., DeMarsh,P.L., White,J.R.,
            McDevitt,P., McNulty,D., Balcarek,J., Jonak,Z.L., Bhatnagar,P.K.
            and Pelus,L.M.
  TITLE     Identification of unique truncated KC/GRO beta chemokines with
            potent hematopoietic and anti-infective activities
  JOURNAL   J Immunol 164 (7), 3774-3782 (2000)
   PUBMED   10725737
REFERENCE   5  (bases 1 to 964)
  AUTHORS   Bozic,C.R., Kolakowski,L.F. Jr., Gerard,N.P., Garcia-Rodriguez,C.,
            von Uexkull-Guldenband,C., Conklyn,M.J., Breslow,R., Showell,H.J.
            and Gerard,C.
  TITLE     Expression and biologic characterization of the murine chemokine KC
  JOURNAL   J Immunol 154 (11), 6048-6057 (1995)
   PUBMED   7751647
REFERENCE   6  (bases 1 to 964)
  AUTHORS   Bozic,C.R., Gerard,N.P., von Uexkull-Guldenband,C., Kolakowski,L.F.
            Jr., Conklyn,M.J., Breslow,R., Showell,H.J. and Gerard,C.
  TITLE     The murine interleukin 8 type B receptor homologue and its ligands.
            Expression and biological characterization
  JOURNAL   J Biol Chem 269 (47), 29355-29358 (1994)
   PUBMED   7961909
REFERENCE   7  (bases 1 to 964)
  AUTHORS   Altherr,M.R., Wasmuth,J.J., Seldin,M.F., Nadeau,J.H., Baehr,W. and
            Pittler,S.J.
  TITLE     Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase
            beta-subunit gene in mouse and human: tight linkage to the
            Huntington disease region (4p16.3)
  JOURNAL   Genomics 12 (4), 750-754 (1992)
   PUBMED   1315306
REFERENCE   8  (bases 1 to 964)
  AUTHORS   Pittler,S.J., Lee,A.K., Altherr,M.R., Howard,T.A., Seldin,M.F.,
            Hurwitz,R.L., Wasmuth,J.J. and Baehr,W.
  TITLE     Primary structure and chromosomal localization of human and mouse
            rod photoreceptor cGMP-gated cation channel
  JOURNAL   J Biol Chem 267 (9), 6257-6262 (1992)
   PUBMED   1372902
REFERENCE   9  (bases 1 to 964)
  AUTHORS   Oquendo,P., Alberta,J., Wen,D.Z., Graycar,J.L., Derynck,R. and
            Stiles,C.D.
  TITLE     The platelet-derived growth factor-inducible KC gene encodes a
            secretory protein related to platelet alpha-granule proteins
  JOURNAL   J Biol Chem 264 (7), 4133-4137 (1989)
   PUBMED   2917992
REFERENCE   10 (bases 1 to 964)
  AUTHORS   Ryseck,R.P., MacDonald-Bravo,H., Mattei,M.G. and Bravo,R.
  TITLE     Cloning and sequence of a secretory protein induced by growth
            factors in mouse fibroblasts
  JOURNAL   Exp Cell Res 180 (1), 266-275 (1989)
   PUBMED   2909392
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY335927.1 and BQ031102.1.
            
            On May 7, 2009 this sequence version replaced NM_008176.2.
            
            Summary: This gene encodes a protein that is a member of the CXC
            subfamily of chemokines. Chemokines, which recruit and activate
            leukocytes, are classified by function (inflammatory or
            homeostatic) or by structure. This secretory protein is proposed to
            bind the G-protein coupled receptor chemokine (C-X-C motif)
            receptor 2 to recruit neutrophils. In mouse, deficiency of this
            gene is associated with colitis and with defects in immune cell
            recruitment to the lung. [provided by RefSeq, Apr 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037997.1, J04596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               BY335927.1         8-328
            322-964             BQ031102.1         1-643               c
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.78 cM"
     gene            1..964
                     /gene="Cxcl1"
                     /gene_synonym="Fsp; gro; Gro1; KC; Mgsa; N51; Scyb1"
                     /note="C-X-C motif chemokine ligand 1"
                     /db_xref="GeneID:14825"
                     /db_xref="MGI:MGI:108068"
     exon            1..136
                     /gene="Cxcl1"
                     /gene_synonym="Fsp; gro; Gro1; KC; Mgsa; N51; Scyb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..357
                     /gene="Cxcl1"
                     /gene_synonym="Fsp; gro; Gro1; KC; Mgsa; N51; Scyb1"
                     /note="growth-regulated alpha protein; secretory protein
                     N51; C-X-C motif chemokine 1; platelet-derived growth
                     factor-inducible protein KC; GRO1 oncogene; KC/GRO-alpha;
                     KC/GR)-alpha; alpha-chemokine; chemokine (C-X-C motif)
                     ligand 1"
                     /codon_start=1
                     /product="growth-regulated alpha protein precursor"
                     /protein_id="NP_032202.1"
                     /db_xref="CCDS:CCDS39143.1"
                     /db_xref="GeneID:14825"
                     /db_xref="MGI:MGI:108068"
                     /translation="MIPATRSLLCAALLLLATSRLATGAPIANELRCQCLQTMAGIHL
                     KNIQSLKVLPSGPHCTQTEVIATLKNGREACLDPEAPLVQKIVQKMLKGVPK"
     exon            137..260
                     /gene="Cxcl1"
                     /gene_synonym="Fsp; gro; Gro1; KC; Mgsa; N51; Scyb1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..341
                     /gene="Cxcl1"
                     /gene_synonym="Fsp; gro; Gro1; KC; Mgsa; N51; Scyb1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..955
                     /gene="Cxcl1"
                     /gene_synonym="Fsp; gro; Gro1; KC; Mgsa; N51; Scyb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      927..932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxcl1"
                     /gene_synonym="Fsp; gro; Gro1; KC; Mgsa; N51; Scyb1"
                     /note="hexamer: AGTAAA"
     polyA_site      939
                     /gene="Cxcl1"
                     /gene_synonym="Fsp; gro; Gro1; KC; Mgsa; N51; Scyb1"
                     /note="major polyA site"
ORIGIN      
        1 aacaggactc agagcctcta accagttcca gcactccaga ctccagccac actccaacac
       61 agcaccatga tcccagccac ccgctcgctt ctctgtgcag cgctgctgct gctggccacc
      121 agccgcctgg ccacaggggc gcctatcgcc aatgagctgc gctgtcagtg cctgcagacc
      181 atggctggga ttcacctcaa gaacatccag agcttgaagg tgttgccctc agggccccac
      241 tgcacccaaa ccgaagtcat agccacactc aagaatggtc gcgaggcttg ccttgaccct
      301 gaagctccct tggttcagaa aattgtccaa aagatgctaa aaggtgtccc caagtaacgg
      361 agaaagaaga cagactgctc tgatggcacc tgtctggtga acgctggctt ctgacaacac
      421 tatacaattt cttttgaggg tcctatttat ttatgtattt atttattcca caaagtgtgt
      481 ggtttttatt ttacattaat atttaacagt gtggatacat ttcatcgatg gtagttcagt
      541 tctgcttgtt cagtttaaag atgggtaggc ttaaaatatt tcattaaact aatatttatt
      601 gggagaccac taagtgtcaa ccactgtgct agtagaaggg tgttgtgcga aaagaagtgc
      661 agagagatag agtttagtat tatgttttgt atgtattagg gtgaggacat gtgtgggagg
      721 ctgtgtttgt atgtcttgaa aagaatgtca gttatttatt gaaagtcgtc tttcatattg
      781 tatggtcaac acgcacgtgt tgacgcttcc cttggacatt ttgtgtctag ttggtagggc
      841 ataatgccct tttacattct ttaaccctgt ttctcctggt ctcgtctcgc tcgggacaga
      901 gacgttcaaa ggactgttac aaatgaagta aaaataaaag ttttattaaa aaaaaaaaaa
      961 aaaa
//
