LOCUS       NM_001025192            5566 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus coxsackie virus and adenovirus receptor (Cxadr),
            transcript variant 1, mRNA.
ACCESSION   NM_001025192
VERSION     NM_001025192.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5566)
  AUTHORS   Kim,H.G., Park,J.H., Shin,H.H., Kim,S.H., Jeon,H.E., Shin,J.H.,
            Won,Y.S., Kwon,H.J., Jeon,E.S. and Lim,B.K.
  TITLE     Liver-specific Coxsackievirus and adenovirus receptor deletion
            develop metabolic dysfunction-associated fatty liver disease
  JOURNAL   Sci Rep 14 (1), 21642 (2024)
   PUBMED   39285218
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5566)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5566)
  AUTHORS   Pelz,L., Dossou,L., Kompier,N., Juttner,R., Siemonsmeier,G.,
            Meyer,N., Lowenstein,E.D., Lahmann,I., Kettenmann,H., Birchmeier,C.
            and Rathjen,F.G.
  TITLE     The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated
            astrocyte-astrocyte coupling in mice
  JOURNAL   eNeuro 11 (3) (2024) In press
   PUBMED   38388443
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 5566)
  AUTHORS   Pazirandeh,A., Sultana,T., Mirza,M., Rozell,B., Hultenby,K.,
            Wallis,K., Vennstrom,B., Davis,B., Arner,A., Heuchel,R., Lohr,M.,
            Philipson,L. and Sollerbrant,K.
  TITLE     Multiple phenotypes in adult mice following inactivation of the
            Coxsackievirus and Adenovirus Receptor (Car) gene
  JOURNAL   PLoS One 6 (6), e20203 (2011)
   PUBMED   21674029
  REMARK    GeneRIF: CAR exerts important functions in the physiology of
            several organs in vivo
REFERENCE   5  (bases 1 to 5566)
  AUTHORS   Chen,J.W., Ghosh,R., Finberg,R.W. and Bergelson,J.M.
  TITLE     Structure and chromosomal localization of the murine coxsackievirus
            and adenovirus receptor gene
  JOURNAL   DNA Cell Biol 22 (4), 253-259 (2003)
   PUBMED   12823902
  REMARK    GeneRIF: The mCAR gene is situated on the distal portion of murine
            chromosome 16, and is composed of at least eight exons, with
            intron-exon boundaries similar to those reported for the human CAR
            gene
REFERENCE   6  (bases 1 to 5566)
  AUTHORS   Honda,T., Saitoh,H., Masuko,M., Katagiri-Abe,T., Tominaga,K.,
            Kozakai,I., Kobayashi,K., Kumanishi,T., Watanabe,Y.G., Odani,S. and
            Kuwano,R.
  TITLE     The coxsackievirus-adenovirus receptor protein as a cell adhesion
            molecule in the developing mouse brain
  JOURNAL   Brain Res Mol Brain Res 77 (1), 19-28 (2000)
   PUBMED   10814828
REFERENCE   7  (bases 1 to 5566)
  AUTHORS   Tomko,R.P., Johansson,C.B., Totrov,M., Abagyan,R., Frisen,J. and
            Philipson,L.
  TITLE     Expression of the adenovirus receptor and its interaction with the
            fiber knob
  JOURNAL   Exp Cell Res 255 (1), 47-55 (2000)
   PUBMED   10666333
REFERENCE   8  (bases 1 to 5566)
  AUTHORS   Bergelson,J.M., Krithivas,A., Celi,L., Droguett,G., Horwitz,M.S.,
            Wickham,T., Crowell,R.L. and Finberg,R.W.
  TITLE     The murine CAR homolog is a receptor for coxsackie B viruses and
            adenoviruses
  JOURNAL   J Virol 72 (1), 415-419 (1998)
   PUBMED   9420240
REFERENCE   9  (bases 1 to 5566)
  AUTHORS   Tomko,R.P., Xu,R. and Philipson,L.
  TITLE     HCAR and MCAR: the human and mouse cellular receptors for subgroup
            C adenoviruses and group B coxsackieviruses
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3352-3356 (1997)
   PUBMED   9096397
REFERENCE   10 (bases 1 to 5566)
  AUTHORS   Bergelson,J.M., Cunningham,J.A., Droguett,G., Kurt-Jones,E.A.,
            Krithivas,A., Hong,J.S., Horwitz,M.S., Crowell,R.L. and
            Finberg,R.W.
  TITLE     Isolation of a common receptor for Coxsackie B viruses and
            adenoviruses 2 and 5
  JOURNAL   Science 275 (5304), 1320-1323 (1997)
   PUBMED   9036860
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC130844.3, AK145569.1 and
            AK141274.1.
            
            On Jan 18, 2013 this sequence version replaced NM_001025192.2.
            
            Summary: This gene encodes a protein that is part of the Cortical
            Thymocyte marker in Xenopus (CTX) subfamily within the
            immunoglobulin superfamily. Members of this subfamily,
            predominantly expressed on the surface of endothelial and
            epithelial cells, help establish cell polarity and provide a
            barrier function, regulating migration of immune cells. This
            protein, first identified as the receptor for adenovirus subgroup C
            and coxsakieviruses group B, is developmentally regulated and plays
            an important role in cardiac development. Alternative splicing
            results in multiple transcript variants that encode different
            protein isoforms. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145569.1, AK004908.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC130844.3         76026-76100
            76-2812             AK145569.1         2-2738
            2813-3504           AK145569.1         2741-3432
            3505-5558           AK141274.1         395-2448
            5559-5566           AC130844.3         115107-115114
FEATURES             Location/Qualifiers
     source          1..5566
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 45.28 cM"
     gene            1..5566
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /note="coxsackie virus and adenovirus receptor"
                     /db_xref="GeneID:13052"
                     /db_xref="MGI:MGI:1201679"
     exon            1..204
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1259
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; coxsackievirus and adenovirus receptor homolog"
                     /codon_start=1
                     /product="coxsackievirus and adenovirus receptor homolog
                     isoform a precursor"
                     /protein_id="NP_001020363.1"
                     /db_xref="CCDS:CCDS28276.1"
                     /db_xref="GeneID:13052"
                     /db_xref="MGI:MGI:1201679"
                     /translation="MARLLCFVLLCGIADFTSGLSITTPEQRIEKAKGETAYLPCKFT
                     LSPEDQGPLDIEWLISPSDNQIVDQVIILYSGDKIYDNYYPDLKGRVHFTSNDVKSGD
                     ASINVTNLQLSDIGTYQCKVKKAPGVANKKFLLTVLVKPSGTRCFVDGSEEIGNDFKL
                     KCEPKEGSLPLQFEWQKLSDSQTMPTPWLAEMTSPVISVKNASSEYSGTYSCTVQNRV
                     GSDQCMLRLDVVPPSNRAGTIAGAVIGTLLALVLIGAILFCCHRKRREEKYEKEVHHD
                     IREDVPPPKSRTSTARSYIGSNHSSLGSMSPSNMEGYSKTQYNQVPSEDFERAPQSPT
                     LAPAKVAAPNLSRMGAVPVMIPAQSKDGSIV"
     exon            205..371
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /inference="alignment:Splign:2.1.0"
     exon            372..576
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /inference="alignment:Splign:2.1.0"
     exon            577..732
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /inference="alignment:Splign:2.1.0"
     exon            733..855
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /inference="alignment:Splign:2.1.0"
     exon            856..994
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /inference="alignment:Splign:2.1.0"
     exon            995..5566
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4965..4970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /note="hexamer: AATAAA"
     polyA_site      4992
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
     regulatory      5542..5547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /note="hexamer: AATAAA"
     polyA_site      5559
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /note="major polyA site"
ORIGIN      
        1 ccggaagtga cgcgttcacc tgccgagctg gggcggggcg cagaggtgcc ttcgctgctg
       61 ccaccgccgg gagccagtcg ggagtgtacc aggctctggg aaaaccaggg ctcccagccg
      121 agatcgttta cctgcaagcc acgacccggc cggcagctac catggcgcgc ctactgtgct
      181 tcgtgctctt gtgcgggatc gcggatttca ccagtggttt gagcatcact acacccgaac
      241 agaggatcga aaaagccaaa ggggaaactg cgtatctacc atgcaagttt actctcagtc
      301 ccgaagacca gggaccactg gacattgaat ggctgatatc cccgtctgat aaccagatag
      361 tggatcaagt gatcattttg tattctggag acaaaattta tgataactac tatccggatc
      421 tgaaaggacg ggtacatttt acgagtaacg atgtcaagtc tggcgacgca tctataaatg
      481 tgaccaacct gcagctgtcg gacattggca cttaccagtg caaagtgaag aaagcccctg
      541 gggttgcaaa taagaaattc ctgctgaccg ttcttgttaa gccttcaggt acaagatgct
      601 tcgtggatgg atcggaagag attggaaatg acttcaagct aaaatgtgaa cccaaggaag
      661 gctcccttcc actacagttt gaatggcaga aactgtcgga ctcccagaca atgcctacgc
      721 catggctggc agaaatgacg tcaccagtta tatctgtgaa gaacgccagt tctgagtatt
      781 ctgggacata cagctgcacg gttcaaaaca gagtgggctc tgaccagtgt atgctgcgac
      841 tagacgttgt cccaccctcc aaccgagccg gaacgatcgc gggcgccgtc atagggacgc
      901 tgctggccct tgtgctcatc ggggccatcc tcttctgctg tcacaggaaa cgcagagaag
      961 agaagtacga gaaggaagtt catcatgata tcagggaaga tgtgcctcct ccaaagagtc
     1021 ggacatccac tgccaggagc tatattggca gcaaccattc ctccctggga tccatgtccc
     1081 cctctaacat ggaggggtat tccaagacgc agtataacca agtccccagt gaagactttg
     1141 aacgtgcgcc tcagagcccg actctggcac ccgctaaggt agctgcccct aatctcagtc
     1201 gaatgggagc ggttcctgtg atgattcctg cacagagcaa ggacgggtct atagtataga
     1261 actccgcacc tctctgttct gctgtccgtg gctcgtttct tctcttgaca tatcaacatt
     1321 tattctattc taaattttgt taacagtagc ccatatatat aatatatatg tgtgtgtatg
     1381 tgtatatata cacatgtgta cacatatacg tatatgtaca catgtgtata tatgcataat
     1441 atatatgcat atatacgcac ttatatatgc atatatatat atgaagaagt ttataagaat
     1501 catactccat aagatttttt tggttattgt gaaacaataa aggcttaaga gtaatagcat
     1561 tgaccatctg gaaaatttgg ggtttcttac caagttgatt ttaaggccct tatcttatat
     1621 ctgaagaaag atatagcact ttgaatatga tgtcatgggt gaagaaattt gtgagtttac
     1681 acacatccca agttgattct tgaatcatct gaaaatgata cttcgtagtt tctaccatta
     1741 ttttcaggat atctgtctca tttattgatg aacatcagta tctctcaaat tgaaaaacaa
     1801 atccatggaa aaactgctta atgtatgaat ttgtttttat agtctgagaa ttctaagtgt
     1861 atttggttac ctgtaaaagt aggagacatg actgttttag aaatgactag ttttctttct
     1921 aagtcattcc taaacatcta tgacacgatt tctttcctgt ctttttttct tttgttgctg
     1981 tttggagata gggcctcagt gtgttcgttg cctaggctgg cctcaaatcc tgatccttct
     2041 gctccctgaa tgctgggctc tcaaggctgt atggctgtag aacagtttcc taagcattta
     2101 accggtacac tacagaggta gcaggaagca ggaagcttta gtgcactaca aaagaagcgt
     2161 ccgctacaca gagctgaaac ccttgatgct gcatgggtcg gggtaggggg aggatcgatg
     2221 aggacagtgt ctgtgcctcg ctcggggcct gtggactgct gcaatcctga gcaggcaggg
     2281 tgagggtggc agatttatgg gtctgtagct aaacactgcc cttctactgt aagtgatggt
     2341 tttgcaattg gaaaggaagg aacagaggga gggaagggag agagggacag aaggaacgaa
     2401 aggaaggaag aaaggaaaga aaactgttaa ttcacttatc tggatgagaa ttctcaaatt
     2461 actgattttt aaatgtgtgt ttttgttttg tggcagaccg tactgcacat tttatgttgt
     2521 aatctaggct tttgagttgt agtacggttc ctggaggcta tttttttcct ctaagagtca
     2581 gtgaacaaag agatttgagg caagttaagt gtcttccctg gtcctgaatt ccagacttga
     2641 gcaatgtgct tgctggcccg tggccgcacc tgcctctctc tagctgtcag aaatcaagtc
     2701 tgagtcttag ttttgtgaaa gtgacttact cttaaaagaa attttaaaag gagtaaaggg
     2761 aatactccta cctgccaaat gtattaaata tagttttcgt aggaaaaaaa aagtgaattt
     2821 attgtatatc ccttaagatt gtgagggagt gtgtgtagcg tgtattgagc cagcatttcc
     2881 tttatagtag ataaggtctg taataaaaga tttcattaac tgcaaaacct ttcccctagg
     2941 gaattggtcc ctgctaatct cttcaggtgc tgtgctggta aatgctacat tataaattaa
     3001 tgttggcatg catttacgac taagcagaat aatgtgtata cttttaaatg gtgaatttaa
     3061 actgaatgtc catgtaatgg attcgtgtac agttttacat atttggaagc atttttttta
     3121 aactaggttt aaacctcacg taaaatcact ttttatattt gtgttgtctt catctgtgcc
     3181 tttttaggta aatttaattt ctacaatgac tttctggtgc ctatgagcta gctatcacct
     3241 accttgaagg tgcttagagg tgaaggtact gttttcaaaa gcacatcact gtggctttct
     3301 acccttagag tccccctctc gccttctctc ctctgctttt cttgatgtca cttaaataat
     3361 accactgttt attaggattt aaaagaaagt cacaccctca gtacgctttg accgtgcttc
     3421 tagtttataa ccatagccat gtttgacttt cagatgtttg gcatttttat aagatattac
     3481 aagaataaac tggaatgcag cttgtaatgg tttcgagaat ggtaatgaag attatgctag
     3541 gtagaaaaca ctacaaaagc agatgtgtgg aatcttttcc ttttcctaga ctttgtattt
     3601 atttaaaggc aaacaaaacc tagagtatcc cgctattttt agtctagatc tgtagcaact
     3661 ataatctgaa agagaaactt gtttaaaaaa aaaacaaaca ctgtgaaccc caacaggcct
     3721 ggaggatcaa gaatcagaga catagttgat tttttaggct ttggcctgca gcgcttctca
     3781 ttgttagcct cagtttcccc caaaggtcag acaagtacta gcaatttccc agacaacctc
     3841 actgatttta gtcaaccaag gagcaagtac ttgctctaga atcaatgttg gtaatggtca
     3901 acagctcatc ggccgtgctg gcgcatctta acgtagagcc agtgtgagtt cagggccagc
     3961 actgtcttcc cagcagacct ttctgattcc gcgctataca cgagagactt attaacccat
     4021 attgtgatgt tccaagaaca ttaaaacatc tctggagtga aatgacactc gtctgtgttc
     4081 tgaatacaga acagtttatg agtattaatt tattgataat cttagtagta ttttcctgtt
     4141 agaaagcctc cccttctgct cagaggctgg catcaatttt tgtgattttg tagttacata
     4201 gacaagtact tccttaaatt tgagttatct accaaggatt tattagtatg gagacagact
     4261 gagtgtgttt agtggggaag atccatatag actatggaaa tgcctaattt ctggcacatg
     4321 tgactgtgca catcatctat gatccctgaa ctcagaggca caggacgatc atggctttga
     4381 ggccagtagc cagttcaaag caagcctgag cttccccgag cgacctggca ccgagagact
     4441 ggactcagta gtacagcatt ttctctagaa tgggcaaaaa gaatgaggtc tgaatctgaa
     4501 ttcttttaaa gaaatgaatt tcagactgta ccctgggaat tagattacgt ggagaggcaa
     4561 gtaagctttt tgattaaaaa gaactcactg catggagttg gctattcttt aatgtgtgac
     4621 ttatgaaata actactgtct ctgtgtgtac agcatgtaaa tttgaagcta tgtgaatgtt
     4681 cattcatagg tttctggggt ttttttctaa aatatttcca atagtgttta gagtgttctc
     4741 agctgcctta tttcagtgtg aacagataac attcctattt tatgtggtga atgctttaaa
     4801 tgtgtcactt acagagtagt tgtagaaaac agctggcacg attttaagtg gtttgcgaca
     4861 ttatatatta tatatgtaca tatatgttta taacattatt gtgtttcata gtataactgt
     4921 tctgggcaag ttttaatatt tcaaatgcct ctggatattc cagcaataaa ggcaacatgt
     4981 tctgcagtca aatttctcgt ttgcctactt tgacactaaa ataatctgta tttgagcaat
     5041 attccttttg aaaatattat agaatgaggg aataaatttg tgaattgtgg ttatttctcc
     5101 tttaggaagg ctgaccattt gtttaccttc cttgaatgtg accttaaatt ttaagttcag
     5161 gcttacaaac tatgtcccag tttgtaattt agagaataga ggccatcagt tgggcttgtt
     5221 gttgattcag acactaagaa gtctgccaaa gacgagcttt gggatttctg ctaatttgtt
     5281 taatgacaca ggtgctgaga aggaccacag ttcaccaact gacttattct tgtccctaat
     5341 cgtgaatttt ggcaataaac acagttgtat taagaacact aatttgacac ccacatttgc
     5401 aaagttatag tgtcagtttc agattttgta tttcaaatat ctggattaca tattcaatga
     5461 tgcagatttc aaagtttgta agaacagttt tgtctaaaca cagaaccttg ctcttagttt
     5521 tgtgaccttg tgtacttttg aaataaaatg aagaaagcag tcccct
//
