LOCUS       NP_001020363             365 aa            linear   ROD 25-APR-2025
DEFINITION  coxsackievirus and adenovirus receptor homolog isoform a precursor
            [Mus musculus].
ACCESSION   NP_001020363
VERSION     NP_001020363.1
DBSOURCE    REFSEQ: accession NM_001025192.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 365)
  AUTHORS   Bastea,L.I., Liu,X., Fleming,A.K., Pandey,V., Doppler,H.,
            Edenfield,B.H., Krishna,M., Zhang,L., Thompson,E.A.,
            Grandgenett,P.M., Hollingsworth,M.A., Fairweather,D., Clemens,D.
            and Storz,P.
  TITLE     Coxsackievirus and adenovirus receptor expression facilitates
            enteroviral infections to drive the development of pancreatic
            cancer
  JOURNAL   Nat Commun 15 (1), 10547 (2024)
   PUBMED   39627248
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 365)
  AUTHORS   Kim,H.G., Park,J.H., Shin,H.H., Kim,S.H., Jeon,H.E., Shin,J.H.,
            Won,Y.S., Kwon,H.J., Jeon,E.S. and Lim,B.K.
  TITLE     Liver-specific Coxsackievirus and adenovirus receptor deletion
            develop metabolic dysfunction-associated fatty liver disease
  JOURNAL   Sci Rep 14 (1), 21642 (2024)
   PUBMED   39285218
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 365)
  AUTHORS   Pelz,L., Dossou,L., Kompier,N., Juttner,R., Siemonsmeier,G.,
            Meyer,N., Lowenstein,E.D., Lahmann,I., Kettenmann,H., Birchmeier,C.
            and Rathjen,F.G.
  TITLE     The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated
            astrocyte-astrocyte coupling in mice
  JOURNAL   eNeuro 11 (3) (2024) In press
   PUBMED   38388443
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 365)
  AUTHORS   Pazirandeh,A., Sultana,T., Mirza,M., Rozell,B., Hultenby,K.,
            Wallis,K., Vennstrom,B., Davis,B., Arner,A., Heuchel,R., Lohr,M.,
            Philipson,L. and Sollerbrant,K.
  TITLE     Multiple phenotypes in adult mice following inactivation of the
            Coxsackievirus and Adenovirus Receptor (Car) gene
  JOURNAL   PLoS One 6 (6), e20203 (2011)
   PUBMED   21674029
  REMARK    GeneRIF: CAR exerts important functions in the physiology of
            several organs in vivo
REFERENCE   5  (residues 1 to 365)
  AUTHORS   Chen,J.W., Ghosh,R., Finberg,R.W. and Bergelson,J.M.
  TITLE     Structure and chromosomal localization of the murine coxsackievirus
            and adenovirus receptor gene
  JOURNAL   DNA Cell Biol 22 (4), 253-259 (2003)
   PUBMED   12823902
  REMARK    GeneRIF: The mCAR gene is situated on the distal portion of murine
            chromosome 16, and is composed of at least eight exons, with
            intron-exon boundaries similar to those reported for the human CAR
            gene
REFERENCE   6  (residues 1 to 365)
  AUTHORS   Honda,T., Saitoh,H., Masuko,M., Katagiri-Abe,T., Tominaga,K.,
            Kozakai,I., Kobayashi,K., Kumanishi,T., Watanabe,Y.G., Odani,S. and
            Kuwano,R.
  TITLE     The coxsackievirus-adenovirus receptor protein as a cell adhesion
            molecule in the developing mouse brain
  JOURNAL   Brain Res Mol Brain Res 77 (1), 19-28 (2000)
   PUBMED   10814828
REFERENCE   7  (residues 1 to 365)
  AUTHORS   Tomko,R.P., Johansson,C.B., Totrov,M., Abagyan,R., Frisen,J. and
            Philipson,L.
  TITLE     Expression of the adenovirus receptor and its interaction with the
            fiber knob
  JOURNAL   Exp Cell Res 255 (1), 47-55 (2000)
   PUBMED   10666333
REFERENCE   8  (residues 1 to 365)
  AUTHORS   Bergelson,J.M., Krithivas,A., Celi,L., Droguett,G., Horwitz,M.S.,
            Wickham,T., Crowell,R.L. and Finberg,R.W.
  TITLE     The murine CAR homolog is a receptor for coxsackie B viruses and
            adenoviruses
  JOURNAL   J Virol 72 (1), 415-419 (1998)
   PUBMED   9420240
REFERENCE   9  (residues 1 to 365)
  AUTHORS   Tomko,R.P., Xu,R. and Philipson,L.
  TITLE     HCAR and MCAR: the human and mouse cellular receptors for subgroup
            C adenoviruses and group B coxsackieviruses
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3352-3356 (1997)
   PUBMED   9096397
REFERENCE   10 (residues 1 to 365)
  AUTHORS   Bergelson,J.M., Cunningham,J.A., Droguett,G., Kurt-Jones,E.A.,
            Krithivas,A., Hong,J.S., Horwitz,M.S., Crowell,R.L. and
            Finberg,R.W.
  TITLE     Isolation of a common receptor for Coxsackie B viruses and
            adenoviruses 2 and 5
  JOURNAL   Science 275 (5304), 1320-1323 (1997)
   PUBMED   9036860
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC130844.3, AK145569.1 and
            AK141274.1.
            
            Summary: This gene encodes a protein that is part of the Cortical
            Thymocyte marker in Xenopus (CTX) subfamily within the
            immunoglobulin superfamily. Members of this subfamily,
            predominantly expressed on the surface of endothelial and
            epithelial cells, help establish cell polarity and provide a
            barrier function, regulating migration of immune cells. This
            protein, first identified as the receptor for adenovirus subgroup C
            and coxsakieviruses group B, is developmentally regulated and plays
            an important role in cardiac development. Alternative splicing
            results in multiple transcript variants that encode different
            protein isoforms. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145569.1, AK004908.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 45.28 cM"
     Protein         1..365
                     /product="coxsackievirus and adenovirus receptor homolog
                     isoform a precursor"
                     /note="coxsackievirus and adenovirus receptor homolog"
                     /calculated_mol_wt=37935
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2031
     mat_peptide     20..365
                     /product="Coxsackievirus and adenovirus receptor homolog.
                     /id=PRO_0000014740"
                     /note="propagated from UniProtKB/Swiss-Prot (P97792.1)"
                     /calculated_mol_wt=37935
     Region          20..136
                     /region_name="IgV_CAR_like"
                     /note="Immunoglobulin Variable (V) domain of the
                     Coxsackievirus and Adenovirus Receptor (CAR), and similar
                     proteins; cd20960"
                     /db_xref="CDD:409552"
     Region          20..44
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409552"
     Region          20..22
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409552"
     Region          26..31
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409552"
     Region          35..45
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409552"
     Region          45..53
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409552"
     Region          53..59
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409552"
     Region          54..59
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409552"
     Region          60..88
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409552"
     Region          69..75
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409552"
     Region          78..81
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409552"
     Region          89..123
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409552"
     Region          90..93
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409552"
     Region          101..110
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409552"
     Site            106
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:20813955; propagated from
                     UniProtKB/Swiss-Prot (P97792.1)"
     Region          116..124
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409552"
     Region          116..124
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409552"
     Region          124..127
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409552"
     Region          128..136
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409552"
     Region          128..136
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409552"
     Region          147..229
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          158..162
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          172..178
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          195..199
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          209..214
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          222..225
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          238..271
                     /region_name="TM_EGFR-like"
                     /note="Transmembrane domain of the Epidermal Growth Factor
                     Receptor family of Protein Tyrosine Kinases; cd12087"
                     /db_xref="CDD:213052"
     Site            238..258
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97792.1)"
     Site            order(238,241..242,244..246,248..249,252)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:213052"
     Region          269..315
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P97792.1)"
     Site            297
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P97792.1)"
     Site            304
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P97792.1)"
     Site            306
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P97792.1)"
     Site            323
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P97792.1)"
     Site            332
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P78310; propagated from
                     UniProtKB/Swiss-Prot (P97792.1)"
     Region          360..365
                     /region_name="PDZ-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P97792.1)"
     Site            363
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P97792.1)"
     CDS             1..365
                     /gene="Cxadr"
                     /gene_synonym="2610206D03Rik; CAR; MCAR; MCVADR"
                     /coded_by="NM_001025192.3:162..1259"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS28276.1"
                     /db_xref="GeneID:13052"
                     /db_xref="MGI:MGI:1201679"
ORIGIN      
        1 marllcfvll cgiadftsgl sittpeqrie kakgetaylp ckftlspedq gpldiewlis
       61 psdnqivdqv iilysgdkiy dnyypdlkgr vhftsndvks gdasinvtnl qlsdigtyqc
      121 kvkkapgvan kkflltvlvk psgtrcfvdg seeigndfkl kcepkegslp lqfewqklsd
      181 sqtmptpwla emtspvisvk nasseysgty sctvqnrvgs dqcmlrldvv ppsnragtia
      241 gavigtllal vligailfcc hrkrreekye kevhhdired vpppksrtst arsyigsnhs
      301 slgsmspsnm egysktqynq vpsedferap qsptlapakv aapnlsrmga vpvmipaqsk
      361 dgsiv
//
