LOCUS       NM_009987               3753 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus C-X3-C motif chemokine receptor 1 (Cx3cr1), mRNA.
ACCESSION   NM_009987 XM_983192 XM_986801
VERSION     NM_009987.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3753)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
REFERENCE   2  (bases 1 to 3753)
  AUTHORS   Van Roy,Z., Kak,G., Fallet,R.W. and Kielian,T.
  TITLE     Interferon-gamma receptor signaling regulates innate immunity
            during Staphylococcus aureus craniotomy infection
  JOURNAL   J Neuroinflammation 22 (1), 46 (2025)
   PUBMED   39987156
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3753)
  AUTHORS   Fremuth,L.E., Hu,H., van de Vlekkert,D., Annunziata,I.,
            Weesner,J.A. and Alessandra,d.'.Azzo.
  TITLE     Neuraminidase 1 regulates neuropathogenesis by governing the
            cellular state of microglia via modulation of Trem2 sialylation
  JOURNAL   Cell Rep 44 (1), 115204 (2025)
   PUBMED   39817909
REFERENCE   4  (bases 1 to 3753)
  AUTHORS   Dong,F.L., Yu,L., Feng,P.D., Ren,J.X., Bai,X.H., Lin,J.Q.,
            Cao,D.L., Deng,Y.T., Zhang,Y., Shen,H.H., Gong,H., Sun,W.X.,
            Chi,D.Q., Mei,Y., Ma,L., Yin,M.Z., Li,M.N., Zhang,P.F., Hu,N.,
            Zhou,B.L., Liu,Y., Zheng,X.J., Chen,Y.F., Zhong,D., Tao,Y.X.,
            Yan,M. and Jiang,B.C.
  TITLE     An atlas of neuropathic pain-associated molecular pathological
            characteristics in the mouse spinal cord
  JOURNAL   Commun Biol 8 (1), 70 (2025)
   PUBMED   39820760
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3753)
  AUTHORS   Brandao,W., Jain,N., Yin,Z., Kleemann,K.L., Carpenter,M., Bao,X.,
            Serrano,J.R., Tycksen,E., Durao,A., Barry,J.L., Baufeld,C.,
            Guneykaya,D., Zhang,X., Litvinchuk,A., Jiang,H., Rosenzweig,N.,
            Pitts,K.M., Aronchik,M., Yahya,T., Cao,T., Takahashi,M.K.,
            Krishnan,R., Davtyan,H., Ulrich,J.D., Blurton-Jones,M., Ilin,I.,
            Weiner,H.L., Holtzman,D.M. and Butovsky,O.
  TITLE     Inhaled xenon modulates microglia and ameliorates disease in mouse
            models of amyloidosis and tauopathy
  JOURNAL   Sci Transl Med 17 (781), eadk3690 (2025)
   PUBMED   39813317
REFERENCE   6  (bases 1 to 3753)
  AUTHORS   Lesnik,P., Haskell,C.A. and Charo,I.F.
  TITLE     Decreased atherosclerosis in CX3CR1-/- mice reveals a role for
            fractalkine in atherogenesis
  JOURNAL   J Clin Invest 111 (3), 333-340 (2003)
   PUBMED   12569158
  REMARK    GeneRIF: CX3CR1 has a role in atherosclerosis
REFERENCE   7  (bases 1 to 3753)
  AUTHORS   Haskell,C.A., Hancock,W.W., Salant,D.J., Gao,W., Csizmadia,V.,
            Peters,W., Faia,K., Fituri,O., Rottman,J.B. and Charo,I.F.
  TITLE     Targeted deletion of CX(3)CR1 reveals a role for fractalkine in
            cardiac allograft rejection
  JOURNAL   J Clin Invest 108 (5), 679-688 (2001)
   PUBMED   11544273
REFERENCE   8  (bases 1 to 3753)
  AUTHORS   Jung,S., Aliberti,J., Graemmel,P., Sunshine,M.J., Kreutzberg,G.W.,
            Sher,A. and Littman,D.R.
  TITLE     Analysis of fractalkine receptor CX(3)CR1 function by targeted
            deletion and green fluorescent protein reporter gene insertion
  JOURNAL   Mol Cell Biol 20 (11), 4106-4114 (2000)
   PUBMED   10805752
REFERENCE   9  (bases 1 to 3753)
  AUTHORS   Haskell,C.A., Cleary,M.D. and Charo,I.F.
  TITLE     Molecular uncoupling of fractalkine-mediated cell adhesion and
            signal transduction. Rapid flow arrest of CX3CR1-expressing cells
            is independent of G-protein activation
  JOURNAL   J Biol Chem 274 (15), 10053-10058 (1999)
   PUBMED   10187784
REFERENCE   10 (bases 1 to 3753)
  AUTHORS   Combadiere,C., Gao,J., Tiffany,H.L. and Murphy,P.M.
  TITLE     Gene cloning, RNA distribution, and functional expression of
            mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine
            fractalkine
  JOURNAL   Biochem Biophys Res Commun 253 (3), 728-732 (1998)
   PUBMED   9918795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044557.1 and AC117245.3.
            
            On Oct 25, 2012 this sequence version replaced NM_009987.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044557.1, AK035902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-541               AK044557.1         2-542
            542-3753            AC117245.3         45477-48688
FEATURES             Location/Qualifiers
     source          1..3753
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.37 cM"
     gene            1..3753
                     /gene="Cx3cr1"
                     /gene_synonym="mCX3CR1"
                     /note="C-X3-C motif chemokine receptor 1"
                     /db_xref="GeneID:13051"
                     /db_xref="MGI:MGI:1333815"
     exon            1..92
                     /gene="Cx3cr1"
                     /gene_synonym="mCX3CR1"
                     /inference="alignment:Splign:2.1.0"
     exon            93..3753
                     /gene="Cx3cr1"
                     /gene_synonym="mCX3CR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1166
                     /gene="Cx3cr1"
                     /gene_synonym="mCX3CR1"
                     /note="C-X3-C CKR-1; fractalkine receptor; chemokine
                     (C-X3-C) receptor 1; chemokine (C-X3-C motif) receptor 1"
                     /codon_start=1
                     /product="CX3C chemokine receptor 1"
                     /protein_id="NP_034117.3"
                     /db_xref="CCDS:CCDS40806.1"
                     /db_xref="GeneID:13051"
                     /db_xref="MGI:MGI:1333815"
                     /translation="MSTSFPELDLENFEYDDSAEACYLGDIVAFGTIFLSVFYALVFT
                     FGLVGNLLVVLALTNSRKPKSITDIYLLNLALSDLLFVATLPFWTHYLISHEGLHNAM
                     CKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAIL
                     VASPQFMFTKRKDNECLGDYPEVLQEMWPVLRNSEVNILGFALPLLIMSFCYFRIIQT
                     LFSCKNRKKARAVRLILLVVFAFFLFWTPYNIMIFLETLKFYNFFPSCDMKRDLRLAL
                     SVTETVAFSHCCLNPFIYAFAGEKFRRYLGHLYRKCLAVLCGHPVHTGFSPESQRSRQ
                     DSILSSFTHYTSEGDGSLLL"
     regulatory      3584..3589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cx3cr1"
                     /gene_synonym="mCX3CR1"
                     /note="hexamer: AATAAA"
     polyA_site      3608
                     /gene="Cx3cr1"
                     /gene_synonym="mCX3CR1"
ORIGIN      
        1 tagagaggga agcacttgcc tctggtggag tctgcgtgag actgggtgag tgactggcac
       61 ttcctgcaga agttcccttc ccatctgctc aggacctcac catgtccacc tccttccctg
      121 aactggatct agagaatttt gagtatgacg attctgctga ggcctgttat ttgggcgaca
      181 ttgtggcctt tggaaccatc ttcctgtccg tcttctacgc cctcgtcttc acgttcggtc
      241 tggtgggaaa tctgttggtg gtcctcgctc tcaccaacag ccggaagccc aagagcatca
      301 ctgacatcta cctcctgaac ctggccttga gcgacctgct ctttgtggcc accttgccct
      361 tctggactca ctacctcatc agccatgagg gcctccacaa tgccatgtgc aagctcacga
      421 ctgccttctt cttcattggc ttctttgggg gcatattctt catcaccgtc atcagcatcg
      481 accggtacct tgccatcgtc ctggccgcca actccatgaa caaccggaca gtgcagcacg
      541 gtgtcaccat tagtctgggc gtctgggcgg cggccatctt agtggcgtca ccccagttca
      601 tgttcacaaa gagaaaggac aacgagtgtc tgggtgacta ccccgaggtc ctgcaggaaa
      661 tgtggcccgt gctccgcaac tcggaagtca acatcctggg cttcgccctg cccttgctta
      721 tcatgagctt ttgctacttc cgcatcatcc agacgctgtt ttcctgcaag aatcgcaaga
      781 aggccagagc cgtcagactc atcctcctgg tggtctttgc cttcttcctc ttctggacac
      841 catacaacat catgattttc ctggagactc tcaagttcta caacttcttc cccagttgtg
      901 acatgaagag ggacctgagg ttggccctca gtgtgacgga gacagtggcg ttcagccact
      961 gttgcctcaa cccctttatc tacgcctttg ccggggaaaa gttcagaaga tacctgggac
     1021 acctgtatag gaagtgcctg gccgtcctgt gcggtcatcc tgtccacacc ggcttctcgc
     1081 cagagtccca gaggagcagg caggacagca ttctgagcag tttcactcac tacacaagcg
     1141 agggagatgg gtctctcctg ctctgaaggg gtctccccga ccctagctcc actaggaacc
     1201 cagagttctt gcatcagatt tccctgccgc tccccctgca tcttatgtgc aagaaatatg
     1261 gaccagatgc ctgcaaacca accccgtggt gtttttttga aaaatttatg ttcaatgtgt
     1321 gaaaaacaca cgtatctctt actgcaaatg ttgaacattg gggcttactg gtgacaaaaa
     1381 ttctaaccag attagtgcaa ttacaaaggg gtttggtgag tcctggttgc atgatcatgt
     1441 gataaaggac aactaagtcc tcagactgag tggaaaccaa ggcttggctc caatgtcccc
     1501 tctctgacct tcagatcctt catagtgaca gatcatccag gttctatcat cagagaagga
     1561 ccacatctct ctgatttcaa aattggtatt cctagggaac acctccgttg gccgagtgtg
     1621 tcgggtgtcc attccttgac taggtggtgt tattgaaata gaagggatac ctaagatgct
     1681 gttggaatct caaggttagc ggttgagaga gacacatctc tcagaagctg gggggtggga
     1741 gctactctga cagcaagaac tgctgactcg ccttaccatg gagctcattc aggctcccct
     1801 tcagtaacta gcagtatctg ttgctagctt ctttaatctt ctgttgagaa tgtcctgaac
     1861 tctccaaggg ttagaatttg ggttactgct cacagcatca aattcaatcc caaggccctg
     1921 tcctccaaga ccaggaagat aggatgcagt tctaacaaga gactccacgc tgactcctca
     1981 ttccacagga ctccgtccac ccagttggcc atgtcccttt ttcttgtctt gacccacatc
     2041 cctccactct tctcagccca ggggaagaaa tagaaagagc catgccccag agtgaaggga
     2101 tcgattcata tcccaactct gttgcttgca cattggggag actggagcca acagagcttc
     2161 agtcccttca atatagaaag gggactgtgg tgccttcatc cattctagca tagtacctca
     2221 gcaaggactt tagcattccc tggatcagga actgttaccc tgcctctgag aaatggagct
     2281 ggtggagtgg gaggaacctg caggctttgc tgcaggacac agccagacaa gaggagacct
     2341 attcctacag catcccccaa catgtgccta gatctacaaa gccattccca tgtccccgct
     2401 gtcagggcaa gacccaggcc acgagagcag cttgctttct cccctgaccc tgcaagcatc
     2461 acgtaggatg tagccacaag aatgtcttca tgcattcact gactccggtc tcatttgcag
     2521 gcttacattg aaagttccag ttctgcaact tgctttttaa aaaacactgg atttcagggg
     2581 ctggagagat ggctcagtgg ttaagagcac agtctgctcc tacagaggtc ccaagttcaa
     2641 ttcccatgtc atgtctgaag acaaggacag tgtagtcaaa aaaaacactg gaattcaaat
     2701 agctccctgt tcctgtgttg gttgtgataa ccatttcaga agtctctccc agcctgttgc
     2761 tcacggcggc atgtctgata tctccttggc agtctgtatg tttgtgtcga ggatgacaga
     2821 cagactgagt catatccccc acaggcatat ccaacccttt gttattgcaa caccatgctg
     2881 tcatattcaa aggtcacaaa tgagaacctc aaaattgagt taccaaagtg ggagcctgga
     2941 gagatggctc agtggttaat agcactggct gctcttccag aggtctgggg ttggattccc
     3001 agcaagcata gtagcttaca atggtctata atataactct agttccaggt gacccaacac
     3061 cctcttctaa tttgtgaggg tagcagacat gtgcattgtg aacattcagg caaacaccca
     3121 tacatacaaa ataagtaaaa aagaaaaaga aaggaaggaa tggagagaga gaaagagggg
     3181 gagagagaga gggagaggga gagggagagg gagagggagg gagggagagg gagggaggga
     3241 gggagggagg gagggaggga gggagggaaa ggaaagaaag aaagaaagaa aggaaggaag
     3301 gaaggaagga aggaaggaag gaagaaagaa agaaagaggg agagagagaa agagagaaag
     3361 agagaaagag aaagagagaa agagagaaag agaaagagag aaagagagaa agaagaaaga
     3421 aagacagaaa attggttttt caagataggt tctctctatg tagcctcggc tgtcctgaaa
     3481 ctctctgtgt agaccaggct ggcctagagc tcaaagaaat ccacctgcct ctgcctcctg
     3541 agtactggga tcgaaggtct gtggcaccat ggcaggctta gtcaataaat gttttatttt
     3601 caaaagtatc ctataatgtt ttaagtaagt ttatgctttg gtgttggtct gtatttcccg
     3661 ctgtctcggg tcacatggtt aagcgtgcct agagtgtgtc tatcccactt gtaattctgt
     3721 caataaacat tggtttcctt ccagctcttg gca
//
