LOCUS       NM_009142               3144 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus C-X3-C motif chemokine ligand 1 (Cx3cl1), mRNA.
ACCESSION   NM_009142
VERSION     NM_009142.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3144)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 3144)
  AUTHORS   Naessens,F., Demuynck,R., Vershinina,O., Efimova,I., Saviuk,M., De
            Smet,G., Mishchenko,T.A., Vedunova,M.V., Krysko,O., Catanzaro,E.
            and Krysko,D.V.
  TITLE     CX3CL1 release during immunogenic apoptosis is associated with
            enhanced anti-tumour immunity
  JOURNAL   Front Immunol 15, 1396349 (2024)
   PUBMED   39011040
  REMARK    GeneRIF: CX3CL1 release during immunogenic apoptosis is associated
            with enhanced anti-tumour immunity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3144)
  AUTHORS   Frias-Anaya,E., Gallego-Gutierrez,H., Gongol,B., Weinsheimer,S.,
            Lai,C.C., Orecchioni,M., Sriram,A., Bui,C.M., Nelsen,B., Hale,P.,
            Pham,A., Shenkar,R., DeBiasse,D., Lightle,R., Girard,R., Li,Y.,
            Srinath,A., Daneman,R., Nudleman,E., Sun,H., Guma,M., Dubrac,A.,
            Mesarwi,O.A., Ley,K., Kim,H., Awad,I.A., Ginsberg,M.H. and
            Lopez-Ramirez,M.A.
  TITLE     Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease
            Through CX3CR1-CX3CL1 Signaling
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (6), 1246-1264 (2024)
   PUBMED   38660801
  REMARK    GeneRIF: Mild Hypoxia Accelerates Cerebral Cavernous Malformation
            Disease Through CX3CR1-CX3CL1 Signaling.
REFERENCE   4  (bases 1 to 3144)
  AUTHORS   Eain,H.S., Kawai,H., Nakayama,M., Oo,M.W., Ohara,T., Fukuhara,Y.,
            Takabatake,K., Shan,Q., Soe,Y., Ono,K., Nakano,K., Mizukawa,N.,
            Iida,S. and Nagatsuka,H.
  TITLE     Double-faced CX3CL1 enhances lymphangiogenesis-dependent metastasis
            in an aggressive subclone of oral squamous cell carcinoma
  JOURNAL   JCI Insight 9 (10), e174618 (2024)
   PUBMED   38775151
  REMARK    GeneRIF: Double-faced CX3CL1 enhances lymphangiogenesis-dependent
            metastasis in an aggressive subclone of oral squamous cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3144)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3144)
  AUTHORS   Kanazawa,N., Nakamura,T., Tashiro,K., Muramatsu,M., Morita,K.,
            Yoneda,K., Inaba,K., Imamura,S. and Honjo,T.
  TITLE     Fractalkine and macrophage-derived chemokine: T cell-attracting
            chemokines expressed in T cell area dendritic cells
  JOURNAL   Eur J Immunol 29 (6), 1925-1932 (1999)
   PUBMED   10382755
REFERENCE   7  (bases 1 to 3144)
  AUTHORS   Schwaeble,W.J., Stover,C.M., Schall,T.J., Dairaghi,D.J.,
            Trinder,P.K., Linington,C., Iglesias,A., Schubart,A., Lynch,N.J.,
            Weihe,E. and Schafer,M.K.
  TITLE     Neuronal expression of fractalkine in the presence and absence of
            inflammation
  JOURNAL   FEBS Lett 439 (3), 203-207 (1998)
   PUBMED   9845323
REFERENCE   8  (bases 1 to 3144)
  AUTHORS   Rossi,D.L., Hardiman,G., Copeland,N.G., Gilbert,D.J., Jenkins,N.,
            Zlotnik,A. and Bazan,J.F.
  TITLE     Cloning and characterization of a new type of mouse chemokine
  JOURNAL   Genomics 47 (2), 163-170 (1998)
   PUBMED   9479488
REFERENCE   9  (bases 1 to 3144)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 3144)
  AUTHORS   Pan,Y., Lloyd,C., Zhou,H., Dolich,S., Deeds,J., Gonzalo,J.A.,
            Vath,J., Gosselin,M., Ma,J., Dussault,B., Woolf,E., Alperin,G.,
            Culpepper,J., Gutierrez-Ramos,J.C. and Gearing,D.
  TITLE     Neurotactin, a membrane-anchored chemokine upregulated in brain
            inflammation
  JOURNAL   Nature 387 (6633), 611-617 (1997)
   PUBMED   9177350
  REMARK    Erratum:[Nature 1997 Sep 4;389(6646):100]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB526167.1, AK138214.1 and AC123826.4.
            
            On Sep 15, 2006 this sequence version replaced NM_009142.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006650.1, AK138472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                CB526167.1         1-24
            25-2696             AK138214.1         2-2673
            2697-3144           AC123826.4         169137-169584
FEATURES             Location/Qualifiers
     source          1..3144
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.79 cM"
     gene            1..3144
                     /gene="Cx3cl1"
                     /gene_synonym="ABCD-3; CX3C; Cxc3; D8Bwg0439e; FK; Scyd1"
                     /note="C-X3-C motif chemokine ligand 1"
                     /db_xref="GeneID:20312"
                     /db_xref="MGI:MGI:1097153"
     exon            1..155
                     /gene="Cx3cl1"
                     /gene_synonym="ABCD-3; CX3C; Cxc3; D8Bwg0439e; FK; Scyd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1273
                     /gene="Cx3cl1"
                     /gene_synonym="ABCD-3; CX3C; Cxc3; D8Bwg0439e; FK; Scyd1"
                     /note="C-X3-C motif chemokine 1; small-inducible cytokine
                     D1; CX3C membrane-anchored chemokine; small inducible
                     cytokine subfamily D, 1; fractalkine; neurotactin;
                     chemokine (C-X3-C motif) ligand 1"
                     /codon_start=1
                     /product="fractalkine precursor"
                     /protein_id="NP_033168.2"
                     /db_xref="CCDS:CCDS22548.1"
                     /db_xref="GeneID:20312"
                     /db_xref="MGI:MGI:1097153"
                     /translation="MAPSPLAWLLRLAAFFHLCTLLPGQHLGMTKCEIMCDKMTSRIP
                     VALLIRYQLNQESCGKRAIVLETTQHRRFCADPKEKWVQDAMKHLDHQAAALTKNGGK
                     FEKRVDNVTPGITLATRGLSPSALTKPESATLEDLALELTTISQEARGTMGTSQEPPA
                     AVTGSSLSTSEAQDAGLTAKPQSIGSFEAADISTTVWPSPAVYQSGSSSWAEEKATES
                     PSTTAPSPQVSTTSPSTPEENVGSEGQPPWVQGQDLSPEKSLGSEEINPVHTDNFQER
                     GPGNTVHPSVAPISSEETPSPELVASGSQAPKIEEPIHATADPQKLSVLITPVPDTQA
                     ATRRQAVGLLAFLGLLFCLGVAMFAYQSLQGCPRKMAGEMVEGLRYVPRSCGSNSYVL
                     VPV"
     exon            156..276
                     /gene="Cx3cl1"
                     /gene_synonym="ABCD-3; CX3C; Cxc3; D8Bwg0439e; FK; Scyd1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..3144
                     /gene="Cx3cl1"
                     /gene_synonym="ABCD-3; CX3C; Cxc3; D8Bwg0439e; FK; Scyd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3116..3121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cx3cl1"
                     /gene_synonym="ABCD-3; CX3C; Cxc3; D8Bwg0439e; FK; Scyd1"
                     /note="hexamer: AATAAA"
     polyA_site      3144
                     /gene="Cx3cl1"
                     /gene_synonym="ABCD-3; CX3C; Cxc3; D8Bwg0439e; FK; Scyd1"
                     /note="major polyA site"
ORIGIN      
        1 aagcaaccga gaccagccgc gagtgactac taggagctgc gacacggccc agcctcctgg
       61 cccgccgaat tcctgcactc cagccatggc tccctcgccg ctcgcgtggc tgctgcgcct
      121 ggccgcgttc ttccatttgt gtactctgct gccgggtcag cacctcggca tgacgaaatg
      181 cgaaatcatg tgcgacaaga tgacctcacg aatcccagtg gctttgctca tccgctatca
      241 gctaaaccag gagtcctgcg gcaagcgtgc cattgtcctg gagacgacac agcacagacg
      301 cttctgtgct gacccgaagg agaaatgggt ccaagacgcc atgaagcatc tggatcacca
      361 ggctgctgcc ctcactaaaa atggtggcaa gtttgagaag cgggtggaca atgtgacacc
      421 tgggatcacc ttggccacta ggggactgtc cccatctgcc ctgacaaagc ctgaatccgc
      481 cacattggaa gaccttgctt tggaactgac tactatttcc caggaggcca gggggaccat
      541 ggggacttcc caagagccac cggcagcagt gaccggatca tctctctcaa cttccgaggc
      601 acaggatgca gggcttacgg ctaagcctca gagcattgga agttttgagg cggctgacat
      661 ctccaccacc gtttggccga gtcctgctgt ctaccaatct ggatctagct cctgggctga
      721 ggaaaaagct actgagtccc cctccactac agccccatct cctcaggtgt ccactacttc
      781 accttcaacc ccagaggaaa atgttgggtc cgaaggccaa cccccatggg tccagggaca
      841 ggacctcagt ccagagaagt ctctagggtc tgaggagata aacccagttc atactgataa
      901 tttccaggag agggggcctg gcaacacagt ccacccctca gtggctccca tctcctctga
      961 agagaccccc agcccagagc tggtggcctc gggcagccag gctcctaaga tagaggaacc
     1021 catccatgcc actgcagatc cccagaaact gagtgtgctt atcactcctg tccccgacac
     1081 ccaggcagcc acaaggaggc aggcagtggg gctactggct ttccttggtc ttcttttctg
     1141 cctaggggtg gccatgtttg cttaccagag ccttcagggc tgtccccgca aaatggcggg
     1201 ggaaatggta gaaggcctcc gctacgtccc ccgtagctgt ggcagtaact catacgtcct
     1261 ggtgccagtg tgagctgctt gcctgcctgc ctgtgtccag agtgtgattc ggacagctgt
     1321 ctggggaccc ccccccccat cctcataccc accttcatcc acgctgggga aatgggaatg
     1381 gagaagctgg accctccagg ggctgtgggc tccatccaat cccccctccc ccgaggggtg
     1441 gccccggagg ccaccctaga ccactattca cttatcagag acagagcagg tgaccttcca
     1501 gctcctctat atttgaaaga atcctctgct gctggctggt tagaggggcc cttgacaccc
     1561 caactccagt gaacaattat ttattggatt cccagcccct gcgacgacac ctgtttcccg
     1621 cgcgcaccgt ggtccgccca tatcacaagc agcaggccag gcctatctgc ctgtccccct
     1681 gacctccttg tgtctcctgg ctttgctgca gtcgccagcc cttctcctcc ccggccagct
     1741 gcggtgctat ctgccctatg tctccctcta tcccctgtac agagcgcacc accatcacca
     1801 tcaacaccgc tgttgtgtct tttcttgcat gaggttaaag ctgtgttttc tggagctctc
     1861 cgggaaggga gacaagcttg cgagagggtt taaagtgttc ctccccagac ttggatgtgc
     1921 tgtgaaggca tgctgcgtct gaaggaaggg tccagtcccc actcggctac cagcaccaca
     1981 aagtgcccca cctgtaaaag gaaagaaacg tggtccagag ctggcaataa cctatggccc
     2041 tgacatcatc actttctctg agatccttgt ctccacccct gggtgcaacc ccacccctta
     2101 tcaacattaa tagtcactgc cattccactg gactgacatt tttgtaccct gtgattctga
     2161 gggctggcaa ggagtggctt gagagtgcag atcgtaccct gtatgccccc cccccaaatg
     2221 gaggctgagt tggggacttg caggaacaga ggccaactca gatggcttcc cctgtgttct
     2281 cactagaaac ccctccccca tgcaccaagg tgacagtcac aggtctgccc tggctaaagg
     2341 acaagccaca taggaaagat taggacaagc ccctcggagg cagaggatcc agggtaaacc
     2401 cctggagtgg ccacaaaccc aatttcagtg tagggacttg tgcatgtgtg tacttgcata
     2461 gtcagacaga ggctgccagg gtcctttcct gtctctgaga gcagtgttca cgccaaggac
     2521 tcacctttgc ccccattgca ggcagggcca gaactcccat agcattctcc aagagccctg
     2581 tgacattttc tggaagggac tctgccctgg gcgcaaagtg actgctgaag caaggagcag
     2641 ctgagcagca ccccagcgga gctgagccgg caggccacgc ccctcggggg gggggggcat
     2701 ttctacccac cctgctctga atagctccaa cttcacctta ggagcctccc aggggcgagc
     2761 ttcacccaga agccagtgac tcactccttg attggtggaa gctcagttgg ctcctgagag
     2821 tgaggaagcc aaccctttgt cgaccctcct cctgggaagc ctgtgggcgg ctctgatcat
     2881 gctccacaga accagttgta ggcctgagcc gcagcagccc gagtgcacta tatcctggct
     2941 ccttcggtgg ggaaccttta agggttggga cacccgtcat cggactttgt tggttcctcc
     3001 ctcccagagc agaatgtggg ccgtaacaat ctgaggagga ctttgaaagt tgttgatcct
     3061 ttagggtttt ttttcaagca tcattaccaa tgtctgtgcc attttgtatt ttactaataa
     3121 aattttaaag tcttgtgaat taaa
//
