LOCUS       NM_181323               2575 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cell wall biogenesis 43 C-terminal homolog (Cwh43),
            transcript variant 1, mRNA.
ACCESSION   NM_181323 NM_145560
VERSION     NM_181323.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2575)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2575)
  AUTHORS   Yang,D., Yang,H., Luiselli,G., Ogagan,C., Dai,H., Chiu,L.,
            Carroll,R.S. and Johnson,M.D.
  TITLE     Increased plasmin-mediated proteolysis of L1CAM in a mouse model of
            idiopathic normal pressure hydrocephalus
  JOURNAL   Proc Natl Acad Sci U S A 118 (33) (2021)
   PUBMED   34380733
  REMARK    GeneRIF: Increased plasmin-mediated proteolysis of L1CAM in a mouse
            model of idiopathic normal pressure hydrocephalus.
REFERENCE   3  (bases 1 to 2575)
  AUTHORS   Yang,H.W., Lee,S., Yang,D., Dai,H., Zhang,Y., Han,L., Zhao,S.,
            Zhang,S., Ma,Y., Johnson,M.F., Rattray,A.K., Johnson,T.A., Wang,G.,
            Zheng,S., Carroll,R.S., Park,P.J. and Johnson,M.D.
  TITLE     Deletions in CWH43 cause idiopathic normal pressure hydrocephalus
  JOURNAL   EMBO Mol Med 13 (3), e13249 (2021)
   PUBMED   33459505
REFERENCE   4  (bases 1 to 2575)
  AUTHORS   Lu,Y., Oura,S., Matsumura,T., Oji,A., Sakurai,N., Fujihara,Y.,
            Shimada,K., Miyata,H., Tobita,T., Noda,T., Castaneda,J.M.,
            Kiyozumi,D., Zhang,Q., Larasati,T., Young,S.A.M., Kodani,M.,
            Huddleston,C.A., Robertson,M.J., Coarfa,C., Isotani,A.,
            Aitken,R.J., Okabe,M., Matzuk,M.M., Garcia,T.X. and Ikawa,M.
  TITLE     CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched
            genes dispensable for male fertility in micedagger
  JOURNAL   Biol Reprod 101 (2), 501-511 (2019)
   PUBMED   31201419
REFERENCE   5  (bases 1 to 2575)
  AUTHORS   Zhou,X., Wang,J., Liu,Q., Shen,J., Zheng,M. and Zhang,Y.
  TITLE     Identification of the gene imds-60 in mouse epididymis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 39 (12), 939-946 (2007)
   PUBMED   18064386
  REMARK    GeneRIF: The imds-60 protein might play an important role in cell
            communication during sperm maturation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108828.17 and AC134551.4.
            
            On Mar 17, 2023 this sequence version replaced NM_181323.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081976.1, BC016523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC108828.17        204635-204813
            180-371             AC108828.17        206546-206737
            372-492             AC108828.17        210261-210381
            493-647             AC108828.17        211419-211573
            648-849             AC108828.17        213341-213542
            850-938             AC108828.17        215117-215205
            939-1196            AC108828.17        216353-216610
            1197-1322           AC134551.4         121113-121238       c
            1323-1402           AC134551.4         118698-118777       c
            1403-1508           AC134551.4         114020-114125       c
            1509-1644           AC134551.4         112145-112280       c
            1645-1794           AC134551.4         110719-110868       c
            1795-1939           AC134551.4         108324-108468       c
            1940-2001           AC134551.4         104196-104257       c
            2002-2157           AC134551.4         101232-101387       c
            2158-2575           AC134551.4         89257-89674         c
FEATURES             Location/Qualifiers
     source          1..2575
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 38.78 cM"
     gene            1..2575
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /note="cell wall biogenesis 43 C-terminal homolog"
                     /db_xref="GeneID:231293"
                     /db_xref="MGI:MGI:2444131"
     exon            1..179
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..2236
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PGAP2-interacting protein; cell wall biogenesis protein 43
                     C-terminal homolog"
                     /codon_start=1
                     /product="PGAP2-interacting protein isoform 1"
                     /protein_id="NP_851840.1"
                     /db_xref="CCDS:CCDS19341.1"
                     /db_xref="GeneID:231293"
                     /db_xref="MGI:MGI:2444131"
                     /translation="MPGLWRAIALETLLGYVSWSLYHGLSPMIYYFPLQTLELTGLEF
                     FCVAFLSPILLTIPPLWKLVNKKWTLSLLRIVTVGSIASFEAPNAKLRLMVLALGVSS
                     SLIVQTVTWWSGSGLQRYLKIWGFILGHVLLLVLRIWYTSLNPIWSYQMSNRVILTLS
                     AVAVLDRIGTDGDYRNPEGKKPREVATGRTSLSSWLLPGAAFGSLLFLTHWIFGEVSI
                     VSRWAVSGHPHPGPDPNPFGGAVLLGFSSGLMLSGSSWLHDAGLAWWMTGAASAMGLL
                     YLRTWAAAVSGCVLAVFTGSMWPQVLGHLVNSGKNSGEAMATGMILYVLQTFFCAWCT
                     AFKFVPGGVYARERSDVLLGTIMVIIGLSMLFGPKKNLDFLLQTKNSPKTLLRCSEKY
                     MKLILWLFVGVGLLGLGLRHRTYERQLGRGAPATVVSAAIWPFRFGYDNEGWPNLERS
                     AQLLKETGADFITILESDASKPYIGNNDLTMWLGEKLGFYTDFGPSTRDHTWGIMVLS
                     RYPIVRSEHHLLPSPEGEIAPAITMTVNVSNRLVDFVVTHFGNHEDDLDRKLQAIAVS
                     KLLKNCSNQVIFLGYITSEPGSRDYIQLTKHGNVKDIDSSDGDRWCEYIMYRGLIRLG
                     YARISHAELSDSEIQMAKFRIPDDPANYRDNQKVVIDHRGVPKNIHFNPRFGSYKEGH
                     NYENTHHFHMNTPKYFV"
     exon            180..371
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            372..492
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            493..647
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            648..849
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            850..938
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1196
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1322
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1402
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1508
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1644
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1794
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1939
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2001
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2157
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2575
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2544..2549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /note="hexamer: AATAAA"
     polyA_site      2575
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /note="major polyA site"
ORIGIN      
        1 aggactcctg ctgccgcctc agacccgcga gctactcggg gacaccgagc aggcagaccg
       61 ggcggacccc gcaggaagcg cggggcgcac gcggggcgag ggaacggtcc tctcggcttt
      121 ccgggtggtc gcagtcatgc caggcctgtg gagagcaatt gccctggaga ccttgctggg
      181 ctacgtctcc tggtctctct accacggact gagccccatg atctattatt ttcccctgca
      241 aacgctggag ctcacagggc tggaattctt ttgtgtagcc tttctctctc cgatactctt
      301 aacaattccc ccactctgga aactcgtcaa taagaagtgg acactctctc tgctgaggat
      361 cgtcactgta ggcagcatag cttcctttga ggctccaaat gctaagcttc gactgatggt
      421 cctcgccctt ggtgtgtctt cttccctgat agtgcaaact gtgacctggt ggtcaggaag
      481 tggattgcaa aggtacctca aaatctgggg attcattctg ggacacgtcc ttcttcttgt
      541 cctccgaata tggtacacat cattaaaccc aatttggagc tatcagatgt ccaacagagt
      601 aattctgaca ttgagtgccg tagctgtgct tgaccgaatt ggcacagatg gtgactacag
      661 aaaccctgag gggaagaagc cccgtgaggt tgccacgggc aggacctctc tatctagttg
      721 gctgttgcca ggcgccgcct ttgggagcct cctgttccta actcactgga tcttcggaga
      781 ggtctccatt gtttccagat gggcagtcag tggtcatccc cacccagggc cagatcctaa
      841 tccttttgga ggtgcggttc tactgggctt ctcaagtgga ctgatgctat cgggttcatc
      901 atggcttcat gatgctgggt tagcctggtg gatgacagga gcagcttcgg ccatgggtct
      961 cctctacctg cgcacatggg cagctgctgt ttctggatgt gtcctggcag tctttacggg
     1021 gtctatgtgg cctcaagtac ttggccatct tgtgaactca gggaaaaact ccggagaagc
     1081 catggccact ggcatgatcc tttatgtttt acaaacattt ttctgtgcct ggtgcacagc
     1141 gtttaagttt gttcccggag gtgtctacgc tagagaaaga tctgatgtgc ttttggggac
     1201 cataatggta attattggat tgagtatgct gtttggacct aagaaaaacc ttgactttct
     1261 tcttcaaaca aaaaacagtc ctaaaacgct tttgagatgc agtgaaaaat acatgaaact
     1321 cattctgtgg ctgtttgttg gtgtggggtt actgggatta gggctacggc acagaaccta
     1381 cgagaggcag ttaggccgag gggcaccagc aacagtggtc tctgctgcca tctggccttt
     1441 taggtttgga tatgacaatg aaggctggcc caatctagag aggtctgctc aactgctcaa
     1501 ggagacaggt gcagatttta tcaccatttt ggagagcgat gcttccaagc cctatatagg
     1561 gaacaacgac ttaacaatgt ggctggggga gaagctgggt ttctacacag actttgggcc
     1621 aagcaccagg gatcacacct gggggattat ggtgctgtct cggtacccga ttgtcagatc
     1681 ggaacatcac cttcttccgt cgccagaggg cgagatcgca ccagccataa ccatgacagt
     1741 taacgtctcc aacagactgg tggattttgt ggtgacacac tttgggaatc atgaagatga
     1801 ccttgacagg aagctacagg ctattgcagt gtcaaaactg ctgaaaaatt gttcaaatca
     1861 agtgatattt ctgggttata tcacttcaga gcccggttcc agagattaca tacaactcac
     1921 aaaacatggc aacgtgaagg atattgacag ctcagatgga gacagatggt gtgagtacat
     1981 catgtaccgg ggtctgatca ggttgggcta tgcaagaatc tctcatgcag aactgagtga
     2041 ctctgagatt cagatggcca aattcaggat cccggatgat cccgccaatt acagagacaa
     2101 ccagaaagtc gtcatagacc accgaggagt tcccaagaac attcacttca accccagatt
     2161 tggctcctac aaagaaggac acaattatga gaacacccat cattttcaca tgaatacacc
     2221 caaatacttc gtttgaaccc ttttagacaa aatgtcacgg ggaagccaaa agaagagttt
     2281 aatgaaaatg gaagagtaca tgggaagaac ttcagaagtt aaataaaaaa agagagaatg
     2341 agaaaagtga catccggcaa tgagaatccc atcaattcat aagctatgtt gtttaataaa
     2401 ggcatctctc taccttactt ttgttttaaa aaaaatcgtg tgataatata ggaaaattaa
     2461 gctcaggcct ggagccagag ctcggtgtaa agggcttgcc ttgtgtgcat ggggccctag
     2521 tttcagtgct cagcactgcc ataaataaag tgagcaggac gcaggaaaaa agaaa
//
