LOCUS       NM_001418155            2317 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cell wall biogenesis 43 C-terminal homolog (Cwh43),
            transcript variant 2, mRNA.
ACCESSION   NM_001418155
VERSION     NM_001418155.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2317)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2317)
  AUTHORS   Yang,D., Yang,H., Luiselli,G., Ogagan,C., Dai,H., Chiu,L.,
            Carroll,R.S. and Johnson,M.D.
  TITLE     Increased plasmin-mediated proteolysis of L1CAM in a mouse model of
            idiopathic normal pressure hydrocephalus
  JOURNAL   Proc Natl Acad Sci U S A 118 (33) (2021)
   PUBMED   34380733
  REMARK    GeneRIF: Increased plasmin-mediated proteolysis of L1CAM in a mouse
            model of idiopathic normal pressure hydrocephalus.
REFERENCE   3  (bases 1 to 2317)
  AUTHORS   Yang,H.W., Lee,S., Yang,D., Dai,H., Zhang,Y., Han,L., Zhao,S.,
            Zhang,S., Ma,Y., Johnson,M.F., Rattray,A.K., Johnson,T.A., Wang,G.,
            Zheng,S., Carroll,R.S., Park,P.J. and Johnson,M.D.
  TITLE     Deletions in CWH43 cause idiopathic normal pressure hydrocephalus
  JOURNAL   EMBO Mol Med 13 (3), e13249 (2021)
   PUBMED   33459505
REFERENCE   4  (bases 1 to 2317)
  AUTHORS   Lu,Y., Oura,S., Matsumura,T., Oji,A., Sakurai,N., Fujihara,Y.,
            Shimada,K., Miyata,H., Tobita,T., Noda,T., Castaneda,J.M.,
            Kiyozumi,D., Zhang,Q., Larasati,T., Young,S.A.M., Kodani,M.,
            Huddleston,C.A., Robertson,M.J., Coarfa,C., Isotani,A.,
            Aitken,R.J., Okabe,M., Matzuk,M.M., Garcia,T.X. and Ikawa,M.
  TITLE     CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched
            genes dispensable for male fertility in micedagger
  JOURNAL   Biol Reprod 101 (2), 501-511 (2019)
   PUBMED   31201419
REFERENCE   5  (bases 1 to 2317)
  AUTHORS   Zhou,X., Wang,J., Liu,Q., Shen,J., Zheng,M. and Zhang,Y.
  TITLE     Identification of the gene imds-60 in mouse epididymis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 39 (12), 939-946 (2007)
   PUBMED   18064386
  REMARK    GeneRIF: The imds-60 protein might play an important role in cell
            communication during sperm maturation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108828.17 and AC134551.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC108828.17        204635-204813
            180-371             AC108828.17        206546-206737
            372-492             AC108828.17        210261-210381
            493-647             AC108828.17        211419-211573
            648-849             AC108828.17        213341-213542
            850-938             AC108828.17        215117-215205
            939-1064            AC134551.4         121113-121238       c
            1065-1144           AC134551.4         118698-118777       c
            1145-1250           AC134551.4         114020-114125       c
            1251-1386           AC134551.4         112145-112280       c
            1387-1536           AC134551.4         110719-110868       c
            1537-1681           AC134551.4         108324-108468       c
            1682-1743           AC134551.4         104196-104257       c
            1744-1899           AC134551.4         101232-101387       c
            1900-2317           AC134551.4         89257-89674         c
FEATURES             Location/Qualifiers
     source          1..2317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 38.78 cM"
     gene            1..2317
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /note="cell wall biogenesis 43 C-terminal homolog"
                     /db_xref="GeneID:231293"
                     /db_xref="MGI:MGI:2444131"
     exon            1..179
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1978
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /note="isoform 2 is encoded by transcript variant 2;
                     PGAP2-interacting protein; cell wall biogenesis protein 43
                     C-terminal homolog"
                     /codon_start=1
                     /product="PGAP2-interacting protein isoform 2"
                     /protein_id="NP_001405084.1"
                     /db_xref="GeneID:231293"
                     /db_xref="MGI:MGI:2444131"
                     /translation="MPGLWRAIALETLLGYVSWSLYHGLSPMIYYFPLQTLELTGLEF
                     FCVAFLSPILLTIPPLWKLVNKKWTLSLLRIVTVGSIASFEAPNAKLRLMVLALGVSS
                     SLIVQTVTWWSGSGLQRYLKIWGFILGHVLLLVLRIWYTSLNPIWSYQMSNRVILTLS
                     AVAVLDRIGTDGDYRNPEGKKPREVATGRTSLSSWLLPGAAFGSLLFLTHWIFGEVSI
                     VSRWAVSGHPHPGPDPNPFGGAVLLGFSSGLMLSGSSWLHDAGLAWWMTGTIMVIIGL
                     SMLFGPKKNLDFLLQTKNSPKTLLRCSEKYMKLILWLFVGVGLLGLGLRHRTYERQLG
                     RGAPATVVSAAIWPFRFGYDNEGWPNLERSAQLLKETGADFITILESDASKPYIGNND
                     LTMWLGEKLGFYTDFGPSTRDHTWGIMVLSRYPIVRSEHHLLPSPEGEIAPAITMTVN
                     VSNRLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKNCSNQVIFLGYITSEPGSRDYIQL
                     TKHGNVKDIDSSDGDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPANY
                     RDNQKVVIDHRGVPKNIHFNPRFGSYKEGHNYENTHHFHMNTPKYFV"
     exon            180..371
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            372..492
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            493..647
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            648..849
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            850..938
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1064
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1144
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1250
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1386
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1536
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1681
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1743
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1899
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2317
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2286..2291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /note="hexamer: AATAAA"
     polyA_site      2317
                     /gene="Cwh43"
                     /gene_synonym="C130090K23Rik; imds-60"
                     /note="major polyA site"
ORIGIN      
        1 aggactcctg ctgccgcctc agacccgcga gctactcggg gacaccgagc aggcagaccg
       61 ggcggacccc gcaggaagcg cggggcgcac gcggggcgag ggaacggtcc tctcggcttt
      121 ccgggtggtc gcagtcatgc caggcctgtg gagagcaatt gccctggaga ccttgctggg
      181 ctacgtctcc tggtctctct accacggact gagccccatg atctattatt ttcccctgca
      241 aacgctggag ctcacagggc tggaattctt ttgtgtagcc tttctctctc cgatactctt
      301 aacaattccc ccactctgga aactcgtcaa taagaagtgg acactctctc tgctgaggat
      361 cgtcactgta ggcagcatag cttcctttga ggctccaaat gctaagcttc gactgatggt
      421 cctcgccctt ggtgtgtctt cttccctgat agtgcaaact gtgacctggt ggtcaggaag
      481 tggattgcaa aggtacctca aaatctgggg attcattctg ggacacgtcc ttcttcttgt
      541 cctccgaata tggtacacat cattaaaccc aatttggagc tatcagatgt ccaacagagt
      601 aattctgaca ttgagtgccg tagctgtgct tgaccgaatt ggcacagatg gtgactacag
      661 aaaccctgag gggaagaagc cccgtgaggt tgccacgggc aggacctctc tatctagttg
      721 gctgttgcca ggcgccgcct ttgggagcct cctgttccta actcactgga tcttcggaga
      781 ggtctccatt gtttccagat gggcagtcag tggtcatccc cacccagggc cagatcctaa
      841 tccttttgga ggtgcggttc tactgggctt ctcaagtgga ctgatgctat cgggttcatc
      901 atggcttcat gatgctgggt tagcctggtg gatgacaggg accataatgg taattattgg
      961 attgagtatg ctgtttggac ctaagaaaaa ccttgacttt cttcttcaaa caaaaaacag
     1021 tcctaaaacg cttttgagat gcagtgaaaa atacatgaaa ctcattctgt ggctgtttgt
     1081 tggtgtgggg ttactgggat tagggctacg gcacagaacc tacgagaggc agttaggccg
     1141 aggggcacca gcaacagtgg tctctgctgc catctggcct tttaggtttg gatatgacaa
     1201 tgaaggctgg cccaatctag agaggtctgc tcaactgctc aaggagacag gtgcagattt
     1261 tatcaccatt ttggagagcg atgcttccaa gccctatata gggaacaacg acttaacaat
     1321 gtggctgggg gagaagctgg gtttctacac agactttggg ccaagcacca gggatcacac
     1381 ctgggggatt atggtgctgt ctcggtaccc gattgtcaga tcggaacatc accttcttcc
     1441 gtcgccagag ggcgagatcg caccagccat aaccatgaca gttaacgtct ccaacagact
     1501 ggtggatttt gtggtgacac actttgggaa tcatgaagat gaccttgaca ggaagctaca
     1561 ggctattgca gtgtcaaaac tgctgaaaaa ttgttcaaat caagtgatat ttctgggtta
     1621 tatcacttca gagcccggtt ccagagatta catacaactc acaaaacatg gcaacgtgaa
     1681 ggatattgac agctcagatg gagacagatg gtgtgagtac atcatgtacc ggggtctgat
     1741 caggttgggc tatgcaagaa tctctcatgc agaactgagt gactctgaga ttcagatggc
     1801 caaattcagg atcccggatg atcccgccaa ttacagagac aaccagaaag tcgtcataga
     1861 ccaccgagga gttcccaaga acattcactt caaccccaga tttggctcct acaaagaagg
     1921 acacaattat gagaacaccc atcattttca catgaataca cccaaatact tcgtttgaac
     1981 ccttttagac aaaatgtcac ggggaagcca aaagaagagt ttaatgaaaa tggaagagta
     2041 catgggaaga acttcagaag ttaaataaaa aaagagagaa tgagaaaagt gacatccggc
     2101 aatgagaatc ccatcaattc ataagctatg ttgtttaata aaggcatctc tctaccttac
     2161 ttttgtttta aaaaaaatcg tgtgataata taggaaaatt aagctcaggc ctggagccag
     2221 agctcggtgt aaagggcttg ccttgtgtgc atggggccct agtttcagtg ctcagcactg
     2281 ccataaataa agtgagcagg acgcaggaaa aaagaaa
//
