LOCUS       NM_026072               1884 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus CWC27 spliceosome-associated protein (Cwc27),
            transcript variant 1, mRNA.
ACCESSION   NM_026072 XM_127535 XM_887416 XM_905807 XM_919513 XM_919526
            XM_980999 XM_981042 XM_981078
VERSION     NM_026072.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1884)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1884)
  AUTHORS   Lu,J., Zheng,K.Q., Bertrand,R.E., Quinlan,J., Ferdous,S.,
            Srinivasan,T., Oh,S., Wang,K. and Chen,R.
  TITLE     Gene augmentation therapy to rescue degenerative photoreceptors in
            a Cwc27 mutant mouse model
  JOURNAL   Exp Eye Res 234, 109596 (2023)
   PUBMED   37479075
REFERENCE   3  (bases 1 to 1884)
  AUTHORS   Bertrand,R.E., Wang,J., Li,Y., Cheng,X., Wang,K., Stoilov,P. and
            Chen,R.
  TITLE     Cwc27, associated with retinal degeneration, functions as a
            splicing factor in vivo
  JOURNAL   Hum Mol Genet 31 (8), 1278-1292 (2022)
   PUBMED   34726245
  REMARK    GeneRIF: Cwc27, associated with retinal degeneration, functions as
            a splicing factor in vivo.
REFERENCE   4  (bases 1 to 1884)
  AUTHORS   Blake,G.E.T., Zhao,X., Yung,H.W., Burton,G.J., Ferguson-Smith,A.C.,
            Hamilton,R.S. and Watson,E.D.
  TITLE     Defective folate metabolism causes germline epigenetic instability
            and distinguishes Hira as a phenotype inheritance biomarker
  JOURNAL   Nat Commun 12 (1), 3714 (2021)
   PUBMED   34140513
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1884)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1884)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 1884)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1884)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 1884)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1884)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK166770.1.
            
            On or before Jul 24, 2006 this sequence version replaced
            XM_127535.7, XM_887416.2, XM_919526.2, XM_905807.2, XM_919513.2,
            XM_981078.1, XM_981042.1, XM_980999.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166770.1, AK075902.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1884
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 56.64 cM"
     gene            1..1884
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /note="CWC27 spliceosome-associated protein"
                     /db_xref="GeneID:67285"
                     /db_xref="MGI:MGI:1914535"
     exon            1..267
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1635
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serologically defined colon cancer antigen 10;
                     peptidyl-prolyl cis-trans isomerase SDCCAG10;
                     peptidyl-prolyl cis-trans isomerase CWC27 homolog; PPIase
                     SDCCAG10; PPIase CWC27; CWC27 spliceosome-associated
                     protein homolog; probable inactive peptidyl-prolyl
                     cis-trans isomerase CWC27 homolog; spliceosome-associated
                     protein CWC27 homolog"
                     /codon_start=1
                     /product="spliceosome-associated protein CWC27 homolog
                     isoform 1"
                     /protein_id="NP_080348.1"
                     /db_xref="CCDS:CCDS26752.1"
                     /db_xref="GeneID:67285"
                     /db_xref="MGI:MGI:1914535"
                     /translation="MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLC
                     LEAYYDNTIFHRVVPGFIVQGGDPTGTGTGGESIYGAPFKDEFHSRLRFNRRGLVAMA
                     NAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLTEVDIDDEERPRNPHR
                     IKSCEVLFNPFDDITPREIKKPKNEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEV
                     NRVSQSMKGRSKSSHDLLKDDPHLSSVPAVESEKDDATGDLEDDGEDDSAERDEYMED
                     DEKNLMRERIAKRLKKDASASVKSAGDGEKKPASRSEELRKEARQLKRELLAAKQKKE
                     TAIKVEEGREEEEAAPDGAVAEYRREKQKYEALRKQQPKKGTSREDQTLALLSQFKSK
                     LTQAITETPENSVPEAEVEDDEGWMSHVLQFEDKTRKVKDASMQDSDTFEIYDPRNPV
                     NKRRREESKKLLREKKERR"
     exon            268..364
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     exon            365..477
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     exon            478..621
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     exon            622..720
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     exon            721..824
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     exon            825..894
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     exon            895..974
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1008
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1160
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1258
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1368
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1472
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1884
                     /gene="Cwc27"
                     /gene_synonym="3110009E13Rik; NY-CO-10; Sdccag10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggttagcg gtgctccggt ccgggagcaa catggcggcg tccatgatgg gctagtttgg
       61 ggagtaacta gtgattagta cggctgtctt gtccgactct gaccgagtga agttttcccc
      121 caaatactca ggttaaagaa ttgtgtgcta acaggtgggc ctcgccggag acccgccatt
      181 cgcttgcggc cacactaagg agcggagtcc tgagcactga gcaagatgag taacatctac
      241 atccaggagc cgcccactaa tgggaaggtt ttactgaaaa ctacggctgg agatattgac
      301 atagagttgt ggtcaaaaga agctcctaaa gcatgcagaa atttcattca gctttgtttg
      361 gaagcctact atgacaacac catttttcat agagttgtac ctggctttat agtccaaggt
      421 ggagatccca caggcactgg gactggtgga gaatctatct atggagcccc attcaaggat
      481 gaatttcact cacggttgcg ttttaatagg agaggactgg ttgccatggc aaatgctggt
      541 ccacatgata atggcagcca gtttttcttt actctgggcc gagcagatga acttaacaat
      601 aagcacacca tctttggaaa ggttacagga gatacagtgt acaacatgct acgcctgaca
      661 gaagtagata ttgatgatga agaaagaccc cgaaatccac atagaatcaa gagttgtgag
      721 gttttgttta atccttttga tgacatcact ccaagagaaa ttaaaaagcc caagaatgag
      781 aagccagaag aagaagtcaa gaaattgaaa cccaaaggca caaaaaattt tagtttactt
      841 tcttttggag aagaagctga ggaggaggag gaagaggtga accgagtcag tcagagcatg
      901 aaggggagaa gtaagagcag ccatgacctg ctcaaggacg acccgcatct aagctctgtc
      961 ccagcagtgg aaagtgaaaa agatgatgca acaggagatt tagaagatga tggtgaggat
     1021 gacagtgcag agcgtgacga atacatggaa gatgatgaga agaacttgat gagagaaaga
     1081 attgcaaaac ggttaaagaa agatgcaagt gccagtgtga agtcagccgg agacggggag
     1141 aagaagccgg caagccgaag tgaagagctc aggaaagaag caaggcagtt aaaacgagaa
     1201 ctcttagcag cgaaacagaa gaaagaaact gccataaaag tggaggaagg aagggaagag
     1261 gaagaagctg ccccagatgg cgctgttgca gagtacaggc gagaaaagca gaagtatgaa
     1321 gctttgcgga agcaacagcc aaagaaggga acttcccgcg aggaccagac cctggcacta
     1381 ctgagccagt ttaaatctaa gctcactcaa gcaattactg aaacacctga aaacagtgtt
     1441 cctgaagcag aagtggagga cgatgaaggc tggatgtcac atgtgctcca gtttgaagac
     1501 aaaaccagaa aagtgaaaga tgcaagcatg caggactcag acacatttga aatctatgat
     1561 cctcggaacc cagtgaacaa aaggagacgg gaagagagca aaaagctgtt gagagagaag
     1621 aaggaaaggc ggtgagagcc agagcggtga tgccagagtg gtggcccctg tggggtgtcc
     1681 tgtcacagcc atgtctatgg aatcgcagag gcggtgggaa ggctgtcaga gcctgtgttc
     1741 tgatttttca gaaaacaggt ctctcctttt gtaaatctgg aatgatgtaa gaaaatgctt
     1801 ttggttactg atacattttt ccctaattga ccttttctat tactaaatct gaaataaaat
     1861 cagtttcttt ccagtttaaa tgtt
//
