LOCUS       NM_001362657            3403 bp    mRNA    linear   ROD 01-JAN-2023
DEFINITION  Mus musculus CWC22 spliceosome-associated protein (Cwc22),
            transcript variant 4, mRNA.
ACCESSION   NM_001362657 XM_006500434
VERSION     NM_001362657.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3403)
  AUTHORS   Kobayashi M, Chandrasekhar A, Cheng C, Martinez JA, Ng H, de la Hoz
            C and Zochodne DW.
  TITLE     Diabetic polyneuropathy, sensory neurons, nuclear structure and
            spliceosome alterations: a role for CWC22
  JOURNAL   Dis Model Mech 10 (3), 215-224 (2017)
   PUBMED   28250049
  REMARK    GeneRIF: These findings identify subtle but significant alterations
            in spliceosome structure and function, including dysregulated Cajal
            bodies and CWC22 overexpression, in diabetic sensory neurons that
            offer new ideas regarding diabetic sensory neurodegeneration in
            polyneuropathy.
REFERENCE   2  (bases 1 to 3403)
  AUTHORS   Morgan AP, Holt JM, McMullan RC, Bell TA, Clayshulte AM, Didion JP,
            Yadgary L, Thybert D, Odom DT, Flicek P, McMillan L and de Villena
            FP.
  TITLE     The Evolutionary Fates of a Large Segmental Duplication in Mouse
  JOURNAL   Genetics 204 (1), 267-285 (2016)
   PUBMED   27371833
  REMARK    GeneRIF: Authors have reconstructed the origin and history of a
            127-kbp segmental duplication, R2d, in the house mouse (Mus
            musculus). R2d contains a single protein-coding gene, Cwc22 De novo
            assembly of both the ancestral (R2d1) and the derived (R2d2) copies
            reveals that they have been subject to nonallelic gene conversion
            events spanning tens of kilobases.
REFERENCE   3  (bases 1 to 3403)
  AUTHORS   Pezer Z, Harr B, Teschke M, Babiker H and Tautz D.
  TITLE     Divergence patterns of genic copy number variation in natural
            populations of the house mouse (Mus musculus domesticus) reveal
            three conserved genes with major population-specific expansions
  JOURNAL   Genome Res 25 (8), 1114-1124 (2015)
   PUBMED   26149421
  REMARK    GeneRIF: Study showed major differences in gene copy number in
            natural populations. CWC22, SFI1, and HJURP are highly conserved
            genes with the most copy-number variation. They all exhibit
            population-specific expansion patterns, perhaps for local
            adaptations.
REFERENCE   4  (bases 1 to 3403)
  AUTHORS   Osipovich AB, Long Q, Manduchi E, Gangula R, Hipkens SB, Schneider
            J, Okubo T, Stoeckert CJ Jr, Takada S and Magnuson MA.
  TITLE     Insm1 promotes endocrine cell differentiation by modulating the
            expression of a network of genes that includes Neurog3 and Ripply3
  JOURNAL   Development 141 (15), 2939-2949 (2014)
   PUBMED   25053427
REFERENCE   5  (bases 1 to 3403)
  AUTHORS   Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J and Lickert H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3403)
  AUTHORS   Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM,
            Basile A, Andre A, Cocchia M, Guardiola O, Ballabio A, Rubenstein
            JL and Zollo M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928791.11 and AL928915.24.
            
            [WARNING] On May 26, 2023 this sequence was replaced by
            NM_001362657.3.
            
            On Jan 19, 2022 this sequence version replaced NM_001362657.1.
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (4).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.126552.1,
                                           SRR1660817.252505.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AL928791.11        13473-13681         c
            210-339             AL928791.11        3916-4045           c
            340-407             AL928915.24        143901-143968       c
            408-518             AL928915.24        142637-142747       c
            519-761             AL928915.24        140458-140700       c
            762-890             AL928915.24        138410-138538       c
            891-1059            AL928915.24        135689-135857       c
            1060-1113           AL928915.24        135342-135395       c
            1114-1249           AL928915.24        132612-132747       c
            1250-1456           AL928915.24        132169-132375       c
            1457-1519           AL928915.24        132020-132082       c
            1520-1627           AL928915.24        128258-128365       c
            1628-1709           AL928915.24        126699-126780       c
            1710-1770           AL928915.24        122712-122772       c
            1771-1848           AL928915.24        119270-119347       c
            1849-2001           AL928915.24        118284-118436       c
            2002-2129           AL928915.24        116559-116686       c
            2130-2231           AL928915.24        115326-115427       c
            2232-2470           AL928915.24        114998-115236       c
            2471-3403           AL928915.24        106848-107780       c
FEATURES             Location/Qualifiers
     source          1..3403
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..3403
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /note="CWC22 spliceosome-associated protein"
                     /db_xref="GeneID:80744"
                     /db_xref="MGI:MGI:2136773"
     exon            1..209
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            210..339
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..3042
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /note="isoform 4 is encoded by transcript variant 4;
                     pre-mRNA-splicing factor CWC22 homolog; nucampholin
                     homolog; CWC22 spliceosome-associated protein homolog"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor CWC22 homolog isoform
                     4"
                     /protein_id="NP_001349586.1"
                     /db_xref="GeneID:80744"
                     /db_xref="MGI:MGI:2136773"
                     /translation="MKSSVAHMKQSSGHNRRETHSSYRRSSSPEDRYTEQERSPRDRG
                     YSDYSRSDYERSRRGYSYDDSMESRSRDREKRRERERDADHRKRSRKSPSPDRSPARG
                     GGQSSPQEEPTWKKKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKSSLAYQRMSWEA
                     LKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALV
                     AIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEM
                     LTLLLERPTDDSVEVAIGFLKECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYM
                     IEVMFAVRKDGFKDHPVILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFME
                     NEEKYKAIKKEILDEGDSDSNTDQGAGSSEDEEEEDEEEEGEDEEGGQKVTIHDKTEI
                     NLVSFRRTIYLAIQSSLDFEECAHKLLKMEFAESQTKELCNMILDCCAQQRTYEKFFG
                     LLAGRFCMLKKEYMESFESIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSLPWSVLE
                     CIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNT
                     RFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPEAEQKKPALTSSSSESSSASDSS
                     DSESDSSESSSESSSDASDSSSSSSTQSSTSGITAHSAKGTRKKRQGKARGEEVDKLA
                     RGHQALERRREGGREDQRHQEGRTERARSERRRAQNSRDADWRDPLAKHIDDRSHENS
                     HSRVGNGREQGSHREPEDRHGEPKKRRERRDSFSENEKQRSRNQDSDNVRRKDRSKSR
                     ERSRRHSGHKGDDARCQNSAERRWEKPGRRPEQSRESKRSQDRRREKSPTTQK"
     exon            340..407
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            408..518
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            519..761
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            762..890
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1059
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1113
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1249
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1456
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1519
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1627
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1709
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1770
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1848
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2001
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2129
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2231
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2470
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..3403
                     /gene="Cwc22"
                     /gene_synonym="B230213M24; mKIAA1604"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatgttctt ttctcgtgtt ctttgtaagg aatgacagtg ttactagctg gattgctttg
       61 actcaaggtg ttactatacc gcattatcat taatcgtatc acatacctgc caattcacta
      121 ccagtttttc actaatttct cgcgctactt tcacccggga aagggaactg acgctcttcc
      181 ggtatgatgg cggcgcggtg gagctttagg tgacgtgtag agacagaaaa agaaaactgt
      241 cgaggaactc aaaccactga gcacgtgtca cttgaatgaa cctgaagaat ctggggcagc
      301 tgacagcaga aaatgaaaag tagtgtggca cacatgaagc agtcctctgg tcacaacaga
      361 agggagaccc acagttcata ccgccggagc tcctccccag aagacagata cacagagcaa
      421 gagcggtccc cccgggatag aggttactct gattacagcc ggtcagacta tgagcgatct
      481 agaagaggat actcttacga tgacagcatg gaatcacgaa gtagggaccg agaaaaacgc
      541 agagagagag agagagatgc agatcatcgg aaacggtccc ggaaatcgcc atcccctgac
      601 aggagtccag cccgaggcgg agggcagagt tctcctcagg aggaaccgac atggaagaag
      661 aagaaggatg agctggaccc gctgctcacc cgcactgggg gagcgtatat ccctcctgcg
      721 aagctcagga tgatgcagga gcagatcaca gataaaagca gcttagcata tcagaggatg
      781 agctgggagg ctctgaagaa atccatcaat ggtctcatca acaaggtcaa catctctaat
      841 ataagcatta ttatccaaga gctccttcaa gagaacattg tcagagggag aggattgctg
      901 tccagatctg ttctgcaagc ccagagtgcg tctccaatct tcactcacgt ttatgcagct
      961 ttggtggcaa taatcaactc aaaattccca cagattggag aattgatcct caagagacta
     1021 attcttaatt ttcggaaagg ctatcgaagg aacgataagc aactttgcct gactgcttca
     1081 aaatttgtgg cacatcttat taaccaaaat gtggcacatg aggttctgtg cctggagatg
     1141 ctcactttgc tactagagag accaacagat gacagtgttg aagtagctat cggcttcctc
     1201 aaagagtgtg gtctcaaatt aacccaggtg tcaccaaggg gaattaatgc aatctttgaa
     1261 cgccttcgaa acattctaca cgagtctgag atcgacaaaa gagttcagta catgattgaa
     1321 gtgatgtttg ctgtacggaa ggatggattc aaggaccacc ctgttattct ggaaggactt
     1381 gatttagtgg aagaggacga tcagtttaca catatgctcc ccttagagga tgactacaat
     1441 ccagaagatg ttcttaatgt tttcaagatg gatcctaatt ttatggagaa tgaagagaag
     1501 tacaaggcta ttaaaaaaga aatccttgac gaaggagaca gtgattcaaa cacagaccaa
     1561 ggagctggaa gtagtgaaga tgaggaggag gaagacgagg aggaggaagg agaagacgag
     1621 gaaggagggc aaaaagtaac tattcatgac aaaacagaaa tcaacctagt ctcgtttcgc
     1681 cgtacaatct atcttgccat tcagtcaagt ttagattttg aagaatgtgc acacaagttg
     1741 ctgaaaatgg agtttgcaga gagccaaaca aaagaactct gcaacatgat acttgattgc
     1801 tgtgcccaac aaaggaccta tgaaaaattt tttggcttgt tagctgggcg gttttgtatg
     1861 ctgaaaaagg aatacatgga atcatttgaa agtatattca aggaacagta cgacaccatc
     1921 catcgcttag agacaaacaa attgagaaat gttgctaaaa tgtttgctca ccttttatac
     1981 acagattcac ttccgtggag tgttctcgaa tgtataaaac tgagtgaaga gaccacgaca
     2041 tcgtctagtc gaatttttgt caagatcttc ttccaggaac tgtgtgaata catgggtctt
     2101 cctaaactga atgcgaggtt gaaggatgaa actctccagc cattctttga aggtctgtta
     2161 cccagagaca acccacgcaa tacccggttt gccatcaact tcttcacttc cataggtctc
     2221 ggaggattga cggatgaact gcgagaacat ctgaaaaata cgcccaaggt catcgtagcc
     2281 cagaaaccag aagctgaaca aaagaaacca gccctgacat cttcatcttc agagtcttcc
     2341 tcggcgtctg attcctctga ctcagaatct gacagcagcg agagcagctc agagtcctct
     2401 agtgatgcga gcgactcctc ctcctcctcc agcactcaga gctctacctc aggtatcacg
     2461 gctcattcag ctaaaggtac aagaaagaag agacaaggga aggccagagg cgaagaagtt
     2521 gataagttag ccaggggcca ccaggcactt gagcggaggc gagaaggagg cagggaggac
     2581 caaaggcacc aggaagggag gactgagaga gcaaggtctg aaagacgcag agctcagaac
     2641 tcacgagatg cagactggag agatccccta gcaaagcaca tagacgacag aagccatgag
     2701 aatagtcaca gcagagttgg caatggccga gaacaaggct cacacagaga gccagaagac
     2761 aggcatggcg agccaaagaa gcggagagag agaagagatt ctttttctga aaatgagaag
     2821 caaagaagcc gaaatcagga cagtgataat gttagaagaa aagatcgctc caagtcaagg
     2881 gagaggagta gaaggcattc tggtcacaag ggagacgacg ccaggtgtca gaacagtgca
     2941 gagaggcgct gggaaaagcc tggcagacgc cctgaacagt ctagagagtc aaagagaagt
     3001 caggaccgga ggagagaaaa gtctccaaca acacagaaat aatcctaatg acaactgaac
     3061 atgccttaca cttaatttag ttcagtgtct tttttacatt gatgaatttt atagagaact
     3121 cttgtataaa gtacctgttt gtaaattttg aagatgtttt ctttttgaca tgttttataa
     3181 ttgatatatc tcaaggttct ttgtgtaaaa tcataaagaa aagggattca acaaaagggt
     3241 aagtcttatg ttttgtgaat aaaaggaaca aatgttcatt gaatcattgt ctttttttct
     3301 aaaatatttt tctttgtgtc agtttctatg aattaccata attattagtg gtttttatgt
     3361 ataacaaaag gccaaaataa ataaacgttt tctagtcttt gca
//
