LOCUS       NM_008411               2270 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus CUB and zona pellucida-like domains 1 (Cuzd1), mRNA.
ACCESSION   NM_008411
VERSION     NM_008411.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2270)
  AUTHORS   Ansarullah, Jain,C., Far,F.F., Homberg,S., Wissmiller,K., von
            Hahn,F.G., Raducanu,A., Schirge,S., Sterr,M., Bilekova,S.,
            Siehler,J., Wiener,J., Oppenlander,L., Morshedi,A.,
            Bastidas-Ponce,A., Collden,G., Irmler,M., Beckers,J.,
            Feuchtinger,A., Grzybek,M., Ahlbrecht,C., Feederle,R.,
            Plettenburg,O., Muller,T.D., Meier,M., Tschop,M.H., Coskun,U. and
            Lickert,H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E1. doi:
            10.1038/s41586-021-03347-z.. PMID: 33712809]
REFERENCE   2  (bases 1 to 2270)
  AUTHORS   Mapes,J., Anandan,L., Li,Q., Neff,A., Clevenger,C.V., Bagchi,I.C.
            and Bagchi,M.K.
  TITLE     Aberrantly high expression of the CUB and zona pellucida-like
            domain-containing protein 1 (CUZD1) in mammary epithelium leads to
            breast tumorigenesis
  JOURNAL   J Biol Chem 293 (8), 2850-2864 (2018)
   PUBMED   29321207
  REMARK    GeneRIF: Data suggest that overexpression of Cuzd1, regulator of
            growth factor signaling pathways controlled by PRLR and STAT5,
            promotes tumorigenesis in mammary epithelial cells. (Cuzd1 = Cub
            and zona pellucida-like domain-containing protein-1; Prlr =
            prolactin receptor; Stat5 = signal transducer and activator of
            transcription-5)
REFERENCE   3  (bases 1 to 2270)
  AUTHORS   Mapes,J., Li,Q., Kannan,A., Anandan,L., Laws,M., Lydon,J.P.,
            Bagchi,I.C. and Bagchi,M.K.
  TITLE     CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway
            that controls mammary gland development during pregnancy
  JOURNAL   PLoS Genet 13 (3), e1006654 (2017)
   PUBMED   28278176
  REMARK    GeneRIF: Data show that CUZD1 interacts with a complex containing
            JAK1/JAK2 and STAT5, downstream transducers of prolactin signaling
            in the mammary gland.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2270)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 2270)
  AUTHORS   Xiang,F., Bai,M., Jin,Y., Ma,W. and Xin,J.
  TITLE     Egr-1 mediates Si0(2)-driven transcription of membrane type I
            matrix metalloproteinase in macrophages
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 27 (1), 13-16 (2007)
   PUBMED   17393098
  REMARK    GeneRIF: ERG-1 mediates SiO(2)-driven transcription of Mmp14 in
            macrophages.
REFERENCE   6  (bases 1 to 2270)
  AUTHORS   Imamura,T., Asada,M., Vogt,S.K., Rudnick,D.A., Lowe,M.E. and
            Muglia,L.J.
  TITLE     Protection from pancreatitis by the zymogen granule membrane
            protein integral membrane-associated protein-1
  JOURNAL   J Biol Chem 277 (52), 50725-50733 (2002)
   PUBMED   12401800
  REMARK    GeneRIF: plays an essential role in trypsinogen activation and both
            impaired and augmented trypsinogen activation can be associated
            with increased severity of pancreatitis
REFERENCE   7  (bases 1 to 2270)
  AUTHORS   Kasik,J.W.
  TITLE     A cDNA cloned from pregnant mouse uterus exhibits temporo-spatial
            expression and predicts a novel protein
  JOURNAL   Biochem J 330 (Pt 2) (Pt 2), 947-950 (1998)
   PUBMED   9480914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156606.12, BY707834.1, AC110885.14 and BY707920.1.
            
            On Mar 20, 2007 this sequence version replaced NM_008411.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. An in-frame
            AUG is located 33 codons upstream of the annotated translation
            start site but is not being annotated as a start site since it
            would disrupt the signal peptide on NP_032437.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U69699.2, BC140992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC156606.12        49627-49860         c
            235-810             BY707834.1         1-576
            811-844             AC156606.12        44176-44209         c
            845-1062            AC156606.12        43621-43838         c
            1063-1235           AC156606.12        42307-42479         c
            1236-1627           AC156606.12        39073-39464         c
            1628-1896           AC110885.14        222383-222651       c
            1897-2206           AC110885.14        221389-221698       c
            2207-2270           BY707920.1         381-444
FEATURES             Location/Qualifiers
     source          1..2270
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 73.81 cM"
     gene            1..2270
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /note="CUB and zona pellucida-like domains 1"
                     /db_xref="GeneID:16433"
                     /db_xref="MGI:MGI:1202881"
     exon            1..327
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..2069
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /note="integral membrane-associated protein 1; CUB and
                     zona pellucida-like domain-containing protein 1; CUB and
                     ZP domain-containing protein 1"
                     /codon_start=1
                     /product="CUB and zona pellucida-like domain-containing
                     protein 1 precursor"
                     /protein_id="NP_032437.3"
                     /db_xref="CCDS:CCDS40157.1"
                     /db_xref="GeneID:16433"
                     /db_xref="MGI:MGI:1202881"
                     /translation="MEVTGRLFIWAILAVSCGAQLNSTEAEGKSRCTASLGGANLGET
                     HKALVLQLSANENCTWTIERPENRSIRIIFSYIKLDPGSRCETENIKVFDGSSTSGPL
                     LGKACSRNDFVPVFESSSNSMTFQIVTGLTKFPRSVFIFYYFFSAATVIPNCGGDLRA
                     LEGSFSSPNYPKPHPELAYCVWHIQVGKGYKIQLKFTDLLLEMDENCKFDFIAVYDGP
                     STTAGLLKQLCGRGKPTLESSSDAMTVVLSTDYANSYKGFSASYTSIYIHDVNTTSLS
                     CVSDKMRVIISKSYLPALNYNESNLQLNDPTCRPNVSNVIEFSIPLHECGTVKKIEDH
                     AISYTNRITFIESPVSAVITRQKLLQIVVTCEMEYNSTVEIMYITEDDIIQNQSVLGK
                     YNTSLALYESDSFENLVQESPYYVDLNQTLFVQATLHTSDPSLVVFLDTCRASPTSDF
                     ASPTYDLISSGCCQDETCKVYPLFGHYGRFQFNAFKFLKHLNSVYLKCKILICDNNDQ
                     TSRCNQGCVPRRKRDIPSYKWKTDSVIGPIRLKRDRSASRDSGLLPQIHEAEISNQPL
                     SRLYLFSFMVLALNVVIVAITTVKHFLNRWMDHRYQKLQVY"
     exon            328..478
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            479..693
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            694..844
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1062
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1235
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1627
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1896
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2256
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2236..2241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /note="hexamer: AATAAA"
     polyA_site      2256
                     /gene="Cuzd1"
                     /gene_synonym="Erg-1; Itmap1; Uo-44; Usg; Utczp"
                     /note="major polyA site"
ORIGIN      
        1 acgtagctgc tgagccctgt gcagaatcgg gctggctggc ttatagccct ctgagatgtg
       61 acctggaaga ctgagcccag tgccaggaac tgctggccag gttgcagctc ctcagctgtg
      121 gagttctcac cagcaccacc cctgggatgg ccaaactgac acgtttccct agataccagg
      181 aagcttacaa aactcggaga attataagaa gcctgagggt gagggccctg aggcaccctg
      241 cgaagatgga ggtcactgga aggctgttca tctgggctat tttagctgtc tcctgtgggg
      301 cacagctgaa ttctacagag gctgaaggca aatcaagatg cacagccagt ctgggagggg
      361 ccaatctggg agagacccat aaagccctgg tcctacagct cagtgcgaat gagaactgca
      421 cttggaccat agagagacct gaaaacagga gcatcagaat catcttctcc tacatcaagt
      481 tggatccagg cagcaggtgt gaaactgaaa acattaaggt gtttgatgga agctccacca
      541 gtgggcctct gctagggaag gcctgcagca gaaatgattt cgtgcctgtg tttgaatcat
      601 catccaactc gatgacattt cagatagtca ctggcttgac aaagttccca aggagtgtct
      661 ttatcttcta ctattttttc tccgctgcta ccgttattcc aaactgcggt ggtgacctgc
      721 gagcattgga agggtccttc agcagcccca attatccaaa gccgcaccct gagctggcat
      781 attgtgtctg gcacatacaa gtggggaaag gctataagat acaattgaag tttacagatc
      841 tcttactaga gatggatgaa aactgcaagt ttgatttcat cgcagtctac gatggcccct
      901 ccaccacggc aggcctgctc aaacaactct gcggccgtgg gaagcctacc ttagaatctt
      961 cctctgacgc catgactgtc gtgctatcta cagattatgc caattcctac aaaggctttt
     1021 ctgcttccta cacttcaatt tacatccacg atgtcaacac tacatctcta agttgtgttt
     1081 ctgacaagat gagagtcatc ataagcaaat catacctacc ggcactcaac tacaatgaga
     1141 gcaatttgca gctaaatgac ccaacttgca gaccgaatgt atcaaatgtc atagagttct
     1201 ctatccctct gcacgaatgc ggtacagtca aaaagataga ggaccacgcg atcagctata
     1261 ccaacaggat caccttcatc gagtctccgg tctctgctgt gatcacccga cagaagctcc
     1321 tccagatcgt ggtgacctgt gagatggagt ataactctac cgtggagatt atgtacataa
     1381 ctgaagacga catcatacag aaccagagtg tcctgggcaa atacaacacc agcctggctc
     1441 tctatgagtc cgactcattt gaaaacctcg tacaggagtc accatattat gtagacttga
     1501 accagactct ctttgtccaa gccaccttgc acacctcgga tccaagcctg gtggtgtttc
     1561 tggatacttg cagagcctcg cctacgtctg actttgcatc tccaacctac gacttaatca
     1621 gcagcggatg ttgtcaagat gagacctgta aggtgtatcc cttatttggg cactatggaa
     1681 ggttccagtt taatgccttt aaattcttga aacatctcaa ctctgtgtat ctcaagtgta
     1741 agattttgat atgtgataac aatgaccaaa catctcgctg caatcaaggc tgtgtcccaa
     1801 gaaggaaacg ggatattcct tcctacaaat ggaagactga ctctgttata ggacccattc
     1861 gcctgaagag ggaccgaagt gcaagtagag attcaggact tctgcctcaa atacatgaag
     1921 cagaaatttc aaaccagccc ctcagtcgcc tgtacctgtt ttccttcatg gttcttgcgc
     1981 taaatgtggt gattgtggcg ataaccacag tgaagcattt cctaaatcgg tggatggatc
     2041 acagatacca gaagctgcag gtctactagc tgtggacccc aagaaaggcc tcttgtcttc
     2101 tcctgggtgc ctgatgaagc agctccctgt gcctacaagg gttcagaata aaccaggaag
     2161 gcctaaaaag caacatgtgt accatcatgt tcaaatcaca tcgacagtgt gtttcattac
     2221 ggaatagctg aaatgaataa atagtacgtc tggtcaaaaa aaaaaaaaaa
//
