LOCUS       NM_001291233           13893 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus cut-like homeobox 1 (Cux1), transcript variant 3,
            mRNA.
ACCESSION   NM_001291233 XM_006504349
VERSION     NM_001291233.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 13893)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   2  (bases 1 to 13893)
  AUTHORS   Tang,I., Nisal,A., Reed,A., Ware,T.B., Johansen,A., Zaki,M.S.,
            Cravatt,B.F. and Gleeson,J.G.
  TITLE     Lipidomic profiling of mouse brain and human neuron cultures
            reveals a role for Mboat7 in mTOR-dependent neuronal migration
  JOURNAL   Sci Transl Med 17 (779), eadp5247 (2025)
   PUBMED   39742503
REFERENCE   3  (bases 1 to 13893)
  AUTHORS   McRae,H.M., Leong,M.P.Y., Bergamasco,M.I., Garnham,A.L., Hu,Y.,
            Corbett,M.A., Whitehead,L., El-Saafin,F., Sheikh,B.N., Wilcox,S.,
            Hannan,A.J., Gecz,J., Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles
            and altered transcription in the cortex of a mouse model of the
            Borjeson-Forssman-Lehmann intellectual disability syndrome
  JOURNAL   PLoS Genet 20 (10), e1011428 (2024)
   PUBMED   39405291
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13893)
  AUTHORS   Barao,S., Xu,Y., Llongueras,J.P., Vistein,R., Goff,L.,
            Nielsen,K.J., Bae,B.I., Smith,R.S., Walsh,C.A., Stein-O'Brien,G.
            and Muller,U.
  TITLE     Conserved transcriptional regulation by BRN1 and BRN2 in
            neocortical progenitors drives mammalian neural specification and
            neocortical expansion
  JOURNAL   Nat Commun 15 (1), 8043 (2024)
   PUBMED   39271675
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 13893)
  AUTHORS   Gillingham,A.K., Pfeifer,A.C. and Munro,S.
  TITLE     CASP, the alternatively spliced product of the gene encoding the
            CCAAT-displacement protein transcription factor, is a Golgi
            membrane protein related to giantin
  JOURNAL   Mol Biol Cell 13 (11), 3761-3774 (2002)
   PUBMED   12429822
REFERENCE   6  (bases 1 to 13893)
  AUTHORS   Lievens,P.M., Tufarelli,C., Donady,J.J., Stagg,A. and Neufeld,E.J.
  TITLE     CASP, a novel, highly conserved alternative-splicing product of the
            CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains,
            and interacts with full-length CDP in vitro
  JOURNAL   Gene 197 (1-2), 73-81 (1997)
   PUBMED   9332351
REFERENCE   7  (bases 1 to 13893)
  AUTHORS   Mailly,F., Berube,G., Harada,R., Mao,P.L., Phillips,S. and
            Nepveu,A.
  TITLE     The human cut homeodomain protein can repress gene expression by
            two distinct mechanisms: active repression and competition for
            binding site occupancy
  JOURNAL   Mol Cell Biol 16 (10), 5346-5357 (1996)
   PUBMED   8816446
REFERENCE   8  (bases 1 to 13893)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (bases 1 to 13893)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
REFERENCE   10 (bases 1 to 13893)
  AUTHORS   Andres,V., Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Clox, a mammalian homeobox gene related to Drosophila cut, encodes
            DNA-binding regulatory proteins differentially expressed during
            development
  JOURNAL   Development 116 (2), 321-334 (1992)
   PUBMED   1363085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087329.10, AC080158.4 and AC083890.4.
            
            On Apr 20, 2022 this sequence version replaced NM_001291233.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY037807.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-991               AC087329.10        47891-48881         c
            992-1102            AC080158.4         131518-131628       c
            1103-1150           AC080158.4         53757-53804         c
            1151-1229           AC080158.4         38092-38170         c
            1230-1367           AC083890.4         194825-194962       c
            1368-1491           AC083890.4         191621-191744       c
            1492-1568           AC083890.4         184762-184838       c
            1569-1635           AC083890.4         181505-181571       c
            1636-1684           AC083890.4         161592-161640       c
            1685-1789           AC083890.4         154127-154231       c
            1790-1978           AC083890.4         148253-148441       c
            1979-2037           AC083890.4         141284-141342       c
            2038-2086           AC083890.4         137502-137550       c
            2087-2183           AC083890.4         135810-135906       c
            2184-2855           AC083890.4         134146-134817       c
            2856-2921           AC083890.4         132998-133063       c
            2922-3023           AC083890.4         131250-131351       c
            3024-3859           AC083890.4         129262-130097       c
            3860-4025           AC083890.4         126952-127117       c
            4026-4082           AC083890.4         126226-126282       c
            4083-4385           AC083890.4         108264-108566       c
            4386-4574           AC083890.4         104371-104559       c
            4575-4839           AC083890.4         100933-101197       c
            4840-13893          AC083890.4         87916-96969         c
FEATURES             Location/Qualifiers
     source          1..13893
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.96 cM"
     gene            1..13893
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /note="cut-like homeobox 1"
                     /db_xref="GeneID:13047"
                     /db_xref="MGI:MGI:88568"
     exon            1..991
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             674..5515
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /note="isoform c is encoded by transcript variant 3;
                     protein CASP; homeobox protein cut-like 1; CCAAT
                     displacement protein; Cux/CDP homeoprotein; homeobox
                     protein cux-1"
                     /codon_start=1
                     /product="homeobox protein cut-like 1 isoform c"
                     /protein_id="NP_001278162.1"
                     /db_xref="GeneID:13047"
                     /db_xref="MGI:MGI:88568"
                     /translation="MERASGPLRAAFSSPVLESKAPGAPLDCKETDCGSSSPRGDGIG
                     ASQSAAELPACPEDAILPATPHRNQLLALGVLPASASSAFAAPGQPQDSARWMLCVAG
                     AKLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI
                     DALSKRSKEAEAAFLTVYKRLIDVPDPVPALDVGQQLEIKVQRLHDIETENQKLRETL
                     EEYNKEFAEVKNQEVTIKALKEKIREYEQTLKSQAETIALEKEQKLQNDFAEKERKLQ
                     ETQMSTTSKLEEAEHKLQTLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER
                     ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKE
                     REIAQLVEDVQRLQASLTKLRENSASQISQLEQQLNAKNSTLKQLEEKLKGQADYEEV
                     KKELNTLKSMEFAPSEGAGTQDSTKPLEVLLLEKNRSLQSENATLRISNSDLSGSARR
                     KGRDQPESRRPGPLPASPPPQLPRNTGEQVSNTNGTHHFSPAGLSQDFFSSNLASPSL
                     PLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSTIFSTGPYSTNSISSPSPLQQSPD
                     VNGMAPSPSQSESAGSISEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSV
                     SEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQE
                     VPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPVQTSSTSSSGNS
                     DDAIRSILQQARREMEAQQAALDPALKPAPLSQPDLTILTPKHLSASPMSTVSTYPPL
                     AISLKKTPAAPETSTAALPSAPALKKEAQDVPTLDPPGSADAAQGVLRPMKSELVRGS
                     TWKDPWWSPIQPERRNLTSSEETKADETTASGKERAGSSQPRAERSQLQGPSASAEYW
                     KEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMAKPAKPSVPPLTPEQYEV
                     YMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKG
                     REPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVASLQDPLQQGCVSSESTPKTSASC
                     SPAPESPMSSSESVKSLTELVQQPCPAIETSKEGKPPEPSDPPASDSQPTTPLPLSGH
                     SALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPK
                     PWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPS
                     VGIDYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKT
                     STVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSSRAAPSSEGDSCDGVEA
                     TDAEEPGGNIVATKSQGGLAEVAAAPADREEATQPAEKAKAQPLCSGTPGQDDGEDAS
                     RPRPLPEGLADAPAPVPSLAAPAAGEDAATSATAPATATEAPGAARAGPAERSSALPS
                     TSAPANAPARRPSSLQSLFGLPEAAGARDNLVRKKKAANLNSIIHRLEKAASREEPIE
                     WEF"
     exon            992..1102
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1150
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1229
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1367
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1491
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1568
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1635
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1684
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1789
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1978
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2037
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2086
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2183
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2855
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2921
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3023
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3859
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3860..4025
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4082
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4083..4385
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4386..4574
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4575..4839
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4840..13893
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13871..13876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /note="hexamer: AGTAAA"
     polyA_site      13893
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /note="major polyA site"
ORIGIN      
        1 agatcggcca ccggcggctg gcggcggtgg cggcgacggc caggctggcg ggtggcccct
       61 tgtcgtgaag acggcgggtg gcttggagct cctggctgct ccttgatcgt tccccttggg
      121 cccagctgcc accattcctc tttccactac tcccgtaagg gattgtcaac cggtgtcgcc
      181 ccggccaggg caccggctac ccggtgtggc gggtccctcc cccaccccgt ttgtttacgt
      241 cccggggcca acccgcaagc cccgcgctct tttgtgtgtc ttctgcgtga aagtgactgc
      301 ggagctggat ctgtccccct tttttgcgcc cggggacttc cccgggaagg ggttgtgggg
      361 gaagctttgg aagggaaaaa cttggcttgc ggggggacac cggtgggtcg cgcagagtgc
      421 gggatcggcc cgggagaagg gaaaaggtgc gggagaaagg ctgcaacttt ccaccgagcg
      481 caggccgctg cgtgacccgg tctcggagcg cttttcctcc ggggtcaccg atcggtgcag
      541 ccagacttag ctgcgtgtct cagggacttc cagggctccc ccctcggtga ccgatagctt
      601 gcatcactcc agcccctcac tctttttcgc gaggggtgtg ttctgtcctc tctgcaaagg
      661 ggccccagga gttatggagc gcgcgtcagg tccgctccga gctgccttct ccagcccggt
      721 tctcgaaagc aaagccccgg gggccccgct ggactgtaag gagactgatt gtggttcctc
      781 gtcgcctcga ggggatggta tcggggcttc ccaatccgcg gcggagctgc ctgcgtgccc
      841 agaggatgct attctgcctg ccacccctca tcggaaccag ctgctcgccc tcggggtcct
      901 ccctgctagt gctagctccg cgttcgcggc gcctggacag ccccaggatt ctgccaggtg
      961 gatgttgtgc gtagccggag ccaagttgaa gagagaactt gatgccaccg caacagtatt
     1021 ggcaaacagg caagatgaga gcgaacagtc cagaaagcgg ctcattgagc agagccgaga
     1081 attcaagaag aacactccag aggatttacg caagcaggta gcaccactgc taaagagctt
     1141 ccaaggggag attgatgcac tgagtaaaag aagcaaagaa gcagaggcag ccttcttgac
     1201 tgtgtacaag agactaattg atgttccaga tccggtacca gccctggacg tcgggcaaca
     1261 gctggaaata aaagtgcagc gtctacacga cattgaaaca gagaaccaga aacttaggga
     1321 aacactagaa gagtacaaca aggagtttgc tgaagtgaaa aatcaagagg ttacgataaa
     1381 agcacttaag gagaaaatcc gagaatacga gcagaccctg aagagtcagg ccgagaccat
     1441 tgctctggag aaagagcaga agctacaaaa tgattttgca gagaaggaga gaaagctgca
     1501 agagacacag atgtccacca cctcaaaact ggaggaagct gagcacaaac tccagactct
     1561 gcaaacagcc ctggaaaaaa ctcgaacaga attatttgac ctgaaaacca aatatgatga
     1621 agaaactact gcaaaggccg atgagatcga gatgatcatg accgaccttg aacgagccaa
     1681 ccagagggca gaggtggcac agagagaagc agagacttta agggaacagc tctcatcggc
     1741 caaccactct ctccaactgg cctcgcagat ccagaaggct ccagatgtgg agcaggccat
     1801 agaggtgctg acccgatcca gcctagaagt agagttggct gccaaagagc gggagatcgc
     1861 ccagctggtg gaagatgtgc agcgactcca ggccagcctc accaagctac gtgagaattc
     1921 cgccagccag atctcacagc tggagcagca actgaatgcc aagaatagca cactcaaaca
     1981 actggaagaa aaactcaaag gccaggctga ctatgaagaa gtgaagaaag agctgaacac
     2041 cctgaagtcc atggagtttg caccatcgga gggagcaggg acacaggact ctaccaagcc
     2101 cctggaggtt ttactcctgg agaagaaccg ctcgctgcag tccgagaatg ccacgctgcg
     2161 catctccaac agtgacctga gcgggtcagc caggagaaaa gggagagacc agcctgagag
     2221 tcggcgcccg ggacccttgc cggcctcccc tcctcctcag ttgccccgca acacggggga
     2281 acaggtttcc aatactaacg gtacacacca cttctcacca gcggggttaa gtcaagactt
     2341 tttcagctca aacctggcca gccccagcct acccctggct tctacaggaa agtttgcact
     2401 aaactctctt ctccagcgac agctaatgca gtccttctac tccaaggcca tgcaggaagc
     2461 cggaagcaca agcaccattt tttcaacagg tccttacagc acaaactcca tatcttcccc
     2521 aagtccatta caacaaagcc cagatgtaaa tggcatggcc ccatctccca gccaatcaga
     2581 aagtgctggg agcatctcag agggcgagga aattgatacc gcagagatcg cccggcaggt
     2641 caaagagcag ctcatcaagc acaacattgg ccagcgcatc ttcggacatt acgtcctggg
     2701 actgtcgcaa ggctctgtga gcgagatcct ggcccggccc aagccctgga acaagctgac
     2761 tgtccgtggc aaggagccat tccacaagat gaagcagttc ctgtctgatg agcagaacat
     2821 cctggcactc cgtagcatcc aaggcagaca gagagagaat ccaggccaga gcctgaacag
     2881 actctttcag gaagtaccga aacgaagaaa tgggtctgaa ggtaacatca ctacccggat
     2941 ccgagcatct gagactggtt ctgatgaagc catcaagtcc atcctggaac aagccaagag
     3001 ggaactacaa gtgcagaaaa ccgctgagcc agtccagaca tcttccacgt ccagcagtgg
     3061 gaactctgac gatgccatcc gctccatcct acagcaggcc cgccgggaaa tggaggccca
     3121 gcaggctgcc cttgaccctg ccttaaagcc agcaccactg tcccagcccg acctcaccat
     3181 cctcaccccc aagcacctgt ctgcctcacc catgtctact gtgtccactt acccgcctct
     3241 tgctatctcc ctgaagaaaa cccctgcagc acctgagacc agtaccgcag ccttgcccag
     3301 tgccccagct ctcaaaaaag aggctcagga tgtacccaca ctggacccac caggatcagc
     3361 tgatgctgcc cagggagtgc tgaggccgat gaagagtgag ctagtccgtg gcagcacctg
     3421 gaaggatccc tggtggagcc ctatacagcc tgaaagaaga aacctcactt cttccgaaga
     3481 gaccaaggcc gatgaaacaa ctgcaagcgg gaaagaaagg gcaggcagca gccagcctcg
     3541 ggctgagcgc agccagcttc agggaccctc agcatccgca gagtactgga aagagtggcc
     3601 aagcgctgag tccccatact cccagagctc agagctgagc ctcactggag ccagccgcag
     3661 tgagacaccc cagaatagcc ctctgccctc ttccccaatt gtgcccatgg cgaagccagc
     3721 caagccttca gtgcccccgc tgactcctga gcagtacgag gtctacatgt atcaggaagt
     3781 ggacactatc gagctcactc ggcaggtcaa agagaagctg gccaagaacg gcatttgcca
     3841 gaggatcttt ggggagaagg tactgggcct gtcccagggc agtgtcagcg acatgctttc
     3901 aaggccaaaa ccatggagca aactgaccca gaaaggccga gaacccttca tccggatgca
     3961 gctctggctg aatggagagc tgggccaagg tgttctgcca gtgcaagggc aacagcaagg
     4021 gccagtcctc cactccgtgg cgtctctgca ggaccccctc cagcagggct gtgtgagctc
     4081 agaaagcact ccaaagacct ctgccagctg cagccctgcc cctgagtccc caatgagttc
     4141 cagcgaatct gtgaagagtc tcaccgagct ggtccagcag ccctgtcccg ccattgagac
     4201 cagtaaagaa ggcaaaccac cagagcccag cgacccgcct gcctcagact cccagcccac
     4261 aacaccgctg cctctctctg gacactcagc cctcagcatc caagaattag tagccatgtc
     4321 tcctgagctg gacacgtatg gcataaccaa gagggtcaaa gaggtgctga cagacaacaa
     4381 cctcggtcag cgcttatttg gggagaccat tttggggctc acccagggtt ctgtctccga
     4441 cctccttgcc cgcccaaagc cttggcataa gcttagtctg aaaggacggg aaccctttgt
     4501 ccgcatgcag ctatggctga acgaccccaa caatgtggag aagctgatgg atatgaagcg
     4561 gatggagaag aaagcctaca tgaagaggcg acacagctct gtcagtgaca gtcagccttg
     4621 tgagcccccc tctgtgggta ttgactatag ccaaggcgcc agcccccagc cacaacacca
     4681 gctgaagaaa cctcgagtgg tgctggctcc agaggagaag gaagcgctga agcgagcata
     4741 tcagcagaag ccatacccat caccaaaaac catcgaggaa cttgccacac aactcaacct
     4801 gaagaccagc accgtcatca actggttcca taattacagg tctcggatcc gcagagaact
     4861 gttcattgag gagattcaag ctggaagcca gggccaggct ggtgccagcg actcaccttc
     4921 agctcgaagt agccgcgctg cacccagctc ggaaggtgac agctgtgacg gcgtggaagc
     4981 caccgacgcc gaggagccag gtggcaacat agtggccacc aagtctcagg gagggctggc
     5041 agaggtggcc gcagccccgg cagaccggga agaagcgacg cagccggcgg agaaggcgaa
     5101 ggcacagcca ctatgctcgg ggaccccagg acaggacgac ggtgaagacg caagccggcc
     5161 taggccactt cccgagggcc tcgccgacgc cccagcgcct gtgccaagcc tcgccgcacc
     5221 cgcggccgga gaggacgccg ctacctcagc cactgccccg gccacggcca ccgaggcccc
     5281 cggggcggcc agggcgggcc ctgccgagag gagttctgcg ttgccaagca ccagcgcgcc
     5341 tgccaacgcg cctgcgcgaa ggcctagctc actgcagagc ctcttcggtc tgcccgaggc
     5401 cgcgggcgcc cgggacaacc tggtgcggaa gaagaaggct gcgaacttga acagcatcat
     5461 ccaccgcctg gagaaggctg ccagccggga ggagcccatc gaatgggagt tctgagggcg
     5521 ccgggcctcc gggcctgacc agcagggcct cgccgggcct tgccgggcct cgccggcctt
     5581 gccaggccca cctgcgccta gcaggtcccc tgggcccagt cagcaccggc agtgtgggct
     5641 ggggctggcg ggtgtgcagg gctgtgccag ccgaggcctg gacgtgttgc gcacttaacg
     5701 ccctgcgggc cacagggcaa aatcgccata ggccaaggtg catatagaaa acaaaggagc
     5761 attaagccca atctatgtcg tgttttcaag gaagaaaacg gaaatgtgta gtcaagcttt
     5821 tttgtaccct gaagtgtttt tttttttttt taaattgccc taagtgattt ccacaggttc
     5881 tggaataact ctttacagct tttgccttgt gccctcctct ttcgtgtggg ctttaaaaaa
     5941 aaaaaaatca aacccacata ttaaaagggg gctttttatc tgccatctaa tggcttcaga
     6001 gcgataatac actattatct tcttaaacca ggaagggggg ggattttttc agaaaaatta
     6061 aaaaaagaaa gtttttgtag ctgttcagtt gccactaaga gattgcacag tcaaaccgac
     6121 tctaaacaca ctagtttgga ttcctaaata ttttcaagaa aagaatcttc tcgtttgaaa
     6181 ctttgaatta aaataaaaca catttactcc acatattttt taacaaaaaa agaaaaaaaa
     6241 agaaaagtca catcaggaaa agtatctgat tttgtggtag ctgatgtagt gttttcttgt
     6301 acgtaactag aatcctgaca tgtagtgcac attgatccat agctttaact gactctgggc
     6361 ttttgctggc cagagtttgt ttaatacact ccattctagg ccaaatcagg acaaaaagaa
     6421 agatccgaat ctaggtattt tataatctgc tttttaacct ctaaccgcag agcacgctga
     6481 tcagacctca tatctcggag gtttaggaga caagttagaa ctgtagcatg taccggttca
     6541 ttttgtttta tttatggtgt ctgtctgtgt tggcacatct gcgcatgtgc aagcgtcgaa
     6601 cggaaggaaa tgtaggcccg caaggtcgca gcagttagtc ccgcacgtgc aggccaccgt
     6661 ctgctcatct ttccttggca cagaaggcac ctcacctcat gccactctcc agggcacctg
     6721 acagactgag ccccccaccc cccaggggaa gatgttccct atgctcgggc agggctggcg
     6781 cagctctgcg tgcacactct cttcctttct cttctcatcc ccttccttcc caccacaagc
     6841 actgataacc ctatgtactc gtgggaagct tcctttcctg cagaagagag aacgctgcag
     6901 tctgggctct attcccatcc ctgtagagat ggcccaaact caccaaaatg gtgacactct
     6961 tcaattccag accagaccat tggcccttca tgaatttctt ctctcacaat gtttttttaa
     7021 tgcacagttt agggcaatct aagtacaaat caaaagtcta acttgtctct tgattcctcc
     7081 cgttgtctat gtgtatatgc gtgagtatag aggtggatga aagtgtgcgt gcgtgtgcgt
     7141 gtgcaatttt atacgtctgt gtattttctt aagtatctgt gcacacatag agtgcattac
     7201 tgccaccttt ttcaataagc tggtttatca gtcatggctt ctacaggttt tgctaattta
     7261 gactccttat tgccatatct ttaaactaac aatagatgat ttcggtatat atatatattt
     7321 ttttttgctt atttataggt gctgtatttt attatctgat tgttaggaag ggatgaaagg
     7381 ggcaaatatt ctttagaggg atagactgcc ggcagtattg ggtataattt acaagctgta
     7441 gctgtcatac tgtatattac tgatggaaaa ctttttgacc gtattgtgta tcattgaaac
     7501 ttttgtctta ggtcaacatc tttggatgac attttaatgg tgcattcatt atttcttaag
     7561 tttaattaat taatagtact ttttttttat ttgggagggt gggagggagt tctaatttta
     7621 aaggcatctc ccactattgc ccctcagtgt gcgtgttatt ccttagcttg taggctttga
     7681 ctgtcagatg tgaaaccaca cttcttgcat gatgtttgga gcttatgtat tttcattcac
     7741 agtctttcaa cctgcagctg caagccctta gttggagttt tcacaaactg taagagtcac
     7801 gacactaaag acaatgcctt ttcatgaacg agaagtttcc aagaggctct aggaggctgg
     7861 gaggcaggcc cctggctctg tctttggatg gttgtatcac tcctaagctt gagatccggg
     7921 ttcggtgaga agagaattca cagtggaggg acggaaggga aacacagagt cccacctggc
     7981 tctgtgcaag gaagtactca ttcacaccag ggagtcgtta gggacacgga ggagcagagt
     8041 gggattgtgc cactccctcc acagaaacct caagggaacc tgtcatcatg ggtgatgatc
     8101 ttaaatacct aactttcact agagtgagaa gcagagttaa caggatcgag gagggtagtg
     8161 tgctagtttc aaaggcatgt ctgttcctta accgcagcct taaatctgcg gaaatggaag
     8221 ttgaggtttt tttccatcct gacacccaca cggtagcagt gtaagacagc ctttgactct
     8281 tccaagcaag tttctttaat ttttgaacta ggttcttatt aatttccatc ctgtctcttg
     8341 tgccagacct ccatctgggt gcttgataca atcacttggt taggtttttg cttgagttct
     8401 gtatttgtat tttcttattt attattatta ttattgttat tattttgaga tcccaacttg
     8461 atggtgtttg gggttaagtt agcactgtct gtagtatgtc taagagctgc cagtagataa
     8521 cacagaaacc tggggggtta tatctgcctc ctcatcatgt cctccctccc ttcccagtgt
     8581 gagtccaagg gttcatcttt catcttgaaa agcaatattc aagtgccttg aacagcgctc
     8641 cctcatgtgg tgaccttccg ctggctggag atccaagcag tagctcccac agacagccaa
     8701 ccatcctctt tatactctca gcttaaaaag ctgaattgta cttctcccca aggggaaaaa
     8761 atggttccat ataaaacact aacacttcat cacaagccac tgttccattt caaatgcctt
     8821 tttcttaatt agaggcagta atcctaacta ggccattacc cagttggcta agtgggagcc
     8881 tggtgtaaaa tccatgttca catcaagccc tcttgacacc tcttgattca tgccaagtcc
     8941 ccttatggca tccgaagtgg caggaatatg agttcttaga catctgccca ctcacttcca
     9001 ctctgacctg gctcccaatc accacctcct tgaaacaata gtcagttgag atgtctgacc
     9061 actgtgtact agacctctct ctttaaaaat aaaattaaat ttataaatgc aggcacttag
     9121 ctgaagtcga tatcttccta gctagccacc ctgaaaaata tcacaccttg aagtggctta
     9181 tcccgggttc gaatcagggc agagtcctgg ggatatagta ttaggtgctg ggccacacca
     9241 ctctgaaaaa tgaggcaaga ggacagctgt cagtctccgt gcacagatgc ttctgcttgc
     9301 aaagctcagg tgtccgtctc cttagtaatc ttccctctga tgggcatctc tttcctcctt
     9361 gttgaaagtc agatctggta gatggctcag agtatagcag ggctgtgagc tgagtgttcc
     9421 tctggactct tgtggccaac agagtccccg cctgtggcca tgccatagac ctacatggcc
     9481 attcttctct acagccaggg ccatgttgag ctgtggagct tataagcaag ctcagcagga
     9541 ggcagcccgc atctagtgca aaggaggcat gctctaggca tcagctaagc acccaaggtt
     9601 gtgtagctgt gaaagcccca gagctgggga gtccaaatgc tgatgctgga gatgccctcc
     9661 ctgcctcagc aagactggct ctttgtcctt tcggagctgt gttctcttac agctcggtgg
     9721 gctctaggga cccttgggat atatgattcc catcacatgc ttctgctctc tgtcagatcc
     9781 ctgaggctgg gagccatcct tgcagaggag atggggtaga gcaaaggtca agaacacatt
     9841 gagggaatgg aaggctcttg gctttgttcc tcctgtcctt caatgtctcc cctttctgtt
     9901 ctcttctacc tcaccacttg atgtcaccca gaattgtgag ggaagtgacc tgggggtggg
     9961 ggtgggggga ggggtggctt aagaggctac aagctagacc gatcatctca tcttgcttgg
    10021 caggtgtgct ttttgcctcc ttcaaagaat acatccagaa gtggtgtctg gagtctgcta
    10081 agcacaggaa ttttcctctt ggcttccagc tgttcttgaa attccagcag ctgttgggtc
    10141 tgtagacagg agtggtctcc agcctcagaa attcttgcct tttgctctgc cttcccgcac
    10201 agctgtcaga ctccatcaca gccattcctt tggtcttggc ttatccccaa atactatgag
    10261 cacacttccc caggaactgt ggctgtccga gtctctcgtc cctagacctt gccatgagct
    10321 ctgctttaca aacacagctc tgtccaggac agaaaaggtt ggacagaatt cttccccatg
    10381 catgcttggt ctctacttcc caaaagaaca ctccagtttc tgttccctgt gggaggcaag
    10441 cagctcccga gacagcagtg ggtctgggcc atactgctcc agagtgtacc tgtagcacgt
    10501 agggaacttt tattttgttg ttcccatcat gaatgtcaaa gtcactaggc acagctgcca
    10561 ctgcagattt tctgaaactg aatcagggga aggctttatg gccactttaa cccaggtggg
    10621 ctgagactct caagtggcta ggttcctacc agtagacttg gatgctaaga gaatgggctg
    10681 atgagaaatt ttcattctgc ccatgctttt tagatggaaa gtgagggtag gaacaagctc
    10741 cttagtaaaa gatacaaccc caagacctca ggctcagcca gtggaagaag acagttgaac
    10801 agcaagggaa aagccaggat ccccctgtgt accgcttaag gacctgctgc ttcaccgaac
    10861 ccccgcccca cccccgtgcc cacccctact cctctcctgc taccttccct ccaaagattc
    10921 catggccacg tcttcagtgg catatcgagt tttcattttt ggacaaagtg acatttagct
    10981 ttaacaagac atttccaaag ctcctggtct cctttgaaat gctgacttta aaagttcagc
    11041 attgttgcca agaatggggg tggggggggc taatgaaaga aagacgttag attatgcatg
    11101 aatgtgcacg ccccaaccct cggttattca aatttcaaat gcctttgagt tgctcttcat
    11161 agatgggttt attttgctca tgttaagtag tctgttactg taatttttgt agtattctgg
    11221 ctttaatttc taccacaaat atgctatgta ctaagctttc tgtgatcaga aaggaaaggt
    11281 gccttaaatc ccaataccac gcctctatcc ctatggagaa tatgtcagaa gcacagcgcc
    11341 aggaagcatt gggacttccg ttggcaaaat aggacaccat tcagcaagac acatccgagt
    11401 ggcacggcac ggggctgctt ttgtttgcta attccttttt tgttttttaa ctcccaaccc
    11461 ataattatct tttatttgtt gtttgtttta tttttttttt tttttgtagt tcgctttaaa
    11521 caggaagcac ttaatagatg gctctgtgtc gaagctctgt gcaatggaaa tcacgttgct
    11581 ttggtggggg gggggtgttt tgtttttctt ttctttttga aaaaagatag cgttattgca
    11641 caccaaatga actcctaagt aagctttaga accaggatcg attcaggtcg tggatgggta
    11701 tgttcactgt agttctgtgt gttcacgaac caacgggcaa gctggcctcc cttggccatt
    11761 gaggctcagc cctgagccct gggtcatggc tgcctgggtt tcagccgcag ggaactttcc
    11821 tggatgtctg gccccacagt cgacccttga agcacttaac cctctctttg tggagataga
    11881 ccaactgcta ctgatctgtc agcgtactcg agggtgatta taaaaggatg tttctttaag
    11941 aaagaaaaaa aaatatttct atctatcctc ttctaattta ttattaggtt aatcatttaa
    12001 gtacttatca ggagtgtgtt gtcattttgt gttgttgtcg cgaatgcttt tgctgtcact
    12061 ccagtggtta actgtccctt gctccccacc tctcttctct ccatccctga gtccaaagag
    12121 gtctggggac cagcagtggg agacatgagg gacagaaggg agtcctccag cacaatcaga
    12181 cacctgtctc cctagtagcc actcaaacct ggcggtctct acatatctta actgttcaat
    12241 ccagagagtt gacgaacaaa gctacccatg tcaggcagta ctgaggggag gcttgctccc
    12301 agaggcgctg cgatgcagtg aggaaaacag aaaagccaag ttcaagtttc cccaaagcct
    12361 cctagagcct ctgttaaaac ttctgggttc atgaatgttt ggcgagcctg gatcaggaga
    12421 gaggcaggca gtctggccaa ggccgtcacc ctgagccgga aggtggtttc tcaatggtcc
    12481 ccacaggtga ccacgacttt gattttcatt gtcagttgtc tttctttgca ttcaaagttg
    12541 gtcaaaagca tcttttgagg caacaggtct ttgctatcac tggaggtggc tagaggcccc
    12601 acacctaggc atgggttgaa gaacccttta ccctcccatg ccgggaaagg tggagaaagg
    12661 actttccatg gctggaaatg caaccagcaa gaagccccca tagcttgctc agcagagggt
    12721 gggggtatgt aggactgaac tctacctggg ggcagcaaac ttaaaaaaga ggctcatccc
    12781 agggacaggc aaagggcctg ctcacccagt aggcagggcc ggatacctgc ctttaccccc
    12841 aaacagtcca ctgagcccaa atccaaattt ctttctgtag cgtatctttc ccattctttg
    12901 aaatctggga gggggagggt cctactcatc tctttggggg taaaagtcct ccaataaaat
    12961 ttccccattt ccccaagggt ttttatttgt cttagtctat gcatttctct ttctacgtct
    13021 ctagttctct cctcccaccc caccccaaac acacacaaaa tagacatctc atgtcccacc
    13081 ctctgagacc accctgcctc agaagaatgc cggacatttg ggagacatga gaatgcattt
    13141 ttttaaaaag ccttcaagca ttttgagagt agcttgtcat aagctgacag tggggaggaa
    13201 tcagctccgt gactttcctg agtcccttcc cataggacaa gagacctagc tctttgcgtt
    13261 tgtgcaataa ctacttgcta ggagagcggg tagcaccacc ctcctctaga ctactaacac
    13321 acagcacaag acacatgtca gcccttccta agcccttccc cccatcatgt gttacatttt
    13381 agcagtattt actttttttt tctgtcaggc actaagtctt aggtgtttat agagcttgtg
    13441 tgttaataca atcacagatc tttttatttt attttaatcc tcaccaagac ccaattgacc
    13501 aaaaagaagc aagaggaaga aaaaaaaatt gtaaaagatg tctctctcct tttttttttt
    13561 ttttttgttt ttgtttttgt tttgttttgt acaagtagtt ttgagaagcc ttgtgttgct
    13621 gtgaccatct cctatcacag tcttgatttt cttgtgattt gttttcggca tttaaaagtt
    13681 ggtcccagct ggcgtggggg tgggggaggc acccgtcggc ccctcagcgc cgtcccttgt
    13741 ctttggttag ccatacgaaa tgtttgttct ctgcactgtc caacggtccc tattatgata
    13801 cggagaagca atatcaccga agctcacacc atgtattatt attcactagc accctaggtg
    13861 tgataattga agtaaatatc ttttatacaa aca
//
