LOCUS       NP_001278162            1613 aa            linear   ROD 25-FEB-2025
DEFINITION  homeobox protein cut-like 1 isoform c [Mus musculus].
ACCESSION   NP_001278162 XP_006504412
VERSION     NP_001278162.1
DBSOURCE    REFSEQ: accession NM_001291233.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1613)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   2  (residues 1 to 1613)
  AUTHORS   Tang,I., Nisal,A., Reed,A., Ware,T.B., Johansen,A., Zaki,M.S.,
            Cravatt,B.F. and Gleeson,J.G.
  TITLE     Lipidomic profiling of mouse brain and human neuron cultures
            reveals a role for Mboat7 in mTOR-dependent neuronal migration
  JOURNAL   Sci Transl Med 17 (779), eadp5247 (2025)
   PUBMED   39742503
REFERENCE   3  (residues 1 to 1613)
  AUTHORS   McRae,H.M., Leong,M.P.Y., Bergamasco,M.I., Garnham,A.L., Hu,Y.,
            Corbett,M.A., Whitehead,L., El-Saafin,F., Sheikh,B.N., Wilcox,S.,
            Hannan,A.J., Gecz,J., Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles
            and altered transcription in the cortex of a mouse model of the
            Borjeson-Forssman-Lehmann intellectual disability syndrome
  JOURNAL   PLoS Genet 20 (10), e1011428 (2024)
   PUBMED   39405291
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1613)
  AUTHORS   Barao,S., Xu,Y., Llongueras,J.P., Vistein,R., Goff,L.,
            Nielsen,K.J., Bae,B.I., Smith,R.S., Walsh,C.A., Stein-O'Brien,G.
            and Muller,U.
  TITLE     Conserved transcriptional regulation by BRN1 and BRN2 in
            neocortical progenitors drives mammalian neural specification and
            neocortical expansion
  JOURNAL   Nat Commun 15 (1), 8043 (2024)
   PUBMED   39271675
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1613)
  AUTHORS   Gillingham,A.K., Pfeifer,A.C. and Munro,S.
  TITLE     CASP, the alternatively spliced product of the gene encoding the
            CCAAT-displacement protein transcription factor, is a Golgi
            membrane protein related to giantin
  JOURNAL   Mol Biol Cell 13 (11), 3761-3774 (2002)
   PUBMED   12429822
REFERENCE   6  (residues 1 to 1613)
  AUTHORS   Lievens,P.M., Tufarelli,C., Donady,J.J., Stagg,A. and Neufeld,E.J.
  TITLE     CASP, a novel, highly conserved alternative-splicing product of the
            CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains,
            and interacts with full-length CDP in vitro
  JOURNAL   Gene 197 (1-2), 73-81 (1997)
   PUBMED   9332351
REFERENCE   7  (residues 1 to 1613)
  AUTHORS   Mailly,F., Berube,G., Harada,R., Mao,P.L., Phillips,S. and
            Nepveu,A.
  TITLE     The human cut homeodomain protein can repress gene expression by
            two distinct mechanisms: active repression and competition for
            binding site occupancy
  JOURNAL   Mol Cell Biol 16 (10), 5346-5357 (1996)
   PUBMED   8816446
REFERENCE   8  (residues 1 to 1613)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (residues 1 to 1613)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
REFERENCE   10 (residues 1 to 1613)
  AUTHORS   Andres,V., Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Clox, a mammalian homeobox gene related to Drosophila cut, encodes
            DNA-binding regulatory proteins differentially expressed during
            development
  JOURNAL   Development 116 (2), 321-334 (1992)
   PUBMED   1363085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087329.10, AC080158.4 and AC083890.4.
            
            On Mar 29, 2014 this sequence version replaced XP_006504412.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY037807.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1613
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.96 cM"
     Protein         1..1613
                     /product="homeobox protein cut-like 1 isoform c"
                     /note="protein CASP; homeobox protein cut-like 1; CCAAT
                     displacement protein; Cux/CDP homeoprotein; homeobox
                     protein cux-1"
                     /calculated_mol_wt=175261
     Region          118..>454
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          643..719
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          843..>1026
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1032..1100
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1215..1292
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1338..1394
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..1613
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /coded_by="NM_001291233.2:674..5515"
                     /note="isoform c is encoded by transcript variant 3"
                     /db_xref="GeneID:13047"
                     /db_xref="MGI:MGI:88568"
ORIGIN      
        1 merasgplra afsspvlesk apgapldcke tdcgsssprg dgigasqsaa elpacpedai
       61 lpatphrnql lalgvlpasa ssafaapgqp qdsarwmlcv agaklkreld atatvlanrq
      121 deseqsrkrl ieqsrefkkn tpedlrkqva pllksfqgei dalskrskea eaafltvykr
      181 lidvpdpvpa ldvgqqleik vqrlhdiete nqklretlee ynkefaevkn qevtikalke
      241 kireyeqtlk sqaetialek eqklqndfae kerklqetqm sttskleeae hklqtlqtal
      301 ektrtelfdl ktkydeetta kadeiemimt dleranqrae vaqreaetlr eqlssanhsl
      361 qlasqiqkap dveqaievlt rsslevelaa kereiaqlve dvqrlqaslt klrensasqi
      421 sqleqqlnak nstlkqleek lkgqadyeev kkelntlksm efapsegagt qdstkplevl
      481 lleknrslqs enatlrisns dlsgsarrkg rdqpesrrpg plpaspppql prntgeqvsn
      541 tngthhfspa glsqdffssn laspslplas tgkfalnsll qrqlmqsfys kamqeagsts
      601 tifstgpyst nsisspsplq qspdvngmap spsqsesags isegeeidta eiarqvkeql
      661 ikhnigqrif ghyvlglsqg svseilarpk pwnkltvrgk epfhkmkqfl sdeqnilalr
      721 siqgrqrenp gqslnrlfqe vpkrrngseg nittrirase tgsdeaiksi leqakrelqv
      781 qktaepvqts stsssgnsdd airsilqqar remeaqqaal dpalkpapls qpdltiltpk
      841 hlsaspmstv stypplaisl kktpaapets taalpsapal kkeaqdvptl dppgsadaaq
      901 gvlrpmksel vrgstwkdpw wspiqperrn ltsseetkad ettasgkera gssqpraers
      961 qlqgpsasae ywkewpsaes pysqsselsl tgasrsetpq nsplpsspiv pmakpakpsv
     1021 ppltpeqyev ymyqevdtie ltrqvkekla kngicqrifg ekvlglsqgs vsdmlsrpkp
     1081 wskltqkgre pfirmqlwln gelgqgvlpv qgqqqgpvlh svaslqdplq qgcvssestp
     1141 ktsascspap espmsssesv ksltelvqqp cpaietskeg kppepsdppa sdsqpttplp
     1201 lsghsalsiq elvamspeld tygitkrvke vltdnnlgqr lfgetilglt qgsvsdllar
     1261 pkpwhklslk grepfvrmql wlndpnnvek lmdmkrmekk aymkrrhssv sdsqpcepps
     1321 vgidysqgas pqpqhqlkkp rvvlapeeke alkrayqqkp ypspktieel atqlnlktst
     1381 vinwfhnyrs rirrelfiee iqagsqgqag asdspsarss raapssegds cdgveatdae
     1441 epggnivatk sqgglaevaa apadreeatq paekakaqpl csgtpgqddg edasrprplp
     1501 egladapapv pslaapaage daatsatapa tateapgaar agpaerssal pstsapanap
     1561 arrpsslqsl fglpeaagar dnlvrkkkaa nlnsiihrle kaasreepie wef
//
