LOCUS       NM_026307                727 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cutA divalent cation tolerance homolog (Cuta),
            transcript variant 1, mRNA.
ACCESSION   NM_026307
VERSION     NM_026307.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 727)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 727)
  AUTHORS   Hou,P., Liu,G., Zhao,Y., Shi,Z., Zheng,Q., Bu,G., Xu,H. and
            Zhang,Y.W.
  TITLE     Role of copper and the copper-related protein CUTA in mediating APP
            processing and Abeta generation
  JOURNAL   Neurobiol Aging 36 (3), 1310-1315 (2015)
   PUBMED   25557959
REFERENCE   3  (bases 1 to 727)
  AUTHORS   Liang,D., Carvalho,S., Bon,S. and Massoulie,J.
  TITLE     Unusual transfer of CutA into the secretory pathway, evidenced by
            fusion proteins with acetylcholinesterase
  JOURNAL   FEBS J 276 (16), 4473-4482 (2009)
   PUBMED   19645739
  REMARK    GeneRIF: an N-terminal CutA domain actually drives AChE into the
            endoplasmic reticulum and allows its secretion
REFERENCE   4  (bases 1 to 727)
  AUTHORS   Liang,D., Nunes-Tavares,N., Xie,H.Q., Carvalho,S., Bon,S. and
            Massoulie,J.
  TITLE     Protein CutA undergoes an unusual transfer into the secretory
            pathway and affects the folding, oligomerization, and secretion of
            acetylcholinesterase
  JOURNAL   J Biol Chem 284 (8), 5195-5207 (2009)
   PUBMED   19049969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA197830.1, AK002828.1 and CA323205.1.
            
            On Nov 7, 2013 this sequence version replaced NM_026307.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY703910.1, BY703330.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AA197830.1         3-59
            58-704              AK002828.1         2-648
            705-727             CA323205.1         618-640
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.6 cM"
     gene            1..727
                     /gene="Cuta"
                     /gene_synonym="0610039D01Rik; 1810022E02Rik;
                     1810060C03Rik; 2700094G22Rik"
                     /note="cutA divalent cation tolerance homolog"
                     /db_xref="GeneID:67675"
                     /db_xref="MGI:MGI:1914925"
     exon            1..88
                     /gene="Cuta"
                     /gene_synonym="0610039D01Rik; 1810022E02Rik;
                     1810060C03Rik; 2700094G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            89..140
                     /gene="Cuta"
                     /gene_synonym="0610039D01Rik; 1810022E02Rik;
                     1810060C03Rik; 2700094G22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..632
                     /gene="Cuta"
                     /gene_synonym="0610039D01Rik; 1810022E02Rik;
                     1810060C03Rik; 2700094G22Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein CutA; divalent cation tolerant protein
                     CUTA; brain acetylcholinesterase putative membrane anchor"
                     /codon_start=1
                     /product="protein CutA isoform 1 precursor"
                     /protein_id="NP_080583.3"
                     /db_xref="CCDS:CCDS28557.1"
                     /db_xref="GeneID:67675"
                     /db_xref="MGI:MGI:1914925"
                     /translation="MNWGRAPGVLLGGGATLLLSFLWMPALLPVASRLLLLPRALLSM
                     ASGSPPSQPPPASGSGYVPGSVSAAFVTCPNEKVAKEIARAVVEKRLAACVNLIPQIT
                     SIYEWKGKIEEDSEVLMMIKTQSSLVPALTEFVRSVHPYEVAEVIALPVEQGNPPYLH
                     WVHQVTESVSNSGTALP"
     exon            141..349
                     /gene="Cuta"
                     /gene_synonym="0610039D01Rik; 1810022E02Rik;
                     1810060C03Rik; 2700094G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            350..409
                     /gene="Cuta"
                     /gene_synonym="0610039D01Rik; 1810022E02Rik;
                     1810060C03Rik; 2700094G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            410..455
                     /gene="Cuta"
                     /gene_synonym="0610039D01Rik; 1810022E02Rik;
                     1810060C03Rik; 2700094G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            456..505
                     /gene="Cuta"
                     /gene_synonym="0610039D01Rik; 1810022E02Rik;
                     1810060C03Rik; 2700094G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            506..710
                     /gene="Cuta"
                     /gene_synonym="0610039D01Rik; 1810022E02Rik;
                     1810060C03Rik; 2700094G22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      688..693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cuta"
                     /gene_synonym="0610039D01Rik; 1810022E02Rik;
                     1810060C03Rik; 2700094G22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      710
                     /gene="Cuta"
                     /gene_synonym="0610039D01Rik; 1810022E02Rik;
                     1810060C03Rik; 2700094G22Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggattggcc aggtctggag actccgggaa ggcagggctg ctcctgtcac gtggtgcaca
       61 ctgttttcgc gtcacgtggc tactgcagcg cgggctgcat gaactggggg cgggcgcccg
      121 gcgtcttgct cggcggaggg gccactctgc tcctgtcgtt tctttggatg ccagcgctac
      181 tgccggtggc ttcccgcctt ctgttgctac cccgagctct gctgtcaatg gcttctggaa
      241 gccctccgtc ccagccccct ccggcctcgg gctccggcta cgttccagga tcagtctctg
      301 cagcctttgt cacttgtccc aacgaaaaag tcgccaagga gatcgccagg gcagtggtag
      361 agaagcgtct ggcagcctgc gtcaacctca tcccgcagat cacatccatc tatgaatgga
      421 aaggaaagat cgaggaagat agtgaggtgc tgatgatgat taaaacccaa agctccctgg
      481 tccctgctct gacagagttt gttcgatctg tgcaccctta tgaagtggcc gaagtgattg
      541 cactgcctgt ggagcaggga aatcccccgt acctgcactg ggtgcaccag gtcacagaat
      601 cggtttcaaa ttctggcaca gccctaccat gaggagccct gttcctgttt taatgccccc
      661 tggcttccat gtgatgaccg aacccccaat aaatcctctc ctgctcctga aaaaaaaaaa
      721 aaaaaaa
//
