LOCUS       NM_001081335            7862 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cullin 9 (Cul9), mRNA.
ACCESSION   NM_001081335 XM_895029
VERSION     NM_001081335.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7862)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7862)
  AUTHORS   Hollville,E., Joers,V., Nakamura,A., Swahari,V., Tansey,M.G.,
            Moy,S.S. and Deshmukh,M.
  TITLE     Characterization of a Cul9-Parkin double knockout mouse model for
            Parkinson's disease
  JOURNAL   Sci Rep 10 (1), 16886 (2020)
   PUBMED   33037272
  REMARK    GeneRIF: Characterization of a Cul9-Parkin double knockout mouse
            model for Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7862)
  AUTHORS   Dai,X., Zhang,M., Lu,Y., Miao,Y., Zhou,C. and Xiong,B.
  TITLE     Cullin9 protects mouse eggs from aneuploidy by controlling
            microtubule dynamics via Survivin
  JOURNAL   Biochim Biophys Acta 1863 (12), 2934-2941 (2016)
   PUBMED   27678504
  REMARK    GeneRIF: The study assigns a new meiotic function to Cullin9 and
            reveals that it prevents mouse eggs from aneuploidy by regulating
            microtubule dynamics via survivin.
REFERENCE   4  (bases 1 to 7862)
  AUTHORS   Gama,V., Swahari,V., Schafer,J., Kole,A.J., Evans,A., Huang,Y.,
            Cliffe,A., Golitz,B., Sciaky,N., Pei,X.H., Xiong,Y. and Deshmukh,M.
  TITLE     The E3 ligase PARC mediates the degradation of cytosolic cytochrome
            c to promote survival in neurons and cancer cells
  JOURNAL   Sci Signal 7 (334), ra67 (2014)
   PUBMED   25028717
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7862)
  AUTHORS   Li,Z., Pei,X.H., Yan,J., Yan,F., Cappell,K.M., Whitehurst,A.W. and
            Xiong,Y.
  TITLE     CUL9 mediates the functions of the 3M complex and ubiquitylates
            survivin to maintain genome integrity
  JOURNAL   Mol Cell 54 (5), 805-819 (2014)
   PUBMED   24793696
  REMARK    GeneRIF: A 3M-CUL9-survivin pathway is implicated in maintaining
            microtubule and genome integrity, normal development, and tumor
            suppression.
REFERENCE   6  (bases 1 to 7862)
  AUTHORS   Pei,X.H., Bai,F., Li,Z., Smith,M.D., Whitewolf,G., Jin,R. and
            Xiong,Y.
  TITLE     Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and
            promotes p53-dependent apoptosis
  JOURNAL   Cancer Res 71 (8), 2969-2977 (2011)
   PUBMED   21487039
REFERENCE   7  (bases 1 to 7862)
  AUTHORS   Barkic,M., Crnomarkovic,S., Grabusic,K., Bogetic,I., Panic,L.,
            Tamarut,S., Cokaric,M., Jeric,I., Vidak,S. and Volarevic,S.
  TITLE     The p53 tumor suppressor causes congenital malformations in
            Rpl24-deficient mice and promotes their survival
  JOURNAL   Mol Cell Biol 29 (10), 2489-2504 (2009)
   PUBMED   19273598
REFERENCE   8  (bases 1 to 7862)
  AUTHORS   Skaar,J.R., Florens,L., Tsutsumi,T., Arai,T., Tron,A.,
            Swanson,S.K., Washburn,M.P. and DeCaprio,J.A.
  TITLE     PARC and CUL7 form atypical cullin RING ligase complexes
  JOURNAL   Cancer Res 67 (5), 2006-2014 (2007)
   PUBMED   17332328
REFERENCE   9  (bases 1 to 7862)
  AUTHORS   Ko,H.S., Kim,S.W., Sriram,S.R., Dawson,V.L. and Dawson,T.M.
  TITLE     Identification of far upstream element-binding protein-1 as an
            authentic Parkin substrate
  JOURNAL   J Biol Chem 281 (24), 16193-16196 (2006)
   PUBMED   16672220
  REMARK    GeneRIF: FUBP1 is an authentic substrate of Parkin that might play
            an important role in development of Parkinson disease pathology
            along with aminoacyl-tRNA synthetase interacting multifunctional
            protein type 2
REFERENCE   10 (bases 1 to 7862)
  AUTHORS   Skaar,J.R., Arai,T. and DeCaprio,J.A.
  TITLE     Dimerization of CUL7 and PARC is not required for all CUL7
            functions and mouse development
  JOURNAL   Mol Cell Biol 25 (13), 5579-5589 (2005)
   PUBMED   15964813
  REMARK    GeneRIF: Dimerization of Cul7 and Parc is not required for all Cul7
            functions and mouse development.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ110581.1, AK147675.1, CF534354.1, AK162968.1, AK051474.1 and
            BP753198.1.
            
            On Aug 23, 2012 this sequence version replaced NM_001081335.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.19305.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               CJ110581.1         1-143
            144-2145            AK147675.1         592-2593
            2146-2553           CF534354.1         4-411
            2554-4317           AK147675.1         2809-4572
            4318-7010           AK147675.1         4908-7600
            7011-7368           AK162968.1         2472-2829
            7369-7843           AK051474.1         2598-3072
            7844-7862           BP753198.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..7862
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..7862
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /note="cullin 9"
                     /db_xref="GeneID:78309"
                     /db_xref="MGI:MGI:1925559"
     exon            1..143
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            144..747
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..7745
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /note="p53-associated parkin-like cytoplasmic protein"
                     /codon_start=1
                     /product="cullin-9"
                     /protein_id="NP_001074804.2"
                     /db_xref="CCDS:CCDS37636.2"
                     /db_xref="GeneID:78309"
                     /db_xref="MGI:MGI:1925559"
                     /translation="MVGERRAGNLLVPLGPRLQAYPEELLRQRPGHDGHPEYLIRWSV
                     LKCSEEGKVSSEEEKTEHLLMWLSAPEVYANCPMLLRERPIPKGPQHEPAGEVGSFPR
                     DPGGLDELAMTEMEADVRALVRRAARQLAEGGTSSLTAAVLHTVHVLSAYASIGPLTG
                     VFRETGALDLLMHMLCNPEPQIRRSAGKMLQALAAHDAGSRAHVLLSLSQHDGIEQHM
                     DFDSRYTLLELFAETTSTEEHCMALEGIHLPQIPGKLLFSLVKRYLCVTSLLDQLNNS
                     PESGAGDQSSPCLTKEKSRAQQELEFSMAVGNLISELVRSMGWARNLSEQGALPPRPS
                     RSIFQPCLSGPPPLLLPTIVTTPRKQGRAFRGRSEFSSRSGYGEYVQQTVQPGMRVRI
                     LDDYEEISAGDEGEFQQSNNGVPPVQVFWQSTGRTYWVHWHMLEILGPEEATGDSASA
                     AVEKGAGAAVLGTVCPSWDWKPTHGLYSLPYLQPEPQKNEEESGYLTQAEWWELLFFI
                     KKLDVGEQQPIFQNLHEKLDEEALGEKALGELSVPIEMAEGVLQVLSNRFEGSNLCDL
                     LNSRIYTKYGLLPKELGSLPSSRRHSCSPEPEEGSRSAANFSEKEEACRANAVPPEAE
                     MELASAKTEPPKAQSDSQLFNQLLVTEGMTLPPETQEAATEMARALRGPGPRSSLDQH
                     VAAVLATVQISSLDTNLQLSGLCALSQAVEEVTERDHPLVRPDRPLREKLVKTLVDLL
                     TNQVGEKMVVVMALRLLYLLMTKHEWRPLFAREGGIYAVLICMQEYKTSVLVQQAGLA
                     ALKMLAIANSSDVPTFIPSRDSIQPLFDTQMTREIFASIDSATRPGSESLLLSVPAAV
                     VLMLNTEGCSSAVRNGLLLLNLLLCNHHTLGDQIITQELRDTLFRHSGIAPGTEPMPT
                     TRTILTMLLSRYSEPRGSPERAVLETPSTQGQDGSPESLIRSLVGDLSAELFLDLERV
                     LCHEGSPPAAVRPLLRRLQQETQPFLLLLRTLDAPGPNRTLLLTILRVMTRLLDHPET
                     MVLPWHEVLEPCLNCLNGPSSDSEVVQEVTCFLHRLALMQKDYAVVLCCLGGKEALSK
                     VLDKHSTQLLLASELRHLVAECEKYSQLCSNLTSSILAGCIQMVLGQIEDHRRTYKPI
                     TIPFFDVFLRHLCQGSSVEVKEDRCWEKVEVSSNPHRASKLTDRNPKTYWESNGSTGS
                     HSITLHMHRGVLIRQLTLLVASEDSSYMPARVVVFGGDNVGCISTELNTVNVMPSASR
                     VTLLENLTRFWPIIQIRIKRCQQGGIDTRVRGVEVLGPKPTFWPLFREQLCRRTCLFY
                     TIRAQAWSRDIAEDRQRLLQLYPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALV
                     SPLVQNITSPDAGGVSSLGWLLDQYLEHRESTRSRQGPAASFASQVRRLCHLLVHVEA
                     PPGPSPEPSSQPLSKNSKGQDGSPTPAPTPVCPSTSLRNLTQCWLSVVQGQVSRFLAA
                     AWRASDFVPRYCSLYQRLQSAGSELFGPRAAFTLALRSGFSGALLQQSFLTAAHISEQ
                     FARHIDQQIHGGLLGGAAGVGMLGRLQRHLEPIMVLSGLELATTFEHFYQHYMADRLL
                     SLGSSWLEGAVLEQIGPCFPNRLPQLMLQSLHTSEELQHRFHLFQLQQLDRQLLEQGD
                     QEEWRPEKVEEDDEGQETGRELFTDPGPAISVLVLSPRCWPVSPLCYLHHPRKHLQAE
                     LCDALERFSSFYSHSQNCPVLDIGPHRRLQWTWLGRAELQFGDQTLHVSTVQMWLLLN
                     FNQSEEVSVETLLRNSDLSPELLHQALLPLTSDNGPLTLEETQDYPQGGVLRLREPRS
                     QTHEEVLWLIPPQTYLSVEKDEGRTLEQKRNLLSCLLVRILKAHREKGLHIDQLVCLV
                     LEAWQKGPDPPGRLGNAAAVGVACSSTDVLSCILHLLGQGYVERRDDRPQVLMYATPE
                     PMGPCRGQADVPFCGNKNTETSRPSPEAVVALASLQLPAGRTMSPQEVEGLMEQTVRQ
                     VQETLNLEPDVAQHLLAHSHWGTEQLLQSYSDDPEPLLLAAGLRVPQAQVVPTRPDQC
                     PVCVTPLGPHDDSPSLCCLHCCCKSCWNEYLTTRIEQNFVLNCTCPIADCPAQPTGAF
                     IRNIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGSGTTCSKCGW
                     ASCFSCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAPIE
                     KNEGCLHMTCARCNHGFCWRCLKSWKPSHKDYYNCSAMVSKAARQEKRFQDYNERCTF
                     HHQAREFAVNLRNQASAIQEVPPPKSFTFLQDACRALEQARKVLAYACVYSFYSQDTE
                     YMDVVEQQTENLELHTNALQILLEETLLRCRDLASSLRFLRADCLSTGTELLRRIQER
                     LLAILQHSTQDFRVGLQSPSVETREVKGSNVPSDQPQGSSGLEVEDEEEEEEEEEEEE
                     EEEEEDVPEWQHEFDEELDNDSFSYDEESENLDRETFFFGDEDEDDESYD"
     exon            748..902
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1406
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1542
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1742
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..2145
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2338
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2546
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2743
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2961
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3208
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3314
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3542
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..3633
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..3805
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            3806..3911
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..4007
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            4008..4183
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4317
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            4318..4497
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            4498..4613
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            4614..4796
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            4797..4957
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            4958..5186
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            5187..5373
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            5374..5519
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            5520..5649
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            5650..5849
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            5850..6100
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            6101..6446
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            6447..6587
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            6588..6752
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            6753..6916
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            6917..7010
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            7011..7085
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            7086..7196
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            7197..7314
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            7315..7448
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            7449..7522
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     exon            7523..7844
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7819..7824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /note="hexamer: AATAAA"
     polyA_site      7840
                     /gene="Cul9"
                     /gene_synonym="1810035I07Rik; Cul-9; mKIAA0708; Parc"
                     /note="major polyA site"
ORIGIN      
        1 gtgggccacc gtaggacccg tagtcgcccg ggtcgtgcgt gcgcccggcg tgtgacccgg
       61 aaaagagctg tggaggaggc gggcccagtt gcgggacccg ctgctgggtg acagcgaggg
      121 tccagccggg agggcggtga gaggagatca ggatggtagg ggaacggcgt gcagggaacc
      181 ttctggtacc cttggggcct cggctgcagg cgtaccctga agaactcctt cgacagaggc
      241 ctggacatga tggccatccc gagtacctga tccgctggag tgtcctcaag tgtagcgaag
      301 agggcaaagt gagctcagag gaggagaaga cagagcatct cctcatgtgg ctgtcagccc
      361 cagaggtcta cgccaactgc cccatgctac tgagggagcg gccaatacct aaaggcccgc
      421 agcacgaacc tgctggagag gtgggaagct tcccacgaga ccctggaggc ctggatgagt
      481 tggcaatgac agagatggag gctgatgtcc gggcgctggt gcgcagggct gccaggcagc
      541 tggcggaggg tgggacctcg agcctgacgg ctgctgtgct tcacaccgtc cacgtgctca
      601 gtgcctatgc cagcatcggg cctctcaccg gagtcttcag ggagaccgga gccctagatc
      661 tgctcatgca catgctgtgc aatcccgagc ctcagatccg ccggagtgca ggcaagatgc
      721 tccaggctct ggcagcccat gatgctggga gccgggctca cgtccttctg tcactgagcc
      781 agcacgacgg catcgagcag cacatggatt ttgacagccg ctacacttta ctggagctgt
      841 ttgcggagac cacgtccaca gaggagcact gcatggcctt ggagggcatc caccttcctc
      901 agatccctgg gaagctgctc ttctccctgg taaagcgcta cctctgtgtc acctccctgc
      961 tggatcagct gaataacagc ccagagtcag gagctgggga ccagagctcc ccgtgtctca
     1021 caaaggagaa gagccgggcg cagcaggagc tggagttcag tatggccgtg ggcaatctca
     1081 tttctgagct ggtgcggagc atgggctggg cacggaacct cagtgagcag ggcgctttgc
     1141 cgcccaggcc atcccgatcc atcttccagc catgcctctc aggccctccg cctctgctgc
     1201 tacccaccat cgtcactaca cccaggaagc aagggcgggc cttccgcggt cgttctgagt
     1261 tttctagccg cagcggttat ggtgaatacg ttcagcagac ggtgcagccc ggcatgcggg
     1321 ttcgcatcct ggatgactac gaggagatca gtgctgggga cgagggcgag ttccagcaga
     1381 gcaacaatgg cgtgccccct gtgcaggtct tctggcagtc gactggccgc acctactggg
     1441 tacactggca catgctagag atcctggggc cggaggaagc tactggggat tcagcgtccg
     1501 cagctgtgga gaagggagca ggggcagctg tactgggcac agtgtgtccc tcctgggact
     1561 ggaagcccac acatggcctg tactcactgc cgtatctcca gcccgaaccc cagaagaacg
     1621 aggaggagtc agggtacctg acccaggcag agtggtggga gctactgttc ttcatcaaga
     1681 agttggacgt gggtgaacag cagccaattt tccagaatct gcatgagaaa ctggatgagg
     1741 aggccctggg agaaaaggcc ctgggagagc tctctgtgcc catagagatg gctgagggtg
     1801 tactacaggt tctcagcaac cgctttgagg gcagcaacct ctgcgacctg ctcaattccc
     1861 gcatctacac taagtacggg ctactgccca aggaactggg gagcttgccg tcttcacggc
     1921 gtcactcctg tagcccagag ccagaggagg gctcaaggtc agctgccaac ttctcagaga
     1981 aggaagaggc ctgcagagcc aatgctgtgc ccccagaggc agagatggag cttgccagtg
     2041 caaagacaga gccccccaaa gcacagagtg actcccagct gtttaatcag cttctggtga
     2101 ctgaggggat gaccctgccc cctgaaacac aggaggcagc tactgaaatg gccagagcct
     2161 tgcggggtcc tggtccgcgc agctccctgg atcagcatgt ggcagcggtc ttggccactg
     2221 tgcagatctc cagcctggat acgaacctgc agctatcagg gctctgtgcc ctctcccagg
     2281 ctgtggagga ggtcactgag cgagaccacc ccctggtccg tcctgacaga ccgttgagag
     2341 agaagctcgt gaagaccctg gtggatttgc taaccaacca ggtgggagag aagatggtgg
     2401 tggtgatggc cctgcgcctc ctctacctgc tcatgaccaa gcatgaatgg cgtccgctct
     2461 ttgccaggga gggtggcatc tacgctgtgc tgatttgcat gcaagaatac aagacatccg
     2521 tcttggtgca gcaggcagga ctggcagcac tcaagatgct ggccattgct aattcctccg
     2581 acgtccccac tttcatcccc agccgagatt ccatccaacc tctgtttgat acccagatga
     2641 ccagagagat ctttgccagc atcgactctg ccacccgccc aggctccgag agtttgctcc
     2701 tcagtgtacc tgcggctgtg gtcctgatgc tgaacactga ggggtgctcc tctgcagtga
     2761 gaaacggcct gcttcttctc aacctgcttc tatgcaacca ccacactttg ggagaccaga
     2821 tcataacgca ggagctgaga gacaccttgt tcaggcactc ggggatagcg ccggggacag
     2881 agccaatgcc caccacacgc accatcctca ccatgctcct cagtcgctac tcagagccac
     2941 ggggaagtcc tgagcgagca gtactggaga caccaagcac ccagggtcag gatgggtccc
     3001 ccgagtcgct catccggtcc ctggtgggtg acctgtcagc agaactcttc cttgacttgg
     3061 aacgcgtgct gtgccatgaa ggcagccctc cagctgccgt gaggcccctc ctcaggcgcc
     3121 tccagcagga aacgcagcca ttcctcctgt tgctgcggac tctagatgcc cccgggccca
     3181 acagaactct gctgctcacg atactcaggg tcatgacccg actgctggat catcctgaga
     3241 caatggtcct cccctggcac gaggtcttgg agccctgcct caactgcctg aatgggccaa
     3301 gcagtgactc tgaggttgtc caggaggtga cctgcttcct gcaccgcctg gctctgatgc
     3361 agaaagacta cgcagtggtg ctttgctgcc tgggaggtaa ggaagccctc tccaaagtcc
     3421 tggacaagca ctccactcag ctcctgctgg cctctgagct gcgccacctg gtggccgagt
     3481 gtgagaagta ctcgcagctc tgcagcaacc tcacctcgag catcctggca ggctgcatcc
     3541 agatggtgct gggccagatt gaagaccaca ggcgaaccta caagcccatc actatcccct
     3601 tctttgatgt gttcctcagg catctctgcc agggctccag tgtggaggtg aaggaggaca
     3661 ggtgctggga gaaagtggag gtgtcctcga acccacaccg ggccagcaag ctgacggacc
     3721 gcaaccccaa gacctactgg gagtccaacg gcagcactgg ctcccactcc atcaccttac
     3781 acatgcaccg tggtgttctt attaggcagc tgaccctgct ggtggccagt gaagattcaa
     3841 gttacatgcc agccagggtg gtggtgtttg ggggtgacaa tgttggctgc atcagcacag
     3901 aacttaacac ggtaaacgtg atgccctctg ccagccgggt gaccctcctg gagaacctga
     3961 cccgcttctg gcccatcatc caaatccgaa taaagcgctg ccagcagggt ggtatcgaca
     4021 ctcgggttcg gggtgtggag gtgctgggcc ccaagcccac attctggcca ttgttccggg
     4081 agcaactatg ccgacgtact tgtctcttct acacaattcg ggcacaagca tggagccggg
     4141 acattgcaga ggaccgccag cgcctcctac agctctatcc gagactgaac agagttttgc
     4201 gccatgaaca gaattttgcc gatcgctttc tccctgatga cgaggccgcc caagcactgg
     4261 gcaagacctg ctgggaggcg ctggtcagcc ccctggtgca gaacatcacg tctcccgatg
     4321 caggaggtgt gagctccctg gggtggctgc tggaccagta cctggaacac agggagagta
     4381 cgcggagccg ccagggtcct gcagcttcct ttgcttccca agttcggcgc ctgtgccact
     4441 tgctggtaca tgtggaagcc cctcctgggc cttctcctga gccatcctcg cagcccctca
     4501 gcaagaacag taagggtcag gatggaagcc ccacaccggc acctactccg gtctgtccca
     4561 gcaccagcct tcggaacctc acccagtgct ggctgagtgt ggtgcaggga caggtcagca
     4621 gattcctggc cgcagcctgg agggcctcag actttgtgcc ccgttactgt agtctctatc
     4681 aacgcttgca aagcgcgggc tcagagctgt tcgggccgcg ggcagccttc actctggctc
     4741 tgcgcagtgg cttctccgga gctctgctgc agcagtcctt cctcacggct gctcacataa
     4801 gcgaacagtt tgctaggcac attgaccaac aaatccacgg tggtttgctt ggcggagcgg
     4861 ctggagtggg gatgctgggg cggctccagc ggcacctaga gcccatcatg gtcctttctg
     4921 gcctagagct ggccacgacg tttgagcact tctatcagca ttacatggct gaccgtctcc
     4981 tgagcttggg ctcgagctgg ctggaggggg ctgtgctgga gcagatcggt ccctgcttcc
     5041 ccaaccgcct cccgcagctg atgctgcaaa gcctgcacac ctcagaggag ctgcagcatc
     5101 gcttccacct cttccagctg cagcagctcg acaggcagct cttggagcag ggagaccagg
     5161 aggaatggag gccagagaaa gtggaggaag atgatgaggg acaggagact ggaagagaac
     5221 tctttacaga cccaggacca gccatttccg tcctggtcct gtcaccgcgc tgctggccgg
     5281 tctccccact gtgctatctg caccacccca gaaagcacct acaggcggag ctctgcgatg
     5341 ccctggagcg cttctccagc ttctacagcc acagtcagaa ctgcccagtc ttggacatag
     5401 gaccacaccg gcgacttcag tggacatggc tgggccgggc tgagctgcag tttggggacc
     5461 agaccctgca cgtgtccact gtacagatgt ggctgctgct gaattttaac caatcagagg
     5521 aggtgtcagt agagaccttg ttgaggaatt ctgacctctc cccagagctc ctgcaccagg
     5581 cccttctgcc cctcacctct gacaatggtc ctttaacact ggaggagact caggactatc
     5641 cacagggcgg ggtgctgcgg cttcgtgagc ctaggtccca gacccatgaa gaggtcctgt
     5701 ggctgatacc tccccagacg tatctcagtg tagaaaagga tgagggccgg accttggaac
     5761 agaagaggaa cctcttgagc tgccttcttg tccggatcct caaagcccac agggagaaag
     5821 gcctgcacat cgatcagctg gtttgtctgg tactggaggc ctggcagaag ggtccagatc
     5881 cacctgggcg cctaggcaac gctgcggcag tgggtgtggc ctgctccagc actgatgttc
     5941 tctcttgcat cctgcatctc ctgggccagg gctatgtgga acggcgtgat gacaggcccc
     6001 aggtcctgat gtatgccact ccagagccca tggggccctg ccggggtcag gcagatgtcc
     6061 ccttttgtgg caacaagaac actgagacct ccaggcctag cccagaagct gtggtggccc
     6121 tggcatctct acagctgcct gcaggccgta ccatgagtcc ccaggaggta gaaggattga
     6181 tggagcagac ggtgcggcag gtgcaggaga cgctgaactt ggagccagat gtagctcagc
     6241 accttctggc tcattcccac tggggcacag agcagctgct gcagagctac agcgatgacc
     6301 cagaaccact gctccttgcg gcagggctgc gagtacccca ggcccaggtg gtccccactc
     6361 gccctgacca atgccctgtg tgcgtcaccc ccttaggacc ccatgacgac tcgccctccc
     6421 tctgctgcct gcactgctgc tgtaagtctt gctggaacga gtacctgaca actcggatag
     6481 aacaaaactt tgtactgaac tgtacctgcc ccatcgctga ctgtcctgcc cagcccactg
     6541 gagccttcat ccgtaacatt gtctcctccc cggaggtcat ctccaagtat gagaaggccc
     6601 ttctgcgagg ctatgtggaa agctgctcca acctgacgtg gtgcaccaac cctcagggct
     6661 gtgaccgcat cctgtgccgc cagggcctgg gcagtgggac cacctgctcc aagtgcggct
     6721 gggcctcttg cttcagctgt agttttcccg aggcacacta ccctgccagc tgtggccaca
     6781 tgtcgcagtg ggtggatgat ggtggctact atgacggcat gagcgtggag gcccagagca
     6841 agcacttggc caagctcatc tccaaacgct gccctagctg tcaggcgccg atcgagaaga
     6901 acgaggggtg tctgcacatg acctgtgcaa gatgtaacca tgggttctgc tggcgctgcc
     6961 tcaagtcctg gaagccaagc cacaaggact actacaactg ctctgccatg gtaagcaaag
     7021 cagctcgcca ggagaagcgg tttcaggact ataacgagag gtgtaccttc catcatcagg
     7081 cccgggagtt tgctgtcaac ctgcggaacc aggcctctgc catccaagag gtgcctccac
     7141 ccaaatcctt caccttcctg caagatgcct gccgggccct cgagcaggct cgaaaggtgc
     7201 tggcctatgc ctgtgtctac agcttctaca gccaggacac agagtacatg gatgtggtag
     7261 aacagcagac ggagaacctg gagctgcata cgaacgccct gcagatcctg ctcgaggaga
     7321 ccctgctgcg ctgccgggac ctggcctcct ccctgcgctt cctgcgggcc gactgcctca
     7381 gcacgggcac agagctgctc cggaggatcc aggagaggct gctggccatc ctacagcact
     7441 ccacccagga cttccgggtt gggctgcaga gtccctcagt agagacccgg gaggtgaaag
     7501 ggtccaacgt gcccagtgat caaccccagg gctcctcagg gctggaagtg gaagacgaag
     7561 aggaggaaga agaggaggaa gaggaggagg aggaggagga ggaagaggat gtgcctgagt
     7621 ggcaacatga atttgatgag gaactagaca atgatagctt ctcctacgac gaggagtctg
     7681 agaacctgga ccgagagacc ttcttctttg gtgatgagga tgaagatgat gagtcctatg
     7741 actgaggggg gaggggcagg gccgcagggt gtcatgggag aggggattcc cagtgtctga
     7801 agcaccttct gtttactgaa taaacctctt ttttcacaca cttcaaaaaa aaaaaaaaaa
     7861 aa
//
