LOCUS       NM_025611               5546 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus cullin 7 (Cul7), mRNA.
ACCESSION   NM_025611 NM_177189 XM_358324
VERSION     NM_025611.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5546)
  AUTHORS   Zhang,Y., Hu,F., Li,H., Duan,Q., Pi,Y., Li,Y. and Zhang,H.
  TITLE     Longitudinal skeletal growth and growth plate morphological
            characteristics of chondro-tissue specific CUL7 knockout mice
  JOURNAL   Ann Anat 253, 152224 (2024)
   PUBMED   38367951
  REMARK    GeneRIF: Longitudinal skeletal growth and growth plate
            morphological characteristics of chondro-tissue specific CUL7
            knockout mice.
REFERENCE   2  (bases 1 to 5546)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5546)
  AUTHORS   Taliani,V., Buonaiuto,G., Desideri,F., Setti,A., Santini,T.,
            Galfre,S., Schirone,L., Mariani,D., Frati,G., Valenti,V.,
            Sciarretta,S., Perlas,E., Nicoletti,C., Musaro,A. and Ballarino,M.
  TITLE     The long noncoding RNA Charme supervises cardiomyocyte maturation
            by controlling cell differentiation programs in the developing
            heart
  JOURNAL   Elife 12, e81360 (2023)
   PUBMED   36877136
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5546)
  AUTHORS   Anger,M., Scheufele,F., Ramanujam,D., Meyer,K., Nakajima,H.,
            Field,L.J., Engelhardt,S. and Sarikas,A.
  TITLE     Genetic ablation of Cullin-RING E3 ubiquitin ligase 7 restrains
            pressure overload-induced myocardial fibrosis
  JOURNAL   PLoS One 15 (12), e0244096 (2020)
   PUBMED   33351822
  REMARK    GeneRIF: Genetic ablation of Cullin-RING E3 ubiquitin ligase 7
            restrains pressure overload-induced myocardial fibrosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5546)
  AUTHORS   Luo,Y., Liu,Y., Wu,L., Ma,X., Liu,Q., Huang,F., Zhang,X., Zhang,Y.,
            Zhang,J., Luo,H., Yang,Y., Lu,G., Tang,X., Li,L., Zeng,Y., Pan,T.
            and Zhang,H.
  TITLE     CUL7 E3 Ubiquitin Ligase Mediates the Degradation of
            Activation-Induced Cytidine Deaminase and Regulates the Ig Class
            Switch Recombination in B Lymphocytes
  JOURNAL   J Immunol 203 (1), 269-281 (2019)
   PUBMED   31092637
  REMARK    GeneRIF: this study shows that CUL7 mediates the degradation of
            activation-Induced Cytidine Deaminase and regulates the Ig class
            switch recombination in B lymphocytes
REFERENCE   6  (bases 1 to 5546)
  AUTHORS   Nakajima,H., Nakajima,H.O., Tsai,S.C. and Field,L.J.
  TITLE     Expression of mutant p193 and p53 permits cardiomyocyte cell cycle
            reentry after myocardial infarction in transgenic mice
  JOURNAL   Circ Res 94 (12), 1606-1614 (2004)
   PUBMED   15142950
  REMARK    GeneRIF: Antagonization of p193 and p53 activity relaxes the
            otherwise stringent regulation of cardiomyocyte cell cycle reentry
            in the injured adult heart.
REFERENCE   7  (bases 1 to 5546)
  AUTHORS   Ali,S.H., Kasper,J.S., Arai,T. and DeCaprio,J.A.
  TITLE     Cul7/p185/p193 binding to simian virus 40 large T antigen has a
            role in cellular transformation
  JOURNAL   J Virol 78 (6), 2749-2757 (2004)
   PUBMED   14990695
  REMARK    GeneRIF: role of binding of Cul7 to simian virus 40 large T antigen
            in cell transformation; may also regulate an important growth
            control pathway
REFERENCE   8  (bases 1 to 5546)
  AUTHORS   Arai,T., Kasper,J.S., Skaar,J.R., Ali,S.H., Takahashi,C. and
            DeCaprio,J.A.
  TITLE     Targeted disruption of p185/Cul7 gene results in abnormal vascular
            morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9855-9860 (2003)
   PUBMED   12904573
REFERENCE   9  (bases 1 to 5546)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   10 (bases 1 to 5546)
  AUTHORS   Dias,D.C., Dolios,G., Wang,R. and Pan,Z.Q.
  TITLE     CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29
            to form an SCF-like complex
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16601-16606 (2002)
   PUBMED   12481031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY749504.1, BC065096.1 and BC059865.1.
            
            On or before Jun 7, 2008 this sequence version replaced
            NM_177189.3, NM_025611.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138998.1, AK170808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               BY749504.1         1-558
            559-2148            BC065096.1         195-1784
            2149-2811           BC059865.1         869-1531
            2812-4751           BC065096.1         2299-4238
            4752-4799           BC059865.1         3268-3315
            4800-5546           BC065096.1         4287-5033
FEATURES             Location/Qualifiers
     source          1..5546
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..5546
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /note="cullin 7"
                     /db_xref="GeneID:66515"
                     /db_xref="MGI:MGI:1913765"
     exon            1..378
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            379..960
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..5456
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /note="CUL-7"
                     /codon_start=1
                     /product="cullin-7"
                     /protein_id="NP_079887.3"
                     /db_xref="CCDS:CCDS28833.1"
                     /db_xref="GeneID:66515"
                     /db_xref="MGI:MGI:1913765"
                     /translation="MVGELRYREFRVPLGPGLHAYPDELIRQRVGHNGHPEYQIRWLI
                     LRRGDDGDRDSTVDCKAEHILLWMSDDEIYANCHKMLGENGQVIAPSRESTEAGALDK
                     SVLGEMETDVKSLIQRALRQLEECVGTVPPAPLLHTVHVLSAYASIEPLTGIFKDRRV
                     VNLLMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCA
                     LLALFAQATLTEHPMSFEGVQLPQVPGRLLFSLVKRYLHVTFLLDRLNGDAGDQGAQN
                     NFIPEELNVGRGRLELEFSMAMGTLISELVQAMRWDGASSRPESSSSSTFQPRPAQFR
                     PYTQRFRRSRRFRPRASFASFNTYALYVRDTLRPGMRVRMLENYEEIAAGDEGQFRQS
                     NDGVPPAQVLWDSTGHTYWVHWHMLEILGFEEDIEDVIDIEELQELGANGALSIVPPS
                     QRWKPITQLFAEPYVVPEEEDREESENLTQAEWWELLFFIRQLSEAERLHIVDLLQDH
                     LEEERVLDYDMLPELTVPVDLAQDLLLSLPQQLEDSALRDLFSCSVYRKYGPEVLVGH
                     LSYPFVPGAQPNLFGANEESEAKDPPLQSASPALQRLVESLGPEGEVLVELEQALGSE
                     APQETEVKSCLLQLQEQPQPFLALMRSLDTSASNKTLHLTVLRILMQLVNFPEALLLP
                     WHEAMDACVTCLRSPNTDREVLQELIFFLHRLTTTSRDYAVILNQLGARDAISKVLEK
                     HRGKLELAQELRDMVSKCEKHAHLYRKLTTNILGGCIQMVLGQIEDHRRTHRPIQIPF
                     FDVFLRYLCQGSSEEMKKNRYWEKVEVSSNPQRASRLTDRNPKTYWESSGRAGSHFIT
                     LHMRPGVIIRQLTLLVAGEDSSYMPAWVVVCGGNSIKSVNKELNTVNVMPSASRVTLL
                     ENLTRFWPIIQIRIKRCQQGGINTRIRGLEVLGPKPTFWPVFREQLCRHTRLFYMVRA
                     QAWSQDIAEDRRSLLHLSSRLNGALRHEQNFAERFLPDMEAAQALSKTCWEALVSPLV
                     QNITSPDEDSTSSLGWLLDQYLGCREAAYNPQSRAAAFSSRVRRLTHLLVHVEPREAA
                     PPVVAIPRSKGRNRIHDWSYLITRGLPSSIMKNLTRCWRSVVEEQMNKFLTASWKDDD
                     FVPRYCERYYVLQKSSSELFGPRAAFLLAMRNGCADAVLRLPFLRAAHVSEQFARHID
                     QRIQGSRMGGARGMEMLAQLQRCLESVLIFSPLEIATTFEHYYQHYMADRLLSVGSSW
                     LEGAVLEQIGPCFPSRLPQQMLQSLNVSEELQRQFHVYQLQQLDQELLKLEDTEKKIQ
                     VAHEDSGREDKSKKEEAIGEAAAVAMAEEEDQGKKEEGEEEGEGEDEEEERYYKGTMP
                     EVCVLVVTPRFWPVASVCQMLNPATCLPAYLRGTINHYTNFYSKSQSRSSLEKEPQRR
                     LQWTWQGRAEVQFGGQILHVSTVQMWLLLHLNNQKEVSVESLQAISELPPDVLHRAIG
                     PLTSSRGPLDLQEQKNVPGGVLKIRDDSEEPRPRRGNVWLIPPQTYLQAEAEEGRNME
                     KRRNLLNCLVVRILKAHGDEGLHVDRLVYLVLEAWEKGPCPARGLVSSLGRGATCRSS
                     DVLSCILHLLVKGTLRRHDDRPQVLYYAVPVTVMEPHMESLNPGSAGPNPPLTFHTLQ
                     IRSRGVPYASCTDNHTFSTFR"
     exon            961..1112
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1586
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1725
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1922
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2148
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2386
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2492
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2720
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2811
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2983
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3089
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3185
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3361
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3495
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3678
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3785
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            3786..3968
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            3969..4129
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            4130..4346
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            4347..4653
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            4654..4799
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            4800..4926
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            4927..5132
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     exon            5133..5529
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5505..5510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /note="hexamer: AATAAA"
     polyA_site      5529
                     /gene="Cul7"
                     /gene_synonym="2510004L20Rik; C230011P08Rik; p185; p193"
                     /note="major polyA site"
ORIGIN      
        1 tggagggctg cgtcgtccag gtggcacccg ctactccgcc cgctgatggc ccccggcccc
       61 cagctttccg ctaaatcagg cggaagcgag cggtggctgg agcaggcggc ggagcctcgg
      121 agcgcctgga gcaccagcca ggactaggct ccaccctgca gcaggcagtg cgccggcgcg
      181 cctcggaggc ctctgctggt cacgccctct gcccgcctgt ctcctgcaga ggcacgcccc
      241 ctcctctgcg cctagacccc ttcagggggc ccaggcgggg cccaaacact cgccagcgcc
      301 gcagccgcca tcgtgttccg cgcgtcccta gctctgcaaa ggacaggcct cgcgccagga
      361 tcccggcgga cttctgaggt gccacgatgg taggggagct acgatacagg gaattcaggg
      421 tgcccctggg gcctggcttg cacgcgtatc cggatgaatt gatccgccaa cgggttggcc
      481 ataatgggca ccccgagtat cagatccgct ggctcatcct caggcgcggg gatgatgggg
      541 accgggactc tacagtggac tgcaaggctg agcatatcct gttatggatg tctgacgatg
      601 agatctatgc caactgccac aagatgctgg gcgagaatgg ccaagtcatc gcaccttccc
      661 gggagtccac tgaggcaggg gccctcgaca agtctgtgct gggggagatg gaaacagatg
      721 tgaagtcctt gattcagagg gcccttcggc agctggagga gtgcgtgggc accgtgcctc
      781 ctgcccctct ccttcacacg gtccatgtac tcagtgccta tgccagcatc gagcccctca
      841 ctggcatctt caaagaccgc agggttgtga acttgctcat gcacatgttg agcagtcctg
      901 attatcagat ccgctggagc gcaggccgga tgatccaagc tctgtcctcc cacgatgctg
      961 ggacccggac ccagatcctt ctgtcattga gccaacaaga ggccattgaa aagcacctgg
     1021 attttgatag ccgctgcgct ctgcttgcac tgttcgccca ggctactctc acggaacacc
     1081 cgatgtcttt cgagggcgtt cagctgccac aggtcccagg acggctgctc ttctccctgg
     1141 taaaacgcta cctgcacgtc accttcctcc tggatcggct gaacggcgat gcaggggatc
     1201 aaggagccca gaacaacttt attcctgagg agttgaatgt agggaggggc cggctggaac
     1261 tggaattcag tatggccatg ggcactctga tctctgagct ggtgcaggcc atgcgctggg
     1321 acggggcctc aagcagacca gagagttctt cctcctccac cttccagcct cggccagcac
     1381 agttccgccc ctacacccag cgtttcagga ggtcgaggcg gtttcgcccc cgtgcctcgt
     1441 ttgccagttt taatacctat gccttgtatg tgcgggacac gctgcggccc gggatgcggg
     1501 tacggatgct ggagaattac gaggagatcg ctgctgggga tgagggccag ttccgacaga
     1561 gcaatgatgg cgttccccca gcgcaggtgt tgtgggattc aacaggccat acctactggg
     1621 tgcactggca catgctggag atcttgggct ttgaggaaga catcgaggat gtgattgata
     1681 ttgaagagtt acaggagcta ggggccaatg gagcactgag catcgtcccg ccgtcccagc
     1741 gctggaagcc cataactcag ctctttgccg agccttacgt ggtacccgag gaggaagaca
     1801 gggaagagag cgagaacttg acccaggctg agtggtggga gctcctcttc ttcatccggc
     1861 agttgagtga ggcagagcgc cttcacatcg tggatctcct gcaagaccac ctggaagagg
     1921 agcgcgttct ggactacgat atgctgcctg agctgaccgt gcccgttgac ttggcccagg
     1981 atctgctgtt gtctctgcct cagcaacttg aggacagtgc tctgagggac ctgttcagct
     2041 gcagtgtcta caggaagtat gggcccgaag tcctggtagg gcatctaagc tacccatttg
     2101 tgccaggtgc ccagccaaat ttattcggag ccaatgaaga gtctgaagcc aaagatcccc
     2161 cacttcagag tgccagccct gccctgcagc gcctggtgga gagcttgggc cccgaagggg
     2221 aggtccttgt ggaactggaa caagccctcg gctccgaggc tccccaggaa actgaggtca
     2281 agtcctgctt gttgcagctc caggagcagc cccagccctt cctcgctctg atgcggagcc
     2341 tggacacttc cgccagcaac aagaccctgc acctcactgt gctcagaatc ttaatgcagc
     2401 tggtgaactt cccagaggcg ctgttgctac cctggcacga ggccatggat gcctgcgtga
     2461 cctgccttcg gtcccccaat actgaccgag aggtgctcca ggaactaatc tttttcctgc
     2521 accgcctgac caccacaagc cgggactatg cggtgatact aaaccagcta ggagcccggg
     2581 acgccatctc caaagtcctg gaaaagcacc gagggaaact ggagttggct caggagctgc
     2641 gggatatggt gtccaagtgt gagaagcatg cccacctcta ccggaaactc accaccaaca
     2701 tcctgggcgg ttgcatccag atggtcctgg gtcagattga agaccacaga cgaacccacc
     2761 ggcccatcca aatcccattc tttgatgtgt ttctcagata tctgtgccag ggctccagtg
     2821 aggaaatgaa gaaaaacagg tactgggaga aggtggaggt gtcctccaac ccacagcggg
     2881 ccagcaggct gacggaccgc aaccccaaga cctactggga gtccagtggc agggccggct
     2941 cccacttcat caccttacac atgcgcccag gtgtcatcat caggcagctg actctactgg
     3001 tggctggcga ggactcaagc tacatgccag cctgggtggt ggtatgcggg ggcaacagca
     3061 tcaagtccgt taataaagaa ctcaacacgg taaacgtgat gccctctgcc agccgggtga
     3121 ccctcctgga gaacctgacc cgcttctggc ccatcatcca aatcagaata aagcgctgcc
     3181 agcagggtgg cattaacacg cgcatccggg gcctagaggt gctgggcccc aagcccacct
     3241 tctggccagt gttccgagag caactgtgcc ggcacacgcg cctcttctac atggttcggg
     3301 cccaggcatg gagtcaggac atagcagagg accgccggag ccttctgcac ctgagttcta
     3361 ggctaaatgg ggctctgcgc catgaacaga attttgcaga gcgcttcctt cctgatatgg
     3421 aggccgccca agcactgagc aagacctgct gggaggcgct ggtcagcccc ctggtgcaga
     3481 acattacatc tcccgatgag gacagcacca gctccttggg ctggctgctg gatcagtact
     3541 tgggatgcag ggaggctgcc tacaatcccc agagcagggc tgctgctttc tcctcccggg
     3601 ttcgccgcct tacccacctc ctggtccatg tggagccccg tgaggcagca cctccggtgg
     3661 tggccatccc tcgatccaag ggcaggaaca gaatccatga ctggagctac ttgatcaccc
     3721 ggggccttcc aagtagcatc atgaagaacc tgacccgctg ttggcggtct gtggtggagg
     3781 agcagatgaa caagtttctg actgcgtcct ggaaagacga tgatttcgta ccccgctatt
     3841 gcgagcgcta ttacgtcctg cagaagtcca gctcagagct gtttgggcca cgagctgcct
     3901 tcttgctggc aatgcggaat ggctgtgctg atgctgtgct gaggctccct ttcctcaggg
     3961 ccgcccatgt gagcgagcag tttgctcggc acattgacca gaggatccaa ggcagtagga
     4021 tgggtggagc ccggggaatg gagatgctgg cacagttgca gcgatgcctg gagtctgtcc
     4081 tgattttctc tcccctggag atagccacca cctttgagca ttactaccag cactacatgg
     4141 ctgaccgtct cctgagcgta ggctccagct ggctggaggg ggccgtactg gagcagatcg
     4201 gtccctgctt ccccagccgt cttccccagc agatgctaca gagcctgaac gtctcagagg
     4261 agttgcagcg tcagttccac gtttaccagc tgcagcagct tgatcaggag ctcctgaagc
     4321 tggaagacac ggaaaagaag atacaggtgg cccatgagga cagtggcaga gaggacaaga
     4381 gcaagaagga agaagccatt ggagaagccg cggctgtggc tatggcagag gaggaggatc
     4441 aagggaagaa ggaggaggga gaggaggaag gggagggaga ggatgaggag gaagagcgct
     4501 attataaagg aacaatgcca gaagtgtgtg tacttgtcgt gacgccacgc ttctggcctg
     4561 tcgcctccgt ctgccaaatg ctcaacccgg caacgtgcct gcccgcatac ctgcggggga
     4621 ccataaacca ctacaccaac ttttacagca agagtcagag ccgctccagc ttagagaaag
     4681 agccacagag gcggctgcag tggacctggc agggccgggc agaagtgcag ttcgggggtc
     4741 agattctgca tgtgtccaca gtacagatgt ggctgctgct gcatctcaac aaccaaaagg
     4801 aggtgtctgt cgagagcctg caggctatct cggagctccc tccagatgtg cttcacaggg
     4861 ccatcgggcc tctcacctca tcaagaggtc ccttggacct gcaggagcag aagaacgtac
     4921 caggaggggt gctcaagatt cgagatgaca gtgaggaacc caggccgagg aggggcaacg
     4981 tgtggctgat cccacctcag acatacctac aagctgaggc cgaagagggc cggaacatgg
     5041 agaagagaag gaatcttctg aattgccttg ttgtccgaat cctcaaggct cacggggatg
     5101 aaggcttgca tgttgaccgg ctcgtctatc tggtgctaga agcgtgggag aaaggcccgt
     5161 gtcctgctag gggtctggtc agcagcctcg gcaggggagc aacctgcagg agctctgatg
     5221 tcctctcctg catcctgcac ctcctggtca agggcacgct gagacgccat gacgaccggc
     5281 cgcaggtgct gtactatgca gttcctgtaa ctgtgatgga gccccacatg gagtccctga
     5341 accctggctc ggcaggcccc aatccacccc tcaccttcca caccctgcag attcgatccc
     5401 ggggtgtgcc ttacgcctcc tgcactgata accacacctt ctccactttc cggtagccct
     5461 ggatatgggg ttgggggtag gtgaggctgg ggctttctac agaaaataaa atgctggaat
     5521 ttgaagctaa aaaaaaaaaa aaaaaa
//
