LOCUS       NM_027807               6024 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus cullin 5 (Cul5), transcript variant 1, mRNA.
ACCESSION   NM_027807 NM_029400
VERSION     NM_027807.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6024)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6024)
  AUTHORS   Liao,X., Li,W., Zhou,H., Rajendran,B.K., Li,A., Ren,J., Luan,Y.,
            Calderwood,D.A., Turk,B., Tang,W., Liu,Y. and Wu,D.
  TITLE     The CUL5 E3 ligase complex negatively regulates central signaling
            pathways in CD8+ T cells
  JOURNAL   Nat Commun 15 (1), 603 (2024)
   PUBMED   38242867
  REMARK    GeneRIF: The CUL5 E3 ligase complex negatively regulates central
            signaling pathways in CD8[+] T cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6024)
  AUTHORS   Zhang,H., Xue,K., Li,W., Yang,X., Gou,Y., Su,X., Qian,F. and Sun,L.
  TITLE     Cullin5 drives experimental asthma exacerbations by modulating
            alveolar macrophage antiviral immunity
  JOURNAL   Nat Commun 15 (1), 252 (2024)
   PUBMED   38177117
  REMARK    GeneRIF: Cullin5 drives experimental asthma exacerbations by
            modulating alveolar macrophage antiviral immunity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6024)
  AUTHORS   Kumar,B., Field,N.S., Kim,D.D., Dar,A.A., Chen,Y., Suresh,A.,
            Pastore,C.F., Hung,L.Y., Porter,N., Sawada,K., Shah,P., Elbulok,O.,
            Moser,E.K., Herbert,D.R. and Oliver,P.M.
  TITLE     The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and
            allergic inflammation
  JOURNAL   Nat Commun 13 (1), 2786 (2022)
   PUBMED   35589717
  REMARK    GeneRIF: The ubiquitin ligase Cul5 regulates CD4(+) T cell fate
            choice and allergic inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6024)
  AUTHORS   Han,J.S., Hino,K., Li,W., Reyes,R.V., Canales,C.P., Miltner,A.M.,
            Haddadi,Y., Sun,J., Chen,C.Y., La Torre,A. and Simo,S.
  TITLE     CRL5-dependent regulation of the small GTPases ARL4C and ARF6
            controls hippocampal morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 117 (37), 23073-23084 (2020)
   PUBMED   32873638
REFERENCE   6  (bases 1 to 6024)
  AUTHORS   Feng,L., Allen,N.S., Simo,S. and Cooper,J.A.
  TITLE     Cullin 5 regulates Dab1 protein levels and neuron positioning
            during cortical development
  JOURNAL   Genes Dev 21 (21), 2717-2730 (2007)
   PUBMED   17974915
REFERENCE   7  (bases 1 to 6024)
  AUTHORS   Lavens,D., Montoye,T., Piessevaux,J., Zabeau,L., Vandekerckhove,J.,
            Gevaert,K., Becker,W., Eyckerman,S. and Tavernier,J.
  TITLE     A complex interaction pattern of CIS and SOCS2 with the leptin
            receptor
  JOURNAL   J Cell Sci 119 (Pt 11), 2214-2224 (2006)
   PUBMED   16684815
REFERENCE   8  (bases 1 to 6024)
  AUTHORS   Kamura,T., Maenaka,K., Kotoshiba,S., Matsumoto,M., Kohda,D.,
            Conaway,R.C., Conaway,J.W. and Nakayama,K.I.
  TITLE     VHL-box and SOCS-box domains determine binding specificity for
            Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases
  JOURNAL   Genes Dev 18 (24), 3055-3065 (2004)
   PUBMED   15601820
REFERENCE   9  (bases 1 to 6024)
  AUTHORS   Arai,T., Kasper,J.S., Skaar,J.R., Ali,S.H., Takahashi,C. and
            DeCaprio,J.A.
  TITLE     Targeted disruption of p185/Cul7 gene results in abnormal vascular
            morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9855-9860 (2003)
   PUBMED   12904573
REFERENCE   10 (bases 1 to 6024)
  AUTHORS   Byrd,P.J., Stankovic,T., McConville,C.M., Smith,A.D., Cooper,P.R.
            and Taylor,A.M.
  TITLE     Identification and analysis of expression of human VACM-1, a cullin
            gene family member located on chromosome 11q22-23
  JOURNAL   Genome Res 7 (1), 71-75 (1997)
   PUBMED   9037604
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158384.2.
            
            On May 20, 2019 this sequence version replaced NM_027807.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031955.1, AK046030.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-470               AC158384.2         110221-110690       c
            471-580             AC158384.2         101754-101863       c
            581-680             AC158384.2         98455-98554         c
            681-857             AC158384.2         89850-90026         c
            858-999             AC158384.2         87670-87811         c
            1000-1145           AC158384.2         85864-86009         c
            1146-1226           AC158384.2         85701-85781         c
            1227-1320           AC158384.2         78155-78248         c
            1321-1451           AC158384.2         77168-77298         c
            1452-1559           AC158384.2         76915-77022         c
            1560-1624           AC158384.2         75456-75520         c
            1625-1757           AC158384.2         72358-72490         c
            1758-1889           AC158384.2         69046-69177         c
            1890-2013           AC158384.2         67341-67464         c
            2014-2189           AC158384.2         66818-66993         c
            2190-2351           AC158384.2         65965-66126         c
            2352-2470           AC158384.2         65041-65159         c
            2471-2594           AC158384.2         64343-64466         c
            2595-6024           AC158384.2         57764-61193         c
FEATURES             Location/Qualifiers
     source          1..6024
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.12 cM"
     gene            1..6024
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /note="cullin 5"
                     /db_xref="GeneID:75717"
                     /db_xref="MGI:MGI:1922967"
     exon            1..470
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             447..2789
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CUL-5; vasopressin-activated calcium-mobilizing receptor
                     protein"
                     /codon_start=1
                     /product="cullin-5 isoform 1"
                     /protein_id="NP_082083.3"
                     /db_xref="CCDS:CCDS40638.2"
                     /db_xref="GeneID:75717"
                     /db_xref="MGI:MGI:1922967"
                     /translation="MATSNLLKNKGSLQFEDKWDFMHPIVLKLLRQESVTKQQWFDLF
                     SDVHAVCLWDDKGSSKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFT
                     QCDILPKPFCQLEVTLLGKQSSNKKSNMEDSIVRKLMLDTWNESIFSNIKNRLQDSAM
                     KLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQA
                     PSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKET
                     ILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETIT
                     TDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQK
                     GVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVF
                     MRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQ
                     AFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNH
                     SGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATE
                     LPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEGTLFSVNQDFSLIKNAKVQK
                     RGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVE
                     ILKNMFLPQKKMIKEQMEWLIEHRYIRRDEADINTFIYMA"
     exon            471..580
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..680
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..857
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..999
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1145
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1226
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1320
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1451
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1559
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1624
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1757
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1889
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2013
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2189
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2351
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2470
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2594
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..6024
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3563..3568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /note="hexamer: AATGAA"
     polyA_site      3587
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
     regulatory      5931..5936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /note="hexamer: AATAAA"
     polyA_site      5952
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /note="major polyA site"
     regulatory      6003..6008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
                     /note="hexamer: AGTAAA"
     polyA_site      6024
                     /gene="Cul5"
                     /gene_synonym="4921514I20Rik; 8430423K24Rik;
                     C030032G03Rik; C330021I08Rik; VACM-1; VACM1"
ORIGIN      
        1 acgcccccgc ccgccgcgtc acgtgacgcc gccacggacc ctgaggtgcg ggccctaagc
       61 cgagataaag tcgttgccgg cggcccaagc gggtgcaagc ccagcggcag aagcgaaggc
      121 gagctgggga ggcccgagga agtggctact acctcttccc ggtctggtcg gctcccggtc
      181 ccttcccacc attcgccgct cgcgtctcct caagcgtttg catgcgctct ctcgcgtggg
      241 caggccgggg tgaccatgta gctggaaagc ccgaggaagc acggctgccc gggacgagct
      301 cggcgctgac ggcacgccgc tccggcgtcc cccgcatccc ccgccgcggc ctgcggggtc
      361 ctgctgggaa ccccggcctc tcgaggaggc ctggccccga gcgccgccaa gtctcgcccc
      421 gtctcgcgag agtccaagtt gagaacatgg cgacgtctaa tctgttaaag aataaaggtt
      481 ctctccagtt tgaagacaag tgggacttca tgcatccaat tgttttgaag cttttacgcc
      541 aggaatctgt aacaaaacag cagtggtttg atctattttc ggatgtacat gctgtctgtc
      601 tctgggatga taaaggctca tcaaaaattc atcaggcttt aaaagaagat attcttgagt
      661 ttattaagca agcacaggct cgtgtactga gccatcaaga tgacacagct ttgctgaagg
      721 catatattgt tgaatggcgg aaattcttca cacagtgtga tattttacca aaaccttttt
      781 gtcaattaga ggtgactcta ttgggtaaac aaagcagcaa taaaaaatca aatatggaag
      841 acagtattgt tcgaaagctc atgcttgata cgtggaatga gtcgattttt tcaaatataa
      901 agaacagact ccaggacagt gcaatgaagc tggtgcatgc tgagagatta ggggaagctt
      961 ttgattccca gctggtcatc ggggtgcgag agtcctatgt taatctttgc tccaaccccg
     1021 aggacaagct tcagatctat agggataatt ttgagaaggc atacttggac tcaacagaga
     1081 ggttttatag aacacaggca ccctcatatt tacagcaaaa tggtgtgcag aattacatga
     1141 aatatgcaga tgctaaatta aaagaagaag aaaaaagagc actccgatac ttagaaacac
     1201 gacgagagtg taactctgtg gaagcactca tggaatgctg tgtaaatgcg ctggtgacct
     1261 cctttaaaga gactatttta gcagaatgcc aaggcatgat caagcgaaat gaaactgaaa
     1321 agttacattt gatgttttcc ttgatggaca aagttcctaa tgggatagag ccgatgttga
     1381 aggacttgga ggagcatatt ataagtgcgg gcctagcaga catggtggcc gcagctgaaa
     1441 ccatcactac tgactctgag aagtatgtgg agcaattact tacactgttt aatagattca
     1501 gtaaactggt caaagaagct tttcaggatg atcctcgttt ccttactgca agagataagg
     1561 catataaagc agttgttaat gatgctacta tatttaaact tgaattgcct ttgaagcaaa
     1621 aaggagtggg gttgaaaact cagcctgagt caaaatgccc cgagttgctt gccaattact
     1681 gtgacatgtt gttaaggaaa acgccattaa gcaaaaaact aacatctgag gagattgaag
     1741 caaagcttaa agaagtgctc ttggtactta aatatgtaca aaacaaagat gtttttatga
     1801 ggtatcacaa agctcatctt acccgacgtc tcatattgga catctctgct gatagtgaga
     1861 ttgaagaaaa catggtagag tggctaagag aagttggtat gccagcagat tatgtgaaca
     1921 agcttgctag aatgtttcag gacataaaag tatctgaaga cttgaaccaa gcttttaagg
     1981 aaatgcacaa aaataataag ttggcattac cagctgattc cgttaatata aagattttga
     2041 atgctggtgc ttggtctaga agctccgaga aagtctttgt ctcacttcct actgaactgg
     2101 aggatttgat acctgaagta gaagaatttt acaaaaaaaa tcacagtggt agaaaattac
     2161 actggcacca tctcatgtca aatggaatta taacatttaa aaatgaagta ggtcagtatg
     2221 atttggaagt aaccacgttt cagttggctg tgttgtttgc atggaaccaa aggcctagag
     2281 agaaaatcag ctttgaaaat ctaaaacttg caacggaact cccagatgct gaacttagaa
     2341 ggactttatg gtctttagta gcttttccca agctcaaacg gcaagttttg ttgtatgacc
     2401 ctcaagtcaa ctcacccaaa gattttacag aaggcaccct cttctcagtg aaccaggact
     2461 tcagtctcat aaaaaatgca aaagtacaga aaagggggaa aatcaatttg attggacgct
     2521 tgcagctcac tacagaacga atgagagaag aagaaaatga agggatagtc caactaagaa
     2581 tattaagaac ccaggaagcc atcatacaaa taatgaaaat gagaaagaaa attagcaatg
     2641 cccagctgca gactgaatta gtagaaattc tgaaaaacat gttcctgcct cagaagaaga
     2701 tgataaagga gcagatggag tggctgattg aacacaggta catccggagg gacgaggccg
     2761 acatcaacac cttcatctac atggcctagc cgggccgctg ctgccgcaca cacgcccctg
     2821 aaggcctggg cagaggctgt cccagcccca gctggaggaa gctttatttg gactttgatt
     2881 acataaatat taaactctgc cttaccttac aaaacgactc tattttgcca gtcacattag
     2941 ttagcatgat ggcattccct tcatgttgca cactctttaa cagcatgctg ttttgtggag
     3001 aaaattgcat tcatgaagag cccattgtga actttcaaag tcaattcaat ttttacccac
     3061 ctagagaaat aacatgtcgg aagggtgagg gtggggttct ttttgcttct tttatcccct
     3121 tttcttcttc aaagaaatat acttgcacaa ggaaggattt tcagatattc atgcactgaa
     3181 aaatgctggg gatttttgtt tgtttgtttg ggttttttaa attctttttt tttttttttt
     3241 tttatgaaat taaagctaga cgtagcacta agctacttct gatgcaaaga atgaatcgtc
     3301 aacactgtgc tgggcaaggg caggcacact tgagaagaca cgtgtgccag tgtcaagttg
     3361 tttgtcaaac actgctttca ctttagtgac tggatcttaa tggtaacctg aaatggtatt
     3421 aaatatttct accttataaa tcctgatttt caatgagcag gagagttctg tttagttatt
     3481 tgttgttaaa tgataaagat ttgggatttt tcttttaaac cttgtacggc tggagagctt
     3541 gttttgaaaa catgaagttt ataatgaatg ttgcttcagt taaaaaatgt gtgggtatac
     3601 gtacattatt gattgcataa tcagaatctt gaagcaaaaa ttaagtgtgt tactaataca
     3661 ctcaattctc atacgtctaa tatttattat actgtacctg aatttgttga aaacaatgca
     3721 gaaatattct gatgcagtgc agtgagagaa ttgctttctt aacctgtagc atagaattat
     3781 ttggtgattg aaagtgttgt gattagggat ttaccacctc agttttctgg aaagacattc
     3841 tctatttaaa agtaataatt acctgccact tagcaggaag aaaggtgaga ttacaacctg
     3901 caacctgaaa agcactcaaa gttgttagtc ttaacatgag cagtaacctt gccaaatatg
     3961 tacatatatt tatatatttt aaaaataaac atttttaaaa tgttcagagg gcaacaccta
     4021 ccttgctcct ctcagtgatc cagagcagtg actcaggact ttacagagca gtggaaactt
     4081 agagattgag gactcaagca actgaagaga attattcccc agcaggaaaa atggctccct
     4141 gtggatttta ctcattgtgg tgcacgtttc gagttttctt gcaaatttta gaacttttga
     4201 tgttaagtag tattttgaag tattggttct gaagctagca gaagatggag tgttgagaag
     4261 catacagtat tatctatcct attaccacag agggctgtgg atctgccctg ctgctcagca
     4321 gctggggtct ccttgctgga aagaagtaaa gtatatgtta gatgtttaag gctttgataa
     4381 ttatagtcat atatctgttg tgaaactcat aggaagttgg aagtgcatgt gtgcttgctg
     4441 tgccctgcag ctctgaggtg atggctaaag caggtgtgca gcgcaaactc agtccctgct
     4501 gctctaccac gtggaggatg gaacatccgg aatttagagg gatagtttta tcatgactgt
     4561 tcaatagctt ggtgttggca aattttcctg tcccaatacc agaatgccaa aggaggaaac
     4621 aatcaaggga aaaattttag gccatttaaa atgacaaaaa agatttgtca ttttaaacca
     4681 tcattttctt tagaacatct ttgaaatttc taatcgcttt ggtcatttaa gaatgagagc
     4741 tgtgatgttt tgatttataa aggcaaactt aatgcaaagt gggtaacact aaatccatag
     4801 caaagttttt tattaaattt ttataaattt tttaatagtt aattatgtcc taattgtatt
     4861 ttggggaatg agcagcagta aataccacag acttaacagt ttcatccttt tttaaaaata
     4921 tatatataag agtgtaacta ctttttggtg tttatcaaaa ctatttagtt gacaaggtgc
     4981 ctataccatt gttgggattt tctttaaatg ttttatgaat agatttgata atttatctga
     5041 agatccagaa ccactgacag cgcccctctc tctccctgca gacttcatag tcttgctatc
     5101 tgagcagggc cagacatgca cagggaggga aggagaggcc agctcccact cacactggga
     5161 ggcattgtta agtgaacggt accgcaggct cagatttgag cacttctgtc tacctaaggt
     5221 ggcgccatct gtaaatgcta acctgtcacc aactcacggc cagagtaagg agacagggaa
     5281 cagatgcatg cagtggaaag gggagactcc tggacgcgca gttagacaaa tgtgaggccg
     5341 tcatcagtct aataatttat aaggatcctc aatcaaattc tgaagtctcc gactttcaca
     5401 gttcttggaa gggatccctg agtttaccag cgtgctcact gaaagctctc actctttgtg
     5461 cagaaatatt aaagtctccg aaaaggtgaa ctgttaatca ttcttatttt ttttaactct
     5521 tcattaaatt gaatatgata tcattagctc tgctccaagg gcaaattttc aagtttaatc
     5581 tgggtgaaat atttgctagt ttacagaaag atttgctatc atatcaatag ctggctcttc
     5641 tgtttttgtg tgaatgactg ggatgctgac acaagttgtc ccaaggtcac agttatgaga
     5701 gaaacactgt tggagagcgt tcctgtcatc tgcactatgt gtggtctgga gttcctaagg
     5761 tgtagcctct catcgtgacc tgtacagttt tgaatgtgca ccactacata cccggatggc
     5821 actgtacagt ttcccacggt agcagtctgt atgcagtagg ctgaaatatt ttgatgaacg
     5881 cttaattttt ggattttatt ttttaagttg tataatttat tttcttgcaa aataaaagtg
     5941 taatataaaa catttcatct atccagaaaa tcttgatgtt ctaccataaa aatttttgca
     6001 acagtaaaaa attttggcaa gcca
//
