LOCUS       NP_082564                970 aa            linear   ROD 08-APR-2025
DEFINITION  cullin-4B [Mus musculus].
ACCESSION   NP_082564
VERSION     NP_082564.3
DBSOURCE    REFSEQ: accession NM_028288.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 970)
  AUTHORS   Liu,K., Hao,X., Gao,Y., Cao,Z., Hou,M., Qin,L., Song,Y., Wang,M.,
            Jiang,B., Liu,Q., Zou,Y., Gong,Y., Liu,G. and Sun,G.
  TITLE     CUL4B protects kidneys from acute injury by restraining p53/PAI-1
            signaling
  JOURNAL   Cell Death Dis 15 (12), 915 (2024)
   PUBMED   39695153
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 970)
  AUTHORS   Guo,B., Zheng,Y., Fan,Y., Yang,Y., Wang,Y., Qin,L., An,Y., Xu,X.,
            Zhang,X., Sun,G., Dou,H., Shao,C., Gong,Y., Jiang,B. and Hu,H.
  TITLE     Enhanced ApcMin/+ adenoma formation after epithelial CUL4B deletion
            by recruitment of myeloid-derived suppressor cells
  JOURNAL   Neoplasia 53, 101005 (2024)
   PUBMED   38761506
  REMARK    GeneRIF: Enhanced Apc[Min/+] adenoma formation after epithelial
            CUL4B deletion by recruitment of myeloid-derived suppressor cells.
REFERENCE   3  (residues 1 to 970)
  AUTHORS   Guo,B., Huo,X., Xie,X., Zhang,X., Lian,J., Zhang,X., Gong,Y.,
            Dou,H., Fan,Y., Mao,Y., Wang,J. and Hu,H.
  TITLE     Dynamic role of CUL4B in radiation-induced intestinal
            injury-regeneration
  JOURNAL   Sci Rep 14 (1), 9906 (2024)
   PUBMED   38689033
  REMARK    GeneRIF: Dynamic role of CUL4B in radiation-induced intestinal
            injury-regeneration.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 970)
  AUTHORS   Dar,A.A., Ortega,Y., Aktas,S., Wu,K., Guha,I., Porter,N., Rosen,S.,
            DeVita,R.J., Pan,Z.Q. and Oliver,P.M.
  TITLE     CRL4b Inhibition Ameliorates Experimental Autoimmune
            Encephalomyelitis Progression
  JOURNAL   J Immunol 212 (6), 982-991 (2024)
   PUBMED   38265261
REFERENCE   5  (residues 1 to 970)
  AUTHORS   Zhang,L., Hao,P., Chen,X., Lv,S., Gao,W., Li,C., Li,Z. and Zhang,W.
  TITLE     CRL4B E3 ligase recruited by PRPF19 inhibits SARS-CoV-2 infection
            by targeting ORF6 for ubiquitin-dependent degradation
  JOURNAL   mBio 15 (2), e0307123 (2024)
   PUBMED   38265236
  REMARK    GeneRIF: CRL4B E3 ligase recruited by PRPF19 inhibits SARS-CoV-2
            infection by targeting ORF6 for ubiquitin-dependent degradation.
REFERENCE   6  (residues 1 to 970)
  AUTHORS   Dooley,S., Hamzavi,J., Ciuclan,L., Godoy,P., Ilkavets,I.,
            Ehnert,S., Ueberham,E., Gebhardt,R., Kanzler,S., Geier,A.,
            Breitkopf,K., Weng,H. and Mertens,P.R.
  TITLE     Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated
            fibrogenesis and protects against liver damage
  JOURNAL   Gastroenterology 135 (2), 642-659 (2008)
   PUBMED   18602923
REFERENCE   7  (residues 1 to 970)
  AUTHORS   Tripathi,R., Kota,S.K. and Srinivas,U.K.
  TITLE     Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin
  JOURNAL   J Biosci 32 (6), 1133-1138 (2007)
   PUBMED   17954973
  REMARK    GeneRIF: Plays a conserved role in the regulation of beta-catenin
            levels.
REFERENCE   8  (residues 1 to 970)
  AUTHORS   Oda,M., Yamagiwa,A., Yamamoto,S., Nakayama,T., Tsumura,A.,
            Sasaki,H., Nakao,K., Li,E. and Okano,M.
  TITLE     DNA methylation regulates long-range gene silencing of an X-linked
            homeobox gene cluster in a lineage-specific manner
  JOURNAL   Genes Dev 20 (24), 3382-3394 (2006)
   PUBMED   17182866
REFERENCE   9  (residues 1 to 970)
  AUTHORS   Tripathi,R., Sastry,K.S., Kota,S.K. and Srinivas,U.K.
  TITLE     Cloning and characterization of mouse cullin4B/E3 ubiquitin ligase
  JOURNAL   J Biosci 30 (3), 329-337 (2005)
   PUBMED   16052071
  REMARK    GeneRIF: The cloning and expression of amino and carboxy-terminal
            halves of cullin4B in mouse PCC4 cells is reported.
REFERENCE   10 (residues 1 to 970)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032701.1, AK160998.1, AK164640.1 and AI037712.1.
            
            On Oct 26, 2007 this sequence version replaced NP_082564.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY330868.1, AK032701.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.81 cM"
     Protein         1..970
                     /product="cullin-4B"
                     /calculated_mol_wt=110569
     Region          1..157
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A432.1)"
     Site            15
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2A432.1)"
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2A432.1)"
     Site            106
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2A432.1)"
     Site            110
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2A432.1)"
     Region          112..115
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:Q13620"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A432.1)"
     Site            154
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13619; propagated from
                     UniProtKB/Swiss-Prot (A2A432.1)"
     Region          189..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A432.1)"
     Site            200
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13620; propagated from
                     UniProtKB/Swiss-Prot (A2A432.1)"
     Site            202
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2A432.1)"
     Site            250
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13620; propagated from
                     UniProtKB/Swiss-Prot (A2A432.1)"
     Region          274..871
                     /region_name="Cullin"
                     /note="Cullin family; pfam00888"
                     /db_xref="CDD:459983"
     Region          902..962
                     /region_name="Cullin_Nedd8"
                     /note="Cullin protein neddylation domain; pfam10557"
                     /db_xref="CDD:463146"
     CDS             1..970
                     /gene="Cul4b"
                     /gene_synonym="2700050M05Rik; CUL-4B; mKIAA0695"
                     /coded_by="NM_028288.5:73..2985"
                     /db_xref="CCDS:CCDS40948.1"
                     /db_xref="GeneID:72584"
                     /db_xref="MGI:MGI:1919834"
ORIGIN      
        1 msrstrsker rendtdsedn ssetsnqerr rcrqgpprpp yppllppvfp pptpppqvrr
       61 trglqdlgam ksvcpgtsgf sspnpsaasa aaqevrsatd gntsttppts akkrklnsss
      121 sssnssnere dfdstsssst ppqprdsasp stssfclgvp vatsshvpiq kklrfedtle
      181 fvgidtkmae esssssssss ptaatsqqqq qqqlktksil issvasvhha nglaksstav
      241 ssfanskpgs akklviknfk dkpklpenyt detwqklkea veaiqnstsi kynleelyqa
      301 venlcshkis anlykqlrqi cedhikaqih qfredsldsv lflkkidrcw qnhcrqmimi
      361 rsiflfldrt yvlqnsmlps iwdmglelfr ahiisdqkvq tktidgilll iererngeai
      421 drsllrslls mlsdlqiyqd sfeqqflqet nrlyaaegqk lmqerevpey lhhvnkrlee
      481 eadrlityld qttqkslias vekqllgehl tailqkglns lldenriqdl sllyqlfsrv
      541 rggvqvllqq wieyikafgs tivinpekdk tmvqelldfk dkvdhiidtc flknekfina
      601 mkeafetfin krpnkpaeli akyvdsklra gnkeatdeel ekmldkimii frfiygkdvf
      661 eafykkdlak rllvgksasv daeksmlskl khecgaafts klegmfkdme lskdimiqfk
      721 qymqnqnvpg nieltvnilt mgywptyvpm evhlppemvk lqeifktfyl gkhsgrklqw
      781 qstlghcvlk aefkegkkel qvslfqtmvl lmfnegeefs leeikhatgi edgelrrtlq
      841 slacgkarvl aknpkgkdie dgdkficndd fkhklfriki nqiqmketve eqasttervf
      901 qdrqyqidaa ivrimkmrkt lshnllvsev ynqlkfpvkp adlkkriesl idrdymerdk
      961 enpnqynyia
//
