LOCUS       NM_016716               4935 bp    mRNA    linear   ROD 07-FEB-2023
DEFINITION  Mus musculus cullin 3 (Cul3), transcript variant 1, mRNA.
ACCESSION   NM_016716 XM_976272 XM_976314 XM_976353
VERSION     NM_016716.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4935)
  AUTHORS   Rapanelli M, Wang W, Hurley E, Feltri ML, Pittenger C, Frick LR and
            Yan Z.
  TITLE     Cholinergic neurons in the basal forebrain are involved in
            behavioral abnormalities associated with Cul3 deficiency: Role of
            prefrontal cortex projections in cognitive deficits
  JOURNAL   Transl Psychiatry 13 (1), 22 (2023)
   PUBMED   36693858
  REMARK    GeneRIF: Cholinergic neurons in the basal forebrain are involved in
            behavioral abnormalities associated with Cul3 deficiency: Role of
            prefrontal cortex projections in cognitive deficits.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4935)
  AUTHORS   Maeoka Y, Cornelius RJ, Ferdaus MZ, Sharma A, Nguyen LT and
            McCormick JA.
  TITLE     Cullin 3 mutant causing familial hyperkalemic hypertension lacks
            normal activity in the kidney
  JOURNAL   Am J Physiol Renal Physiol 323 (5), F564-F576 (2022)
   PUBMED   36007890
  REMARK    GeneRIF: Cullin 3 mutant causing familial hyperkalemic hypertension
            lacks normal activity in the kidney.
REFERENCE   3  (bases 1 to 4935)
  AUTHORS   Dong M, Qian M and Ruan Z.
  TITLE     CUL3/SPOP complex prevents immune escape and enhances chemotherapy
            sensitivity of ovarian cancer cells through degradation of PD-L1
            protein
  JOURNAL   J Immunother Cancer 10 (10) (2022)
   PUBMED   36198437
  REMARK    GeneRIF: CUL3/SPOP complex prevents immune escape and enhances
            chemotherapy sensitivity of ovarian cancer cells through
            degradation of PD-L1 protein.
REFERENCE   4  (bases 1 to 4935)
  AUTHORS   Shen J, Li Y, Li M, Li Z, Deng H, Xie X and Liu J.
  TITLE     Restoration of Cullin3 gene expression enhances the improved
            effects of sonic hedgehog signaling activation for hypertension and
            attenuates the dysfunction of vascular smooth muscle cells
  JOURNAL   Biomed Eng Online 21 (1), 39 (2022)
   PUBMED   35715796
  REMARK    GeneRIF: Restoration of Cullin3 gene expression enhances the
            improved effects of sonic hedgehog signaling activation for
            hypertension and attenuates the dysfunction of vascular smooth
            muscle cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4935)
  AUTHORS   Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu
            C, Nair AR, Wackman KK, Agbor LN, Grobe JL and Sigmund CD.
  TITLE     Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated
            Vasodilation and Promotes Salt-Induced Hypertension
  JOURNAL   Function (Oxf) 3 (3), zqac017 (2022)
   PUBMED   35493997
  REMARK    GeneRIF: Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated
            Vasodilation and Promotes Salt-Induced Hypertension.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4935)
  AUTHORS   McEvoy JD, Kossatz U, Malek N and Singer JD.
  TITLE     Constitutive turnover of cyclin E by Cul3 maintains quiescence
  JOURNAL   Mol Cell Biol 27 (10), 3651-3666 (2007)
   PUBMED   17339333
  REMARK    GeneRIF: Data show that the constitutive degradation pathway for
            cyclin E that is regulated by the Cullin3-based E3 ligase is
            essential to maintain quiescence in mammalian cells.
REFERENCE   7  (bases 1 to 4935)
  AUTHORS   Salinas GD, Blair LA, Needleman LA, Gonzales JD, Chen Y, Li M,
            Singer JD and Marshall J.
  TITLE     Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate
            receptor subunits to the ubiquitin-proteasome pathway
  JOURNAL   J Biol Chem 281 (52), 40164-40173 (2006)
   PUBMED   17062563
REFERENCE   8  (bases 1 to 4935)
  AUTHORS   He X, Chen MG, Lin GX and Ma Q.
  TITLE     Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the
            Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the
            antioxidant response element enhancer
  JOURNAL   J Biol Chem 281 (33), 23620-23631 (2006)
   PUBMED   16785233
REFERENCE   9  (bases 1 to 4935)
  AUTHORS   Boettger-Tong HL, Rohozinski J, Agoulnik AI, Dohmae K, Nishimune Y,
            Levy N and Bishop CE.
  TITLE     Identification and sequencing the juvenile spermatogonial depletion
            critical interval on mouse chromosome 1 reveals the presence of
            eight candidate genes
  JOURNAL   Biochem Biophys Res Commun 288 (5), 1129-1135 (2001)
   PUBMED   11700028
REFERENCE   10 (bases 1 to 4935)
  AUTHORS   Singer JD, Gurian-West M, Clurman B and Roberts JM.
  TITLE     Cullin-3 targets cyclin E for ubiquitination and controls S phase
            in mammalian cells
  JOURNAL   Genes Dev 13 (18), 2375-2387 (1999)
   PUBMED   10500095
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161416.2, AF129738.1, AK003885.1, AK034695.1, BE991461.1 and
            BM899470.1.
            
            [WARNING] On May 18, 2023 this sequence was replaced by
            NM_016716.6.
            
            On Aug 27, 2015 this sequence version replaced NM_016716.4.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027304.2, AF129738.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               AC161416.2         106460-106829
            371-2782            AF129738.1         1-2412
            2783-3515           AK003885.1         375-1107
            3516-4106           AK034695.1         436-1026
            4107-4487           BE991461.1         135-515
            4488-4935           BM899470.1         1-448               c
FEATURES             Location/Qualifiers
     source          1..4935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..4935
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /note="cullin 3"
                     /db_xref="GeneID:26554"
                     /db_xref="MGI:MGI:1347360"
     exon            1..445
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..2686
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="cullin-3 isoform 1"
                     /protein_id="NP_057925.1"
                     /db_xref="CCDS:CCDS15094.1"
                     /db_xref="GeneID:26554"
                     /db_xref="MGI:MGI:1347360"
                     /translation="MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEI
                     QRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFL
                     QTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDH
                     LRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQ
                     MESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTI
                     VEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSCYLREQGKALVSEEGE
                     GKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFI
                     DDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDS
                     EKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVL
                     TTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGP
                     VKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPE
                     RELVRALQSLACGKPTQRVLTKEPKSKEIESGHIFTVNDQFTSKLHRVKIQTVAAKQG
                     ESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVV
                     IKKRIEGLIEREYLARTPEDRKVYTYVA"
     exon            446..643
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            644..757
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            758..918
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1033
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1262
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1408
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1585
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1756
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1864
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1989
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2086
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2221
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2408
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2554
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..4919
                     /gene="Cul3"
                     /gene_synonym="KIAA0617"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcgctga ggcggaggag gagaaggagg aggaggacgt tcggcctgcg cagtgagatg
       61 tttgtccgtc gccgccgccg ccgccatcgc ggaggagcgc gataaaggga gccgagcccg
      121 gcgcgagggg aagcccgcgg agccgccgcg ccagcgcagc ccccggccga gcccgagccg
      181 cccgagcccg agccgccgcc cccgccgccg cggccgccca ggggccggcc cgccgcccag
      241 cccagcccgg gggccgcgcc gccgcccccc gccgagcccc gcggctgccc tcccgccttc
      301 aatgtgacac cggcgcctcc gagtgcgagc cgcagccgcc gccgccgtca gcgccgccgc
      361 cggggagggg ccgagcacca tgtcgaatct gagcaaaggc acgggcagcc ggaaggacac
      421 caagatgcgg atccgggcct ttccgatgac catggatgaa aaatatgtaa acagcatttg
      481 ggaccttctg aaaaatgcaa ttcaagaaat ccagcgtaag aataacagtg gtcttagttt
      541 tgaggagctc tatagaaatg catatacaat ggttttgcat aaacatggag aaaagctcta
      601 cactggacta agagaagttg ttactgaaca tctcataaat aaggtgcgag aagatgtact
      661 aaattcattg aataacaact ttcttcaaac actaaatcaa gcttggaatg atcatcaaac
      721 agccatggtg atgattagag acatattaat gtatatggac cgtgtatatg tacaacagaa
      781 taatgtagaa aatgtctaca atttgggatt aataattttt cgagatcaag ttgtacggta
      841 tgggtgtatt agggatcatc ttcggcaaac tttattggat atgattgcca gagagcggaa
      901 aggagaagtt gtagacagag gagcaataag aaatgcttgc cagatgttaa tgattttagg
      961 tcttgaagga agatcagtct atgaggaaga ttttgaggct ccgtttttgg aaatgtctgc
     1021 agaatttttt cagatggaaa gccagaaatt tttagcagaa aacagtgctt cagtatatat
     1081 aaagaaagta gaagctagga ttaatgagga aatagagcgg gtgatgcact gccttgacaa
     1141 atccacagaa gagcctattg tgaaggtggt ggagagggaa ctcatttcca agcacatgaa
     1201 gactattgta gaaatggaaa attctgggct agtacatatg ctgaaaaatg gaaagacaga
     1261 agaccttgct tgcatgtaca aattatttag tcgtgtgcca aatggtttga agaccatgtg
     1321 tgaatgtatg agttgttatt tgagggaaca aggaaaagcc cttgtttctg aggaaggaga
     1381 agggaagaat cctgttgact atatccaggg cttattggat ctaaagagta ggtttgatcg
     1441 cttcctccaa gaatccttca ataatgaccg gctctttaaa cagactattg ctggggactt
     1501 cgagtatttc ttaaacctca actctaggtc tcctgaatac ctctcattat ttattgatga
     1561 taaactgaaa aagggagtca aagggctaac agaacaagaa gtagaaacaa tattggataa
     1621 ggcaatggtc ctttttaggt ttatgcaaga aaaagatgta tttgaacgtt attataaaca
     1681 acacctggca agaagactgc tcacaaataa aagtgtttct gatgactctg agaaaaatat
     1741 gatttctaaa ttaaagactg agtgtggatg tcaattcaca tcgaaactgg aaggaatgtt
     1801 tagggatatg agcatctcaa acacaactat ggatgagttc aggcaacatc tacaggcaac
     1861 gggggtctct ttaggtggtg ttgatctcac agtccgggtt ctcacaacgg gatattggcc
     1921 tactcagtca gccacaccaa agtgcaacat cccaccagca ccaagacatg cttttgagat
     1981 atttagaagg ttctacttag ccaaacacag tggtcgacag ctcacactcc agcatcacat
     2041 gggttctgca gatctcaatg ccacctttta tggtccagtt aaaaaggaag atggatctga
     2101 ggttggtgtt ggcggtgcac aagtaactgg ttctaataca cggaagcaca tactgcaagt
     2161 ctccactttc cagatgacca tattaatgct ttttaataat agagagaagt acacatttga
     2221 ggaaattcaa caagagacag atatccctga aagagaactt gttagagccc tccagtccct
     2281 cgcctgtggt aaaccaacac agcgggtcct cacaaaagaa cccaagtcca aggagataga
     2341 aagtggccac atatttacag ttaatgatca attcacatct aaactacaca gagtcaagat
     2401 tcaaacagtt gcagccaaac aaggtgaatc cgacccagaa aggaaagaaa caagacagaa
     2461 agtagatgat gacagaaaac atgagataga agctgctata gtgcgaataa tgaagtctag
     2521 gaagaagatg cagcacaatg ttttagtagc agaggtaact cagcaactga aggctcgatt
     2581 cttaccaagt ccagttgtta ttaagaaacg tattgaagga cttattgaga gagaatattt
     2641 ggcacgaaca cctgaggatc gcaaagtata cacatatgta gcataaaatg cattcagaaa
     2701 tttgatttat tcttggactg tactcttcgc atggactggg aagttctttt aaatcatact
     2761 attaagacga ccatctcttc tgttaaattg cagtacgtgt tatagaccac tcagatcaag
     2821 cctctactcc ctctgagagt tttcaacatc agttgattga gcttcaggct ttccaacgtt
     2881 atccctgtag agatcatctt tacagttcct cgggaaaatg tgaatgtgcc gcgttttgtt
     2941 ttcaatattg tatgaaaaca ggaaaaaaat aaaacaaatt tagaaaacac agctcattaa
     3001 aataaaattg ttggatttca tttccccagg tcttcagtgt tgatgtaaat gtgtttctgt
     3061 agtgttgctt attagcactt tgcgcattgt gtaagttggg tagcaaaaat ggcaaaagag
     3121 atgcaaaatt cccagttatc ttgctctgct tgtgacattt ccttcgctgg tattgtttaa
     3181 aggtttgata catatacaaa gacccaggca tacaattggc gcatgcttta tcctaccact
     3241 tgcacttcct agtctcacag ccttatgacc aaggaccttt atttggacat caatacatac
     3301 cctgacttgt ttttctctat tgtaatctga ggttttccaa attaagttct aagattatta
     3361 ggttttgctc tgagttattt ctagagaaag aaaatatttt agtatgtata aattgtacaa
     3421 taattttttt gctgttgtac ttactgctaa cagtggattg tatagggtgg tgtttttatt
     3481 tcatttattg tagacaaaat aaataaattt agtattcaca tacacactaa ctcaagtatg
     3541 tcagagcaca aaggtggcag ctggttctat ttaatttagt tcctttgaaa agcacatcca
     3601 tccattctac catttgttta taaatatatc ccccatcccc ccacacacag tttaaatata
     3661 tattttggtg aagctgtggt acaccattaa ttgtttcaaa atgcaatcta aagatgcaat
     3721 aaatagagta ccttgatagt ttgaaggaat tcttcagttc ttgcagctgt gttttagaaa
     3781 gtgattaagc aatatttttc aaacgtggat atttagctat ccattgtcct ctgaagagtc
     3841 cttttcatgt tttcaaagat gtgctttgtg ctgaagattt gtgtgtccgt tcctctgtgc
     3901 ttccaactat cactgaagtc ttctacctga ttgatctgcc aaggattata gtttgcttta
     3961 acttcagagt atttttatct tccattttat ttaattttgt tcctttttct tttctttcaa
     4021 gataatgttt tagatatgta attggggaaa accactagat ttctgtcaaa aaaatgaaat
     4081 gttactgaat tcaagtaacc aactctccat tgaatatcaa tactgttgat atacttatta
     4141 gaatgtatgt ctcagaagat ggtttctgtt aaatatatga agttacaatt actgaattct
     4201 aatatggatt aaaagctcca cataaatatt ttccccatgc gtcttggatt ataattttcc
     4261 ttttagactt gcttttattg catttaaatt tgcttttata tgtactgtta attttaagtc
     4321 ttaggatctt aatctctaca tgttctccac ctttccatga gacagtaaag gtgtgggcag
     4381 tacggacagg ttctcggtgc accttgctgt gcttgcacag gtacggtggg acactgatgg
     4441 attgctttct ggtgtaaata gaatttttac gaaggaagct acttttaaca gtttggaagt
     4501 gaagacagct cagctgtaca gattaggtct aatgtatatg tagggacata aaggtttgct
     4561 aattgttctg gtagatgctt gcttctgagt taaagtaaat gtatttgttg ggcaatgctg
     4621 gctctgctac cttacaaaat tcatgtgatg catttggtat ttctcagcaa taggtcattg
     4681 acatttttat cctctaaatg ttttaaaaga ataatgtgat gagattcttt tttgtgactt
     4741 gaattttagg aaagatggat aatttttcca gctataaaaa atgatgtcat taattgttaa
     4801 gttattcttt gctgtcattc tttgtgggac agcatttttt tatttgtcat ttaaatattg
     4861 aaaatttatt ccaattagga aacagcttca caaaataaaa aatatggttg taattccaaa
     4921 aaaaaaaaaa aaaaa
//
