LOCUS       NM_029402               4158 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus cullin 2 (Cul2), transcript variant 2, mRNA.
ACCESSION   NM_029402
VERSION     NM_029402.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4158)
  AUTHORS   Littlejohn,R., Zambrano-Carrasco,J., Zou,J., Yao,Y., Kim,I.M.,
            Zhou,J., Li,J. and Su,H.
  TITLE     Inhibition of cardiomyocyte neddylation impairs embryonic cardiac
            morphogenesis
  JOURNAL   J Mol Cell Cardiol 197, 40-44 (2024)
   PUBMED   39437885
REFERENCE   2  (bases 1 to 4158)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4158)
  AUTHORS   Wang,Q., Li,H., Tajima,K., Verkerke,A.R.P., Taxin,Z.H., Hou,Z.,
            Cole,J.B., Li,F., Wong,J., Abe,I., Pradhan,R.N., Yamamuro,T.,
            Yoneshiro,T., Hirschhorn,J.N. and Kajimura,S.
  TITLE     Post-translational control of beige fat biogenesis by PRDM16
            stabilization
  JOURNAL   Nature 609 (7925), 151-158 (2022)
   PUBMED   35978186
REFERENCE   4  (bases 1 to 4158)
  AUTHORS   Zou,J., Ma,W., Li,J., Littlejohn,R., Zhou,H., Kim,I.M.,
            Fulton,D.J.R., Chen,W., Weintraub,N.L., Zhou,J. and Su,H.
  TITLE     Neddylation mediates ventricular chamber maturation through
            repression of Hippo signaling
  JOURNAL   Proc Natl Acad Sci U S A 115 (17), E4101-E4110 (2018)
   PUBMED   29632206
REFERENCE   5  (bases 1 to 4158)
  AUTHORS   Curtis,V.F., Ehrentraut,S.F., Campbell,E.L., Glover,L.E.,
            Bayless,A., Kelly,C.J., Kominsky,D.J. and Colgan,S.P.
  TITLE     Stabilization of HIF through inhibition of Cullin-2 neddylation is
            protective in mucosal inflammatory responses
  JOURNAL   FASEB J 29 (1), 208-215 (2015)
   PUBMED   25326537
REFERENCE   6  (bases 1 to 4158)
  AUTHORS   Kamura,T., Maenaka,K., Kotoshiba,S., Matsumoto,M., Kohda,D.,
            Conaway,R.C., Conaway,J.W. and Nakayama,K.I.
  TITLE     VHL-box and SOCS-box domains determine binding specificity for
            Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases
  JOURNAL   Genes Dev 18 (24), 3055-3065 (2004)
   PUBMED   15601820
REFERENCE   7  (bases 1 to 4158)
  AUTHORS   Vuong,B.Q., Arenzana,T.L., Showalter,B.M., Losman,J., Chen,X.P.,
            Mostecki,J., Banks,A.S., Limnander,A., Fernandez,N. and
            Rothman,P.B.
  TITLE     SOCS-1 localizes to the microtubule organizing complex-associated
            20S proteasome
  JOURNAL   Mol Cell Biol 24 (20), 9092-9101 (2004)
   PUBMED   15456882
  REMARK    Erratum:[Mol Cell Biol. 2005 Sep;25(17):7927]
REFERENCE   8  (bases 1 to 4158)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4158)
  AUTHORS   Zheng,N., Schulman,B.A., Song,L., Miller,J.J., Jeffrey,P.D.,
            Wang,P., Chu,C., Koepp,D.M., Elledge,S.J., Pagano,M., Conaway,R.C.,
            Conaway,J.W., Harper,J.W. and Pavletich,N.P.
  TITLE     Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase
            complex
  JOURNAL   Nature 416 (6882), 703-709 (2002)
   PUBMED   11961546
REFERENCE   10 (bases 1 to 4158)
  AUTHORS   Yang,X., Menon,S., Lykke-Andersen,K., Tsuge,T., Di,Xiao., Wang,X.,
            Rodriguez-Suarez,R.J., Zhang,H. and Wei,N.
  TITLE     The COP9 signalosome inhibits p27(kip1) degradation and impedes
            G1-S phase progression via deneddylation of SCF Cul1
  JOURNAL   Curr Biol 12 (8), 667-672 (2002)
   PUBMED   11967155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004875.2, AK144693.1, AK162910.1 and AC124336.10.
            
            On Mar 15, 2008 this sequence version replaced NM_029402.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.216382.1, AK220287.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               AK004875.2         1-417
            418-461             AK144693.1         391-434
            462-2843            AK004875.2         418-2799
            2844-3865           AK162910.1         120-1141
            3866-3866           AC124336.10        13884-13884         c
            3867-4158           AK162910.1         1142-1433
FEATURES             Location/Qualifiers
     source          1..4158
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 2.21 cM"
     gene            1..4158
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /note="cullin 2"
                     /db_xref="GeneID:71745"
                     /db_xref="MGI:MGI:1918995"
     exon            1..173
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            174..314
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            315..417
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            418..512
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            513..618
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            619..701
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            702..798
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            799..909
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1072
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1197
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1305
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1365
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1494
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1581
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1734
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1812
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1879
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2082
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2184
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2301
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..4158
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2759..2764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /note="hexamer: AATAAA"
     polyA_site      2785
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /note="major polyA site"
     regulatory      3814..3819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /note="hexamer: ATTAAA"
     polyA_site      3835
                     /gene="Cul2"
                     /gene_synonym="1300003D18Rik; 4932411N15Rik; mKIAA4106"
                     /note="major polyA site"
ORIGIN      
        1 ggtggccggc cggggaggcg gcctcggcgc acagtaatgg cagcgctgtg agccggggaa
       61 cgcgagctga cagccgccgc cgccgcccac cctccgagcc cggggcttcg tccttcacgc
      121 ctgcgggttg cctccctccc cgggcccctg ccctcgccct gcttctgcag aaggtttcaa
      181 cactaaactt gcacaatgtc tttaaaacca agagtagtgg attttgatga gacatggaac
      241 aaactcctaa ctacaatcaa agctgttgtt atgttggaat atgtcgagcg agcaacatgg
      301 aatgaccgct tctcagatat ctatgcttta tgtgtggcct atcctgaacc acttggagaa
      361 agactttatg cggaaacaaa gatttttttg gaaagtcacg ttcggcattt gtataagaga
      421 gttctggagt ctgaagaaca agtgcttgtt atgtatcata ggtactggga agaatacagc
      481 aaaggcgccg actatatgga ctgcttatat aggtatctca atacccagta tattaaaaag
      541 aataaattga cagaagctga tatacagtat ggctatggtg gagtagatat gaatgaacca
      601 cttatggaaa taggagagct agcattggat atgtggagga agttaatggt tgaacccctt
      661 cagaacatcc tcatccggat gctgcttcga gaaattaaaa atgatcgtgg tggtgaagat
      721 ccaaaccaga aagtaatcca tggggttatt aactcctttg ttcatgttga acagtataag
      781 aaaaaatttc ccttaaagtt ttatcaggga atattcgtgt ctccctttct gactgaaacg
      841 ggagaatatt acaagcaaga agcttcaaat ttattacaag aatcaaattg ttcacagtat
      901 atggaaaagg ttctaggtag attaaaagat gaagaaatta gatgtcgaaa atatttgcat
      961 ccaagttcat atactaaagt gattcatgag tgtcagcagc ggatggtagc agaccactta
     1021 cagttcttac attcagagtg ccacagcatc attcagcaag agaggaagaa cgacatggca
     1081 aatatgtacg tcttactccg tgctgtgtcc agtggtttac ctcatatgat tgaggagctg
     1141 cagaaacata tccatgacga gggcctcaga gcgaccagta accttactca ggaacatatg
     1201 ccaacactat ttgtggaatc agttttggaa gtacatggta aattcgttca acttatcaac
     1261 actgttttga atggtgatca gcattttatg agtgctttag ataaggccct tacatctgtt
     1321 gtaaattaca gagaacccaa gtctgtttgc aaagcgcctg aactgcttgc taagtactgt
     1381 gacaacttgc taaagaagtc agcgaagggg atgactgaaa atgaagtgga ggacaagctc
     1441 actagcttca tcacagtttt caagtacatt gatgacaagg acgtctttca gaagttctat
     1501 gcaagaatgc tagcaaaacg tctaattcac gggttgtcta tgtctatgga ttctgaagaa
     1561 gccatgatca ataaattaaa gcaagcctgt ggttatgagt ttaccagcaa gctgcatcga
     1621 atgtatacag acatgagtgt cagcgctgat ttgaacaata agttcaacaa tttcatcaga
     1681 aaccaagaca ccgtgattga cttggggatt agtttccaaa tatatgttct tcaggctggt
     1741 gcgtggcctc tcactcaggc tccttcatct acatttgcaa ttccccaaga gctagagaaa
     1801 agtgtacaga tgtttgaatt gttttatagc cagcatttca gtggacggaa gctgacatgg
     1861 ttgcattatc tctgtacagg tgaagttaaa atgaactatt tgggaaaacc atatgtagct
     1921 atggttacaa cctaccaaat ggcagttctt cttgccttta acaacagtga aactgtcagc
     1981 tacaaagaac ttcaagacag tacccagatg aatgaaaagg agctgaccaa aacaatcaaa
     2041 tcattacttg atgtgaaaat gattaaccat gattcagaaa aggaagatat cgatgcagaa
     2101 tcttcatttt cattaaatat gagcttcagc agtaagagaa caaaatttaa gattactacg
     2161 tcaatgcaga aggatacgcc acaagaactg gaacagacta gaagtgctgt agatgaggac
     2221 cggaaaatgt atcttcaagc tgctattgtc cgcatcatga aagcacgaaa agtgcttcgg
     2281 cacaacgccc tcattcaaga ggtaatcagc cagtcaagag ccaggttcaa tcccagtatc
     2341 agcatgatta agaagtgcat agaagttctg atagacaaac agtacatcga gcgcagccaa
     2401 gcatctgcag atgaatacag ttacgtcgca tgacaccttc tcctggtgca gctgtgaggt
     2461 cattgccatc cccatttggt gagctcctgt gggagaaagc aggcctgtgc ctccatactt
     2521 tggtcgtctg gcagcccctg tttttctgct gtttacaaca tcaccagtgc cacgtcatga
     2581 gcgtcagaga aaatgcctag agatatttca agctcatgtc attatgacgt ttcttaaaac
     2641 tttattaaaa gaatgagtga agtattgctg aaatgtggaa tttggttggg taccatgctt
     2701 tctcccctca cgtttgcagt tgatgtgttt tttttttaat gtatcttaaa ggacaaaaaa
     2761 taaaaactta aatattgtaa tatgacagat aacctaataa ttgtatctac attaaaatga
     2821 caaacatgat gttgctgctt gtcaaataaa aaaaaaaaaa aataagcata atgccttttt
     2881 ctatgatgac ggaatatcag gttggacaga aaatgagaca tctgtaaatg cctatgagtc
     2941 acccaagcag caaacagcat ttcgtcattt catcatttcg tcatggtgat gaatttactt
     3001 gggctcccat ctaaagttca attaaaagtg ccagggttct gtctttgaat acataagatt
     3061 gtgaatttga gctaatggca taagcagttt ttgcattttg agtaggatgt aattctatct
     3121 ggttttggtg atgagctgta ccacagaaac ggaatactat gcagtgactt ctaggctggc
     3181 agaaaagaac tgctcactct tgacccattc ttcatgatac atctatgcta acataatggc
     3241 tgtggctcat ctcccagagt ttaggagact atgagtacag tgaattcctt ccagctcccc
     3301 ctgctcatcg ctggcaccct tccacagtgc agatgactcc cccatcacaa gttgatagca
     3361 gggcccctca atgctaagga gttccaccag gcatcttgta tagggacatg agatttcatg
     3421 agtttgtttc tagtagataa caggggcatt cagatactct ggttactata ttctccatct
     3481 gccatctcta gatcacattg ctgttttaaa ccagagtatt tatatctaac agataaggcc
     3541 ttaaatccac aataatattc tgaacaaata aatagaactt aatttgcatt ctcatgtggt
     3601 tcatattaaa tttaatgatt ggttatttga ttgcaccttt tgtatcttaa gctttcaaaa
     3661 atctgctgga cttctaatga cttctactgt ctttattatt ttgccttcct acctcgtgta
     3721 gataatggca aagcatatac tattgtacat tcatggtcaa agaacaagcc ccttgttttg
     3781 ataacttgtt acaagttttc caaatttata aatattaaat taagtcataa cctgatacca
     3841 attgtcaaga aatgttatat tgaaaagtag aaaaaatatt tgtgacaaat tcaagttttc
     3901 ttaacatttc cttcttattt attgatgagc agaaagaaga agggagttca ggtaagtcta
     3961 ggctctactg agaaagtgaa aatgtattca ttgaattctg tcccgcccac ttcctcccct
     4021 gaggagcccc tgacaagagc tccagcttgg ctttactggc tgccatagtg agtgcttatg
     4081 ggcagagtgg gtcaactaca ggaaggtagg agaggtagga aggtaggaga gggaagggac
     4141 ttttttatac cttattgc
//
