LOCUS       NM_001355550            3434 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus cullin 1 (Cul1), transcript variant 2, mRNA.
ACCESSION   NM_001355550 XM_006506190
VERSION     NM_001355550.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3434)
  AUTHORS   Yang,T., Hu,J., Zhang,L., Liu,L., Pan,X., Zhou,Y., Wu,Y., Shi,X.,
            Obiegbusi,C.N. and Dong,X.
  TITLE     CircCUL1 inhibits trophoblast cell migration and invasion and
            promotes cell autophagy by sponging hsa-miR-30e-3p in fetal growth
            restriction via the ANXA1/PI3K/AKT axis
  JOURNAL   J Biochem Mol Toxicol 38 (7), e23759 (2024)
   PUBMED   39003567
  REMARK    GeneRIF: CircCUL1 inhibits trophoblast cell migration and invasion
            and promotes cell autophagy by sponging hsa-miR-30e-3p in fetal
            growth restriction via the ANXA1/PI3K/AKT axis.
REFERENCE   2  (bases 1 to 3434)
  AUTHORS   Huang,X., Liu,X., Li,X., Zhang,Y., Gao,J., Yang,Y., Jiang,Y.,
            Gao,H., Sun,C., Xuan,L., Zhao,L., Song,J., Bao,H., Zhou,Z., Li,S.,
            Zhang,X., Lu,Y., Zhong,X., Yang,B. and Pan,Z.
  TITLE     Cullin-associated and neddylation-dissociated protein 1 (CAND1)
            alleviates NAFLD by reducing ubiquitinated degradation of ACAA2
  JOURNAL   Nat Commun 14 (1), 4620 (2023)
   PUBMED   37528093
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3434)
  AUTHORS   Li,R., Dai,Z., Liu,X., Wang,C., Huang,J., Xin,T., Tong,Y. and
            Wang,Y.
  TITLE     Interaction between dual specificity phosphatase-1 and cullin-1
            attenuates alcohol-related liver disease by restoring p62-mediated
            mitophagy
  JOURNAL   Int J Biol Sci 19 (6), 1831-1845 (2023)
   PUBMED   37063418
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3434)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3434)
  AUTHORS   Zeng,L., Luo,T., He,L., Tan,Y. and Zhang,Q.
  TITLE     New insights into the roles of CUL1 in mouse placenta development
  JOURNAL   Biochem Biophys Res Commun 559, 70-77 (2021)
   PUBMED   33933992
  REMARK    GeneRIF: New insights into the roles of CUL1 in mouse placenta
            development.
REFERENCE   6  (bases 1 to 3434)
  AUTHORS   Miura,M., Hatakeyama,S., Hattori,K. and Nakayama,K.
  TITLE     Structure and expression of the gene encoding mouse F-box protein,
            Fwd2
  JOURNAL   Genomics 62 (1), 50-58 (1999)
   PUBMED   10585767
REFERENCE   7  (bases 1 to 3434)
  AUTHORS   Wang,Y., Penfold,S., Tang,X., Hattori,N., Riley,P., Harper,J.W.,
            Cross,J.C. and Tyers,M.
  TITLE     Deletion of the Cul1 gene in mice causes arrest in early
            embryogenesis and accumulation of cyclin E
  JOURNAL   Curr Biol 9 (20), 1191-1194 (1999)
   PUBMED   10531039
REFERENCE   8  (bases 1 to 3434)
  AUTHORS   Dealy,M.J., Nguyen,K.V., Lo,J., Gstaiger,M., Krek,W., Elson,D.,
            Arbeit,J., Kipreos,E.T. and Johnson,R.S.
  TITLE     Loss of Cul1 results in early embryonic lethality and dysregulation
            of cyclin E
  JOURNAL   Nat Genet 23 (2), 245-248 (1999)
   PUBMED   10508527
REFERENCE   9  (bases 1 to 3434)
  AUTHORS   Hatakeyama,S., Kitagawa,M., Nakayama,K., Shirane,M., Matsumoto,M.,
            Hattori,K., Higashi,H., Nakano,H., Okumura,K., Onoe,K., Good,R.A.
            and Nakayama,K.
  TITLE     Ubiquitin-dependent degradation of IkappaBalpha is mediated by a
            ubiquitin ligase Skp1/Cul 1/F-box protein FWD1
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3859-3863 (1999)
   PUBMED   10097128
REFERENCE   10 (bases 1 to 3434)
  AUTHORS   Michel,J.J. and Xiong,Y.
  TITLE     Human CUL-1, but not other cullin family members, selectively
            interacts with SKP1 to form a complex with SKP2 and cyclin A
  JOURNAL   Cell Growth Differ 9 (6), 435-449 (1998)
   PUBMED   9663463
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154014.4 and AC154015.3.
            
            On Aug 10, 2022 this sequence version replaced NM_001355550.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.124050.1,
                                           SRR1660817.25647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               AC154014.4         21126-21557         c
            433-733             AC154015.3         104144-104444       c
            734-908             AC154015.3         93947-94121         c
            909-1076            AC154015.3         91800-91967         c
            1077-1127           AC154015.3         87970-88020         c
            1128-1218           AC154015.3         87399-87489         c
            1219-1382           AC154015.3         86598-86761         c
            1383-1545           AC154015.3         80800-80962         c
            1546-1676           AC154015.3         80085-80215         c
            1677-1784           AC154015.3         74286-74393         c
            1785-1891           AC154015.3         74103-74209         c
            1892-1940           AC154015.3         72665-72713         c
            1941-2072           AC154015.3         71955-72086         c
            2073-2190           AC154015.3         70906-71023         c
            2191-2267           AC154015.3         69976-70052         c
            2268-2399           AC154015.3         69409-69540         c
            2400-2492           AC154015.3         68303-68395         c
            2493-2540           AC154015.3         66063-66110         c
            2541-2623           AC154015.3         65902-65984         c
            2624-2729           AC154015.3         65384-65489         c
            2730-2843           AC154015.3         64558-64671         c
            2844-3434           AC154015.3         63044-63634         c
FEATURES             Location/Qualifiers
     source          1..3434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.9 cM"
     gene            1..3434
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /note="cullin 1"
                     /db_xref="GeneID:26965"
                     /db_xref="MGI:MGI:1349658"
     exon            1..432
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..733
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             594..2924
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /codon_start=1
                     /product="cullin-1"
                     /protein_id="NP_001342479.1"
                     /db_xref="CCDS:CCDS20095.1"
                     /db_xref="GeneID:26965"
                     /db_xref="MGI:MGI:1349658"
                     /translation="MSSNRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYME
                     LYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTN
                     LLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIY
                     SLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDA
                     FAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQ
                     VYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLG
                     ELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFV
                     AALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVM
                     VVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMF
                     QDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRF
                     TAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQ
                     LTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRV
                     NINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSS
                     RFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA"
     exon            734..908
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1076
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1127
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1218
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1382
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1545
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1676
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1784
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1891
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1940
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2072
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2190
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2267
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2399
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2492
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2540
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2623
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2729
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2843
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..3434
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3331..3336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /note="hexamer: AATAAA"
     regulatory      3341..3346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3357
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /note="major polyA site"
     polyA_site      3366
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /note="major polyA site"
     regulatory      3405..3410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /note="hexamer: AATAAA"
     polyA_site      3434
                     /gene="Cul1"
                     /gene_synonym="Cul-1"
                     /note="major polyA site"
ORIGIN      
        1 acccggccgg ccaggctcgg cctgggccgg gactcgcagg gccaggccct ggctacgcac
       61 tgggaaaaag ccggactcac cgcggcctgt ggcgccgacc tcggcgcctc acgcgccacc
      121 cctcccttcc cctcggccct gggggttccg cttggccggg gtggctcagg gccgggggac
      181 tcgtgctctc ggggatccgg gggcactcat tgttgcgacg gtgcggggca tgattattgg
      241 gtaacagtgg tgccgggctc cgttctctct gggagcgtgg ccgagcaagg cgcgccggga
      301 tgcggtgtgc ttttccaaag gaacggagcc cccgggcgtc cgccagctct cctcagtcga
      361 actgggccct ccctgtgcgg cggcctcggc gcgtccccgg tcccggcggg agcgcgcgct
      421 ctgaccccaa aggtttgcct gcaatgagac tttactctct acacttaaag aacattcttt
      481 ctgagctgct gtgaataaat ttggaatgat tttgtctatt ttcaactaat ggagaactag
      541 ctgtaacttg aacaaggatt actgtactgg acaacttcag aacattgctc acaatgtcat
      601 caaacaggag tcagaatcct catggactga agcagattgg tcttgaccag atctgggatg
      661 acctcagagc tggaattcag caggtgtata ccagacaaag catggcaaag tccagataca
      721 tggaactcta cactcatgtt tataactact gtactagtgt gcatcagtcc aaccaagccc
      781 ggggtgctgg agtccctcct tccaagtcaa aaaaggggca gactcctggg ggagctcagt
      841 ttgttggctt ggagttatac aagcgattga aggaattttt gaagaattat ttgacaaatc
      901 ttcttaagga tggagaagat ttaatggatg agagtgtcct gaagttctac actcagcagt
      961 gggaagatta ccgattctcc agcaaagtgc tgaatggaat ctgtgcctac ctcaatagac
     1021 attgggttcg ccgtgaatgt gatgaaggac gaaaaggaat atatgaaatc tattcacttg
     1081 cattggtgac atggagagat tgtttgttca ggccattgaa taaacaggta acaaatgctg
     1141 ttttaaagtt gattgaaaag gaaagaaatg gagaaaccat caatacaaga ctgattagtg
     1201 gagttgtaca atcttatgtg gaattggggc tgaatgaaga tgatgcattt gcaaagggcc
     1261 ctacgttaac agtgtataaa gaatcctttg aatctcaatt tttggctgac acagagagat
     1321 tttataccag agaaagtact gaattcttac agcagaaccc agttactgaa tatatgaaaa
     1381 aggctgaagc tcgtttgctt gaggaacagc ggagagttca ggtttacctc cacgagagca
     1441 cacaagatga actagcacgg aaatgtgagc aggtcctcat tgaaaaacac ttggaaattt
     1501 ttcacacaga gtttcagaat ttattggatg ctgacaagaa tgaagatttg ggccgcatgt
     1561 ataatcttgt atctagaatt caggatggcc taggagaatt gaaaaaacta ctagagacac
     1621 atattcataa tcagggtctt gcagcaattg agaagtgtgg agaagctgct ctaaatgacc
     1681 ccaagatgta tgtgcagaca gtgctggatg ttcataaaaa atacaatgcc ctggtgatgt
     1741 cagcattcaa caacgatgct ggcttcgtag ctgctcttga taaggcttgt ggtcgcttca
     1801 taaacaacaa tgcggttacc aaaatggccc agtcatccag taaatcccct gagctgcttg
     1861 ctcggtactg tgactccttg ctgaagaaaa gttccaagaa cccagaagag gcagaactag
     1921 aagacaccct caatcaagtg atggtggtct tcaagtacat cgaggacaaa gatgtatttc
     1981 agaagttcta tgcaaagatg cttgccaaga gactggtaca tcaaaacagt gcgagtgacg
     2041 atgctgaagc aagcatgatc tccaagttaa agcaagcttg tggttttgag tacacttcca
     2101 aacttcagcg aatgtttcaa gacattggtg taagcaaaga tctgaatgaa cagttcaaaa
     2161 aacacctgac gaattcagaa ccgctggact tggacttcag tattcaggtc ctgagttctg
     2221 gatcgtggcc ctttcagcag tcttgcacgt ttgccttgcc gtcagagttg gagcgcagtt
     2281 atcagcgatt tacagctttc tacgccagcc gtcacagtgg cagaaaattg acatggttgt
     2341 atcaactgtc caaaggggaa ctagtcacta actgcttcaa aaacagatac actttgcagg
     2401 cgtccacatt tcagatggca atcctgcttc agtataacac agaagacgcc tatactgtgc
     2461 agcagttgac tgacagcact cagattaaaa tggacatttt ggcacaagtc ctacagattt
     2521 tactgaagtc gaaattgctg gtcttagaag atgaaaatgc caatgttgat gaggtggaat
     2581 tgaagccaga caccttaata aagttatatc ttggttataa aaataagaaa ttgagggtta
     2641 atatcaatgt accaatgaaa actgaacaga agcaggaaca agaaactaca cacaaaaata
     2701 tagaggaaga ccgcaaacta ctgattcagg cggccatcgt gagaatcatg aaaatgagga
     2761 aggtcctgaa acaccagcag ttacttggtg aagtcctcac tcagctctcc tccaggttca
     2821 aacctcgggt cccggtgatc aagaaatgca ttgatattct catcgaaaaa gaatatttgg
     2881 agcgagtcga tggtgagaag gacacctaca gttacttggc ttaacccatc tagcagggtc
     2941 tgcatgaccc acaagcagat agttccagtg aataaaatgg aaacaactca agttcatagc
     3001 agccagcctg ccgccatttg gaccttcatt tttaaagctg agaccacagt tcccaccagc
     3061 tggtttcagg ctacagcagg actgctcagg actgactgac acatttcagt ctgtaaacag
     3121 acgccaatgc catttaccct aactcacaga cagaggggaa ccgaaccttc catgctgagg
     3181 ctgcatgcta ccgcacttaa atcaatacat tggctccctg gttaacagct gtcgtctgag
     3241 gcagcacacg agagcgagtc tgaatggacc cacgtgtaat ctgctatgaa aaccatttgt
     3301 atagtgtgtt tcattttttt aatgtgtgaa aataaagaaa attaaaggat ttctgtacaa
     3361 gttgcatttg gttttgtttt aagtttttct aatttctata tgtaaataaa agatttaatg
     3421 attgtgcaag tgta
//
