LOCUS       NM_001164291            1833 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus CUE domain containing 2 (Cuedc2), transcript variant
            3, mRNA.
ACCESSION   NM_001164291
VERSION     NM_001164291.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1833)
  AUTHORS   Zhang,Z., Yu,T., Li,H., Du,L., Jin,Z., Peng,X., Yan,Y., Zhou,J. and
            Gu,J.
  TITLE     Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via
            the miR-324-5p-CUEDC2 Axis
  JOURNAL   Microbiol Spectr 11 (3), e0420622 (2023)
   PUBMED   37036350
  REMARK    GeneRIF: Long Noncoding RNA AROD Inhibits Host Antiviral Innate
            Immunity via the miR-324-5p-CUEDC2 Axis.
REFERENCE   2  (bases 1 to 1833)
  AUTHORS   Kim,J.W., Oh,S.H., Lee,M.N., Song,J.H., Jeong,B.C., Yang,J.W.,
            Piao,X., Zang,Y., Ryu,J.H. and Koh,J.T.
  TITLE     CUEDC2 controls osteoblast differentiation and bone formation via
            SOCS3-STAT3 pathway
  JOURNAL   Cell Death Dis 11 (5), 344 (2020)
   PUBMED   32393737
  REMARK    GeneRIF: CUEDC2 controls osteoblast differentiation and bone
            formation via SOCS3-STAT3 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1833)
  AUTHORS   Jian,Z., Liang,B., Pan,X., Xu,G., Guo,S.S., Li,T., Zhou,T.,
            Xiao,Y.B. and Li,A.L.
  TITLE     CUEDC2 modulates cardiomyocyte oxidative capacity by regulating
            GPX1 stability
  JOURNAL   EMBO Mol Med 8 (7), 813-829 (2016)
   PUBMED   27286733
  REMARK    GeneRIF: Notably, CUEDC2 promoted E3 ubiquitin ligases tripartite
            motif-containing 33 (TRIM33)-mediated the antioxidant enzyme,
            glutathione peroxidase 1 (GPX1) ubiquitination, and
            proteasome-dependent degradation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1833)
  AUTHORS   Wang,S., Pu,J., Li,N., Li,C., Li,C., Yu,L., Wang,X., Fu,S. and
            Cui,L.
  TITLE     CUEDC2 Protects Against Experimental Colitis and Suppresses
            Excessive Proliferation of Intestinal Mucosa
  JOURNAL   Dig Dis Sci 60 (12), 3603-3609 (2015)
   PUBMED   26182901
  REMARK    GeneRIF: These findings demonstrate that CUEDC2 plays an important
            role in protection from colonic inflammation, primarily by
            inhibiting the NF-kappaB and STAT3 signaling pathways and
            preventing excessive proliferation of the inflammatory epithelial
            cell.
REFERENCE   5  (bases 1 to 1833)
  AUTHORS   Chen,Y., Wang,S.X., Mu,R., Luo,X., Liu,Z.S., Liang,B., Zhuo,H.L.,
            Hao,X.P., Wang,Q., Fang,D.F., Bai,Z.F., Wang,Q.Y., Wang,H.M.,
            Jin,B.F., Gong,W.L., Zhou,T., Zhang,X.M., Xia,Q. and Li,T.
  TITLE     Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage
            dysfunction and is associated with colon cancer
  JOURNAL   Cell Rep 7 (6), 1982-1993 (2014)
   PUBMED   24882011
  REMARK    GeneRIF: CUEDC2 plays a crucial role in modulating macrophage
            function and is associated with both colitis and colon
            tumorigenesis.
REFERENCE   6  (bases 1 to 1833)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY279028.1, CX207621.1, AK008842.1, AK013884.1 and AC114539.8.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3865110.1,
                                           ERR3363658.4344902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                BY279028.1         3-94
            93-318              CX207621.1         392-617
            319-715             AK008842.1         282-678
            716-1210            AK013884.1         674-1168
            1211-1211           AC114539.8         100098-100098       c
            1212-1833           AK013884.1         1170-1791
FEATURES             Location/Qualifiers
     source          1..1833
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.81 cM"
     gene            1..1833
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /note="CUE domain containing 2"
                     /db_xref="GeneID:67116"
                     /db_xref="MGI:MGI:1914366"
     exon            1..92
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            93..176
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..957
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /note="isoform a is encoded by transcript variant 3; CUE
                     domain-containing protein 2"
                     /codon_start=1
                     /product="CUE domain-containing protein 2 isoform a"
                     /protein_id="NP_001157763.1"
                     /db_xref="CCDS:CCDS29876.1"
                     /db_xref="GeneID:67116"
                     /db_xref="MGI:MGI:1914366"
                     /translation="MELERIVGSALLTFVQAHLPEADLSGLDEVIFSYVLGVLEDLGP
                     SGPSEENFDMEAFTEMMEAYVPGFAHIPRGIIGDMMQKLSVQLSDARNKENLHPQSSC
                     VQGQVPIFPETPRQAEKLEEESRPPAAPGNTLDEAAAAEELPGVDVLLEVFPTCSMEQ
                     AQWVLAKARGDLEEAVHMLVEGKEEGPPGWDGPSQDLPRRLRGPQKDDLKSFILQKYM
                     MVDRAEDQKTHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLK
                     PARKYRFH"
     exon            177..320
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            321..382
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            383..510
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            511..687
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            688..749
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            750..810
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1833
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1082..1087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1105
                     /gene="Cuedc2"
                     /gene_synonym="3010002G01Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggccccgcc tttgatctcg ttggtggggc tagggggggt gataagaact gcaccgcgcg
       61 ggacaagttg ctggcggcgc ctgacggagc agaagaccca gcatggagtt ggagaggatc
      121 gtcggctcag ccctcctcac cttcgttcag gcacacctgc cagaggcaga cctcagtggc
      181 ttggatgaag tcatcttctc ctatgtgctt ggggtcctgg aggacctggg cccctcagga
      241 ccatcagagg agaactttga tatggaggcc ttcactgaaa tgatggaggc ttatgtgcct
      301 ggctttgccc acatccccag aggtataata ggagacatga tgcagaagct ctcggtgcag
      361 ctgagcgatg ctaggaacaa agagaacctg cacccacaga gctcctgtgt ccaaggtcag
      421 gtgcccattt ttccagagac cccgaggcaa gctgaaaagc tcgaagaaga gagcaggcct
      481 cccgctgctc ccgggaacac cctagatgag gcagctgcgg cagaagaact gccaggagtc
      541 gatgtgctcc tggaggtctt ccctacctgc tctatggagc aggcccagtg ggtgctggcc
      601 aaagctcggg gggacttgga ggaagctgtg cacatgctgg tagagggcaa ggaagagggg
      661 cctccaggct gggacggccc aagtcaggac ttgcccaggc gtctcagagg cccccaaaag
      721 gatgacttga agtctttcat ccttcagaag tacatgatgg tggacagggc ggaggaccag
      781 aagactcacc gacctatggc tcccaaggag gcccccaaga agctgatccg atacatcgac
      841 aaccaagtag tgagcaccaa gggagagcga ttcaaagatg tccggaaccc tgaggccgag
      901 gagatgaagg ccacatacat caacctcaag ccggccagaa agtaccgctt ccactgagac
      961 agtgctggat cctgccgagc actgctgatc ccagagggat gcagacaccc tcccatccac
     1021 cctgtccctt ctggaggccc ttgctctagt gttctattct tggggcttcc ttcaagagca
     1081 cagtaaaagt ggtccaagga aggtatatgc tcattctgct catttctgcc cccagggcag
     1141 ggaaaaaacc tgtctctctg actagttccc agcttcccgt cccctatgca ccacgcaaga
     1201 aggggtaaaa agctctttat ttgaaattcc agggtgggac aggggatttc acaggcctgt
     1261 caaccacagg cccccacagt tcagtttccc tatggctcag ggtcaagccc gggctacaca
     1321 gtccagctgt gctcccaccc caaggaaagt tagtcagacc tgtaggttga caaagggtgc
     1381 gaagcctgcc atgtcctgga gtagcaccag agcctggtgc aggggtggtt ccacgtcgat
     1441 gtccacacca cgcttccgca agcggctcag gctcggttca gccacatggt ggcagtgccg
     1501 cacccgcaga gagcgcagcg ccgggcagta ctcggccagt gtcctgaggg aggagtatgg
     1561 tgatgctagg tgctgaatct cacggtctgg agggccagcc ctctaaaccc gcagctggct
     1621 ccagcaagtt ctagctttcc ctccagctca gggtctgctc ttttttactg tacctaaagg
     1681 aaggggccag gaaggaatta cagactccag gctcatttgg ggtttctggt tcttagagag
     1741 taccaatcca tagttccttc cagtgtttct agattaccca ccttgttgca gaaatgccag
     1801 aaatcaactt tatgtgacat ttctcagtgt gtc
//
