LOCUS       NM_001081084           11339 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cubilin (Cubn), mRNA.
ACCESSION   NM_001081084 XM_130038
VERSION     NM_001081084.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11339)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 11339)
  AUTHORS   Rbaibi,Y., Long,K.R., Shipman,K.E., Ren,Q., Baty,C.J., Kashlan,O.B.
            and Weisz,O.A.
  TITLE     Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal
            tubule cells
  JOURNAL   Mol Biol Cell 34 (7), ar74 (2023)
   PUBMED   37126375
  REMARK    GeneRIF: Megalin, cubilin, and Dab2 drive endocytic flux in kidney
            proximal tubule cells.
REFERENCE   3  (bases 1 to 11339)
  AUTHORS   Zhang,M., Salbaum,J.M., Jones,S., Burk,D. and Kappen,C.
  TITLE     Aberrant lipid accumulation in the mouse visceral yolk sac
            resulting from maternal diabetes and obesity
  JOURNAL   Front Cell Dev Biol 11, 1073807 (2023)
   PUBMED   36936697
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11339)
  AUTHORS   Niborski,L.L., Paces-Fessy,M., Ricci,P., Bourgeois,A.,
            Magalhaes,P., Kuzma-Kuzniarska,M., Lesaulnier,C., Reczko,M.,
            Declercq,E., Zurbig,P., Doucet,A., Umbhauer,M. and Cereghini,S.
  TITLE     Hnf1b haploinsufficiency differentially affects developmental
            target genes in a new renal cysts and diabetes mouse model
  JOURNAL   Dis Model Mech 14 (5) (2021)
   PUBMED   33737325
REFERENCE   5  (bases 1 to 11339)
  AUTHORS   Seelan,R.S., Mukhopadhyay,P., Philipose,J., Greene,R.M. and
            Pisano,M.M.
  TITLE     Gestational folate deficiency alters embryonic gene expression and
            cell function
  JOURNAL   Differentiation 117, 1-15 (2021)
   PUBMED   33302058
REFERENCE   6  (bases 1 to 11339)
  AUTHORS   Crider-Pirkle,S., Billingsley,P., Faust,C., Hardy,D.M., Lee,V. and
            Weitlauf,H.
  TITLE     Cubilin, a binding partner for galectin-3 in the murine
            utero-placental complex
  JOURNAL   J Biol Chem 277 (18), 15904-15912 (2002)
   PUBMED   11856751
REFERENCE   7  (bases 1 to 11339)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 11339)
  AUTHORS   Burmeister,R., Boe,I.M., Nykjaer,A., Jacobsen,C., Moestrup,S.K.,
            Verroust,P., Christensen,E.I., Lund,J. and Willnow,T.E.
  TITLE     A two-receptor pathway for catabolism of Clara cell secretory
            protein in the kidney
  JOURNAL   J Biol Chem 276 (16), 13295-13301 (2001)
   PUBMED   11278724
REFERENCE   9  (bases 1 to 11339)
  AUTHORS   Hammad,S.M., Barth,J.L., Knaak,C. and Argraves,W.S.
  TITLE     Megalin acts in concert with cubilin to mediate endocytosis of high
            density lipoproteins
  JOURNAL   J Biol Chem 275 (16), 12003-12008 (2000)
   PUBMED   10766831
REFERENCE   10 (bases 1 to 11339)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773538.7, AK141391.1, CK623807.1, AL928807.3, CK390258.1,
            CK391977.1, CK391058.1, CF165743.1, CF169457.1, CK391475.1 and
            AF197159.1.
            
            On May 23, 2007 this sequence version replaced NM_001081084.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164134
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AL773538.7         141449-141624       c
            177-306             AL773538.7         140929-141058       c
            307-402             AL773538.7         139646-139741       c
            403-441             AL773538.7         139067-139105       c
            442-543             AL773538.7         136503-136604       c
            544-647             AL773538.7         135795-135898       c
            648-774             AL773538.7         128818-128944       c
            775-937             AL773538.7         127808-127970       c
            938-1069            AL773538.7         125785-125916       c
            1070-1171           AL773538.7         123146-123247       c
            1172-1293           AL773538.7         119510-119631       c
            1294-1480           AL773538.7         118462-118648       c
            1481-1593           AL773538.7         117358-117470       c
            1594-1828           AL773538.7         115563-115797       c
            1829-2010           AL773538.7         108694-108875       c
            2011-2173           AL773538.7         106353-106515       c
            2174-3392           AK141391.1         89-1307
            3393-3553           AL773538.7         78356-78516         c
            3554-3735           AL773538.7         77585-77766         c
            3736-3892           AL773538.7         76700-76856         c
            3893-4080           AL773538.7         74420-74607         c
            4081-4231           AL773538.7         53714-53864         c
            4232-4413           AL773538.7         38587-38768         c
            4414-4588           AL773538.7         33618-33792         c
            4589-4758           AL773538.7         31506-31675         c
            4759-4918           AL773538.7         11951-12110         c
            4919-5032           AL773538.7         10005-10118         c
            5033-5405           CK623807.1         85-457
            5406-5611           AL928807.3         97822-98027         c
            5612-5796           AL928807.3         96801-96985         c
            5797-5989           AL928807.3         94950-95142         c
            5990-6453           CK390258.1         75-538
            6454-6944           CK391977.1         102-592
            6945-7193           CK391058.1         181-429
            7194-7273           AL928807.3         80296-80375         c
            7274-7414           AL928807.3         79263-79403         c
            7415-7596           AL928807.3         78431-78612         c
            7597-7858           CF165743.1         183-444
            7859-8125           CF169457.1         179-445
            8126-8247           AL928807.3         68119-68240         c
            8248-8473           CK391475.1         48-273
            8474-11339          AF197159.1         38-2903
FEATURES             Location/Qualifiers
     source          1..11339
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 9.86 cM"
     gene            1..11339
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /note="cubilin"
                     /db_xref="GeneID:65969"
                     /db_xref="MGI:MGI:1931256"
     exon            1..176
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..10935
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /note="intrinsic factor-cobalamin receptor"
                     /codon_start=1
                     /product="cubilin precursor"
                     /protein_id="NP_001074553.1"
                     /db_xref="CCDS:CCDS38048.1"
                     /db_xref="GeneID:65969"
                     /db_xref="MGI:MGI:1931256"
                     /translation="MASHFLWGFVTLLMVPGLDGETGTPEQKLQKRIADLHQPRMTTE
                     EGNLVFLTSSAQNIEFRTGSLGKIKLNDDDLGECLHQIQRNKDDIIDLKRNTTGLPQN
                     ILSQVHQLNSKLVDLERDFQSLQQNVERKVCSSNPCHNGGTCVNLHDSFICICPSQWK
                     GLFCSEDVNECVLYAGTPFGCQSGSTCVNTMGSFRCDCTPDTYGPQCASKYNDCEQGS
                     QQLCKHGICEDLQRVYHGQLRFNCICDAGWTTLPNGISCTEDKDECSLQPSPCSEHAQ
                     CFNTQGSFYCGACPKGWQGNGYQCQDINECEINNGGCSQAPLVPCLNTPGSFTCGNCP
                     AGFSGDGRVCTPLDICSIHNGGCHPDATCSSSSVLGSLLPVCTCPPGYTGNGYGSNGC
                     VRLSNMCSRHPCVNGQCIETVSSYFCKCDSGWFGQNCTENINECVSNPCLNGGTCIDG
                     VNGFTCDCTSSWTGYYCQTPQAACGGILSGTQGTFAYQSPNDTYVHNVNCFWVVRTDE
                     EKVLHITFTFFDLESASNCPREYLQIHDGDSSADFPLGRYCGSTPPQGVHSSANSLYF
                     HLYSEYIKRGRGFTARWEAKLPECGGILTGNYGSITSPGYPGNYPPGRDCVWNLLVSP
                     GSLITFTFGTLSLESHNDCSKDYLEIRDGPFHHDPILGKFCTSLSTPPLQTTGPAARI
                     HFHSDSETSDKGFHITYLTTPSDLYCGGNYTDTEGELLLPPLTGPFSHSRQCVYLISQ
                     PQGEQIVINFTHVELESQRGCSHTFIEVGDHESLLRKICGNETLFPIRSISNNVWIRL
                     RIDALVQKASFRADYQVACGGELRGEGVIRSPFYPNAYAGRRTCRWTISQPPREVVLL
                     NFTDFQIGSSSSCDTDYIEIGPSSVLGSPGNEKFCGTNIPSFITSVYNVLYVTFVKSS
                     SMENRGFMAMFSSEKLECGKVLTESTGIIESPGHPNVYPSGVNCTWHIVVQRGQLIRL
                     VFSSFYLEFHYNCANDYLEVYDTIAQTSLGRYCGKSIPPSLTSSSHSIKLIFVSDSAL
                     AHEGFSINYEAINASSVCLYDYTDNFGRLSSPNFPNNYPHNWNCVYRITVGLNQQIAL
                     HFTDFALEDYFGPKCVDFVEIRDGGFETSPLIGIYCGSVFPPRIISHSNKLWLRFKSD
                     TALTARGFSAYWDASSTGCGGNLTTPTGVLTSPNYPMPYYHSSECYWRLEASRGSPFL
                     LEFQDFHLEHHPNCSLDYLAVFDGPSTNSRLINKLCGDTPPAPIRSSKDIVLLKLRTD
                     AGQQGRGFEINYRQTCDNVVIVNKTSGILESINYPNPYDKDQRCNWTIQATTGNTVNY
                     TFLEFDVENYVNCSTDYLELYDGPQRIGRYCGENIPPPGATTGSKLIVVFHTDGVDSG
                     EKGFKMHWFIHGCGGEMSGTMGSFSSPGYPNSYPHNKECIWNIRVAPGNSIQLTIHDF
                     DVEYHASCKYDTLEIYTGLDFHSPRIAQLCSRSPSANPMQISSTDNELAIRFKTDSSL
                     NGRGFNASWRAVPGGCGGIFQVSRGEIHSPNYPNNYRANTECSWIIQVEKYHRVLLNI
                     TDFDLEATDSCLMTYDGSSSANTRVATVCGRQQPPNSITSSGNSLFVRFQSGSSSQSR
                     GFRAQFRQECGAHIITDSSDSISSPLYPANYPNNQNCTWIIEAQPPFNHIALSFTHFH
                     LQSSTDCTRDFVEILDGRDSDAPVQGRYCGTSLPHPIISFGNALTVRFVSDSVYGFDG
                     FHAIYSASTSACGGTFYTGDGIFNSPGYPEDYHSNTECVWNIASSPGNHLQLSFLSFQ
                     LENSLNCNKDFVEIREGNATGHLMGRYCGNSLPGNYSSIEGHNLWVRFVSDGSGTGMG
                     FQARFKNIFGNDNIVGTHGKIATPFWPGNYPLNSNYRWTVNVDSSHIIHGRILEMDIE
                     LTTNCFYDSLKIYDGFDIHSRLIGTYCGTQRESFSSSRNSLTFQFSSDSSKSGRGFLL
                     EWFAVDVSNVTLPTIAPGACGGYMVTGDTPVFFFSPGWPGPYGNGADCIWIIYAPDST
                     VELNILSMDIEAQLSCSYDKLIIKDGDSRLSQQLAVLCGRSVPGPIRSTGEYMYIRFT
                     SDGSVTGAGFNASFQKSCGGYLHADRGIITSPKYPDNYLPNLNCSWHVLVQSGLTIAV
                     HFEQPFQIQNRDSSCSQGDYLVLRNGPDNHSPPLGPSGGNGRFCGIYTPSTLFTSDNE
                     MFIQFISDNSNGGQGFKIRYEAKSLACGGTIYIHDANSDGYVTSPNYPANYPQHAECI
                     WILEAPSGRSIQLQFEDQFNIEETPNCSASYLELRDGANSNAPVLSKLCGHTLPRNWV
                     SSRGLMYLKFHTEGGSGYMGFKAKYSIVSCGGTVSGDSGVIESVGYPTRLYANNVFCQ
                     WHIQGLPGHYLTIRFEDFNLQSSPGCAKDFVEIWENHTSGILLGRYCGNSIPSSVDTS
                     SNVASIRFVTDGSVTDSGFRLQFKSSREVCGGDLHGPTGTFTSPNYPNPNPHPRICEW
                     TINVHEGRQIILTFTNLRLSTQQSCNTEHLIVFNGIRNNSPRLQKLCSRVNVTNEFKS
                     SGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCGGTLPSVSGGNFSSPGYNGIRDYARN
                     LDCEWTLSNPNRENSSISIHFLGLSLESHQDCTFDVLEFRVGNADGPLIEKFCSLSAP
                     RVPLVIPYPQVWIHFVSNERVEYTGFYVEYSFTNCGGIQTGENGVISSPNYPNLYSRW
                     TQCSWLLEAPEGHTITLTFSDFSVENHPTCTSDSVTVRNGDSPGSPIIGRYCGQSVPG
                     PIQSGSNQLVVTFNTNNQGQSRGFYATWNTNTLGCGGTLHSDNGTIKSPHWPQTFPEN
                     SRCSWTAVTHESKHWEISFDSNFRIPSSDSQCRNSFVKVWEGMLETNDALLATSCGNV
                     APSPIVTLGNIFTAVFQSEEMPAQGFSASFISRCGRTFNSSTGDIVSPNFPKHYDNNM
                     NCNYYIDVAPQSLVILTFVSFHLEDRSAVSGTCDYDGLHIIKGHNLSSTPLVTICGSE
                     TLRPLTIDGPVMLNFYSDAYITDFGFKISYRVANCGGIYSGTYGVLNSPSFSYTNYPN
                     NVYCVYSLQVRNDRLILLRFNDFEIVPSNLCSHDYLEVFDGPSIGNRSIGKFCGSTLP
                     QVIKSTNNSLTLLFKTDSSQTARGWKVSFRETIGPQQGCGGYLTEDSKSFVSPDHDSD
                     GLYDKGLNCIWYIIAPENKLVKLTFNAFTLEEPSSPGKCTFDYVQIADGASINSYLGG
                     RFCGSSRPAPFISSGNFLTVQFVSDISIQMRGFNATYTFVDMPCGGTYNATSMPQNTS
                     SPQLSNIRRPFSTCTWVIEAPPHQQVQITVWKLQLPSQDCSRSSLELQDSEQTNGNQV
                     TQFCGANYTTLPVFYSSGSTAVVVFKSDFLNRNSRVHFTYEIADCNREYNQAFGNLKS
                     PGWPQGYANNLDCSIILRAPQNHRISLFFYWFQLEDSRQCMNDFLEVRNGSSSSSPLL
                     GKYCSNLLPNPIFSQSNELYLHFHSDDSDTHHGYEIIWASSPTGCGGTLLGNEGILAN
                     PGFPDSYPNNTHCEWTIVAPSGRPLSVGFPFLSIDSPGGCDQNYLILFNGPDANSPPF
                     GPFCGIDTVVAPFHASSNRVFIRFHAEYATVSSGFEIMWSS"
     exon            177..306
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            307..402
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            403..441
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            442..543
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            544..647
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            648..774
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            775..937
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1069
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1171
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1293
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1480
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1593
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1828
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2010
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2173
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2364
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2509
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2688
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2854
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3071
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3202
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3392
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3553
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3735
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..3892
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4080
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            4081..4231
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4413
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            4414..4588
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            4589..4758
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            4759..4918
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            4919..5032
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            5033..5143
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            5144..5272
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            5273..5405
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            5406..5611
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            5612..5796
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            5797..5989
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            5990..6187
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            6188..6334
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            6335..6525
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            6526..6709
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            6710..6884
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            6885..7063
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            7064..7273
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            7274..7414
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            7415..7596
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            7597..7768
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            7769..7975
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            7976..8125
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            8126..8247
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            8248..8473
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            8474..8661
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            8662..8818
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            8819..8968
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            8969..9169
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            9170..9299
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            9300..9517
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            9518..9726
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            9727..9889
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            9890..10095
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            10096..10243
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            10244..10425
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            10426..10591
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            10592..10827
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
     exon            10828..11325
                     /gene="Cubn"
                     /gene_synonym="D2Wsu88e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggactcagc tggccagagt ggtctccctc ttgccggcga ggtgagcggg ggagctgcgg
       61 agcatggcct cacattttct ctggggtttt gttactttat tgatggtacc cggattagac
      121 ggtgaaactg gaacaccaga gcagaagcta cagaaaagaa ttgctgatct ccaccagcct
      181 cggatgacta cggaggaggg aaacttagtg tttcttacaa gctctgccca aaacattgaa
      241 tttagaactg gttccctggg gaaaatcaaa ttaaatgatg atgaccttgg cgaatgttta
      301 caccagatcc agagaaacaa agatgatatt atagatttaa aaaggaatac aactggtctt
      361 cctcaaaata tacttagtca agtccaccaa cttaactcga agctcgtgga tcttgagaga
      421 gattttcaaa gcttacagca gaatgtggag agaaaagttt gcagtagcaa tccctgccac
      481 aatggtggca cctgtgtcaa cctgcacgac tcctttattt gtatctgccc ttcacagtgg
      541 aagggtctct tctgctcaga ggatgttaac gagtgtgtac tttatgctgg aacacccttt
      601 ggctgccaga gtggatccac ctgtgtgaac actatgggga gtttcagatg tgactgcacg
      661 cctgatacgt atggacctca gtgtgcatcc aaatataatg actgtgaaca gggctctcag
      721 cagctctgta agcatggcat ctgcgaggat ttacagcgag tttatcatgg acagctgaga
      781 tttaactgta tctgtgatgc tgggtggaca acactgccaa atggtatctc ctgcacagag
      841 gacaaagatg aatgcagcct ccagccttca ccttgttcag aacatgcaca gtgtttcaat
      901 acacaaggtt ccttctactg tggcgcctgc ccaaaaggtt ggcaaggaaa tggttaccaa
      961 tgccaggata tcaacgaatg tgagatcaac aatggtggct gttcccaggc tccactggtc
     1021 ccctgcctga acactccagg atcattcacc tgtgggaact gtccagcagg tttcagtggt
     1081 gatgggagag tgtgcacccc cttggacatc tgctcgatcc ataatggagg ctgccatcca
     1141 gatgcaacct gttcctcctc ttctgttcta gggtccttgt tgcctgtctg cacctgtcct
     1201 ccgggatata caggaaatgg ttacgggtct aatggatgtg tacgcctcag taatatgtgc
     1261 tcaagacacc cgtgtgtaaa tggacagtgc attgaaacag tatcaagtta cttctgtaag
     1321 tgtgactcag gctggtttgg acagaactgt acagaaaaca ttaatgagtg tgtgagcaac
     1381 ccctgtttga atggagggac ctgtattgat ggtgtcaacg gcttcacctg cgactgcacg
     1441 agctcctgga ctggttatta ctgtcagact ccccaggcag cttgtggagg gatcctctca
     1501 gggacacaag gaacctttgc ctaccagagc ccgaatgata cctatgtcca caatgtgaac
     1561 tgtttctggg ttgtcagaac cgatgaggaa aaggttctgc atattacctt cacgtttttt
     1621 gatttagaat cggccagcaa ttgtccccgg gagtaccttc agattcatga tggagactcc
     1681 tctgcagatt tcccacttgg tagatactgt ggctccacgc ccccccaggg ggtccacagc
     1741 agtgccaact ctctctattt ccatctctac tcagaataca taaaacgggg gagaggcttt
     1801 accgcacggt gggaagcgaa gctaccagag tgtggcggca tactgactgg taattatggt
     1861 tctattacat ctccggggta ccctggaaac taccccccag gaagagattg tgtctggaac
     1921 cttctagtca gtcctggctc cttgataaca tttacctttg gcaccttgag cctggagagc
     1981 cacaatgact gcagtaaaga ctatttggag attcgagatg gtcctttcca tcatgacccc
     2041 attcttggga aattctgtac ttctctgtct accccaccac tccagactac aggtcccgca
     2101 gcaagaattc atttccattc tgactccgag actagtgaca aaggcttcca catcacctat
     2161 ctaacgacac catctgatct gtactgtggt gggaattaca cagacacgga gggtgagctc
     2221 ctccttcctc ccttgactgg acctttcagt cacagcagac agtgtgtcta tctcatctca
     2281 caaccccaag gagagcaaat agttatcaac ttcacccacg tggagctgga gagccagagg
     2341 ggctgttctc acactttcat cgaggttgga gaccatgaga gcctgcttcg aaagatctgt
     2401 ggcaatgaaa ccttgttccc cattagatca atttctaata atgtctggat cagactgaga
     2461 atagacgctt tagtccagaa ggctagtttc agagctgact atcaagttgc ttgtgggggt
     2521 gaattaagag gagaaggagt cattcgttca cctttctatc ctaatgcata tgctggacga
     2581 agaacctgta ggtggaccat ctcccaaccc ccaagagaag ttgttcttct taacttcacc
     2641 gactttcaga ttggaagttc ttcttcctgt gatacagatt acattgagat tggtcccagc
     2701 tctgtcttgg gatctcctgg aaatgagaag ttttgtggca caaacatacc atcatttata
     2761 acatctgtat acaatgttct ttatgttaca tttgtgaaaa gttcttctat ggaaaatcgt
     2821 ggcttcatgg ctatgttcag cagtgagaag ttagaatgtg gaaaagttct cacagaatct
     2881 actggaatca ttgaaagtcc tggtcatcca aatgtctacc caagcggtgt aaattgtacc
     2941 tggcatatag tagtccaacg cggccaactg attcgtttgg tattcagctc cttttacctg
     3001 gagtttcatt acaactgcgc aaatgactac ctggaagttt atgacactat tgctcagacg
     3061 tctcttggga gatactgtgg aaaatccatc ccgccttctc ttaccagcag ctctcattca
     3121 ataaagctga tattcgtgtc tgactctgct cttgcccacg aaggcttttc cataaattat
     3181 gaagcaatta atgcatcatc agtgtgttta tatgactata cagataattt tgggaggctc
     3241 tcctccccga acttccccaa caattacccc cataactgga actgcgtcta caggatcact
     3301 gtgggactca accaacagat tgcattgcat ttcacggact ttgccttgga ggactatttt
     3361 gggccaaagt gtgtagattt tgtagaaatc agagatggag gcttcgaaac gtcaccactc
     3421 attgggattt actgcggctc agttttccct cccagaatca tctcccacag taacaagcta
     3481 tggctaaggt ttaagagtga cacggcactc acagcaaggg gtttttcagc ttactgggat
     3541 gcgtcatcaa caggctgtgg aggcaatctc accaccccca caggggtgct cacatcgccc
     3601 aactacccga tgccctacta ccacagctcc gaatgctact ggcggctgga agccagccgt
     3661 ggcagccctt tcctgcttga attccaagac ttccacctgg aacaccaccc caactgctct
     3721 ctggattact tggccgtgtt tgatggcccg agtaccaact cccgtctgat aaataaacta
     3781 tgtggggata caccacctgc tcccattcgt tccagtaaag acattgtatt gttgaagctg
     3841 aggactgatg caggtcaaca aggacgtggc tttgagatca actatcggca gacatgtgac
     3901 aatgtggtaa tagtgaataa aacctctggc atcttggaga gcataaatta cccaaatccc
     3961 tacgataaag accaacgttg taactggacc atccaagcaa caacaggcaa cacggtgaac
     4021 tacacatttc tggaatttga tgtggaaaat tacgtaaact gctccacaga ttacttagag
     4081 ctctatgatg gaccacaacg gataggacgc tactgtggag aaaatatccc cccaccagga
     4141 gctacaacag gttccaaact tattgtagtg ttccatacag atggggttga ctctggagag
     4201 aaaggattta agatgcactg gttcatccat ggctgtggtg gagagatgtc tggaaccatg
     4261 ggctccttta gcagccctgg gtaccctaac agctatcctc ataacaagga gtgtatctgg
     4321 aacattcgcg tggccccagg gaatagcatt cagctcacca tccatgactt tgatgtggaa
     4381 tatcatgcaa gctgcaagta tgacaccctg gagatctaca caggtcttga ttttcactct
     4441 ccaagaatag cccagttgtg ttctcgatca ccatcggcga atcccatgca gatttccagc
     4501 actgataatg aactagcaat ccgatttaag acagacagct ctttaaatgg aagaggtttc
     4561 aatgcctcat ggcgagcagt ccctggaggt tgcggtggga ttttccaggt ttccagagga
     4621 gaaattcatt ctccaaatta ccccaacaac tacagagcta acacggagtg ctcttggatc
     4681 attcaagttg agaaatatca ccgtgttctt ttgaacatta ctgactttga ccttgaagct
     4741 acagattctt gtcttatgac atatgatggc tcaagttctg caaacacccg tgtcgccact
     4801 gtgtgtggaa gacagcagcc acctaattcc atcacctctt caggaaacag cctctttgtg
     4861 agattccagt ctggatcttc cagccagagc aggggcttcc gagctcaatt caggcaagag
     4921 tgcggagccc acatcattac tgactcttca gatagcatct cctctccact gtacccagcc
     4981 aactatccaa acaaccagaa ctgtacctgg ataattgaag ctcaacctcc attcaatcat
     5041 attgctctct cctttactca ctttcatctg caaagcagca cagattgcac acgggacttt
     5101 gtagaaattt tggatggcag agactctgat gcacctgtcc aaggccgtta ctgtggtacc
     5161 tctctgcccc atcccatcat atcatttggc aatgccctga cagtgaggtt tgtctctgat
     5221 tctgtgtacg gttttgacgg tttccatgcc atctactctg catcaacatc agcttgtggt
     5281 ggaaccttct acacgggcga tggcatcttc aatagccctg gctacccaga agactaccat
     5341 tctaatacag aatgtgtctg gaacattgcc agctcccctg gaaatcacct gcagctgtct
     5401 tttctatcct tccagttgga gaactctcta aactgtaaca aggattttgt ggaaatccga
     5461 gaaggaaatg ccacgggcca cttgatggga cgatactgtg gaaactccct ccctggcaat
     5521 tattcatcaa tcgagggaca taatctgtgg gtcagatttg tctctgatgg ctcaggcact
     5581 ggaatgggct tccaggccag attcaaaaat atatttggca atgataatat tgtgggaact
     5641 catgggaaaa tcgcaactcc attctggcct ggaaattacc cacttaactc caactacaga
     5701 tggacagtaa atgtggattc ttctcatatt atccatggta gaatcttaga gatggacata
     5761 gaattgacaa caaactgctt ttatgacagt ttaaagattt atgatgggtt tgacattcat
     5821 tcccgtctga ttggcactta ctgtggtacc caaagagaat cctttagctc cagcagaaac
     5881 tctctgacat tccagttttc ttctgactct tccaagtcag gaaggggatt ccttctggag
     5941 tggtttgcag tagatgtttc taatgtaacc ctgcccacca ttgctccagg agcttgtgga
     6001 gggtatatgg tgacaggaga cacccctgtc ttttttttct ccccgggttg gcctggacca
     6061 tatggtaatg gtgctgactg tatatggata atttatgctc ctgattctac tgtggaactc
     6121 aacattctct ccatggacat tgaagctcag ctatcttgtt cctatgacaa gctgatcata
     6181 aaagatggag acagtagatt atcccagcag ctggctgttc tgtgtggcag aagtgttccc
     6241 ggacccatcc gctcaactgg agaatacatg tacatccgct tcacatcaga tggcagtgtc
     6301 accggagcag gcttcaacgc ctcctttcaa aagagctgtg gtggatattt gcatgcagac
     6361 cgagggatca ttacatcccc caagtaccca gacaactacc ttcccaatct caactgctcc
     6421 tggcacgttc tggtccagag tggtctgacc atcgccgtcc attttgagca gcctttccag
     6481 attcaaaaca gagactcttc ttgcagccag ggggactact tggtgctaag aaatggacca
     6541 gataaccact ctccaccatt gggaccctct ggaggaaatg gtcgtttctg tggaatttat
     6601 actccatcaa ctctcttcac ctcagacaat gaaatgttta ttcagttcat ctctgataat
     6661 agtaacggtg gacaaggatt taagatcaga tatgaggcaa agagtttagc ctgcgggggt
     6721 actatctaca tccatgatgc taactctgat ggatacgtga cctcccccaa ctaccctgcc
     6781 aattatcccc agcatgctga atgcatttgg atcttagagg caccttcagg gagaagcata
     6841 cagctccaat ttgaagatca attcaatatt gaagaaacac ccaactgttc tgcaagctat
     6901 cttgagttgc gtgatggagc caactcaaat gcacctgtgc tttccaaatt gtgtgggcac
     6961 actttgcctc gaaactgggt atcctcaaga ggactaatgt acttgaaatt tcatactgaa
     7021 ggtggttccg gctacatggg gttcaaggct aagtattcta tagtttcgtg cggaggaact
     7081 gtctcagggg acagtggggt catcgagagc gttggttacc caacccgtct atatgcaaac
     7141 aacgtgtttt gtcagtggca tatccaaggc ctcccaggac actatctcac tatccgtttt
     7201 gaagatttta accttcagag ctcccctggt tgtgcaaaag actttgtgga gatctgggag
     7261 aatcatacct ctggtatttt gctggggaga tactgtggaa actccattcc tagcagtgtt
     7321 gacacttcta gcaatgttgc ttcaatcagg tttgtcacag atggctctgt cactgactca
     7381 ggatttaggc tgcaatttaa gtccagcaga gaagtgtgtg gtggggattt acatggccct
     7441 actggcacat ttacttctcc caactaccca aacccaaatc ctcatcccag gatctgtgag
     7501 tggacgatca atgtacacga aggaaggcag attatcctca cttttaccaa tttgaggcta
     7561 agtacccagc aatcctgcaa cactgagcac ctcattgtat tcaatggcat tagaaacaac
     7621 tctccccgac tacagaaact gtgcagccgt gtgaatgtga ccaatgagtt caaatcttca
     7681 ggaaacacga tgaaagtgat atttttcact gatggctccc ggccatatgg aggcttcact
     7741 gcttcctaca cctccagtga agatgcagtg tgtggtggaa ctcttccaag tgtctctggt
     7801 ggaaactttt cttctcctgg ctataatgga atccgtgatt acgcgagaaa tctagactgt
     7861 gaatggactc tcagtaatcc aaatcgggaa aattcatcca taagtatcca ttttctagga
     7921 ctttccctcg aaagtcatca agactgtaca tttgatgtcc tcgagtttcg agtaggtaat
     7981 gctgatggac ccctaataga gaagttttgc agcctgtcag caccaagagt gcccttggtc
     8041 atcccctacc ctcaggtgtg gatacatttt gtcagcaatg aacgtgtaga atatactgga
     8101 ttctacgtag agtattcctt tacaaactgt ggtggaatac agacaggtga gaatggagtg
     8161 atctcaagtc ctaactatcc aaacttgtac agcagatgga cccaatgttc atggctacta
     8221 gaagccccag aaggacatac catcactctc acatttagtg actttagtgt ggagaaccat
     8281 ccaacttgca cgtcagactc ggtcactgtc aggaatggtg actcccctgg atcacccatc
     8341 ataggacgat actgtggaca gtcagtccct gggccaatac agtctggttc caaccagctt
     8401 gtagtaacct ttaacacaaa caatcaaggg caaagtcgtg gattttatgc aacatggaac
     8461 acaaacactt taggttgtgg tggaacactt cactcagata atggtacaat caaatctcct
     8521 cattggcctc agacattccc agaaaacagc agatgttcct ggacagctgt cactcatgaa
     8581 agtaaacact gggagattag ctttgacagc aatttccgaa tccccagcag tgacagccag
     8641 tgtcggaaca gctttgtgaa ggtctgggaa ggaatgttag agaccaacga tgccctgtta
     8701 gccacaagct gtgggaatgt ggctccaagt cccattgtca cattaggaaa cattttcact
     8761 gctgtcttcc aatctgagga gatgccagcc cagggcttct ctgcatcctt cattagccgt
     8821 tgtggacgta cattcaatag ctctacaggt gacatcgtct ctccaaactt cccaaagcac
     8881 tatgacaaca acatgaactg taactactac atagatgttg caccacagtc tctggtcatc
     8941 ctgacgtttg tgtcctttca tttggaagat cgctcagctg tctcgggaac ctgcgattac
     9001 gatggcttgc atatcatcaa aggtcacaac ctctcttcca ctcctctcgt gaccatatgt
     9061 ggttctgaaa ccttgcgtcc cctcaccata gatggcccag tgatgctcaa cttctattct
     9121 gacgcatata tcacagactt tgggttcaag atttcctaca gagtcgccaa ctgtggtgga
     9181 atctacagtg gaacctatgg agtccttaac agtccttcct tctcatacac caactacccc
     9241 aacaatgtct actgtgtcta cagtctgcaa gttagaaacg acagattgat actacttcgg
     9301 ttcaatgatt ttgagattgt tccctccaac ctttgctcac atgattacct ggaggttttc
     9361 gatggtccca gcattggaaa tcgatctatt ggaaagttct gtggttccac acttccacaa
     9421 gttattaaga gcaccaataa cagcctgacc ctgctattca agacagattc ttctcaaaca
     9481 gcaagaggtt ggaaagtatc tttccgggag acaataggac cacagcaagg gtgtggtggg
     9541 tacctgactg aggacagcaa gagctttgtg tctcctgatc atgactcaga tggactttat
     9601 gacaaaggtc taaactgcat atggtacata attgcccctg aaaacaaact tgttaagctc
     9661 accttcaatg catttactct ggaggaacca tcgtcgccag gaaaatgcac ctttgattac
     9721 gtgcagatag cagatggtgc aagcataaac tcatatttag gcggaagatt ttgtggttcc
     9781 agtaggcctg ccccttttat ttcttctggc aactttctta cagttcaatt tgtctctgac
     9841 ataagtattc aaatgagagg atttaatgca acatatacct ttgtggacat gccttgtggg
     9901 ggaacatata atgcaacttc gatgcctcaa aacacatcat cacctcagtt gtcaaacatc
     9961 agacggccat tttccacctg tacttgggtc attgaagctc ccccacacca gcaggtccag
    10021 ataactgtgt ggaaactgca gctgccctca caagactgct caaggagctc cttagaactt
    10081 caggattcag aacagactaa tggaaaccaa gtgactcagt tctgcggtgc aaactataca
    10141 accttgcccg tgttctattc ctcaggaagt accgcagttg ttgttttcaa atctgacttt
    10201 ttaaacagaa actctcgagt gcatttcacc tatgagattg cagactgcaa cagagaatac
    10261 aaccaagcat ttggcaatct aaagagtcct gggtggcctc agggctatgc caataacctg
    10321 gactgctcca tcattctcag agccccgcag aaccacagaa tttccctctt tttttactgg
    10381 tttcagctgg aagattcaag acaatgcatg aatgacttct tggaggtaag aaatggcagc
    10441 agcagcagtt caccactgct tggcaagtac tgcagcaacc tgctgcccaa ccccatcttc
    10501 tctcagagca atgaactgta tctgcacttc cacagcgatg actcagacac ccaccatgga
    10561 tatgaaatta tctgggcctc ctctcctact ggctgtggag ggactctttt gggcaacgaa
    10621 ggtatattag ccaaccctgg ctttcctgac agctacccaa acaacactca ttgtgaatgg
    10681 accatcgttg ctccttctgg aaggcctctc tctgttgggt ttccctttct cagtatcgac
    10741 tctccaggtg gctgtgacca gaactacctc atactcttca atggtccaga tgccaactca
    10801 ccaccctttg gaccgttctg tggcatcgac actgtggtag caccctttca tgcttcatca
    10861 aatcgggtct tcataagatt ccatgcggag tatgcaaccg tttcttcagg atttgaaata
    10921 atgtggagta gctgaatcgg gagagctgtg tgtaacccct ctggctctgc cccgcgccgt
    10981 cagacgcaac ccgcaaccct gcccagaact ctgtggttct catccccatc tctgcccacg
    11041 ccatcaaaca cggactgagc ttctatggcc tttacaagag aaagtgtatg accaattttt
    11101 ttacatttgg tgttctgaag gcagagcctg gtggtgttcc actcaggtgt acatgccatc
    11161 cttactggat gcaccattta gtggagacct tttaaaacgt tctttaaagg gtagaaatta
    11221 tcctggcaca ctgatgtaca tttctaaaag ttggtgatac aaatagctgt atggtttcca
    11281 ctatacaaaa gtcaaagtac gggtaataaa catttcttaa aaccaaaaaa aaaaaaaaa
//
