LOCUS       NM_001162934             970 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus cortexin 2 (Ctxn2), mRNA.
ACCESSION   NM_001162934
VERSION     NM_001162934.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 970)
  AUTHORS   Zambrowicz,B.P., Abuin,A., Ramirez-Solis,R., Richter,L.J.,
            Piggott,J., BeltrandelRio,H., Buxton,E.C., Edwards,J., Finch,R.A.,
            Friddle,C.J., Gupta,A., Hansen,G., Hu,Y., Huang,W., Jaing,C.,
            Key,B.W. Jr., Kipp,P., Kohlhauff,B., Ma,Z.Q., Markesich,D.,
            Payne,R., Potter,D.G., Qian,N., Shaw,J., Schrick,J., Shi,Z.Z.,
            Sparks,M.J., Van Sligtenhorst,I., Vogel,P., Walke,W., Xu,N.,
            Zhu,Q., Person,C. and Sands,A.T.
  TITLE     Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap
            screen to identify potential targets for therapeutic intervention
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 14109-14114 (2003)
   PUBMED   14610273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929451.8.
            
            On Apr 8, 2021 this sequence version replaced NM_001162934.1.
            
            CCDS Note: The coding region has been updated to start at a
            downstream in-frame start codon that is supported by conservation
            data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141570.1, BY729778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               AL929451.8         43398-43924
            528-970             AL929451.8         54045-54487
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.21 cM"
     gene            1..970
                     /gene="Ctxn2"
                     /gene_synonym="Gm1638"
                     /note="cortexin 2"
                     /db_xref="GeneID:381418"
                     /db_xref="MGI:MGI:2139444"
     exon            1..527
                     /gene="Ctxn2"
                     /gene_synonym="Gm1638"
                     /inference="alignment:Splign:2.1.0"
     exon            528..970
                     /gene="Ctxn2"
                     /gene_synonym="Gm1638"
                     /inference="alignment:Splign:2.1.0"
     CDS             585..830
                     /gene="Ctxn2"
                     /gene_synonym="Gm1638"
                     /codon_start=1
                     /product="cortexin-2"
                     /protein_id="NP_001156406.3"
                     /db_xref="CCDS:CCDS50692.1"
                     /db_xref="GeneID:381418"
                     /db_xref="MGI:MGI:2139444"
                     /translation="MSSTYCGNSSAKMSVHEVSESSLSLEQKTGFAFVGILCIFLGLL
                     IIRCFKILLDPYSSMPSSTWEDEVEEFDKGTFEYALA"
     regulatory      941..946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctxn2"
                     /gene_synonym="Gm1638"
                     /note="hexamer: AATAAA"
     polyA_site      970
                     /gene="Ctxn2"
                     /gene_synonym="Gm1638"
                     /note="major polyA site"
ORIGIN      
        1 agcattcacc aacagggttc cagcgccagt ccccaggaga aggtgtcctt tttctcttgg
       61 attttagaaa caggagagcc gagtgggggg cagggagagc ttgtaggttt ggtgagctca
      121 aattctaaaa agaaacgaat gcctctgcag ctgctgatgc tgtcaagaaa gaaaaaagaa
      181 agaaagaaaa cgtgttgtgt gtatacagat tgctgatgtt tctcccatag tgtcttgtag
      241 gaagtttcca tgcttcctgc agtttaatat gtagaaggca actggcgaca acgcaaggta
      301 gaacactagc aatggtctag gcttctttag tgagacatgt tgagaatttt cagatcgacc
      361 agtgctttgg aaggaatggg tgtctgagga gccagccagt tgttctctta aggaaaatct
      421 ctcaaggttg acgtctccag agctttgggg tagattcttg aagatccgag gttttggaac
      481 tctaggaaac caaaatgcat gcacttcagc atgatgaaga catctgggca gagaaccgat
      541 tccggcagga actctgaaga gccaccacga tgcagccgtg aatgatgagt agcacctact
      601 gtggcaattc ttcagcaaag atgagtgtcc acgaagtctc tgaatcctcc ctgtctctgg
      661 agcaaaagac cggctttgcc tttgtgggca tcttgtgcat tttcttggga cttctcatta
      721 tcagatgctt caagattctg ttagacccat atagtagcat gccctcttct acatgggaag
      781 atgaagttga agagtttgat aaggggacct ttgagtatgc acttgcctga tagtggctct
      841 gattcatggt attcccagtt ccattgagac atgtgataaa cacatctgta attagcttgc
      901 ctgtgctgtt ggagagaaaa tcattccatt catgacattc aataaacatc tatgattggt
      961 ttatccacca
//
