LOCUS       NM_007803               3032 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus cortactin (Cttn), transcript variant 1, mRNA.
ACCESSION   NM_007803
VERSION     NM_007803.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3032)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3032)
  AUTHORS   Kumar,R., Rottner,K. and Rao,G.N.
  TITLE     Requirement of Site-Specific Tyrosine Phosphorylation of Cortactin
            in Retinal Neovascularization and Vascular Leakage
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (2), 366-390 (2024)
   PUBMED   38126170
  REMARK    GeneRIF: Requirement of Site-Specific Tyrosine Phosphorylation of
            Cortactin in Retinal Neovascularization and Vascular Leakage.
REFERENCE   3  (bases 1 to 3032)
  AUTHORS   Wang,Y., Qiu,W., Chen,J., Meng,W., Zhao,R., Lin,W., Mei,P.,
            Diao,M., Xiao,H. and Liao,Y.
  TITLE     ERbeta promoted invadopodia formation-mediated non-small cell lung
            cancer metastasis via the ICAM1/p-Src/p-Cortactin signaling pathway
  JOURNAL   Int J Cancer 153 (6), 1287-1299 (2023)
   PUBMED   37212571
  REMARK    GeneRIF: ERbeta promoted invadopodia formation-mediated non-small
            cell lung cancer metastasis via the ICAM1/p-Src/p-Cortactin
            signaling pathway.
REFERENCE   4  (bases 1 to 3032)
  AUTHORS   Castellanos-Martinez,R., Leon-Vega,I.I., Guerrero-Fonseca,I.M.,
            Vargas-Robles,H., Jimenez-Camacho,K.E., Hernandez-Galicia,G.,
            Ortiz-Navarrete,V.F., Rottner,K., Medina-Contreras,O. and
            Schnoor,M.
  TITLE     T cell functions and organ infiltration by leukemic T cells require
            cortactin
  JOURNAL   J Leukoc Biol 113 (3), 315-325 (2023)
   PUBMED   36808495
  REMARK    Erratum:[J Leukoc Biol. 2023 Oct 26;114(5):513. doi:
            10.1093/jleuko/qiad105.. PMID: 37703329]
REFERENCE   5  (bases 1 to 3032)
  AUTHORS   Jones,N.M., Sysol,J.R., Singla,S., Smith,P., Sandusky,G.E.,
            Wang,H., Natarajan,V., Dudek,S.M. and Machado,R.F.
  TITLE     Cortactin loss protects against hemin-induced acute lung injury in
            sickle cell disease
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 322 (6), L890-L897 (2022)
   PUBMED   35503995
REFERENCE   6  (bases 1 to 3032)
  AUTHORS   Esterbauer,H., Oberkofler,H., Krempler,F. and Patsch,W.
  TITLE     Human peroxisome proliferator activated receptor gamma coactivator
            1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal
            localization, and tissue expression
  JOURNAL   Genomics 62 (1), 98-102 (1999)
   PUBMED   10585775
REFERENCE   7  (bases 1 to 3032)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
REFERENCE   8  (bases 1 to 3032)
  AUTHORS   Chan,D.C., Bedford,M.T. and Leder,P.
  TITLE     Formin binding proteins bear WWP/WW domains that bind proline-rich
            peptides and functionally resemble SH3 domains
  JOURNAL   EMBO J 15 (5), 1045-1054 (1996)
   PUBMED   8605874
REFERENCE   9  (bases 1 to 3032)
  AUTHORS   Miglarese,M.R., Mannion-Henderson,J., Wu,H., Parsons,J.T. and
            Bender,T.P.
  TITLE     The protein tyrosine kinase substrate cortactin is differentially
            expressed in murine B lymphoid tumors
  JOURNAL   Oncogene 9 (7), 1989-1997 (1994)
   PUBMED   7516062
REFERENCE   10 (bases 1 to 3032)
  AUTHORS   Zhan,X., Hu,X., Hampton,B., Burgess,W.H., Friesel,R. and Maciag,T.
  TITLE     Murine cortactin is phosphorylated in response to fibroblast growth
            factor-1 on tyrosine residues late in the G1 phase of the BALB/c
            3T3 cell cycle
  JOURNAL   J Biol Chem 268 (32), 24427-24431 (1993)
   PUBMED   7693700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140268.2.
            
            On Dec 21, 2021 this sequence version replaced NM_007803.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168699.1, AK146856.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC140268.2         76735-76797
            64-157              AC140268.2         81439-81532
            158-244             AC140268.2         83488-83574
            245-318             AC140268.2         84110-84183
            319-448             AC140268.2         86178-86307
            449-559             AC140268.2         89707-89817
            560-614             AC140268.2         90991-91045
            615-725             AC140268.2         92700-92810
            726-836             AC140268.2         94828-94938
            837-947             AC140268.2         95349-95459
            948-1058            AC140268.2         96398-96508
            1059-1114           AC140268.2         97871-97926
            1115-1184           AC140268.2         101614-101683
            1185-1333           AC140268.2         105639-105787
            1334-1423           AC140268.2         107388-107477
            1424-1589           AC140268.2         108555-108720
            1590-1661           AC140268.2         109466-109537
            1662-3032           AC140268.2         110385-111755
FEATURES             Location/Qualifiers
     source          1..3032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.84 cM"
     gene            1..3032
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /note="cortactin"
                     /db_xref="GeneID:13043"
                     /db_xref="MGI:MGI:99695"
     exon            1..63
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            64..157
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1798
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /note="isoform 1 is encoded by transcript variant 1; src
                     substrate cortactin; mammary tumor and squamous cell
                     carcinoma associated (p80/85 src substrate)"
                     /codon_start=1
                     /product="src substrate cortactin isoform 1"
                     /protein_id="NP_031829.2"
                     /db_xref="CCDS:CCDS22049.1"
                     /db_xref="GeneID:13043"
                     /db_xref="MGI:MGI:99695"
                     /translation="MWKASAGHAVSITQDDGGADDWETDPDFVNDVSEKEQRWGAKTV
                     QGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDRSAVGH
                     EYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGG
                     KYGVQADRVDKSAVGFDYQGKTEKHESQKDYSKGFGGKYGIDKDKVDKSAVGFEYQGK
                     TEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQ
                     SERQDSSAVGFDYKERLAKHESQQDYAKGFGGKYGVQKDRMDKNASTFEEVVQVPSAY
                     QKTVPIEAVTSKTSNIRANFENLAKEREQEDRRKAEAERAQRMAKERQEQEEARRKLE
                     EQARAKKQTPPASPSPQPIEDRPPSSPIYEDAAPFKAEPSYRGSEPEPEYSIEAAGIP
                     EAGSQQGLTYTSEPVYETTEAPGHYQAEDDTYDGYESDLGITAIALYDYQAAGDDEIS
                     FDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ"
     exon            158..244
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..318
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..448
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..559
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..614
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..725
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..836
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..947
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1058
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1114
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1184
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1333
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1423
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1589
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1661
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..3032
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3010..3015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /note="hexamer: AATAAA"
     polyA_site      3032
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgagc gggcacaggg agcggcgggg cgcggcggga gcctggtgga ccctgctggt
       61 gcggtaatca ttgatcatcg cagatgccct catattccac tttggattcc ttggattcgg
      121 acagactctg aactgctttt cccagcaaaa gagaaagatg tggaaagcct ctgcaggcca
      181 tgctgtgtcc atcacgcagg atgatggagg agctgatgac tgggagactg atcctgattt
      241 tgtgaatgat gtgagtgaaa aggagcagag atggggtgct aaaaccgtgc agggatcggg
      301 gcaccaggaa cacatcaaca ttcacaagct tcgagagaat gtcttccaag aacaccagac
      361 gctcaaggag aaggagctgg aaacgggacc caaggcttcc cacggctatg gcgggaagtt
      421 cggtgtggag caggatagga tggacagatc agccgtgggc catgagtacc agtcgaagct
      481 ttccaagcac tgctcacaag tggactcggt ccggggcttc ggaggcaagt tcggtgtcca
      541 gatggacagg gtggatcagt ctgctgtagg ctttgaatac caggggaaga ctgagaagca
      601 tgcctcccag aaagactact ctagtggctt cggtggcaaa tacggtgtgc aagctgaccg
      661 tgtagacaag agtgccgtgg gctttgacta ccagggcaag acggagaagc atgagtctca
      721 gaaagattac tccaaaggtt ttggtggcaa atatgggatt gacaaggaca aggtggataa
      781 aagtgctgtg ggctttgagt atcaaggcaa gacagagaag cacgaatccc agaaagacta
      841 tgtaaaaggc tttggaggaa agtttggtgt gcagacagac agacaggaca agtgtgccct
      901 tggctgggac catcaggaga agctgcagct gcatgaatcc caaaaagact ataagactgg
      961 tttcggaggc aaatttggtg ttcagtccga gaggcaggac tcctccgctg tggggtttga
     1021 ttacaaggag agattggcca agcacgagtc ccagcaagac tatgccaaag gattcggcgg
     1081 gaagtatggg gtgcagaagg atcggatgga caagaatgca tccacctttg aagaagtggt
     1141 ccaggtgcca tctgcctatc agaagactgt ccccattgag gccgtaacca gcaaaaccag
     1201 taatatccgt gctaactttg aaaacctggc aaaggagaga gagcaggagg acaggcggaa
     1261 ggcagaagcc gagagagctc agcggatggc caaagaaaga caggagcagg aggaggcgcg
     1321 caggaagctg gaagagcaag ccagagccaa gaagcagacg ccccctgcat cccctagtcc
     1381 tcaaccaatt gaagacagac caccctccag ccccatctat gaggatgcag ctccgttcaa
     1441 ggccgagccg agctaccgag gtagcgaacc tgagcctgag tacagcatcg aggccgcagg
     1501 cattcctgag gctggcagcc agcaaggcct gacctataca tcagagcccg tgtacgagac
     1561 tacagaggct cctggccact atcaagcaga ggatgacacc tacgatgggt atgagagtga
     1621 cctgggcatc acagccatcg ccctgtatga ctaccaggct gctggcgatg atgagatctc
     1681 ctttgaccct gatgacatca tcaccaacat agaaatgatt gacgatggct ggtggcgtgg
     1741 ggtgtgcaag ggcagatacg ggctcttccc agccaactat gtggagctgc ggcagtaggg
     1801 ctgccaccca gagcctaccg gcaccagcac agggttcaca ctacagagca tctgcgtgtg
     1861 tttgagttgg tttctgcttc cgtttctgtt tttgttcttt ttctgaaggt ggggagggga
     1921 atattcatat tgactttata tttaatacat ctgctgatgc ttcggggcat gtcctgccac
     1981 aggatttgct aatgtctgat gatcatgttc acagagaaca tgggtgatta cttgcagcca
     2041 tcccaggtgt tttagttttg ccaagctgac tgtggtatgt agccacttca ggggttgcgc
     2101 ttctcactag gttggcggta catgtggcct tgtgcccacc cccatcccca ttgtagtcag
     2161 gttcccagga tggagacagt gctcctgggg tggccactca gtgaggaggc tctctggggt
     2221 ccagtgtttg gaagaggagg aaaggggacc aaagggaagt gaggtcctag agcgttgaca
     2281 ctgagggaag tcctatctgt cagtcctgac cacttaagcc aggaccccat gcttccttta
     2341 ctctgtctcc tcatctctgt acctcccctg acaccccagt cctggttggc cctttctcct
     2401 gccttgccct gaagtcttac cttctcccat tgcattcaag gcctatagca caaagtgcat
     2461 ctcagagatg tgctagtggc ttatcctggg cttggcctgc aacatgggag gcttgggacg
     2521 ggggtcttgg acctgctcat gacccctgag cagcctgcaa tgaggtgtgt gtgcccagcc
     2581 acttggctgg gcagggagat agatagcttc ttcctgcaag cttccagaag cacgctgtgt
     2641 tctttttgcc aaatatgttc agttatagtc agctgataga ttgatgtggc tgaaaacagg
     2701 accgagtgaa ctgatgctcc cacctgggtg cctccatggc ttccttgagc aactgtccct
     2761 aagatgcttt caagtgtatg agacatgagg aggctgggcc actctggtta tgcacagtca
     2821 ggcaaactgt ccttgtagac gagtccccga ctctgggata catgaggatc aatgcccgtt
     2881 ttctccccgt gtgctttcct gcagaatcct tgcctttccg ttgttaggtt gggttttcta
     2941 tatgaattat catctggaat tctgtagcac acctcatagg tatggaattt ttttaaatta
     3001 aatattcaga ataaactttt ttgatccatt ta
//
