LOCUS       NM_001252572            2921 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus cortactin (Cttn), transcript variant 2, mRNA.
ACCESSION   NM_001252572
VERSION     NM_001252572.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2921)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2921)
  AUTHORS   Kumar,R., Rottner,K. and Rao,G.N.
  TITLE     Requirement of Site-Specific Tyrosine Phosphorylation of Cortactin
            in Retinal Neovascularization and Vascular Leakage
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (2), 366-390 (2024)
   PUBMED   38126170
  REMARK    GeneRIF: Requirement of Site-Specific Tyrosine Phosphorylation of
            Cortactin in Retinal Neovascularization and Vascular Leakage.
REFERENCE   3  (bases 1 to 2921)
  AUTHORS   Wang,Y., Qiu,W., Chen,J., Meng,W., Zhao,R., Lin,W., Mei,P.,
            Diao,M., Xiao,H. and Liao,Y.
  TITLE     ERbeta promoted invadopodia formation-mediated non-small cell lung
            cancer metastasis via the ICAM1/p-Src/p-Cortactin signaling pathway
  JOURNAL   Int J Cancer 153 (6), 1287-1299 (2023)
   PUBMED   37212571
  REMARK    GeneRIF: ERbeta promoted invadopodia formation-mediated non-small
            cell lung cancer metastasis via the ICAM1/p-Src/p-Cortactin
            signaling pathway.
REFERENCE   4  (bases 1 to 2921)
  AUTHORS   Castellanos-Martinez,R., Leon-Vega,I.I., Guerrero-Fonseca,I.M.,
            Vargas-Robles,H., Jimenez-Camacho,K.E., Hernandez-Galicia,G.,
            Ortiz-Navarrete,V.F., Rottner,K., Medina-Contreras,O. and
            Schnoor,M.
  TITLE     T cell functions and organ infiltration by leukemic T cells require
            cortactin
  JOURNAL   J Leukoc Biol 113 (3), 315-325 (2023)
   PUBMED   36808495
  REMARK    Erratum:[J Leukoc Biol. 2023 Oct 26;114(5):513. doi:
            10.1093/jleuko/qiad105.. PMID: 37703329]
REFERENCE   5  (bases 1 to 2921)
  AUTHORS   Jones,N.M., Sysol,J.R., Singla,S., Smith,P., Sandusky,G.E.,
            Wang,H., Natarajan,V., Dudek,S.M. and Machado,R.F.
  TITLE     Cortactin loss protects against hemin-induced acute lung injury in
            sickle cell disease
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 322 (6), L890-L897 (2022)
   PUBMED   35503995
REFERENCE   6  (bases 1 to 2921)
  AUTHORS   Esterbauer,H., Oberkofler,H., Krempler,F. and Patsch,W.
  TITLE     Human peroxisome proliferator activated receptor gamma coactivator
            1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal
            localization, and tissue expression
  JOURNAL   Genomics 62 (1), 98-102 (1999)
   PUBMED   10585775
REFERENCE   7  (bases 1 to 2921)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
REFERENCE   8  (bases 1 to 2921)
  AUTHORS   Chan,D.C., Bedford,M.T. and Leder,P.
  TITLE     Formin binding proteins bear WWP/WW domains that bind proline-rich
            peptides and functionally resemble SH3 domains
  JOURNAL   EMBO J 15 (5), 1045-1054 (1996)
   PUBMED   8605874
REFERENCE   9  (bases 1 to 2921)
  AUTHORS   Miglarese,M.R., Mannion-Henderson,J., Wu,H., Parsons,J.T. and
            Bender,T.P.
  TITLE     The protein tyrosine kinase substrate cortactin is differentially
            expressed in murine B lymphoid tumors
  JOURNAL   Oncogene 9 (7), 1989-1997 (1994)
   PUBMED   7516062
REFERENCE   10 (bases 1 to 2921)
  AUTHORS   Zhan,X., Hu,X., Hampton,B., Burgess,W.H., Friesel,R. and Maciag,T.
  TITLE     Murine cortactin is phosphorylated in response to fibroblast growth
            factor-1 on tyrosine residues late in the G1 phase of the BALB/c
            3T3 cell cycle
  JOURNAL   J Biol Chem 268 (32), 24427-24431 (1993)
   PUBMED   7693700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140268.2.
            
            On Dec 21, 2021 this sequence version replaced NM_001252572.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            coding region, compared to variant 1. The resulting protein
            (isoform 2) is shorter when it is compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011434.1, AK168945.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC140268.2         76735-76797
            64-157              AC140268.2         81439-81532
            158-244             AC140268.2         83488-83574
            245-318             AC140268.2         84110-84183
            319-448             AC140268.2         86178-86307
            449-559             AC140268.2         89707-89817
            560-614             AC140268.2         90991-91045
            615-725             AC140268.2         92700-92810
            726-836             AC140268.2         94828-94938
            837-947             AC140268.2         95349-95459
            948-1003            AC140268.2         97871-97926
            1004-1073           AC140268.2         101614-101683
            1074-1222           AC140268.2         105639-105787
            1223-1312           AC140268.2         107388-107477
            1313-1478           AC140268.2         108555-108720
            1479-1550           AC140268.2         109466-109537
            1551-2921           AC140268.2         110385-111755
FEATURES             Location/Qualifiers
     source          1..2921
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.84 cM"
     gene            1..2921
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /note="cortactin"
                     /db_xref="GeneID:13043"
                     /db_xref="MGI:MGI:99695"
     exon            1..63
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            64..157
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1687
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /note="isoform 2 is encoded by transcript variant 2; src
                     substrate cortactin; mammary tumor and squamous cell
                     carcinoma associated (p80/85 src substrate)"
                     /codon_start=1
                     /product="src substrate cortactin isoform 2"
                     /protein_id="NP_001239501.1"
                     /db_xref="CCDS:CCDS57599.1"
                     /db_xref="GeneID:13043"
                     /db_xref="MGI:MGI:99695"
                     /translation="MWKASAGHAVSITQDDGGADDWETDPDFVNDVSEKEQRWGAKTV
                     QGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDRSAVGH
                     EYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGG
                     KYGVQADRVDKSAVGFDYQGKTEKHESQKDYSKGFGGKYGIDKDKVDKSAVGFEYQGK
                     TEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYAKGFGGKYGVQ
                     KDRMDKNASTFEEVVQVPSAYQKTVPIEAVTSKTSNIRANFENLAKEREQEDRRKAEA
                     ERAQRMAKERQEQEEARRKLEEQARAKKQTPPASPSPQPIEDRPPSSPIYEDAAPFKA
                     EPSYRGSEPEPEYSIEAAGIPEAGSQQGLTYTSEPVYETTEAPGHYQAEDDTYDGYES
                     DLGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELR
                     Q"
     exon            158..244
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..318
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..448
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..559
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..614
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..725
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..836
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..947
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1003
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1073
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1222
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1312
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1478
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1550
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..2921
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2899..2904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /note="hexamer: AATAAA"
     polyA_site      2921
                     /gene="Cttn"
                     /gene_synonym="1110020L01Rik; Ems1"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgagc gggcacaggg agcggcgggg cgcggcggga gcctggtgga ccctgctggt
       61 gcggtaatca ttgatcatcg cagatgccct catattccac tttggattcc ttggattcgg
      121 acagactctg aactgctttt cccagcaaaa gagaaagatg tggaaagcct ctgcaggcca
      181 tgctgtgtcc atcacgcagg atgatggagg agctgatgac tgggagactg atcctgattt
      241 tgtgaatgat gtgagtgaaa aggagcagag atggggtgct aaaaccgtgc agggatcggg
      301 gcaccaggaa cacatcaaca ttcacaagct tcgagagaat gtcttccaag aacaccagac
      361 gctcaaggag aaggagctgg aaacgggacc caaggcttcc cacggctatg gcgggaagtt
      421 cggtgtggag caggatagga tggacagatc agccgtgggc catgagtacc agtcgaagct
      481 ttccaagcac tgctcacaag tggactcggt ccggggcttc ggaggcaagt tcggtgtcca
      541 gatggacagg gtggatcagt ctgctgtagg ctttgaatac caggggaaga ctgagaagca
      601 tgcctcccag aaagactact ctagtggctt cggtggcaaa tacggtgtgc aagctgaccg
      661 tgtagacaag agtgccgtgg gctttgacta ccagggcaag acggagaagc atgagtctca
      721 gaaagattac tccaaaggtt ttggtggcaa atatgggatt gacaaggaca aggtggataa
      781 aagtgctgtg ggctttgagt atcaaggcaa gacagagaag cacgaatccc agaaagacta
      841 tgtaaaaggc tttggaggaa agtttggtgt gcagacagac agacaggaca agtgtgccct
      901 tggctgggac catcaggaga agctgcagct gcatgaatcc caaaaagact atgccaaagg
      961 attcggcggg aagtatgggg tgcagaagga tcggatggac aagaatgcat ccacctttga
     1021 agaagtggtc caggtgccat ctgcctatca gaagactgtc cccattgagg ccgtaaccag
     1081 caaaaccagt aatatccgtg ctaactttga aaacctggca aaggagagag agcaggagga
     1141 caggcggaag gcagaagccg agagagctca gcggatggcc aaagaaagac aggagcagga
     1201 ggaggcgcgc aggaagctgg aagagcaagc cagagccaag aagcagacgc cccctgcatc
     1261 ccctagtcct caaccaattg aagacagacc accctccagc cccatctatg aggatgcagc
     1321 tccgttcaag gccgagccga gctaccgagg tagcgaacct gagcctgagt acagcatcga
     1381 ggccgcaggc attcctgagg ctggcagcca gcaaggcctg acctatacat cagagcccgt
     1441 gtacgagact acagaggctc ctggccacta tcaagcagag gatgacacct acgatgggta
     1501 tgagagtgac ctgggcatca cagccatcgc cctgtatgac taccaggctg ctggcgatga
     1561 tgagatctcc tttgaccctg atgacatcat caccaacata gaaatgattg acgatggctg
     1621 gtggcgtggg gtgtgcaagg gcagatacgg gctcttccca gccaactatg tggagctgcg
     1681 gcagtagggc tgccacccag agcctaccgg caccagcaca gggttcacac tacagagcat
     1741 ctgcgtgtgt ttgagttggt ttctgcttcc gtttctgttt ttgttctttt tctgaaggtg
     1801 gggaggggaa tattcatatt gactttatat ttaatacatc tgctgatgct tcggggcatg
     1861 tcctgccaca ggatttgcta atgtctgatg atcatgttca cagagaacat gggtgattac
     1921 ttgcagccat cccaggtgtt ttagttttgc caagctgact gtggtatgta gccacttcag
     1981 gggttgcgct tctcactagg ttggcggtac atgtggcctt gtgcccaccc ccatccccat
     2041 tgtagtcagg ttcccaggat ggagacagtg ctcctggggt ggccactcag tgaggaggct
     2101 ctctggggtc cagtgtttgg aagaggagga aaggggacca aagggaagtg aggtcctaga
     2161 gcgttgacac tgagggaagt cctatctgtc agtcctgacc acttaagcca ggaccccatg
     2221 cttcctttac tctgtctcct catctctgta cctcccctga caccccagtc ctggttggcc
     2281 ctttctcctg ccttgccctg aagtcttacc ttctcccatt gcattcaagg cctatagcac
     2341 aaagtgcatc tcagagatgt gctagtggct tatcctgggc ttggcctgca acatgggagg
     2401 cttgggacgg gggtcttgga cctgctcatg acccctgagc agcctgcaat gaggtgtgtg
     2461 tgcccagcca cttggctggg cagggagata gatagcttct tcctgcaagc ttccagaagc
     2521 acgctgtgtt ctttttgcca aatatgttca gttatagtca gctgatagat tgatgtggct
     2581 gaaaacagga ccgagtgaac tgatgctccc acctgggtgc ctccatggct tccttgagca
     2641 actgtcccta agatgctttc aagtgtatga gacatgagga ggctgggcca ctctggttat
     2701 gcacagtcag gcaaactgtc cttgtagacg agtccccgac tctgggatac atgaggatca
     2761 atgcccgttt tctccccgtg tgctttcctg cagaatcctt gcctttccgt tgttaggttg
     2821 ggttttctat atgaattatc atctggaatt ctgtagcaca cctcataggt atggaatttt
     2881 tttaaattaa atattcagaa taaacttttt tgatccattt a
//
