LOCUS       NM_022325               1454 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cathepsin Z (Ctsz), mRNA.
ACCESSION   NM_022325
VERSION     NM_022325.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1454)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1454)
  AUTHORS   Mitrovic,A., Zavrsnik,J., Mikhaylov,G., Knez,D., Pecar Fonovic,U.,
            Matjan Stefin,P., Butinar,M., Gobec,S., Turk,B. and Kos,J.
  TITLE     Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and
            their ability to improve cathepsin-B-directed antitumor therapy
  JOURNAL   Cell Mol Life Sci 79 (1), 34 (2022)
   PUBMED   34989869
  REMARK    GeneRIF: Evaluation of novel cathepsin-X inhibitors in vitro and in
            vivo and their ability to improve cathepsin-B-directed antitumor
            therapy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1454)
  AUTHORS   Campden,R.I., Warren,A.L., Greene,C.J., Chiriboga,J.A.,
            Arnold,C.R., Aggarwal,D., McKenna,N., Sandall,C.F., MacDonald,J.A.
            and Yates,R.M.
  TITLE     Extracellular cathepsin Z signals through the alpha5 integrin and
            augments NLRP3 inflammasome activation
  JOURNAL   J Biol Chem 298 (1), 101459 (2022)
   PUBMED   34864055
  REMARK    GeneRIF: Extracellular cathepsin Z signals through the alpha5
            integrin and augments NLRP3 inflammasome activation.
REFERENCE   4  (bases 1 to 1454)
  AUTHORS   Schwenck,J., Maurer,A., Fehrenbacher,B., Mehling,R., Knopf,P.,
            Mucha,N., Haupt,D., Fuchs,K., Griessinger,C.M., Bukala,D.,
            Holstein,J., Schaller,M., Menendez,I.G., Ghoreschi,K.,
            Quintanilla-Martinez,L., Gutschow,M., Laufer,S., Reinheckel,T.,
            Rocken,M., Kalbacher,H., Pichler,B.J. and Kneilling,M.
  TITLE     Cysteine-type cathepsins promote the effector phase of acute
            cutaneous delayed-type hypersensitivity reactions
  JOURNAL   Theranostics 9 (13), 3903-3917 (2019)
   PUBMED   31281521
  REMARK    GeneRIF: Cysteine-type cathepsins promote the effector phase of
            acute cutaneous delayed-type hypersensitivity reactions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1454)
  AUTHORS   Zhou,X., Paushter,D.H., Feng,T., Sun,L., Reinheckel,T. and Hu,F.
  TITLE     Lysosomal processing of progranulin
  JOURNAL   Mol Neurodegener 12 (1), 62 (2017)
   PUBMED   28835281
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1454)
  AUTHORS   Mandel,S., Rechavi,G. and Gozes,I.
  TITLE     Activity-dependent neuroprotective protein (ADNP) differentially
            interacts with chromatin to regulate genes essential for
            embryogenesis
  JOURNAL   Dev Biol 303 (2), 814-824 (2007)
   PUBMED   17222401
REFERENCE   7  (bases 1 to 1454)
  AUTHORS   Frankenberg,S., Smith,L., Greenfield,A. and Zernicka-Goetz,M.
  TITLE     Novel gene expression patterns along the proximo-distal axis of the
            mouse embryo before gastrulation
  JOURNAL   BMC Dev Biol 7, 8 (2007)
   PUBMED   17302988
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1454)
  AUTHORS   Lennon-Dumenil,A.M., Bakker,A.H., Maehr,R., Fiebiger,E.,
            Overkleeft,H.S., Rosemblatt,M., Ploegh,H.L. and
            Lagaudriere-Gesbert,C.
  TITLE     Analysis of protease activity in live antigen-presenting cells
            shows regulation of the phagosomal proteolytic contents during
            dendritic cell activation
  JOURNAL   J Exp Med 196 (4), 529-540 (2002)
   PUBMED   12186844
  REMARK    GeneRIF: regulation of the phagosomal CatZ, CatB, CatL and CatS
            contents during dendritic cell activation
REFERENCE   9  (bases 1 to 1454)
  AUTHORS   Deussing,J., von Olshausen,I. and Peters,C.
  TITLE     Murine and human cathepsin Z: cDNA-cloning, characterization of the
            genes and chromosomal localization
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 93-106 (2000)
   PUBMED   10760573
REFERENCE   10 (bases 1 to 1454)
  AUTHORS   Santamaria,I., Velasco,G., Pendas,A.M., Fueyo,A. and Lopez-Otin,C.
  TITLE     Cathepsin Z, a novel human cysteine proteinase with a short
            propeptide domain and a unique chromosomal location
  JOURNAL   J Biol Chem 273 (27), 16816-16823 (1998)
   PUBMED   9642240
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL844534.4, BY319344.1,
            AK159618.1 and AI834947.1.
            
            On Aug 14, 2015 this sequence version replaced NM_022325.4.
            
            Summary: This gene encodes a member of the peptidase C1 (papain)
            family of cysteine proteases. The encoded preproprotein is
            proteolytically processed to generate a mature enzyme with
            carboxypeptidase activity. An enzymatically inactive form of the
            protein, that is associated with the propeptide, may be involved in
            cancer cell invasion and proliferation. Homozygous knockout mice
            for this gene exhibit impaired cancer cell invasion in a breast
            cancer model. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008619.1, AF136277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL844534.4         82862-82876         c
            16-35               BY319344.1         2-21
            36-1439             AK159618.1         2-1405
            1440-1454           AI834947.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..1454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 97.94 cM"
     gene            1..1454
                     /gene="Ctsz"
                     /gene_synonym="CTSX; D2Wsu143e"
                     /note="cathepsin Z"
                     /db_xref="GeneID:64138"
                     /db_xref="MGI:MGI:1891190"
     exon            1..290
                     /gene="Ctsz"
                     /gene_synonym="CTSX; D2Wsu143e"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1062
                     /gene="Ctsz"
                     /gene_synonym="CTSX; D2Wsu143e"
                     /EC_number="3.4.18.1"
                     /note="cathepsin X"
                     /codon_start=1
                     /product="cathepsin Z preproprotein"
                     /protein_id="NP_071720.1"
                     /db_xref="CCDS:CCDS17152.1"
                     /db_xref="GeneID:64138"
                     /db_xref="MGI:MGI:1891190"
                     /translation="MASSGSVQQLPLVLLMLLLASAARARLYFRSGQTCYHPIRGDQL
                     ALLGRRTYPRPHEYLSPADLPKNWDWRNVNGVNYASVTRNQHIPQYCGSCWAHGSTSA
                     MADRINIKRKGAWPSILLSVQNVIDCGNAGSCEGGNDLPVWEYAHKHGIPDETCNNYQ
                     AKDQDCDKFNQCGTCTEFKECHTIQNYTLWRVGDYGSLSGREKMMAEIYANGPISCGI
                     MATEMMSNYTGGIYAEHQDQAVINHIISVAGWGVSNDGIEYWIVRNSWGEPWGEKGWM
                     RIVTSTYKGGTGDSYNLAIESACTFGDPIV"
     exon            291..454
                     /gene="Ctsz"
                     /gene_synonym="CTSX; D2Wsu143e"
                     /inference="alignment:Splign:2.1.0"
     exon            455..634
                     /gene="Ctsz"
                     /gene_synonym="CTSX; D2Wsu143e"
                     /inference="alignment:Splign:2.1.0"
     exon            635..785
                     /gene="Ctsz"
                     /gene_synonym="CTSX; D2Wsu143e"
                     /inference="alignment:Splign:2.1.0"
     exon            786..951
                     /gene="Ctsz"
                     /gene_synonym="CTSX; D2Wsu143e"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1440
                     /gene="Ctsz"
                     /gene_synonym="CTSX; D2Wsu143e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1420..1425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctsz"
                     /gene_synonym="CTSX; D2Wsu143e"
                     /note="hexamer: AGTAAA"
     polyA_site      1440
                     /gene="Ctsz"
                     /gene_synonym="CTSX; D2Wsu143e"
                     /note="major polyA site"
ORIGIN      
        1 ccccgccctc ggggtgtgtc caacttgggc gcctcctaaa ggaccgggcg gggcgtcccg
       61 agcgcgtggg cctgcgggtc gggtcaagag gtcgaaggtg ctgcgcgtga tccaggatcc
      121 gaattggccc ggagcaggag catggcgtcg tcggggtcgg tgcagcagct gcccctggtg
      181 ctgctgatgt tgctgttggc gagtgcggca cgggccagac tctacttccg ctcgggccag
      241 acttgctacc atcccattcg cggggaccag ctggctctgc tggggcgcag gacttatcct
      301 cggccgcatg agtacctgtc cccagcggat ctccccaaga attgggactg gagaaatgtg
      361 aacggtgtca actatgccag cgtcaccagg aaccagcaca tcccacagta ctgtggttcc
      421 tgctgggccc acggcagcac cagtgccatg gcagaccgaa tcaacatcaa gaggaaaggt
      481 gcatggccct ccatcctgct gtccgtacag aatgtcattg actgtggcaa tgctggctct
      541 tgtgaagggg gcaatgacct tccggtgtgg gagtatgccc acaagcatgg catccccgat
      601 gagacctgca acaactacca ggccaaggac caagactgtg acaagtttaa ccagtgtggg
      661 acctgcactg aattcaaaga gtgtcacacc atccagaatt acaccctctg gagagtgggt
      721 gattacggct ccctgtccgg gagggagaag atgatggccg agatctatgc caatggtccc
      781 atcagctgcg ggataatggc aacagagatg atgtctaact acactggggg catctatgct
      841 gagcaccagg accaggccgt tatcaaccac atcatctctg tagctggctg gggtgtcagc
      901 aacgatggca tcgagtactg gattgtccga aattcatggg gcgaaccctg gggtgagaaa
      961 ggctggatga ggatcgtgac cagcacctac aagggaggca caggtgacag ctacaacctt
     1021 gccatcgaga gtgcctgcac atttggggac cccattgttt aggtagatgt ctctggaagc
     1081 agcgctgtga accatgacag ggaggggtga ttaattactg acactggaca tgtccagaca
     1141 gctataaaca gtgcttgtgg acatgaggac cagagtgtgg actgcatccc gagaggagac
     1201 ggtaaaggat gaaacacaac tgcactggga ccctccgccg taccctccag gcctgcctcc
     1261 tccaccactg agccctccag gcctgcctcc tcttctacag tgcttgcctt cagccacccg
     1321 gagaagagag ctatggttta ggacagctca acttatcacc agatctggag ccctggaatc
     1381 catgggaggg gggaacaagt ccagactgct taagaaatga gtaaaatatc tggcttccca
     1441 aaaaaaaaaa aaaa
//
