LOCUS       NM_009985               1438 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus cathepsin W (Ctsw), mRNA.
ACCESSION   NM_009985
VERSION     NM_009985.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1438)
  AUTHORS   Gunther,S.C., Martinez-Romero,C., Sempere Borau,M., Pham,C.T.N.,
            Garcia-Sastre,A. and Stertz,S.
  TITLE     Proteomic Identification of Potential Target Proteins of Cathepsin
            W for Its Development as a Drug Target for Influenza
  JOURNAL   Microbiol Spectr 10 (4), e0092122 (2022)
   PUBMED   35867415
  REMARK    GeneRIF: Proteomic Identification of Potential Target Proteins of
            Cathepsin W for Its Development as a Drug Target for Influenza.
REFERENCE   2  (bases 1 to 1438)
  AUTHORS   Oghumu,S., Terrazas,C.A., Varikuti,S., Kimble,J., Vadia,S., Yu,L.,
            Seveau,S. and Satoskar,A.R.
  TITLE     CXCR3 expression defines a novel subset of innate CD8+ T cells that
            enhance immunity against bacterial infection and cancer upon
            stimulation with IL-15
  JOURNAL   FASEB J 29 (3), 1019-1028 (2015)
   PUBMED   25466888
REFERENCE   3  (bases 1 to 1438)
  AUTHORS   Korpos,E., Kadri,N., Kappelhoff,R., Wegner,J., Overall,C.M.,
            Weber,E., Holmberg,D., Cardell,S. and Sorokin,L.
  TITLE     The peri-islet basement membrane, a barrier to infiltrating
            leukocytes in type 1 diabetes in mouse and human
  JOURNAL   Diabetes 62 (2), 531-542 (2013)
   PUBMED   23139348
REFERENCE   4  (bases 1 to 1438)
  AUTHORS   Ondr,J.K. and Pham,C.T.
  TITLE     Characterization of murine cathepsin W and its role in
            cell-mediated cytotoxicity
  JOURNAL   J Biol Chem 279 (26), 27525-27533 (2004)
   PUBMED   15087452
  REMARK    GeneRIF: mCtsW does not have a unique role in target cell apoptosis
            or cytotoxic cell survival in vitro.
REFERENCE   5  (bases 1 to 1438)
  AUTHORS   Brown,J., Matutes,E., Singleton,A., Price,C., Molgaard,H.,
            Buttle,D. and Enver,T.
  TITLE     Lymphopain, a cytotoxic T and natural killer cell-associated
            cysteine proteinase
  JOURNAL   Leukemia 12 (11), 1771-1781 (1998)
   PUBMED   9823953
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122861.4, BB850740.1 and
            BE447240.1.
            
            On Aug 14, 2015 this sequence version replaced NM_009985.4.
            
            Summary: This gene encodes a member of the peptidase C1 (papain)
            family of cysteine proteases. The encoded preproprotein is
            proteolytically processed to generate a mature protein product.
            Expression of the encoded protein is upregulated following
            lymphocyte activation. Data from a human cell line suggests that
            the encoded enzyme may be important for viral entry into host
            cells. [provided by RefSeq, Aug 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088375.1, AF014941.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC122861.4         203004-203012       c
            10-408              BB850740.1         2-400
            409-459             AC122861.4         201086-201136       c
            460-556             AC122861.4         200894-200990       c
            557-637             AC122861.4         200736-200816       c
            638-661             AC122861.4         200627-200650       c
            662-1233            BE447240.1         1-572               c
            1234-1438           AC122861.4         199548-199752       c
FEATURES             Location/Qualifiers
     source          1..1438
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.33 cM"
     gene            1..1438
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /note="cathepsin W"
                     /db_xref="GeneID:13041"
                     /db_xref="MGI:MGI:1338045"
     exon            1..105
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1140
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /codon_start=1
                     /product="cathepsin W preproprotein"
                     /protein_id="NP_034115.2"
                     /db_xref="CCDS:CCDS29465.1"
                     /db_xref="GeneID:13041"
                     /db_xref="MGI:MGI:1338045"
                     /translation="MTLTAHLSYFLVLLLAGQGLSDSLLTKDAGPRPLELKEVFKLFQ
                     IRFNRSYWNPAEYTRRLSIFAHNLAQAQRLQQEDLGTAEFGETPFSDLTEEEFGQLYG
                     QERSPERTPNMTKKVESNTWGESVPRTCDWRKAKNIISSVKNQGSCKCCWAMAAADNI
                     QALWRIKHQQFVDVSVQELLDCERCGNGCNGGFVWDAYLTVLNNSGLASEKDYPFQGD
                     RKPHRCLAKKYKKVAWIQDFTMLSNNEQAIAHYLAVHGPITVTINMKLLQHYQKGVIK
                     ATPSSCDPRQVDHSVLLVGFGKEKEGMQTGTVLSHSRKRRHSSPYWILKNSWGAHWGE
                     KGYFRLYRGNNTCGVTKYPFTAQVDSPVKKARTSCPP"
     exon            106..190
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /inference="alignment:Splign:2.1.0"
     exon            191..304
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /inference="alignment:Splign:2.1.0"
     exon            305..459
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /inference="alignment:Splign:2.1.0"
     exon            460..556
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /inference="alignment:Splign:2.1.0"
     exon            557..637
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /inference="alignment:Splign:2.1.0"
     exon            638..763
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /inference="alignment:Splign:2.1.0"
     exon            764..828
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1029
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1438
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1220..1225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /note="hexamer: CATAAA"
     polyA_site      1241
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /note="major polyA site"
     regulatory      1415..1420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
                     /note="hexamer: AACAAG"
     polyA_site      1434
                     /gene="Ctsw"
                     /gene_synonym="lymphopain"
ORIGIN      
        1 tagcttagca cttgtggctg caccatgaca ctgactgccc acctctccta ctttctggtc
       61 ctgttgttag cgggccaagg cctcagtgac tccctcctca ccaaggatgc aggtccccgg
      121 ccactggagc tgaaggaagt cttcaagctg ttccagatcc ggttcaaccg gagttactgg
      181 aacccagcag agtacactcg ccgtctgagc atctttgccc acaatctggc tcaggctcaa
      241 aggctacagc aagaagactt gggtacagct gagtttggag agactccatt cagtgacctc
      301 acagaggagg agtttggcca gttatacggg caggagaggt caccagaaag gacccccaac
      361 atgaccaaaa aggtagagtc taacacgtgg ggggaatctg tgccccgcac ctgtgactgg
      421 cgtaaagcaa agaacatcat ctcgtcggtc aagaaccagg gaagctgcaa atgctgctgg
      481 gccatggcag ctgccgacaa catccaggct ctgtggcgca tcaaacacca gcagtttgtg
      541 gacgtctctg tgcaggagct gctggactgc gaacgctgtg gaaatggttg caatggtggc
      601 ttcgtgtggg acgcatatct aactgtcctc aacaacagtg gcctggccag tgaaaaggat
      661 tatccattcc agggggacag aaagcctcac agatgcctag ccaagaagta caagaaggtg
      721 gcctggatcc aggatttcac catgttgtcc aataatgagc aggcaattgc ccactacctg
      781 gccgtgcatg gacctatcac cgtgaccatc aacatgaaac tactccagca ttaccagaag
      841 ggtgtcatca aggctacacc cagctcctgt gaccctcggc aagtggacca ctctgtcttg
      901 ctggtgggct ttggcaagga gaaagagggc atgcagacag ggacagtctt gtcccattct
      961 cgaaaacgtc gccactcctc cccatactgg atcctgaaga actcctgggg agctcactgg
     1021 ggcgagaagg gttacttcag gctgtatcgg ggaaacaaca cctgtggagt caccaagtat
     1081 cccttcacag ctcaagtgga ctcaccagta aagaaggcac ggacctcttg tcctccctga
     1141 aggcagcagc cactcttctg cttctcccac atggccactg ccccttgtca gccctgccca
     1201 catcctctct gtatggcttc ataaaccaag actgctccgt ggctcctgtg tggattcagc
     1261 tggggtgtgg agaggcgagg tggggctggg aagaccccga atgtgtcatg gtccggtccc
     1321 tgaggtgcta gtgcacacat ccttacgcgt gatggcacag cacttgagca cacatgtgtg
     1381 cactgtggga atccccatga gcccttcaac ctggaacaag gaccagtctc caaactta
//
