LOCUS       NM_001267695            1360 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus cathepsin S (Ctss), transcript variant 1, mRNA.
ACCESSION   NM_001267695
VERSION     NM_001267695.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1360)
  AUTHORS   Scholand,K.K., Galletti,J., Haap,W., Santos-Ferreira,T., Ullmer,C.
            and de Paiva,C.S.
  TITLE     Inhibition of Cathepsin S in Autoimmune CD25KO Mouse Improves
            Sjogren Disease-Like Lacrimal Gland Pathology
  JOURNAL   Invest Ophthalmol Vis Sci 65 (8), 26 (2024)
   PUBMED   39017634
  REMARK    GeneRIF: Inhibition of Cathepsin S in Autoimmune CD25KO Mouse
            Improves Sjogren Disease-Like Lacrimal Gland Pathology.
REFERENCE   2  (bases 1 to 1360)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1360)
  AUTHORS   Zhou,Z., Jiang,W.J., Li,L. and Si,J.Q.
  TITLE     Noise exposure increase apoptosis in the hippocampus of AD mice
            through the upregulation of CTSS
  JOURNAL   Biochem Biophys Res Commun 681, 283-290 (2023)
   PUBMED   37801777
  REMARK    GeneRIF: Noise exposure increase apoptosis in the hippocampus of AD
            mice through the upregulation of CTSS.
REFERENCE   4  (bases 1 to 1360)
  AUTHORS   Wan,Y., Piao,L., Xu,S., Meng,X., Huang,Z., Inoue,A., Wang,H.,
            Yue,X., Jin,X., Nan,Y., Shi,G.P., Murohara,T., Umegaki,H.,
            Kuzuya,M. and Cheng,X.W.
  TITLE     Cathepsin S activity controls chronic stress-induced muscle atrophy
            and dysfunction in mice
  JOURNAL   Cell Mol Life Sci 80 (9), 254 (2023)
   PUBMED   37589754
  REMARK    GeneRIF: Cathepsin S activity controls chronic stress-induced
            muscle atrophy and dysfunction in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1360)
  AUTHORS   Galletti,J.G., Scholand,K.K., Trujillo-Vargas,C.M., Haap,W.,
            Santos-Ferreira,T., Ullmer,C., Yu,Z. and de Paiva,C.S.
  TITLE     Effects of Cathepsin S Inhibition in the Age-Related Dry Eye
            Phenotype
  JOURNAL   Invest Ophthalmol Vis Sci 64 (11), 7 (2023)
   PUBMED   37540176
  REMARK    GeneRIF: Effects of Cathepsin S Inhibition in the Age-Related Dry
            Eye Phenotype.
            Erratum:[Invest Ophthalmol Vis Sci. 2023 Aug 1;64(11):32. doi:
            10.1167/iovs.64.11.32.. PMID: 37639250]
REFERENCE   6  (bases 1 to 1360)
  AUTHORS   Shi,G.P., Villadangos,J.A., Dranoff,G., Small,C., Gu,L.,
            Haley,K.J., Riese,R., Ploegh,H.L. and Chapman,H.A.
  TITLE     Cathepsin S required for normal MHC class II peptide loading and
            germinal center development
  JOURNAL   Immunity 10 (2), 197-206 (1999)
   PUBMED   10072072
REFERENCE   7  (bases 1 to 1360)
  AUTHORS   Saftig,P., Hunziker,E., Wehmeyer,O., Jones,S., Boyde,A.,
            Rommerskirch,W., Moritz,J.D., Schu,P. and von Figura,K.
  TITLE     Impaired osteoclastic bone resorption leads to osteopetrosis in
            cathepsin-K-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 95 (23), 13453-13458 (1998)
   PUBMED   9811821
REFERENCE   8  (bases 1 to 1360)
  AUTHORS   Dandoy-Dron,F., Guillo,F., Benboudjema,L., Deslys,J.P.,
            Lasmezas,C., Dormont,D., Tovey,M.G. and Dron,M.
  TITLE     Gene expression in scrapie. Cloning of a new scrapie-responsive
            gene and the identification of increased levels of seven other mRNA
            transcripts
  JOURNAL   J Biol Chem 273 (13), 7691-7697 (1998)
   PUBMED   9516475
REFERENCE   9  (bases 1 to 1360)
  AUTHORS   Deussing,J., Roth,W., Rommerskirch,W., Wiederanders,B., von
            Figura,K. and Peters,C.
  TITLE     The genes of the lysosomal cysteine proteinases cathepsin B, H, L,
            and S map to different mouse chromosomes
  JOURNAL   Mamm Genome 8 (4), 241-245 (1997)
   PUBMED   9096102
REFERENCE   10 (bases 1 to 1360)
  AUTHORS   Shi,G.P., Webb,A.C., Foster,K.E., Knoll,J.H., Lemere,C.A.,
            Munger,J.S. and Chapman,H.A.
  TITLE     Human cathepsin S: chromosomal localization, gene structure, and
            tissue distribution
  JOURNAL   J Biol Chem 269 (15), 11530-11536 (1994)
   PUBMED   8157683
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK028366.1, AK150274.1,
            AC092203.16 and BB072817.1.
            
            On Jun 5, 2013 this sequence version replaced NM_001267695.1.
            
            Summary: This gene encodes a member of the peptidase C1 (papain)
            family of cysteine proteases. Alternative splicing results in
            multiple transcript variants, which encode preproproteins that are
            proteolytically processed to generate mature protein products. This
            enzyme is secreted by antigen-presenting cells during inflammation
            and may induce pain and itch via activation of G-protein coupled
            receptors. Homozygous knockout mice for this gene exhibit impaired
            wound healing, reduced tumorigenesis in a pancreatic cancer model,
            and reduced pathogenesis in a myasthenia gravis model. [provided by
            RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150274.1, SRR7652917.900530.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AK028366.1         3-72
            71-452              AK150274.1         2-383
            453-453             AC092203.16        72707-72707         c
            454-1356            AK150274.1         385-1287
            1357-1360           BB072817.1         239-242
FEATURES             Location/Qualifiers
     source          1..1360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..1360
                     /gene="Ctss"
                     /gene_synonym="Cats"
                     /note="cathepsin S"
                     /db_xref="GeneID:13040"
                     /db_xref="MGI:MGI:107341"
     exon            1..140
                     /gene="Ctss"
                     /gene_synonym="Cats"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1140
                     /gene="Ctss"
                     /gene_synonym="Cats"
                     /EC_number="3.4.22.27"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; Cat S"
                     /codon_start=1
                     /product="cathepsin S isoform 1 preproprotein"
                     /protein_id="NP_001254624.2"
                     /db_xref="CCDS:CCDS71291.1"
                     /db_xref="GeneID:13040"
                     /db_xref="MGI:MGI:107341"
                     /translation="MRAPGHAAIRRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTH
                     EKEYKDKNEEEVRRLIWEKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMG
                     ALRIPRQSPKTVTFRSYSNRTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQ
                     LKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKA
                     TDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGV
                     YDDPSCTGNVNHGVLVVGYGTLDGKDYWLVKNSWGLNFGDQGYIRMARNNKNHCGIAS
                     YCSYPEI"
     exon            141..267
                     /gene="Ctss"
                     /gene_synonym="Cats"
                     /inference="alignment:Splign:2.1.0"
     exon            268..390
                     /gene="Ctss"
                     /gene_synonym="Cats"
                     /inference="alignment:Splign:2.1.0"
     exon            391..540
                     /gene="Ctss"
                     /gene_synonym="Cats"
                     /inference="alignment:Splign:2.1.0"
     exon            541..771
                     /gene="Ctss"
                     /gene_synonym="Cats"
                     /inference="alignment:Splign:2.1.0"
     exon            772..937
                     /gene="Ctss"
                     /gene_synonym="Cats"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1040
                     /gene="Ctss"
                     /gene_synonym="Cats"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1360
                     /gene="Ctss"
                     /gene_synonym="Cats"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1334..1339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctss"
                     /gene_synonym="Cats"
                     /note="hexamer: AATAAA"
     polyA_site      1358
                     /gene="Ctss"
                     /gene_synonym="Cats"
                     /note="major polyA site"
ORIGIN      
        1 ttcctcattg tggatgcttc atgtgacaag ctccgatttc tttttagagt catttcaagc
       61 agcctcctgc tgccagggac atctttggag tgagcaccac acttcaggat gaccatgagg
      121 gctcctggcc acgctgccat cagaagatgg ctgttttgga tgcccctggt gtgctctgtg
      181 gcaatggagc aactgcagag agaccctacc ctggactacc attgggatct ctggaagaaa
      241 acccatgaga aagaatacaa ggataagaat gaagaagaag tacggcgtct catctgggaa
      301 aagaatctga agtttataat gattcacaat ctcgaatatt ctatgggaat gcatacctac
      361 caagtgggca tgaacgatat gggagacatg accaatgaag aaatcttgtg tcggatgggt
      421 gctctgagaa ttccccgaca gtctccgaag actgtcactt tcaggtcata ctctaatcgg
      481 acattgcctg acactgtgga ctggagagag aagggctgcg tcactgaggt gaaataccag
      541 ggttcttgtg gtgcctgctg ggctttcagt gctgtggggg cccttgaagg gcagctgaag
      601 ctgaaaacgg ggaagctgat atccctcagt gctcagaacc tggtggactg ctcaaatgaa
      661 gaaaagtatg ggaataaagg ctgtggaggc ggctacatga ccgaagcttt ccagtacatc
      721 attgataatg ggggcataga ggcagacgct tcctatccct acaaagccac ggatgaaaag
      781 tgtcactata actcaaaaaa tcgagctgcc acgtgttcaa ggtacattca gctcccgttt
      841 ggtgacgagg atgccctgaa agaagcagtg gccactaaag ggcctgtctc tgtgggcatc
      901 gacgccagcc attcctcctt cttcttctac aaaagcggtg tctatgacga cccctcctgt
      961 acgggcaatg tgaatcatgg tgttcttgtg gttggctatg ggactcttga tggcaaagat
     1021 tactggcttg tgaaaaacag ttggggcctt aactttggtg atcaaggata cattcggatg
     1081 gcaagaaata ataaaaatca ctgcggaatt gctagttatt gctcttaccc agaaatctaa
     1141 accatttctt ctttttctaa caagtcacaa agatggaata tactctaact taatttgcct
     1201 gcaatatcca gaggaaccaa gtgtgtcgtg atcaatgtgt agttactgta ctaactaggt
     1261 tatagctatt tttacaccct gttgtctagt gttttctaat aaccatttgt aacatgatag
     1321 ccccaaagtg cttaataaaa tctgtcattt caaatatcta
//
