LOCUS       NM_020284               1335 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus cathepsin R (Ctsr), mRNA.
ACCESSION   NM_020284
VERSION     NM_020284.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1335)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   2  (bases 1 to 1335)
  AUTHORS   Kim,J., Frey,W.D., He,H., Kim,H., Ekram,M.B., Bakshi,A., Faisal,M.,
            Perera,B.P., Ye,A. and Teruyama,R.
  TITLE     Peg3 mutational effects on reproduction and placenta-specific gene
            families
  JOURNAL   PLoS One 8 (12), e83359 (2013)
   PUBMED   24391757
  REMARK    Erratum:[PLoS One. 2014;9(1).
            doi:10.1371/annotation/8de03ec5-e62c-4135-87ee-4928475090a8]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1335)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   4  (bases 1 to 1335)
  AUTHORS   Liu,P., Wang,Y., Vikis,H., Maciag,A., Wang,D., Lu,Y., Liu,Y. and
            You,M.
  TITLE     Candidate lung tumor susceptibility genes identified through
            whole-genome association analyses in inbred mice
  JOURNAL   Nat Genet 38 (8), 888-895 (2006)
   PUBMED   16862160
REFERENCE   5  (bases 1 to 1335)
  AUTHORS   Zimonjic,D.B., Liu,J., Xu,W.H., Zhou,X., Popescu,N.C. and Shi,G.P.
  TITLE     Assignment of murine placental cathepsin R to mouse chromosome
            bands 13B2-B3 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Genome Res 111 (1), 96 (2005)
   PUBMED   16097084
  REMARK    GeneRIF: chromosome mapping of this enzyme in mouse placenta.
REFERENCE   6  (bases 1 to 1335)
  AUTHORS   Ishida,M., Ono,K., Taguchi,S., Ohashi,S., Naito,J., Horiguchi,K.
            and Harigaya,T.
  TITLE     Cathepsin gene expression in mouse placenta during the latter half
            of pregnancy
  JOURNAL   J Reprod Dev 50 (5), 515-523 (2004)
   PUBMED   15514457
  REMARK    GeneRIF: Possible association of cathepsins with placental
            lactogen-II may play important roles in placental functions during
            the latter half of pregnancy in mice.
REFERENCE   7  (bases 1 to 1335)
  AUTHORS   Deussing,J., Kouadio,M., Rehman,S., Werber,I., Schwinde,A. and
            Peters,C.
  TITLE     Identification and characterization of a dense cluster of
            placenta-specific cysteine peptidase genes and related genes on
            mouse chromosome 13
  JOURNAL   Genomics 79 (2), 225-240 (2002)
   PUBMED   11829493
REFERENCE   8  (bases 1 to 1335)
  AUTHORS   Sol-Church,K., Frenck,J., Bertenshaw,G. and Mason,R.W.
  TITLE     Characterization of mouse cathepsin R, a new member of a family of
            placentally expressed cysteine proteases
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 488-492 (2000)
   PUBMED   11004518
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF245399.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF245399.1, AK014432.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.67 cM"
     gene            1..1335
                     /gene="Ctsr"
                     /note="cathepsin R"
                     /db_xref="GeneID:56835"
                     /db_xref="MGI:MGI:1861723"
     exon            1..58
                     /gene="Ctsr"
                     /inference="alignment:Splign:2.1.0"
     exon            59..195
                     /gene="Ctsr"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1074
                     /gene="Ctsr"
                     /note="lysosomal cysteine protease"
                     /codon_start=1
                     /product="cathepsin R precursor"
                     /protein_id="NP_064680.1"
                     /db_xref="CCDS:CCDS26585.1"
                     /db_xref="GeneID:56835"
                     /db_xref="MGI:MGI:1861723"
                     /translation="MAAVVFIAFLYLGVASGVPVLDSSLDAEWQDWKIKYNKSYSLKE
                     EKLKRVVWEEKLKMIKLHNRENSLGKNGFTMKMNEFGDQTDEEFRKMMIEISVWTHRE
                     GKSIMKREAGSILPKFVDWRKKGYVTPVRRQGDCDACWAFAVTGAIEAQAIWQTGKLT
                     PLSVQNLVDCSKPQGNNGCLGGDTYNAFQYVLHNGGLESEATYPYEGKDGPCRYNPKN
                     SKAEITGFVSLPQSEDILMAAVATIGPITAGIDASHESFKNYKGGIYHEPNCSSDTVT
                     HGVLVVGYGFKGIETDGNHYWLIKNSWGKRWGIRGYMKLAKDKNNHCGIASYAHYPTI
                     "
     exon            196..318
                     /gene="Ctsr"
                     /inference="alignment:Splign:2.1.0"
     exon            319..468
                     /gene="Ctsr"
                     /inference="alignment:Splign:2.1.0"
     exon            469..693
                     /gene="Ctsr"
                     /inference="alignment:Splign:2.1.0"
     exon            694..856
                     /gene="Ctsr"
                     /inference="alignment:Splign:2.1.0"
     exon            857..974
                     /gene="Ctsr"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1335
                     /gene="Ctsr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaactttt gaagagttga gtctgtggag tggattgagg cagaggcagt cacctcaggt
       61 acttgagaca tggctgctgt tgtcttcata gccttcctgt atttgggagt ggcctcaggt
      121 gttccagtac ttgattcaag tttggatgct gaatggcaag actggaagat aaagtataac
      181 aaatcatata gcctgaagga agaaaaactg aagagagtgg tttgggaaga aaaattgaaa
      241 atgatcaaac tacacaacag ggagaacagc ctgggtaaga atggcttcac catgaaaatg
      301 aatgaatttg gtgaccagac tgatgaagaa ttcaggaaaa tgatgattga aatttcagtt
      361 tggactcaca gagaggggaa aagtatcatg aaacgggaag ctggcagtat tctccccaaa
      421 tttgtcgatt ggcgaaagaa aggatatgtg actcctgtac ggagacaggg agattgtgat
      481 gcttgttggg catttgctgt gactggtgcc atagaagcac aggcaatctg gcaaacgggc
      541 aaactcaccc ctctgagtgt gcagaacctg gtggactgtt ctaaacctca aggcaacaat
      601 ggttgtcttg gtggtgatac atacaatgcc ttccagtatg ttttgcacaa tggtggtctg
      661 gagtctgagg caacatatcc atatgaaggg aaagatggac catgcaggta taatccaaag
      721 aattctaagg ctgaaatcac aggatttgtg tccctccccc aaagtgagga tatcctaatg
      781 gctgctgtag caactattgg gcccatcact gctggaattg atgcttcaca tgagtctttc
      841 aagaactata agggaggtat ttaccatgag ccaaattgta gcagtgatac tgtgactcat
      901 ggagtcctcg tggttggtta cggatttaag ggaattgaga ccgatggtaa tcactactgg
      961 ctgatcaaga atagctgggg taaacgatgg ggcattagag gctacatgaa gctcgccaaa
     1021 gacaagaaca accactgtgg aattgcttca tatgctcact accctactat ttgagcaacc
     1081 tggtggccac aaggaaggtt ttggcacaag acagcatttc taggggaggg ctatctgcta
     1141 gtcagcgacc agcctttgct tggtatattc aagacttgtg tccctgaaga gcaaccttgt
     1201 aatgtgattc tgggaccctt caactatttt gacatcatga acactattgc tctaactaac
     1261 gtatgtttat tattccttca aaaaaatcag ctttaccgat tgtgcaaata aaatccttta
     1321 aaaaataaaa tgcaa
//
