LOCUS       NM_177662               3468 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus cathepsin O (Ctso), mRNA.
ACCESSION   NM_177662
VERSION     NM_177662.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3468)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3468)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   3  (bases 1 to 3468)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 3468)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3468)
  AUTHORS   Fenske,T.S., McMahon,C., Edwin,D., Jarvis,J.C., Cheverud,J.M.,
            Minn,M., Mathews,V., Bogue,M.A., Province,M.A., McLeod,H.L. and
            Graubert,T.A.
  TITLE     Identification of candidate alkylator-induced cancer susceptibility
            genes by whole genome scanning in mice
  JOURNAL   Cancer Res 66 (10), 5029-5038 (2006)
   PUBMED   16707424
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK143683.1, AC159260.3,
            BC098219.1 and AK034490.1.
            
            On Jan 27, 2016 this sequence version replaced NM_177662.2.
            
            Summary: This gene encodes a member of the cathepsin family of
            cysteine proteases that are involved in the degradation of cellular
            proteins. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, functional enzyme. [provided by
            RefSeq, Jan 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034490.1, AK143683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-738               AK143683.1         2-739
            739-739             AC159260.3         33900-33900         c
            740-974             AK143683.1         741-975
            975-2320            BC098219.1         934-2279
            2321-2828           AC159260.3         29215-29722         c
            2829-3468           AK034490.1         2814-3453
FEATURES             Location/Qualifiers
     source          1..3468
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 35.97 cM"
     gene            1..3468
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /note="cathepsin O"
                     /db_xref="GeneID:229445"
                     /db_xref="MGI:MGI:2139628"
     exon            1..175
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            176..281
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            282..421
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            422..589
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            590..711
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            712..875
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            876..968
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            969..3468
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2298..2303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2320
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /note="major polyA site"
     regulatory      2723..2728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2744
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
     regulatory      2878..2883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
                     /note="hexamer: ATTATA"
     polyA_site      2900
                     /gene="Ctso"
                     /gene_synonym="A330105D01Rik"
ORIGIN      
        1 agtgggcgga gccaagaaac cgaaagagaa agcgggccgg gcacagtgga cctcgggcac
       61 cgggatgaag ccgcagttgg tgaacctctt gctactgtgt tgctgctgtc tcggccgcca
      121 cggggtcgcc gggacctggt cttggagcca ccagcgggag gccgccgcct tgcgggaaag
      181 ccttcataga caccgatact tgaactcttt tcctcatgaa aactccactg ccttctatgg
      241 agtaaatcag ttttcttatt tgtttcctga agagtttaaa gctttgtatt taggcagcaa
      301 atatgcctgg gctcccagat acccagcaga aggacagaga cctatcccca atgtgtcttt
      361 gccattgaga tttgactgga gggacaagca tgttgtgaat cctgtaagga accaggagat
      421 gtgtggagga tgctgggcct tcagcgtggt gagtgccata gagtcagctc gtgcaatcca
      481 agggaaatct ctggattacc tgagcgtgca gcaggtcatc gactgctcct ttaataattc
      541 tggctgcctc ggtggctctc ctctctgtgc cttgcgctgg ctaaatgaga cacagttgaa
      601 gttggtggca gattcacagt acccattcaa ggcagtaaat ggccagtgtc gccactttcc
      661 tcaatcacaa gctggagttt cagtcaagga tttttctgca tataacttca ggggccaaga
      721 ggatgaaatg gccagagcac ttctgtcctt cggccctttg gttgtgatag ttgatgcgat
      781 gagctggcag gattatctgg ggggcataat ccaacatcac tgctccagtg gggaggccaa
      841 ccatgccgtt ctcatcacag gctttgatag gacaggaaat acaccatatt ggatggtgcg
      901 aaactcctgg ggatcctcct ggggagtaga aggctatgcc cacgtgaaaa tgggaggtaa
      961 tgtttgtggc attgcagact ctgtagctgc tgtctttgtg tgatcatgaa ttgttttgga
     1021 ttcaccatga gacaactacg aaaatgatgc acttcatagt gtgatccaac atcatactca
     1081 actctaagca ttatgcacct tcaagttcca acaatttgtc tacagagagg ttctaagagc
     1141 aaactggcat tttgtaaagc aacctaggac attctatttt ttgcaaagac atggacagcc
     1201 aaacttcata ggaaatcccc aggacgttga ctgatcaacg gactctgtgg gatagtgtgc
     1261 acctctgaga gtttggtggg atcagaagtc acatagtatt ctcctcctgg aagcagttgg
     1321 gacttttgct tgcttgttgt ctttctggct gtctacatta aggaagtatt ttggtcaggg
     1381 tgaattgaag atatgatgag cctttgtttt tcccttgtga cttataatca ccagtcttag
     1441 attacctcat ctacaagaac tctcaacctg atgcaatgtg tgcctcataa ttagaatggc
     1501 cttctgttcc atgtgaacag atttggaata tcagttgttt tatttcagca aatggaactt
     1561 actctagaca gtagaacaaa tgtgcaccaa gatgaaacaa cgatgcacaa agagaatccc
     1621 atcttcagag agacaatcca actggagtta aataaacacg tgacaacagt gtgataagga
     1681 gtacactatg ccacttccag ggagtcatga tgtctataaa gcttcacttt taaacaccca
     1741 aaatgtttag cttcttgcct tcttccctct gaggtagaga atgaagtatt gtccacattt
     1801 attccctctc ttgtccttta tggtacaagt cctatggttt cctggtggtt taccttccag
     1861 tccaaagtaa ctcagtaccg ttggttgtat tccatttctg ttacccaatc tcttacttaa
     1921 aaacaaaatc tctgacacag gctcacattg ctccttgttt atgtccttca ttagaatacc
     1981 agcatcaata acaaagctcc ttactctttt gtctgtacca gtgagaagca atcttgaatg
     2041 tgcagatcat ggagggtaaa gaaacggcag aagacatttc ttaaggtttt gaataaagta
     2101 gcctaattat cgaaggaatc caggaaggaa tgtagttcag ctatagtgtt tcttaatgac
     2161 tttcattatg ttatcagcaa tgtttctaat acccagtttc aaatgcagat aaacttgaaa
     2221 ttttcaaaat cactgttact ctttaagtat tctggattga taacatttat aataatacaa
     2281 cctacatttg actttgaatt aaaagtaact tattcttaaa tatgtagtct atgatttatt
     2341 attatttatg agcactaata gatatttatt agtatcgata agctttatat ttacattttc
     2401 ttggatttga acccttatat ccaatgtgct tttctccata gatgatttta attccaccat
     2461 gtccaagatt cctctcatca tcttcccata tctgttgtca atgctcagtg gtcctcttct
     2521 ccttaccttt tctttctgtc agcagcattg ctattgtata agcaggccat agagtcaaaa
     2581 ggaattctag acaatcaagt tgtctcctcc ttagaaccca ttcctacatc tgtctccatc
     2641 ctctctttca cgcatccttt ctgggaggta cactttttat tatctcctat ctacactctt
     2701 cagttgtttc cagccaacct aaaataaaaa gggagatatc ttcataaaag tttaggtttt
     2761 ttttttgttt gtttgtttgt ttggttggct tttgtctttt atttttgtat agagttatga
     2821 tgagttttga tgtgatgcac ttcaaacact ttttgtgata gtttttgtta tgtatcaatt
     2881 atatgtaaca ctccctttca gtgacttgtt agctttattc ctttcgtttt cttgttagtg
     2941 cctggtgtaa gtaactccct atggttctga caacctttat tagtaactaa actatgtgac
     3001 ctttaacaca gtaggtcctg aacagtaatc tccagagcag aacagatggc tttgaaagat
     3061 gctactataa tgtgtcctat atttccccag atttatattt ctaaaatgat gttatcattt
     3121 tactcacaag ttttacagca ctggaaatca gtaagataac atgcaaattt tttcaaataa
     3181 gcattatgga gaggtctctc tctacctttg tatcccctgt aaataagtga tgacgcatat
     3241 acaccagctc atgggtgctc ctgccccaga aaaccagaga cagagcagcc gaatgtgttc
     3301 cttactacac agcattcata ctgaagatca ccaacaggtc ctgaaagtga tttgacaagg
     3361 tccccattgc aactgttaaa tgggtcaact ttgcagtgcc tttgaaatat cccatcactt
     3421 gggaggcaga ggcaggtgaa tttctgaggt caaggccagc ccccccac
//
