LOCUS       NM_001360721            1977 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cathepsin M (Ctsm), transcript variant 2, mRNA.
ACCESSION   NM_001360721 XM_006517309
VERSION     NM_001360721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1977)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1977)
  AUTHORS   Reichmann,J., Reddington,J.P., Best,D., Read,D., Ollinger,R.,
            Meehan,R.R. and Adams,I.R.
  TITLE     The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons
            in the placenta and prevents intra-uterine growth retardation in
            mice
  JOURNAL   Hum Mol Genet 22 (9), 1791-1806 (2013)
   PUBMED   23364048
REFERENCE   3  (bases 1 to 1977)
  AUTHORS   Labied,S., Blacher,S., Carmeliet,P., Noel,A., Frankenne,F.,
            Foidart,J.M. and Munaut,C.
  TITLE     Transient reduction of placental angiogenesis in PAI-1-deficient
            mice
  JOURNAL   Physiol Genomics 43 (4), 188-198 (2011)
   PUBMED   21119013
REFERENCE   4  (bases 1 to 1977)
  AUTHORS   Knox,K. and Baker,J.C.
  TITLE     Genomic evolution of the placenta using co-option and duplication
            and divergence
  JOURNAL   Genome Res 18 (5), 695-705 (2008)
   PUBMED   18340042
REFERENCE   5  (bases 1 to 1977)
  AUTHORS   Bode,S., Peters,C. and Deussing,J.M.
  TITLE     Placental cathepsin M is alternatively spliced and exclusively
            expressed in the spongiotrophoblast layer
  JOURNAL   Biochim Biophys Acta 1731 (3), 160-167 (2005)
   PUBMED   16297992
  REMARK    GeneRIF: Placental cathepsin M is alternatively spliced and
            exclusively expressed in the spongiotrophoblast layer
REFERENCE   6  (bases 1 to 1977)
  AUTHORS   Ishida,M., Ono,K., Taguchi,S., Ohashi,S., Naito,J., Horiguchi,K.
            and Harigaya,T.
  TITLE     Cathepsin gene expression in mouse placenta during the latter half
            of pregnancy
  JOURNAL   J Reprod Dev 50 (5), 515-523 (2004)
   PUBMED   15514457
  REMARK    GeneRIF: Possible association of cathepsins with placental
            lactogen-II may play important roles in placental functions during
            the latter half of pregnancy in mice.
REFERENCE   7  (bases 1 to 1977)
  AUTHORS   Sol-Church,K., Picerno,G.N., Stabley,D.L., Frenck,J., Xing,S.,
            Bertenshaw,G.P. and Mason,R.W.
  TITLE     Evolution of placentally expressed cathepsins
  JOURNAL   Biochem Biophys Res Commun 293 (1), 23-29 (2002)
   PUBMED   12054558
  REMARK    GeneRIF: shows evolution in placental expression by gene
            duplidatoin
REFERENCE   8  (bases 1 to 1977)
  AUTHORS   Deussing,J., Kouadio,M., Rehman,S., Werber,I., Schwinde,A. and
            Peters,C.
  TITLE     Identification and characterization of a dense cluster of
            placenta-specific cysteine peptidase genes and related genes on
            mouse chromosome 13
  JOURNAL   Genomics 79 (2), 225-240 (2002)
   PUBMED   11829493
REFERENCE   9  (bases 1 to 1977)
  AUTHORS   Sol-Church,K., Frenck,J. and Mason,R.W.
  TITLE     Mouse cathepsin M, a placenta-specific lysosomal cysteine protease
            related to cathepsins L and P
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 289-294 (2000)
   PUBMED   10760593
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030254.7.
            
            On Feb 11, 2018 this sequence version replaced XM_006517309.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF202528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                CT030254.7         25766-25854
            90-289              CT030254.7         27218-27417
            290-412             CT030254.7         27689-27811
            413-559             CT030254.7         27908-28054
            560-784             CT030254.7         28475-28699
            785-947             CT030254.7         29059-29221
            948-1065            CT030254.7         29793-29910
            1066-1977           CT030254.7         30951-31862
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.74 cM"
     gene            1..1977
                     /gene="Ctsm"
                     /gene_synonym="1600027J17Rik; Catm"
                     /note="cathepsin M"
                     /db_xref="GeneID:64139"
                     /db_xref="MGI:MGI:1927229"
     exon            1..89
                     /gene="Ctsm"
                     /gene_synonym="1600027J17Rik; Catm"
                     /inference="alignment:Splign:2.1.0"
     exon            90..289
                     /gene="Ctsm"
                     /gene_synonym="1600027J17Rik; Catm"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1165
                     /gene="Ctsm"
                     /gene_synonym="1600027J17Rik; Catm"
                     /note="Cat M"
                     /codon_start=1
                     /product="cathepsin M precursor"
                     /protein_id="NP_001347650.1"
                     /db_xref="CCDS:CCDS36694.1"
                     /db_xref="GeneID:64139"
                     /db_xref="MGI:MGI:1927229"
                     /translation="MTSAIFLAMLCLGMALPSPAPDPILDVEWQKWKIKYGKAYSLEE
                     EGQKRAVWEDNMKKIKLHNGENGLGKHGFTMEMNAFGDMTLEEFRKVMIEIPVPTVKK
                     GKSVQKRLSVNLPKFINWKKRGYVTPVQTQGRCNSCWAFSVTGAIEGQMFRKTGQLIP
                     LSVQNLVDCSRPQGNWGCYLGNTYLALHYVMENGGLESEATYPYEEKDGSCRYSPENS
                     TANITGFEFVPKNEDALMNAVASIGPISVAIDARHASFLFYKRGIYYEPNCSSSVVTH
                     SMLLVGYGFTGRESDGRKYWLVKNSMGTQWGNKGYMKISRDKGNHCGIATYALYPRV"
     exon            290..412
                     /gene="Ctsm"
                     /gene_synonym="1600027J17Rik; Catm"
                     /inference="alignment:Splign:2.1.0"
     exon            413..559
                     /gene="Ctsm"
                     /gene_synonym="1600027J17Rik; Catm"
                     /inference="alignment:Splign:2.1.0"
     exon            560..784
                     /gene="Ctsm"
                     /gene_synonym="1600027J17Rik; Catm"
                     /inference="alignment:Splign:2.1.0"
     exon            785..947
                     /gene="Ctsm"
                     /gene_synonym="1600027J17Rik; Catm"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1065
                     /gene="Ctsm"
                     /gene_synonym="1600027J17Rik; Catm"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1977
                     /gene="Ctsm"
                     /gene_synonym="1600027J17Rik; Catm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaattaagt aacctttgga aagctgtgca gtggaccgag gcagcagcag tcaccacagg
       61 tggcatcctg catccaccag agtagaaaag aaggaatagg aaagcatttt agaagtgttg
      121 ttgtcacatc ttcatttctc ttccctctct acattcttga gatatgactt ctgctatctt
      181 cctggccatg ctctgcttgg gaatggcttt accatcacca gcacctgatc ccattttgga
      241 tgttgaatgg cagaaatgga aaataaaata tggaaaagca tacagtctgg aggaagaagg
      301 acagaagaga gcagtatggg aagacaatat gaaaaagatc aaactgcaca atggggagaa
      361 tggcctgggg aagcatggtt tcaccatgga aatgaatgcc tttggtgaca tgacacttga
      421 agaatttagg aaagtgatga ttgaaatccc agtcccaact gtcaagaaag ggaaaagtgt
      481 ccagaaacgt ctgtctgtta acctgcccaa gtttataaac tggaaaaaga gaggctatgt
      541 cactcctgtg cagacacagg gcagatgtaa ttcttgttgg gctttttctg tgactggtgc
      601 catagaagga cagatgttcc ggaaaacagg tcaactgatc cctctgagtg tacagaacct
      661 tgtggactgt tctaggcctc aaggcaactg gggctgttat ttgggcaata cataccttgc
      721 attgcactat gtgatggaaa atggaggtct agagtctgag gcaacctatc cttatgaaga
      781 aaaggatgga tcatgcaggt acagtccaga aaattctact gctaatataa caggctttga
      841 gtttgttcca aagaatgagg atgccctaat gaatgctgtg gcaagtatag ggcccatttc
      901 tgttgcaatc gatgcaaggc atgcatcttt cctgttctat aaaagaggta tatattatga
      961 gccaaactgc agtagctctg ttgtcacaca ttctatgtta ctagttggct atggctttac
     1021 aggaagagaa tcagatggca ggaaatactg gctggtcaag aacagcatgg gtacacaatg
     1081 gggcaataaa ggctatatga agatttccag agacaaggga aaccactgtg gaattgctac
     1141 atatgccctt taccccagag tgtgaactac ctggtgctga caaggaagga atggacagaa
     1201 gacaccatgt agagaagagg cacttccatt tcaaaataac aggccactgc tgtgtatata
     1261 aaacactaca gttattgaaa agtcagttgt gatgtgaatt ttgtgatata cttattctcg
     1321 taagtcatga ccattactgt aattgagacc atacacagat ttgtatttga tttctataac
     1381 aatttttaaa attaatttgg atttgtcagt aatatgttgt tctaaggatg tgtcaggaaa
     1441 atagcaagcc aggggaaaag tcattacaca ttgccagaat cttgcagttc aaagtccatg
     1501 tgcaggaaaa taaaccttgg agatgaaaat gtgtttagtg acactgaagt agcattttgt
     1561 acatttttta attaagaagg taaaaacacc tctgtaagat aatgttttta attagagatt
     1621 caatgtaagc taatttgaaa tatatgccaa tgtcttcatt atatttcaac acagacaacc
     1681 taaacaaaat tgaaatcttg cagaaggttt tgaaaaaggt tatttgtctt aaaataactt
     1741 gaatgtagtt tataaagcct ttgttcattt gtaccttgtt aaatggagat agacaaatgt
     1801 gaaactcccc agaacatgcc acatccctta atggggatcc caaatgagac ctgaggtgaa
     1861 agacattgaa gaaagaggcc ccaggatgag ggtgctatcc cagtgttaga gtgcttgttc
     1921 agcaggtgca ccccctacta ccaaaaacac aagaatgaat aaaaggtggt ctctgtc
//
