LOCUS       NM_009984               3509 bp    mRNA    linear   ROD 13-MAR-2024
DEFINITION  Mus musculus cathepsin L (Ctsl), mRNA.
ACCESSION   NM_009984
VERSION     NM_009984.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3509)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3509)
  AUTHORS   Zhu,C.S., Qiang,X., Chen,W., Li,J., Lan,X., Yang,H., Gong,J.,
            Becker,L., Wang,P., Tracey,K.J. and Wang,H.
  TITLE     Identification of procathepsin L (pCTS-L)-neutralizing monoclonal
            antibodies to treat potentially lethal sepsis
  JOURNAL   Sci Adv 9 (5), eadf4313 (2023)
   PUBMED   36735789
REFERENCE   3  (bases 1 to 3509)
  AUTHORS   Pan,X., Yu,Y., Chen,Y., Wang,Y. and Fu,G.
  TITLE     Cathepsin L was involved in vascular aging by mediating phenotypic
            transformation of vascular cells
  JOURNAL   Arch Gerontol Geriatr 104, 104828 (2023)
   PUBMED   36206719
  REMARK    GeneRIF: Cathepsin L was involved in vascular aging by mediating
            phenotypic transformation of vascular cells.
REFERENCE   4  (bases 1 to 3509)
  AUTHORS   Chen,W., Imasaka,M., Iwama,H., Nishiura,H. and Ohmuraya,M.
  TITLE     Double deficiency of cathepsin B and L in the mouse pancreas alters
            trypsin activity without affecting acute pancreatitis severity
  JOURNAL   Pancreatology 22 (7), 880-886 (2022)
   PUBMED   36038449
  REMARK    GeneRIF: Double deficiency of cathepsin B and L in the mouse
            pancreas alters trypsin activity without affecting acute
            pancreatitis severity.
REFERENCE   5  (bases 1 to 3509)
  AUTHORS   Wen,Y., Ma,X., Wang,X., Wang,F., Dong,J., Wu,Y., Lv,C., Liu,K.,
            Zhang,Y., Zhang,Z. and Yuan,S.
  TITLE     hnRNPU in Sertoli cells cooperates with WT1 and is essential for
            testicular development by modulating transcriptional factors Sox8/9
  JOURNAL   Theranostics 11 (20), 10030-10046 (2021)
   PUBMED   34815802
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3509)
  AUTHORS   Mason,R.W. and Massey,S.D.
  TITLE     Surface activation of pro-cathepsin L
  JOURNAL   Biochem Biophys Res Commun 189 (3), 1659-1666 (1992)
   PUBMED   1482371
REFERENCE   7  (bases 1 to 3509)
  AUTHORS   Hamilton,R.T., Bruns,K.A., Delgado,M.A., Shim,J.K., Fang,Y.,
            Denhardt,D.T. and Nilsen-Hamilton,M.
  TITLE     Developmental expression of cathepsin L and c-rasHa in the mouse
            placenta
  JOURNAL   Mol Reprod Dev 30 (4), 285-292 (1991)
   PUBMED   1751032
REFERENCE   8  (bases 1 to 3509)
  AUTHORS   Spies,T. and DeMars,R.
  TITLE     Restored expression of major histocompatibility class I molecules
            by gene transfer of a putative peptide transporter
  JOURNAL   Nature 351 (6324), 323-324 (1991)
   PUBMED   2034277
REFERENCE   9  (bases 1 to 3509)
  AUTHORS   Stearns,N.A., Dong,J.M., Pan,J.X., Brenner,D.A. and Sahagian,G.G.
  TITLE     Comparison of cathepsin L synthesized by normal and transformed
            cells at the gene, message, protein, and oligosaccharide levels
  JOURNAL   Arch Biochem Biophys 283 (2), 447-457 (1990)
   PUBMED   2275556
REFERENCE   10 (bases 1 to 3509)
  AUTHORS   Troen,B.R., Ascherman,D., Atlas,D. and Gottesman,M.M.
  TITLE     Cloning and expression of the gene for the major excreted protein
            of transformed mouse fibroblasts. A secreted lysosomal protease
            regulated by transformation
  JOURNAL   J Biol Chem 263 (1), 254-261 (1988)
   PUBMED   2826441
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ076620.1, AK049466.1,
            CT030159.11 and AV023994.2.
            
            [WARNING] On Mar 15, 2024 this sequence was replaced by
            NM_009984.5.
            
            On Aug 13, 2015 this sequence version replaced NM_009984.3.
            
            Summary: This gene encodes a member of the peptidase C1 (papain)
            family of cysteine proteases. The encoded preproprotein is
            proteolytically processed to generate multiple protein products.
            These products include the activation peptide and the cathepsin L1
            heavy and light chains. The mature enzyme appears to be important
            in embryonic development through its processing of histone H3 and
            may play a role in disease progression in a model of kidney
            disease. Homozygous knockout mice for this gene exhibit hair loss,
            skin thickening, bone and heart defects, and enhanced
            susceptibility to bacterial infection. A pseudogene of this gene
            has been identified in the genome. [provided by RefSeq, Aug 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049466.1, BC068163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               CJ076620.1         50-263
            215-2185            AK049466.1         2-1972
            2186-2818           CT030159.11        156767-157399       c
            2819-3509           AV023994.2         1-691
FEATURES             Location/Qualifiers
     source          1..3509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 33.26 cM"
     gene            1..3509
                     /gene="Ctsl"
                     /gene_synonym="1190035F06Rik; CatL; Ctsl1; fs; MEP; nkt"
                     /note="cathepsin L"
                     /db_xref="GeneID:13039"
                     /db_xref="MGI:MGI:88564"
     exon            1..285
                     /gene="Ctsl"
                     /gene_synonym="1190035F06Rik; CatL; Ctsl1; fs; MEP; nkt"
                     /inference="alignment:Splign:2.1.0"
     exon            286..422
                     /gene="Ctsl"
                     /gene_synonym="1190035F06Rik; CatL; Ctsl1; fs; MEP; nkt"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1301
                     /gene="Ctsl"
                     /gene_synonym="1190035F06Rik; CatL; Ctsl1; fs; MEP; nkt"
                     /EC_number="3.4.22.15"
                     /note="cathepsin L1; procathepsin L; p39 cysteine
                     proteinase; major excreted protein"
                     /codon_start=1
                     /product="procathepsin L preproprotein"
                     /protein_id="NP_034114.1"
                     /db_xref="CCDS:CCDS26600.1"
                     /db_xref="GeneID:13039"
                     /db_xref="MGI:MGI:88564"
                     /translation="MNLLLLLAVLCLGTALATPKFDQTFSAEWHQWKSTHRRLYGTNE
                     EEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKK
                     GRLFQEPLMLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLIS
                     LSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFA
                     VANDTGFVDIPQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDH
                     GVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVVN
                     "
     exon            423..545
                     /gene="Ctsl"
                     /gene_synonym="1190035F06Rik; CatL; Ctsl1; fs; MEP; nkt"
                     /inference="alignment:Splign:2.1.0"
     exon            546..692
                     /gene="Ctsl"
                     /gene_synonym="1190035F06Rik; CatL; Ctsl1; fs; MEP; nkt"
                     /inference="alignment:Splign:2.1.0"
     exon            693..917
                     /gene="Ctsl"
                     /gene_synonym="1190035F06Rik; CatL; Ctsl1; fs; MEP; nkt"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1080
                     /gene="Ctsl"
                     /gene_synonym="1190035F06Rik; CatL; Ctsl1; fs; MEP; nkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1198
                     /gene="Ctsl"
                     /gene_synonym="1190035F06Rik; CatL; Ctsl1; fs; MEP; nkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..3509
                     /gene="Ctsl"
                     /gene_synonym="1190035F06Rik; CatL; Ctsl1; fs; MEP; nkt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccaaggca ccacgctggc gtggaccctc caaagtggat cagcctcgcc ccaaggcttg
       61 caccacagga caggttacga cccggcggcg tcacgcgccc ggactcccgc aggctccgcc
      121 ccgaggcagg catagccaat gacggggcgg gggcgggccc tgtcggggct gtagcctgag
      181 aggctttaaa gcctgagccc ggcgctgttc ctccagattc tcggacctcg gcgacctccg
      241 gggatccgag tttgcagact tcttgtgcgc agctagccgc ctcaggtgtt tgaaccatga
      301 atcttttact ccttttggct gtcctctgct tgggaacagc cttagctact ccaaaatttg
      361 atcaaacctt tagtgcagag tggcaccagt ggaagtccac acacagaaga ctgtatggca
      421 cgaatgagga agagtggagg agagcgatat gggagaagaa catgagaatg atccagctac
      481 acaacgggga atacagcaac gggcagcacg gcttttccat ggagatgaac gccttcggtg
      541 acatgaccaa tgaggaattc aggcaggtgg tgaatggcta ccgccaccag aagcacaaga
      601 aggggaggct ttttcaggaa ccgctgatgc ttaagatccc caagtctgtg gactggagag
      661 aaaagggttg tgtgactcct gtgaagaacc agggccagtg cgggtcttgt tgggcgttta
      721 gcgcatcggg ttgcctagaa ggacagatgt tccttaagac cggcaaactg atctcactga
      781 gtgaacagaa ccttgtggac tgttctcacg ctcaaggcaa tcagggctgt aacggaggcc
      841 tgatggattt tgctttccag tacattaagg aaaatggagg tctggactcg gaggagtctt
      901 acccctatga agcgaaggac ggatcttgta aatacagagc cgagttcgct gtggctaatg
      961 acacagggtt cgtggatatc cctcagcaag agaaagccct catgaaggct gtggcgactg
     1021 tggggcctat ttctgttgct atggacgcaa gccatccgtc tctccagttc tatagttcag
     1081 gcatctacta tgaacccaac tgtagcagca agaacctcga ccatggggtt ctgttggtgg
     1141 gctatggcta tgaaggaaca gattcaaata agaataaata ttggcttgtc aagaacagct
     1201 ggggaagtga atggggtatg gaaggctaca tcaaaatagc caaagaccgg gacaaccact
     1261 gtggacttgc caccgcggcc agctatcctg tcgtgaattg atgggtagcg gtaatgagga
     1321 cttatggaca ctatgtccaa aggaattcag cttaaaactg accaaaccct tattgagtca
     1381 aaccatggta cttgaatcat tgaggatcca agtcatgatt tgaattctgt tgccattttt
     1441 acatgggtta aatgttacca ctacttaaaa ctcctgttat aaacagcttt ataatattga
     1501 aaacttagtg cttaattctg agtctggaat atttgtttta tataaaggtt gtataaaact
     1561 ttctttacct cttaaaaata aattttagct cagtgtgtgt gtatgtggga cttcagtgtg
     1621 taatgtgttg acaaatgttc gggactaaat actgattcag ggtgacatgg tacagcaaga
     1681 aaaaggtggc aggtgctctg gagccttcgg atttcacctc agtgtcccat cagattaggt
     1741 atgtgttagt gaatctagct tgggataatt gttttctttt tgtgtgtgta catggtaaat
     1801 gtgtggagtt cagagaacaa ctcagttcca cagtgttggt cctatcaggt cctagccatc
     1861 aaaataaggt tgtcaggctg ggccacaggt gccttttact actgagctat cttgccagcc
     1921 ccactagttt ttaagtgaca taattacgta tgtttatact ataatgtgtt tttgatatga
     1981 tgtgtatact acaaaatgat ctgatagggc taataagctt acctcaaata tttaattact
     2041 ttgttgaact tttctagctg tttttaaaat acacagtata ttattgttgg aaactgtcct
     2101 gttatgtaga ccaggctggc cttaagccca tgatctccct tcctcagcct tctaagggct
     2161 aagataaaca tgtaatgtta tacccagtct caagtctcat atctggcaaa acttgacagt
     2221 ccagaagaac atgagtaaat cgctcagcac aggagtctca acttttctaa ttctgtgacc
     2281 tttcaatata gttcctcctg tgtgactcaa accataaaat tatttttgtt actactttat
     2341 aactaatatt gctacagtta taaatcataa tgtagatttt tttttttttt tttttggaaa
     2401 tagaggtttg tcaaaggagt cacagcgctg agaaccactg ttctagaaac ttgcaggttt
     2461 tacatattag gctgactgga agaaggttga agtgctagtt tcagtagtgc ctgtccacat
     2521 tgccagtgaa gaccacaatc ctgctatgta gttctagaaa gggccataca caggtgggct
     2581 gtaggctgac attattccca attggcctga gaaaccccat gctacccagg aatgacaaaa
     2641 aaataaatga ataaatacat taagcagttg tgattaactt cccaggtgat gacaatactg
     2701 gagatgggca tgcccctgag gtagaatgat ccaggcatgg gcgtagccag ccttgaaaat
     2761 gtcaatgact tagcagggtt cttttcaaaa ctgaattttt acaagggagt tcatagatgg
     2821 accttgatgg aaactgacta ccagaaaaga ctcgatctct ctgccatgtt ggggtcagca
     2881 aacaaatacc acaagataaa tgcacttcag catttcaatt ataccgtttg tatgccctct
     2941 gccttgctac tttcacacca gattgtctaa aatgcctgac ggacgccgct tcaggaagga
     3001 aggaaggatt cgtgttaggt catagtggtc agaggggtac aggtcatgat ggtgatgggg
     3061 cacgggagga ccagaacagt ttgtttcact ggtcaggaag gaaggtcagg aagcaaggtg
     3121 aaggctgatg ctcagctggc ttttttgttt ccaaatcctt ttattatctg agccctgagt
     3181 atatgctatg gtgccatcca caatcagggt agatcttacc ttagtcttct ctgaaaatgt
     3241 cccactgaac acacagcatc tcttagatta tttttatttt gggtgttggg gatggagtat
     3301 gggtatgtgt ttgcatagca cgtgtgcgtg tacttaaaag gtcaaagttc gggctggcga
     3361 ggtggctcag tgggtaagag cacccgactg ctcttccaaa ggtccagagt tcaaatccca
     3421 gcaaccacat ggtggctcac aaccatctgt aacaagaact gactccctct tctggtgtgt
     3481 ctgaagacag ctacagtgta cttacatat
//
