LOCUS       NM_007802               1583 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus cathepsin K (Ctsk), mRNA.
ACCESSION   NM_007802
VERSION     NM_007802.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1583)
  AUTHORS   Qin,L., Yao,Y., Wang,W., Qin,Q., Liu,J., Liu,H., Yuan,L., Yuan,Y.,
            Du,X., Zhao,B., Wu,X., Qing,B., Huang,L., Wang,G., Xiang,Y., Qu,X.,
            Zhang,X., Yang,M., Xia,Z. and Liu,C.
  TITLE     Airway epithelial overexpressed cathepsin K induces airway
            remodelling through epithelial-mesenchymal trophic unit activation
            in asthma
  JOURNAL   Br J Pharmacol 181 (19), 3700-3716 (2024)
   PUBMED   38853468
  REMARK    GeneRIF: Airway epithelial overexpressed cathepsin K induces airway
            remodelling through epithelial-mesenchymal trophic unit activation
            in asthma.
REFERENCE   2  (bases 1 to 1583)
  AUTHORS   Deng,D., Liu,X., Huang,W., Yuan,S., Liu,G., Ai,S., Fu,Y., Xu,H.,
            Zhang,X., Li,S., Xu,S., Bai,X. and Zhang,Y.
  TITLE     Osteoclasts control endochondral ossification via regulating
            acetyl-CoA availability
  JOURNAL   Bone Res 12 (1), 49 (2024)
   PUBMED   39198395
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1583)
  AUTHORS   Zhang,M., Yue,X., Xu,S., Piao,J., Zhao,L., Shu,S., Kuzuya,M.,
            Li,P., Hong,L., Kim,W., Liu,B. and Cheng,X.W.
  TITLE     Dipeptidyl peptidase-4 disturbs adipocyte differentiation via the
            negative regulation of the glucagon-like
            peptide-1/adiponectin-cathepsin K axis in mice under chronic stress
            conditions
  JOURNAL   FASEB J 38 (10), e23684 (2024)
   PUBMED   38795334
REFERENCE   4  (bases 1 to 1583)
  AUTHORS   Jin,X., Yue,X., Huang,Z., Meng,X., Xu,S., Wu,Y., Wan,Y., Inoue,A.,
            Narisawa,M., Hu,L., Shi,G.P., Umegaki,H., Murohara,T., Lei,Y.,
            Kuzuya,M. and Cheng,X.W.
  TITLE     Cathepsin K deficiency prevented stress-related thrombosis in a
            mouse FeCl3 model
  JOURNAL   Cell Mol Life Sci 81 (1), 205 (2024)
   PUBMED   38703204
  REMARK    GeneRIF: Cathepsin K deficiency prevented stress-related thrombosis
            in a mouse FeCl3 model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1583)
  AUTHORS   Li,Y.P. and Chen,W.
  TITLE     Characterization of mouse cathepsin K gene, the gene promoter, and
            the gene expression
  JOURNAL   J Bone Miner Res 14 (4), 487-499 (1999)
   PUBMED   10234569
REFERENCE   6  (bases 1 to 1583)
  AUTHORS   Dodds,R.A., Connor,J.R., Drake,F., Feild,J. and Gowen,M.
  TITLE     Cathepsin K mRNA detection is restricted to osteoclasts during
            fetal mouse development
  JOURNAL   J Bone Miner Res 13 (4), 673-682 (1998)
   PUBMED   9556067
REFERENCE   7  (bases 1 to 1583)
  AUTHORS   Smit,J.W., Schinkel,A.H., Muller,M., Weert,B. and Meijer,D.K.
  TITLE     Contribution of the murine mdr1a P-glycoprotein to hepatobiliary
            and intestinal elimination of cationic drugs as measured in mice
            with an mdr1a gene disruption
  JOURNAL   Hepatology 27 (4), 1056-1063 (1998)
   PUBMED   9537446
REFERENCE   8  (bases 1 to 1583)
  AUTHORS   Gelb,B.D., Moissoglu,K., Zhang,J., Martignetti,J.A., Bromme,D. and
            Desnick,R.J.
  TITLE     Cathepsin K: isolation and characterization of the murine cDNA and
            genomic sequence, the homologue of the human pycnodysostosis gene
  JOURNAL   Biochem Mol Med 59 (2), 200-206 (1996)
   PUBMED   8986645
REFERENCE   9  (bases 1 to 1583)
  AUTHORS   Rantakokko,J., Aro,H.T., Savontaus,M. and Vuorio,E.
  TITLE     Mouse cathepsin K: cDNA cloning and predominant expression of the
            gene in osteoclasts, and in some hypertrophying chondrocytes during
            mouse development
  JOURNAL   FEBS Lett 393 (2-3), 307-313 (1996)
   PUBMED   8814310
REFERENCE   10 (bases 1 to 1583)
  AUTHORS   Gelb,B.D., Shi,G.P., Chapman,H.A. and Desnick,R.J.
  TITLE     Pycnodysostosis, a lysosomal disease caused by cathepsin K
            deficiency
  JOURNAL   Science 273 (5279), 1236-1238 (1996)
   PUBMED   8703060
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092203.16, AK132648.1 and
            D18958.1.
            
            On Aug 13, 2013 this sequence version replaced NM_007802.3.
            
            Summary: This gene encodes a member of the cathepsin family of
            cysteine proteases that is highly expressed in osteoclasts and is
            involved in the degradation of collagen and other matrix proteins
            in bone. The encoded preproprotein undergoes proteolytic processing
            to generate a mature, functional enzyme. Mice lacking the encoded
            protein exhibit phenotypic features of pycnodysostosis such as
            increased bone density and bone deformity, which become
            progressively more pronounced with age. [provided by RefSeq, Jan
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046320.1, AK132648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC092203.16        116502-116572       c
            72-1577             AK132648.1         2-1507
            1578-1583           D18958.1           179-184
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..1583
                     /gene="Ctsk"
                     /gene_synonym="catK; MMS10-Q; Ms10q"
                     /note="cathepsin K"
                     /db_xref="GeneID:13038"
                     /db_xref="MGI:MGI:107823"
     exon            1..127
                     /gene="Ctsk"
                     /gene_synonym="catK; MMS10-Q; Ms10q"
                     /inference="alignment:Splign:2.1.0"
     exon            128..248
                     /gene="Ctsk"
                     /gene_synonym="catK; MMS10-Q; Ms10q"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1118
                     /gene="Ctsk"
                     /gene_synonym="catK; MMS10-Q; Ms10q"
                     /EC_number="3.4.22.38"
                     /note="Cat K"
                     /codon_start=1
                     /product="cathepsin K preproprotein"
                     /protein_id="NP_031828.2"
                     /db_xref="CCDS:CCDS17615.1"
                     /db_xref="GeneID:13038"
                     /db_xref="MGI:MGI:107823"
                     /translation="MWVFKFLLLPMVSFALSPEEMLDTQWELWKKTHQKQYNSKVDEI
                     SRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRSYS
                     NDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLL
                     ALSPQNLVDCVTENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKA
                     AKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNH
                     AVLVVGYGTQKGSKHWIIKNSWGESWGNKGYALLARNKNNACGITNMASFPKM"
     exon            249..371
                     /gene="Ctsk"
                     /gene_synonym="catK; MMS10-Q; Ms10q"
                     /inference="alignment:Splign:2.1.0"
     exon            372..527
                     /gene="Ctsk"
                     /gene_synonym="catK; MMS10-Q; Ms10q"
                     /inference="alignment:Splign:2.1.0"
     exon            528..746
                     /gene="Ctsk"
                     /gene_synonym="catK; MMS10-Q; Ms10q"
                     /inference="alignment:Splign:2.1.0"
     exon            747..912
                     /gene="Ctsk"
                     /gene_synonym="catK; MMS10-Q; Ms10q"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1018
                     /gene="Ctsk"
                     /gene_synonym="catK; MMS10-Q; Ms10q"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1583
                     /gene="Ctsk"
                     /gene_synonym="catK; MMS10-Q; Ms10q"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1535..1540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctsk"
                     /gene_synonym="catK; MMS10-Q; Ms10q"
                     /note="hexamer: AATAAA"
     polyA_site      1560
                     /gene="Ctsk"
                     /gene_synonym="catK; MMS10-Q; Ms10q"
                     /note="major polyA site"
ORIGIN      
        1 tttccagcca ctgctggagt tgacttccgc aatccttacc gaataaatct agcaccctta
       61 gtcttccgct cacagtagcc acgcttccta tccgaaaaga gcctagcgaa cagattctca
      121 acagcaggat gtgggtgttc aagtttctgc tgctacccat ggtgagcttt gctctgtctc
      181 cggaggaaat gctggacacc cagtgggagc tatggaagaa gactcaccag aagcagtata
      241 acagcaaggt ggatgaaatc tctcggcgtt taatttggga gaaaaacctg aagcaaatct
      301 ctgcccataa cctggaggcc tctcttggtg tccatacata tgaactggcc atgaaccact
      361 tgggagacat gaccagtgaa gaagtggttc agaagatgac gggactcaga atacctccct
      421 ctcgatccta cagtaatgac actctctata ccccagagtg ggaaggcagg gtcccagact
      481 ccatcgacta tcgaaagaaa ggatacgtta ctccagtcaa gaaccagggc cagtgtggtt
      541 cctgttgggc tttcagctct gccggggccc tggagggcca actcaagaag aaaactggta
      601 aactcttagc tctgagtccc cagaatcttg tggactgtgt gactgagaat tatggctgtg
      661 gaggcggcta tatgaccact gccttccaat acgtgcagca gaacggaggc attgactctg
      721 aagatgctta cccatatgtg ggccaggatg aaagttgtat gtataacgcc acggcaaagg
      781 cagctaaatg cagagggtac agagagattc ctgtggggaa cgagaaagcc ctgaagagag
      841 cagtggcgcg ggtaggaccc atctctgtgt ccatcgatgc aagcttggca tctttccagt
      901 tttacagcag aggtgtgtac tatgatgaaa attgtgaccg tgataatgtg aaccatgcag
      961 tgttggtggt gggctatggc acccagaagg gaagcaagca ctggataatt aaaaacagct
     1021 ggggagagag ctggggaaac aaaggatatg ctctcttggc tcggaataag aacaacgcct
     1081 gcggcattac caacatggcc agcttcccca agatgtgatt ccagccagcc agcccatctc
     1141 ttctcagatt ccttccttca tggtgcaaga tattggtggc tttggaaggg agtgggcatg
     1201 gcgctcctga gagggacgca gcgatgctaa ctaagattgt ttcatttctc ctctcgttgg
     1261 tgcttccagt gacaactcta cttcccttct ctctgcccag ggcccttttc tttgtggaca
     1321 caacagggca tttttctgag agttgtggac tctgtgctgg tagacattgg agtcctccag
     1381 caggctggag gactaaggtg accttcccga gcccctgtct tctgtataca ccagtgaaca
     1441 tttcagtctt ccactgagat gcacaaatct attcgtgatt ctttgacaaa tttacatgat
     1501 attaaaaaaa gtgtttttcc ttctttgtat ttgaaataaa gtatctcatt tacaatttaa
     1561 taaagaacac tgcgtccata cta
//
