LOCUS       NM_001356291            1387 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cathepsin J (Ctsj), transcript variant 1, mRNA.
ACCESSION   NM_001356291 XM_006517255
VERSION     NM_001356291.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1387)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1387)
  AUTHORS   Kim,J., Frey,W.D., He,H., Kim,H., Ekram,M.B., Bakshi,A., Faisal,M.,
            Perera,B.P., Ye,A. and Teruyama,R.
  TITLE     Peg3 mutational effects on reproduction and placenta-specific gene
            families
  JOURNAL   PLoS One 8 (12), e83359 (2013)
   PUBMED   24391757
  REMARK    Erratum:[PLoS One. 2014;9(1).
            doi:10.1371/annotation/8de03ec5-e62c-4135-87ee-4928475090a8]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1387)
  AUTHORS   Hassanein,M., Xue,F., Seto,C.T. and Mason,R.W.
  TITLE     Development of a specific inhibitor for the placental protease,
            cathepsin P
  JOURNAL   Arch Biochem Biophys 464 (2), 288-294 (2007)
   PUBMED   17531191
REFERENCE   4  (bases 1 to 1387)
  AUTHORS   Liu,P., Wang,Y., Vikis,H., Maciag,A., Wang,D., Lu,Y., Liu,Y. and
            You,M.
  TITLE     Candidate lung tumor susceptibility genes identified through
            whole-genome association analyses in inbred mice
  JOURNAL   Nat Genet 38 (8), 888-895 (2006)
   PUBMED   16862160
REFERENCE   5  (bases 1 to 1387)
  AUTHORS   Puzer,L., Barros,N.M., Oliveira,V., Juliano,M.A., Lu,G.,
            Hassanein,M., Juliano,L., Mason,R.W. and Carmona,A.K.
  TITLE     Defining the substrate specificity of mouse cathepsin P
  JOURNAL   Arch Biochem Biophys 435 (1), 190-196 (2005)
   PUBMED   15680921
  REMARK    GeneRIF: These results show that cathepsin P, in contrast to other
            mammalian cathepsins, has a restricted catalytic specificity.
REFERENCE   6  (bases 1 to 1387)
  AUTHORS   Sol-Church,K., Frenck,J. and Mason,R.W.
  TITLE     Mouse cathepsin M, a placenta-specific lysosomal cysteine protease
            related to cathepsins L and P
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 289-294 (2000)
   PUBMED   10760593
REFERENCE   7  (bases 1 to 1387)
  AUTHORS   Ramakrishnan,V., Reeves,P.S., DeGuzman,F., Deshpande,U.,
            Ministri-Madrid,K., DuBridge,R.B. and Phillips,D.R.
  TITLE     Increased thrombin responsiveness in platelets from mice lacking
            glycoprotein V
  JOURNAL   Proc Natl Acad Sci U S A 96 (23), 13336-13341 (1999)
   PUBMED   10557321
REFERENCE   8  (bases 1 to 1387)
  AUTHORS   Tisljar,K., Deussing,J. and Peters,C.
  TITLE     Cathepsin J, a novel murine cysteine protease of the papain family
            with a placenta-restricted expression
  JOURNAL   FEBS Lett 459 (3), 299-304 (1999)
   PUBMED   10526153
REFERENCE   9  (bases 1 to 1387)
  AUTHORS   Sol-Church,K., Frenck,J., Troeber,D. and Mason,R.W.
  TITLE     Cathepsin P, a novel protease in mouse placenta
  JOURNAL   Biochem J 343 Pt 2 (Pt 2), 307-309 (1999)
   PUBMED   10510293
REFERENCE   10 (bases 1 to 1387)
  AUTHORS   Conliffe,P.R., Ogilvie,S., Simmen,R.C., Michel,F.J., Saunders,P.
            and Shiverick,K.T.
  TITLE     Cloning and expression of a rat placental cDNA encoding a novel
            cathepsin L-related protein
  JOURNAL   Mol Reprod Dev 40 (2), 146-156 (1995)
   PUBMED   7766407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005526.1.
            
            On Sep 28, 2017 this sequence version replaced XM_006517255.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005526.1, AK131661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1387              AK005526.1         2-1388
FEATURES             Location/Qualifiers
     source          1..1387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.62 cM"
     gene            1..1387
                     /gene="Ctsj"
                     /gene_synonym="CATP; CatRLP; Ctsp"
                     /note="cathepsin J"
                     /db_xref="GeneID:26898"
                     /db_xref="MGI:MGI:1349426"
     exon            1..73
                     /gene="Ctsj"
                     /gene_synonym="CATP; CatRLP; Ctsp"
                     /inference="alignment:Splign:2.1.0"
     exon            74..210
                     /gene="Ctsj"
                     /gene_synonym="CATP; CatRLP; Ctsp"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1089
                     /gene="Ctsj"
                     /gene_synonym="CATP; CatRLP; Ctsp"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cathepsin L-related protein; Cat P; cathepsin
                     P; catlrp-p; gene/Cathepsin L-related protein"
                     /codon_start=1
                     /product="cathepsin J isoform 1 precursor"
                     /protein_id="NP_001343220.1"
                     /db_xref="CCDS:CCDS88467.1"
                     /db_xref="GeneID:26898"
                     /db_xref="MGI:MGI:1349426"
                     /translation="MTPTVLLLILCFGVASGAQAHDPKLDAEWKDWKTKYAKSYSPKE
                     EALRRAVWEENMRMIKLHNKENSLGKNNFTMKMNKFGDQTSEEFRKSIDNIPIPAAMT
                     DPHAQNHVSIGLPDYKDWREEGYVTPVRNQGKCGSCWAFAAAGAIEGQMFWKTGNLTP
                     LSVQNLLDCSKTVGNKGCQSGTAHQAFEYVLKNKGLEAEATYPYEGKDGPCRYRSENA
                     SANITDYVNLPPNELYLWVAVASIGPVSAAIDASHDSFRFYNGGIYYEPNCSSYFVNH
                     AVLVVGYGSEGDVKDGNNYWLIKNSWGEEWGMNGYMQIAKDHNNHCGIASLASYPNIF
                     "
     exon            211..333
                     /gene="Ctsj"
                     /gene_synonym="CATP; CatRLP; Ctsp"
                     /inference="alignment:Splign:2.1.0"
     exon            334..480
                     /gene="Ctsj"
                     /gene_synonym="CATP; CatRLP; Ctsp"
                     /inference="alignment:Splign:2.1.0"
     exon            481..705
                     /gene="Ctsj"
                     /gene_synonym="CATP; CatRLP; Ctsp"
                     /inference="alignment:Splign:2.1.0"
     exon            706..868
                     /gene="Ctsj"
                     /gene_synonym="CATP; CatRLP; Ctsp"
                     /inference="alignment:Splign:2.1.0"
     exon            869..986
                     /gene="Ctsj"
                     /gene_synonym="CATP; CatRLP; Ctsp"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1387
                     /gene="Ctsj"
                     /gene_synonym="CATP; CatRLP; Ctsp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1260..1265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctsj"
                     /gene_synonym="CATP; CatRLP; Ctsp"
                     /note="hexamer: ATTAAA"
     polyA_site      1289
                     /gene="Ctsj"
                     /gene_synonym="CATP; CatRLP; Ctsp"
                     /note="major polyA site"
ORIGIN      
        1 agaactcagg accacagcaa cctctgaaga gttgagtctg tggagtggac taaggcggca
       61 tcagtcacca caggttcttg aaacatgact cctactgtcc ttctgttaat cctgtgcttt
      121 ggagtggcct caggtgccca agcacatgat cccaaattgg atgctgagtg gaaagactgg
      181 aagactaaat atgcaaaatc atacagtccg aaggaagaag cactgaggag agcagtatgg
      241 gaagaaaaca tgagaatgat caaactgcac aacaaggaga atagtctggg gaagaataac
      301 ttcaccatga aaatgaataa atttggtgac cagaccagtg aagaattcag aaaatcaata
      361 gacaatattc caattcctgc tgccatgaca gacccacatg cccagaacca tgtatctatt
      421 ggtttacccg attataagga ttggagagag gaaggctatg tgactcctgt acggaatcag
      481 ggtaaatgtg gctcttgttg ggcttttgct gcagctggtg ccatagaagg tcagatgttc
      541 tggaaaactg gcaacctcac ccctctaagt gtgcagaacc tattggactg ttctaaaact
      601 gtaggaaaca aaggctgcca atcgggtact gcacaccaag cattcgagta tgttttgaaa
      661 aataaaggtc ttgaagctga ggcaacctat ccatacgaag gaaaagacgg accctgcagg
      721 taccgtagtg agaacgctag tgctaatatc acagattatg tgaacctccc accgaatgag
      781 ctttacctat gggttgctgt agcatctatt gggcctgtct ctgctgccat tgatgcttct
      841 catgactctt tcaggttcta caatggaggt atttattatg agccaaattg cagcagttac
      901 tttgtgaatc atgcagttct ggtggttggc tatggatctg agggagatgt gaaagatggt
      961 aataactact ggctgatcaa gaacagctgg ggtgaagaat ggggcatgaa tggctacatg
     1021 cagattgcca aagatcacaa caaccactgt ggaattgctt cacttgccag ctatcccaat
     1081 atattttgat ctgcctgttg gtcacaaagg aagacatggt ggagacagtg tttagtgcct
     1141 tccaccttca cagtaaccag tctctcctga gtgttttcaa cagttgagtg gctaaaaagc
     1201 caccttgtgg tgtggaatct ggaacctgct tgttctacaa cagcatggca actactataa
     1261 ttaaattctc tactgatgtg tcttcatgat tcctgtagta attttatttt aaattttagt
     1321 ggttgtgcaa atggtgtctt ttaaaaggtt aaattgaaat atagtttgta gcttctttct
     1381 gttttgc
//
