LOCUS       NM_007801               1630 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus cathepsin H (Ctsh), transcript variant 1, mRNA.
ACCESSION   NM_007801
VERSION     NM_007801.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1630)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1630)
  AUTHORS   Zhang,S., Mo,X., Jin,Y., Niu,Z., Yao,M., Zhang,Y., Li,L., Hu,G. and
            Ning,W.
  TITLE     Single-cell transcriptome analysis reveals cellular heterogeneity
            and highlights Fstl1-regulated alveolar myofibroblasts in mouse
            lung at birth
  JOURNAL   Genomics 115 (5), 110677 (2023)
   PUBMED   37406975
REFERENCE   3  (bases 1 to 1630)
  AUTHORS   Ni,J., Zhao,J., Zhang,X., Reinheckel,T., Turk,V. and Nakanishi,H.
  TITLE     Cathepsin H deficiency decreases hypoxia-ischemia-induced
            hippocampal atrophy in neonatal mice through attenuated
            TLR3/IFN-beta signaling
  JOURNAL   J Neuroinflammation 18 (1), 176 (2021)
   PUBMED   34376208
  REMARK    GeneRIF: Cathepsin H deficiency decreases hypoxia-ischemia-induced
            hippocampal atrophy in neonatal mice through attenuated
            TLR3/IFN-beta signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1630)
  AUTHORS   Okada,R., Zhang,X., Harada,Y., Wu,Z. and Nakanishi,H.
  TITLE     Cathepsin H deficiency in mice induces excess Th1 cell activation
            and early-onset of EAE though impairment of toll-like receptor 3
            cascade
  JOURNAL   Inflamm Res 67 (5), 371-374 (2018)
   PUBMED   29470604
  REMARK    GeneRIF: CatH deficiency impaired toll-like receptor 3-mediated
            activation of interferon regulatory factor 3 and consequent
            secretion of IFN-beta
REFERENCE   5  (bases 1 to 1630)
  AUTHORS   Yan,D., Wang,H.W., Bowman,R.L. and Joyce,J.A.
  TITLE     STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin
            Secretion from Macrophages via IRE1alpha Activation
  JOURNAL   Cell Rep 16 (11), 2914-2927 (2016)
   PUBMED   27626662
REFERENCE   6  (bases 1 to 1630)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   7  (bases 1 to 1630)
  AUTHORS   Sol-Church,K., Frenck,J. and Mason,R.W.
  TITLE     Mouse cathepsin M, a placenta-specific lysosomal cysteine protease
            related to cathepsins L and P
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 289-294 (2000)
   PUBMED   10760593
REFERENCE   8  (bases 1 to 1630)
  AUTHORS   Soderstrom,M., Salminen,H., Glumoff,V., Kirschke,H., Aro,H. and
            Vuorio,E.
  TITLE     Cathepsin expression during skeletal development
  JOURNAL   Biochim Biophys Acta 1446 (1-2), 35-46 (1999)
   PUBMED   10395917
REFERENCE   9  (bases 1 to 1630)
  AUTHORS   Deussing,J., Roth,W., Rommerskirch,W., Wiederanders,B., von
            Figura,K. and Peters,C.
  TITLE     The genes of the lysosomal cysteine proteinases cathepsin B, H, L,
            and S map to different mouse chromosomes
  JOURNAL   Mamm Genome 8 (4), 241-245 (1997)
   PUBMED   9096102
REFERENCE   10 (bases 1 to 1630)
  AUTHORS   Lafuse,W.P., Brown,D., Castle,L. and Zwilling,B.S.
  TITLE     IFN-gamma increases cathepsin H mRNA levels in mouse macrophages
  JOURNAL   J Leukoc Biol 57 (4), 663-669 (1995)
   PUBMED   7722423
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC140392.3, BG078538.2,
            AK160026.1 and DV043764.1.
            
            On Aug 12, 2015 this sequence version replaced NM_007801.2.
            
            Summary: This gene encodes a member of the peptidase C1 (papain)
            family of cysteine proteases. Alternative splicing results in
            multiple transcript variants, at least one of which encodes a
            preproprotein that is proteolytically processed to generate
            multiple protein products. These products include the cathepsin H
            mini, heavy, and light chains. In rat and human, these three chains
            can associate to form the mature enzyme, which has both
            aminopeptidase and endopeptidase activities. Homozygous knockout
            mice for this gene exhibit impaired lung surfactant processing and
            reduced tumorigenesis in a pancreatic cancer model. Multiple
            pseudogenes of this gene have been identified in the genome.
            [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006878.1, AK157376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC140392.3         72393-72498
            107-270             BG078538.2         1-164
            271-1616            AK160026.1         2-1347
            1617-1630           DV043764.1         772-785
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.4 cM"
     gene            1..1630
                     /gene="Ctsh"
                     /note="cathepsin H"
                     /db_xref="GeneID:13036"
                     /db_xref="MGI:MGI:107285"
     exon            1..368
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1285
                     /gene="Ctsh"
                     /EC_number="3.4.22.16"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; cathepsin B3; cathepsin BA; pro-cathepsin H;
                     Cat H"
                     /codon_start=1
                     /product="pro-cathepsin H isoform 1 preproprotein"
                     /protein_id="NP_031827.2"
                     /db_xref="CCDS:CCDS23399.1"
                     /db_xref="GeneID:13036"
                     /db_xref="MGI:MGI:107285"
                     /translation="MWAALPLLCAGAWLLSTGATAELTVNAIEKFHFKSWMKQHQKTY
                     SSVEYNHRLQMFANNWRKIQAHNQRNHTFKMALNQFSDMSFAEIKHKFLWSEPQNCSA
                     TKSNYLRGTGPYPSSMDWRKKGNVVSPVKNQGACGSCWTFSTTGALESAVAIASGKML
                     SLAEQQLVDCAQAFNNHGCKGGLPSQAFEYILYNKGIMEEDSYPYIGKDSSCRFNPQK
                     AVAFVKNVVNITLNDEAAMVEAVALYNPVSFAFEVTEDFLMYKSGVYSSKSCHKTPDK
                     VNHAVLAVGYGEQNGLLYWIVKNSWGSQWGENGYFLIERGKNMCGLAACASYPIPQV"
     exon            369..400
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            401..506
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            507..577
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            578..682
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            683..769
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            770..825
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            826..907
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            908..976
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1083
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1209
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1623
                     /gene="Ctsh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1595..1600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctsh"
                     /note="hexamer: AATAAA"
     polyA_site      1615
                     /gene="Ctsh"
                     /note="major polyA site"
ORIGIN      
        1 gaaggccagg gagctatggt tcaagaaacc ttcacggaga cggagttacc agagatgggg
       61 acagacagga aactggggat taggctgcgc ttcctcccac ttggcaggga ctagccttca
      121 gggtcagacc ctgagaaccc ttcttcccaa gagcaggagt gtaatggcca cagggggcag
      181 gagaggaacc atcatcacct aggcggaggc cagagtcgcc ccacctcctt tccacaggct
      241 gggctcagag ggcactcggt gggaccgggc agtgagcgcc gagatgtggg ctgcgctgcc
      301 gctgctgtgc gctggggcct ggctgctgag tactggggcc accgccgagc tgaccgtgaa
      361 cgccatagaa aagtttcact ttaagtcatg gatgaaacag catcaaaaga cgtacagctc
      421 ggtggagtac aaccacagac tgcagatgtt tgccaacaac tggaggaaga ttcaagccca
      481 caaccagagg aaccacacat ttaaaatggc attgaaccag ttttcagata tgagctttgc
      541 tgaaataaaa cacaaattcc tttggtcaga gcctcagaat tgctcagcca ccaaaagtaa
      601 ctacctccga ggtacaggcc cctacccttc ctccatggac tggaggaaga aaggaaatgt
      661 tgtttcgcca gtgaaaaatc agggggcctg tggcagctgc tggactttct ctaccacggg
      721 ggccctagag tcagctgtgg ctattgccag tgggaaaatg ctgtctttgg ctgagcagca
      781 gctggtggat tgtgcccaag ccttcaacaa tcatggctgc aaaggaggtc tccccagcca
      841 ggccttcgag tacatcctat acaacaaggg catcatggaa gaagacagct acccttacat
      901 aggcaaggat agttcatgca gattcaaccc ccaaaaagct gttgcattcg tcaagaatgt
      961 tgtcaacatc acactcaatg acgaggctgc aatggttgag gctgtggctc tatacaaccc
     1021 tgtgagcttc gcctttgagg tgactgaaga ttttttgatg tataaaagtg gcgtctactc
     1081 cagtaaatcc tgtcataaaa ctccagataa agtaaaccat gcagtcctgg cggttggcta
     1141 tggagaacag aatggattac tctactggat tgtgaaaaac tcttggggct cccagtgggg
     1201 ggagaatggg tacttcctca ttgaacgtgg gaagaacatg tgtggcctgg ctgcttgtgc
     1261 ctcctatccc attcctcagg tataagccac ggctgcacgg gcaactgatt ggcagaccaa
     1321 gggaggaact ggtccttcga tgagaatgcc accctggaga aaattgtgtg gaaatccacc
     1381 cagaggccct ctcactcctg agtctagacg cctaaagaca ggaaggacaa acttgaatag
     1441 cgacaagccc acccacgtga catcatcacc agaaatacgc ttggattgtg gttttttaat
     1501 gacccaaacc cacgtggacc tagaatcgtc tctctttcca gctctcttca tgtactggga
     1561 gctgtaatgg ttaccttttc tatgttgtgt attcaataaa cacacagtaa atacctccct
     1621 gggaaaaaaa
//
