LOCUS       NM_007800               1015 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus cathepsin G (Ctsg), mRNA.
ACCESSION   NM_007800
VERSION     NM_007800.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1015)
  AUTHORS   Yang,W.H., Aziz,P.V., Heithoff,D.M., Kim,Y., Ko,J.Y., Cho,J.W.,
            Mahan,M.J., Sperandio,M. and Marth,J.D.
  TITLE     Innate mechanism of mucosal barrier erosion in the pathogenesis of
            acquired colitis
  JOURNAL   iScience 26 (10), 107883 (2023)
   PUBMED   37752945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1015)
  AUTHORS   Aghdassi,A.A., John,D.S., Sendler,M., Storck,C., van den Brandt,C.,
            Kruger,B., Weiss,F.U., Mayerle,J. and Lerch,M.M.
  TITLE     Absence of the neutrophil serine protease cathepsin G decreases
            neutrophil granulocyte infiltration but does not change the
            severity of acute pancreatitis
  JOURNAL   Sci Rep 9 (1), 16774 (2019)
   PUBMED   31727956
  REMARK    GeneRIF: Absence of the neutrophil serine protease cathepsin G
            decreases neutrophil granulocyte infiltration but does not change
            the severity of acute pancreatitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1015)
  AUTHORS   Burgener,S.S., Leborgne,N.G.F., Snipas,S.J., Salvesen,G.S.,
            Bird,P.I. and Benarafa,C.
  TITLE     Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed
            Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven
            Inflammation
  JOURNAL   Cell Rep 27 (12), 3646-3656 (2019)
   PUBMED   31216481
REFERENCE   4  (bases 1 to 1015)
  AUTHORS   Kish,D.D., Min,S., Dvorina,N., Baldwin,W.M. 3rd, Stohlman,S.A. and
            Fairchild,R.L.
  TITLE     Neutrophil Cathepsin G Regulates Dendritic Cell Production of IL-12
            during Development of CD4 T Cell Responses to Antigens in the Skin
  JOURNAL   J Immunol 202 (4), 1045-1056 (2019)
   PUBMED   30617225
REFERENCE   5  (bases 1 to 1015)
  AUTHORS   Dai,R., Cowan,C., Heid,B., Khan,D., Liang,Z., Pham,C.T. and
            Ahmed,S.A.
  TITLE     Neutrophils and neutrophil serine proteases are increased in the
            spleens of estrogen-treated C57BL/6 mice and several strains of
            spontaneous lupus-prone mice
  JOURNAL   PLoS One 12 (2), e0172105 (2017)
   PUBMED   28192517
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1015)
  AUTHORS   Grisolano,J.L., Sclar,G.M. and Ley,T.J.
  TITLE     Early myeloid cell-specific expression of the human cathepsin G
            gene in transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 91 (19), 8989-8993 (1994)
   PUBMED   8090757
REFERENCE   7  (bases 1 to 1015)
  AUTHORS   Huang,R. and Hellman,L.
  TITLE     Genes for mast-cell serine protease and their molecular evolution
  JOURNAL   Immunogenetics 40 (6), 397-414 (1994)
   PUBMED   7959952
REFERENCE   8  (bases 1 to 1015)
  AUTHORS   Abraham,C.R., Kanemaru,K. and Mucke,L.
  TITLE     Expression of cathepsin G-like and alpha 1-antichymotrypsin-like
            proteins in reactive astrocytes
  JOURNAL   Brain Res 621 (2), 222-232 (1993)
   PUBMED   8242336
REFERENCE   9  (bases 1 to 1015)
  AUTHORS   Nakamura,N., Tsuru,A., Hirayoshi,K. and Nagata,K.
  TITLE     Purification and characterization of a vimentin-specific protease
            in mouse myeloid leukemia cells. Regulation during differentiation
            and identity with cathepsin G
  JOURNAL   Eur J Biochem 205 (3), 947-954 (1992)
   PUBMED   1577012
REFERENCE   10 (bases 1 to 1015)
  AUTHORS   Hohn,P.A., Popescu,N.C., Hanson,R.D., Salvesen,G. and Ley,T.J.
  TITLE     Genomic organization and chromosomal localization of the human
            cathepsin G gene
  JOURNAL   J Biol Chem 264 (23), 13412-13419 (1989)
   PUBMED   2569462
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091783.9, CJ056088.1 and
            BU755975.1.
            
            On Aug 12, 2015 this sequence version replaced NM_007800.1.
            
            Summary: This gene encodes a member of the peptidase S1
            (chymotrypsin) family of serine endopeptidases. The encoded
            preproprotein is proteolytically processed to generate a mature
            protein product. This product appears to play a role in host
            defense, including inflammation and antigen processing. Homozygous
            knockout mice for this gene exhibit enhanced susceptibility to
            bacterial and fungal infection. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X78544.1, BC125513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC091783.9         41605-41712         c
            109-761             CJ056088.1         2-654
            762-952             BU755975.1         64-254              c
            953-953             AC091783.9         39068-39068         c
            954-1015            BU755975.1         1-62                c
FEATURES             Location/Qualifiers
     source          1..1015
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1015
                     /gene="Ctsg"
                     /gene_synonym="CatG; VSP"
                     /note="cathepsin G"
                     /db_xref="GeneID:13035"
                     /db_xref="MGI:MGI:88563"
     exon            1..193
                     /gene="Ctsg"
                     /gene_synonym="CatG; VSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..924
                     /gene="Ctsg"
                     /gene_synonym="CatG; VSP"
                     /EC_number="3.4.21.20"
                     /note="vimentin-specific protease"
                     /codon_start=1
                     /product="cathepsin G preproprotein"
                     /protein_id="NP_031826.1"
                     /db_xref="CCDS:CCDS27142.1"
                     /db_xref="GeneID:13035"
                     /db_xref="MGI:MGI:88563"
                     /translation="MQPLLLLLTFILLQGDEAGKIIGGREARPHSYPYMAFLLIQSPE
                     GLSACGGFLVREDFVLTAAHCLGSSINVTLGAHNIQMRERTQQLITVLRAIRHPDYNP
                     QNIRNDIMLLQLRRRARRSGSVKPVALPQASKKLQPGDLCTVAGWGRVSQSRGTNVLQ
                     EVQLRVQMDQMCANRFQFYNSQTQICVGNPRERKSAFRGDSGGPLVCSNVAQGIVSYG
                     SNNGNPPAVFTKIQSFMPWIKRTMRRFAPRYQRPANSLSQAQT"
     exon            194..341
                     /gene="Ctsg"
                     /gene_synonym="CatG; VSP"
                     /inference="alignment:Splign:2.1.0"
     exon            342..477
                     /gene="Ctsg"
                     /gene_synonym="CatG; VSP"
                     /inference="alignment:Splign:2.1.0"
     exon            478..732
                     /gene="Ctsg"
                     /gene_synonym="CatG; VSP"
                     /inference="alignment:Splign:2.1.0"
     exon            733..998
                     /gene="Ctsg"
                     /gene_synonym="CatG; VSP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaacctt tcacacgagc aggaaaatag atctgtgacc tctcagaacc acccttcctt
       61 cctctctctc caggggagga taaaagtctg gcagagaaaa gccccggcag caactgacta
      121 agcaacggtt ctggaaagat gcagcctctc ctgctcctgt tgacctttat tctactccaa
      181 ggagatgagg cagggaagat cattggaggc cgagaagcca ggccccattc ctacccctac
      241 atggcatttc ttctgatcca gagtccagaa gggctgagtg cttgtggagg gtttctggtg
      301 cgagaagact tcgtcctaac agcagctcat tgcttgggaa gctccataaa tgttactcta
      361 ggggcccaca acatccaaat gcgagaaagg acccagcaac tcatcacagt gctcagagcc
      421 atccgccatc ctgattacaa tccgcagaac atccggaatg acatcatgct tctgcagctg
      481 aggcgcagag cccggaggag tggatcggtg aagcctgtgg ctctgcctca ggccagcaaa
      541 aaactgcagc caggggattt gtgcacagtg gctggctggg gccgggtaag ccagagcagg
      601 ggaacaaatg tactccagga ggtgcagcta agagtgcaga tggaccaaat gtgcgccaat
      661 cgcttccagt tctacaacag ccagactcag atctgtgtgg gaaacccgag agaaaggaag
      721 tctgccttca ggggtgattc tggtggcccc ctggtatgta gcaatgtggc ccagggcatc
      781 gtctcctatg gaagcaacaa tggtaaccct ccagctgtat tcaccaaaat ccagagcttc
      841 atgccctgga tcaaaagaac aatgagacgc tttgcaccaa gatatcagag acctgctaac
      901 tccctgtctc aggcacagac ctagggactt ccatagccct tattaatgcc ttctggggag
      961 tgtacatttt catttattaa atattatata gtgctgtcaa aaaaaaaaaa aaaaa
//
