LOCUS       NM_019861               1945 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus cathepsin F (Ctsf), mRNA.
ACCESSION   NM_019861
VERSION     NM_019861.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1945)
  AUTHORS   Blednov,Y.A., Ponomarev,I., Geil,C., Bergeson,S., Koob,G.F. and
            Harris,R.A.
  TITLE     Neuroimmune regulation of alcohol consumption: behavioral
            validation of genes obtained from genomic studies
  JOURNAL   Addict Biol 17 (1), 108-120 (2012)
   PUBMED   21309947
  REMARK    GeneRIF: This gene is known to be important for immune responses
            and may potentially regulate alcohol consumption.
REFERENCE   2  (bases 1 to 1945)
  AUTHORS   Tang,C.H., Lee,J.W., Galvez,M.G., Robillard,L., Mole,S.E. and
            Chapman,H.A.
  TITLE     Murine cathepsin F deficiency causes neuronal lipofuscinosis and
            late-onset neurological disease
  JOURNAL   Mol Cell Biol 26 (6), 2309-2316 (2006)
   PUBMED   16508006
  REMARK    GeneRIF: cathepsin F inactivation causes a lysosomal storage defect
            and progressive neurological features in mice
REFERENCE   3  (bases 1 to 1945)
  AUTHORS   Wada,R., Tifft,C.J. and Proia,R.L.
  TITLE     Microglial activation precedes acute neurodegeneration in Sandhoff
            disease and is suppressed by bone marrow transplantation
  JOURNAL   Proc Natl Acad Sci U S A 97 (20), 10954-10959 (2000)
   PUBMED   11005868
REFERENCE   4  (bases 1 to 1945)
  AUTHORS   Deussing,J., Tisljar,K., Papazoglou,A. and Peters,C.
  TITLE     Mouse cathepsin F: cDNA cloning, genomic organization and
            chromosomal assignment of the gene
  JOURNAL   Gene 251 (2), 165-173 (2000)
   PUBMED   10876093
REFERENCE   5  (bases 1 to 1945)
  AUTHORS   Tisljar,K., Deussing,J. and Peters,C.
  TITLE     Cathepsin J, a novel murine cysteine protease of the papain family
            with a placenta-restricted expression
  JOURNAL   FEBS Lett 459 (3), 299-304 (1999)
   PUBMED   10526153
REFERENCE   6  (bases 1 to 1945)
  AUTHORS   Santamaria,I., Velasco,G., Pendas,A.M., Paz,A. and Lopez-Otin,C.
  TITLE     Molecular cloning and structural and functional characterization of
            human cathepsin F, a new cysteine proteinase of the papain family
            with a long propeptide domain
  JOURNAL   J Biol Chem 274 (20), 13800-13809 (1999)
   PUBMED   10318784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141437.4.
            
            On Jul 24, 2018 this sequence version replaced NM_019861.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058758.1, AF136280.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               AC141437.4         55244-55565         c
            323-421             AC141437.4         54934-55032         c
            422-506             AC141437.4         54576-54660         c
            507-568             AC141437.4         54422-54483         c
            569-644             AC141437.4         54143-54218         c
            645-758             AC141437.4         52647-52760         c
            759-904             AC141437.4         52398-52543         c
            905-1001            AC141437.4         52218-52314         c
            1002-1082           AC141437.4         52058-52138         c
            1083-1202           AC141437.4         51208-51327         c
            1203-1267           AC141437.4         51064-51128         c
            1268-1358           AC141437.4         50882-50972         c
            1359-1417           AC141437.4         50422-50480         c
            1418-1945           AC141437.4         49812-50339         c
FEATURES             Location/Qualifiers
     source          1..1945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.12 cM"
     gene            1..1945
                     /gene="Ctsf"
                     /note="cathepsin F"
                     /db_xref="GeneID:56464"
                     /db_xref="MGI:MGI:1861434"
     exon            1..322
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1492
                     /gene="Ctsf"
                     /EC_number="3.4.22.41"
                     /codon_start=1
                     /product="cathepsin F precursor"
                     /protein_id="NP_063914.1"
                     /db_xref="CCDS:CCDS29440.1"
                     /db_xref="GeneID:56464"
                     /db_xref="MGI:MGI:1861434"
                     /translation="MAPLLQLLWLLTLLSTVALSPVPAKPWADDEQAWNLSSQELLAP
                     ARFALDMYNYGRAAGTRAVLGAVRGRVRRAGQGSLFSLEATLEEPPCNDPLVCPLPET
                     KKTVLCSFEVLEELKEHLLLRRDCSPVNAKVTEFRNATFSSFLPLLDKDPLPQDFSVK
                     MAPLFKDFMTTYNRTYESREEAQWRLTVFARNMIRAQKIQALDRGTAQYGITKFSDLT
                     EEEFHTIYLNPLLQKESGRKMSPAKSINDLAPPEWDWRKKGAVTEVKNQGMCGSCWAF
                     SVTGNVEGQWFLNRGTLLSLSEQELLDCDKVDKACLGGLPSNAYAAIKNLGGLETEDD
                     YGYQGHVQTCNFSAQMAKVYINDSVELSRNENKIAAWLAQKGPISVAINAFGMQFYRH
                     GIAHPFRPLCSPWFIDHAVLLVGYGNRSNIPYWAIKNSWGSDWGEEGYYYLYRGSGAC
                     GVNTMASSAVVN"
     exon            323..421
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     exon            422..506
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     exon            507..568
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     exon            569..644
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     exon            645..758
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     exon            759..904
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1001
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1082
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1202
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1267
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1358
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1417
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1945
                     /gene="Ctsf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1920..1925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctsf"
                     /note="hexamer: AATAAA"
     polyA_site      1938
                     /gene="Ctsf"
                     /note="major polyA site"
ORIGIN      
        1 gtagggaaac tctctgtggc ctctgacagc aggctccgcc tcgggtctct tgatccgtgt
       61 gtttgtgggt cagtgaatcc gggcgagcag cttcgacctc gctatggcgc ccctactgca
      121 gcttctgtgg ctgctgacac tgctctcgac tgtggccctg agccccgtcc ccgccaagcc
      181 ctgggcagat gacgagcagg cctggaactt gtcgtcccag gagctgctgg cccccgcccg
      241 cttcgcgctg gacatgtaca attacggccg tgctgcgggg acaagggccg tgctaggagc
      301 ggtgcgcgga cgcgtccgcc gggccggcca gggctctctg ttctccctgg aagccacact
      361 agaggagcca ccttgcaatg atcccctggt gtgcccactg cctgagacga agaaaacagt
      421 gctctgcagt tttgaagtcc tggaagagct aaaagaacac ttgctgctga ggagggactg
      481 tagcccagtg aatgccaagg tcacagagtt tagaaatgcg actttcagct cattccttcc
      541 attgttggac aaggatcccc tgccccagga cttctctgtg aagatggctc cactcttcaa
      601 ggacttcatg accacctata accggactta tgaatcaagg gaagaagccc agtggcgatt
      661 gactgtcttt gcaagaaata tgatacgagc acagaagatt caggccctgg accgcggcac
      721 agctcagtat gggatcacca agttcagtga cctcacagag gaggaattcc acaccatcta
      781 cctgaatccc ctcttacaga aggagtctgg caggaagatg agtccagcca agtccataaa
      841 tgatcttgcc ccgcctgaat gggactggag gaagaaaggg gctgtcactg aagtgaagaa
      901 ccagggcatg tgtggctcct gctgggcctt ttctgtcaca ggcaacgtgg agggccagtg
      961 gttcctgaac cgggggactc tgctctccct gtcagagcag gagctcttgg attgtgacaa
     1021 ggtggacaag gcctgcttgg gtggattgcc ctccaacgcc tatgcagcca taaagaattt
     1081 gggagggctg gagacagagg atgactacgg ctaccagggc catgttcaga cctgcaactt
     1141 ctcagcacag atggcaaaag tctacatcaa tgattcagtg gagctgagcc ggaatgaaaa
     1201 taagatagca gcctggctgg cccagaaagg acctatctca gttgccatta acgccttcgg
     1261 catgcagttc tatcgccacg ggattgctca cccattccgg cccctctgca gcccttggtt
     1321 catcgaccat gctgtgttgc tggtgggcta tggcaaccgc tctaacattc cttactgggc
     1381 catcaagaac agctggggca gtgactgggg tgaggagggt tactactact tgtaccgtgg
     1441 atctggagcc tgtggtgtga ataccatggc cagctcagcc gtggtgaact gagagttgct
     1501 ggctcaggac ctatgttgtc acagtggccc cttccttagc ccgactcatg cccaggccct
     1561 tcctcacgag acagagctgg ttggctgagg gccgggcact ttggacctca cggtgagccc
     1621 tgggccctgg gccccttcgt ccctctttcc tctagtgctc atctgaagtt ccccagctgc
     1681 acctgtgtcc gattgtggta gctaggagga tcctgaggtg caggaggctt tcatggaagc
     1741 cagcgccggg gcaagaacct ggctacagta tgatgcagga tgaaaatatg ctcgtcataa
     1801 aactagatct gtcctcagca ggctctgtct ttttgctttg gtgctcctcg gtctgatgct
     1861 gtcagttttc tggtcccttt ccacatccag gaaagttgtg accggccttc tctaagggca
     1921 ataaagaggt agcctgctct ccttg
//
