LOCUS       NP_063914                462 aa            linear   ROD 28-APR-2025
DEFINITION  cathepsin F precursor [Mus musculus].
ACCESSION   NP_063914
VERSION     NP_063914.1
DBSOURCE    REFSEQ: accession NM_019861.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 462)
  AUTHORS   Blednov,Y.A., Ponomarev,I., Geil,C., Bergeson,S., Koob,G.F. and
            Harris,R.A.
  TITLE     Neuroimmune regulation of alcohol consumption: behavioral
            validation of genes obtained from genomic studies
  JOURNAL   Addict Biol 17 (1), 108-120 (2012)
   PUBMED   21309947
  REMARK    GeneRIF: This gene is known to be important for immune responses
            and may potentially regulate alcohol consumption.
REFERENCE   2  (residues 1 to 462)
  AUTHORS   Tang,C.H., Lee,J.W., Galvez,M.G., Robillard,L., Mole,S.E. and
            Chapman,H.A.
  TITLE     Murine cathepsin F deficiency causes neuronal lipofuscinosis and
            late-onset neurological disease
  JOURNAL   Mol Cell Biol 26 (6), 2309-2316 (2006)
   PUBMED   16508006
  REMARK    GeneRIF: cathepsin F inactivation causes a lysosomal storage defect
            and progressive neurological features in mice
REFERENCE   3  (residues 1 to 462)
  AUTHORS   Wada,R., Tifft,C.J. and Proia,R.L.
  TITLE     Microglial activation precedes acute neurodegeneration in Sandhoff
            disease and is suppressed by bone marrow transplantation
  JOURNAL   Proc Natl Acad Sci U S A 97 (20), 10954-10959 (2000)
   PUBMED   11005868
REFERENCE   4  (residues 1 to 462)
  AUTHORS   Deussing,J., Tisljar,K., Papazoglou,A. and Peters,C.
  TITLE     Mouse cathepsin F: cDNA cloning, genomic organization and
            chromosomal assignment of the gene
  JOURNAL   Gene 251 (2), 165-173 (2000)
   PUBMED   10876093
REFERENCE   5  (residues 1 to 462)
  AUTHORS   Tisljar,K., Deussing,J. and Peters,C.
  TITLE     Cathepsin J, a novel murine cysteine protease of the papain family
            with a placenta-restricted expression
  JOURNAL   FEBS Lett 459 (3), 299-304 (1999)
   PUBMED   10526153
REFERENCE   6  (residues 1 to 462)
  AUTHORS   Santamaria,I., Velasco,G., Pendas,A.M., Paz,A. and Lopez-Otin,C.
  TITLE     Molecular cloning and structural and functional characterization of
            human cathepsin F, a new cysteine proteinase of the papain family
            with a long propeptide domain
  JOURNAL   J Biol Chem 274 (20), 13800-13809 (1999)
   PUBMED   10318784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141437.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058758.1, AF136280.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.12 cM"
     Protein         1..462
                     /product="cathepsin F precursor"
                     /EC_number="3.4.22.41"
                     /calculated_mol_wt=49570
     sig_peptide     1..19
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R013.1)"
                     /calculated_mol_wt=2110
     Site            35
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R013.1)"
     Site            138
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R013.1)"
     Region          165..221
                     /region_name="Inhibitor_I29"
                     /note="Cathepsin propeptide inhibitor domain (I29);
                     smart00848"
                     /db_xref="CDD:214853"
     Site            173
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R013.1)"
     mat_peptide     249..462
                     /product="Cathepsin F. /id=PRO_0000026205"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R013.1)"
                     /calculated_mol_wt=23610
     Region          249..460
                     /region_name="Peptidase_C1"
                     /note="Papain family cysteine protease; pfam00112"
                     /db_xref="CDD:425470"
     Site            order(267,273,409,429)
                     /site_type="active"
                     /db_xref="CDD:239068"
     Site            order(315..316,381,407,410,455)
                     /site_type="active"
                     /note="S2 subsite [active]"
                     /db_xref="CDD:239068"
     Site            345
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R013.1)"
     Site            356
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R013.1)"
     Site            418
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R013.1)"
     CDS             1..462
                     /gene="Ctsf"
                     /coded_by="NM_019861.2:104..1492"
                     /db_xref="CCDS:CCDS29440.1"
                     /db_xref="GeneID:56464"
                     /db_xref="MGI:MGI:1861434"
ORIGIN      
        1 mapllqllwl ltllstvals pvpakpwadd eqawnlssqe llaparfald mynygraagt
       61 ravlgavrgr vrragqgslf sleatleepp cndplvcplp etkktvlcsf evleelkehl
      121 llrrdcspvn akvtefrnat fssflplldk dplpqdfsvk maplfkdfmt tynrtyesre
      181 eaqwrltvfa rnmiraqkiq aldrgtaqyg itkfsdltee efhtiylnpl lqkesgrkms
      241 paksindlap pewdwrkkga vtevknqgmc gscwafsvtg nvegqwflnr gtllslseqe
      301 lldcdkvdka clgglpsnay aaiknlggle teddygyqgh vqtcnfsaqm akvyindsve
      361 lsrnenkiaa wlaqkgpisv ainafgmqfy rhgiahpfrp lcspwfidha vllvgygnrs
      421 nipywaikns wgsdwgeegy yylyrgsgac gvntmassav vn
//
