LOCUS       NM_007799               2120 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus cathepsin E (Ctse), mRNA.
ACCESSION   NM_007799
VERSION     NM_007799.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2120)
  AUTHORS   Laubreton,D., Djebali,S., Angleraux,C., Chain,B., Dubois,M.,
            Henry,F., Leverrier,Y., Teixeira,M., Markossian,S. and Marvel,J.
  TITLE     Generation of a C57BL/6J mouse strain expressing the CD45.1 epitope
            to improve hematopoietic stem cell engraftment and adoptive cell
            transfer experiments
  JOURNAL   Lab Anim (NY) 52 (12), 324-331 (2023)
   PUBMED   38017180
REFERENCE   2  (bases 1 to 2120)
  AUTHORS   Xie,Z., Meng,J., Kong,W., Wu,Z., Lan,F., Narengaowa, Hayashi,Y.,
            Yang,Q., Bai,Z., Nakanishi,H., Qing,H. and Ni,J.
  TITLE     Microglial cathepsin E plays a role in neuroinflammation and
            amyloid beta production in Alzheimer's disease
  JOURNAL   Aging Cell 21 (3), e13565 (2022)
   PUBMED   35181976
REFERENCE   3  (bases 1 to 2120)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2120)
  AUTHORS   Harada,Y., Zhang,J., Imari,K., Yamasaki,R., Ni,J., Wu,Z.,
            Yamamoto,K., Kira,J.I., Nakanishi,H. and Hayashi,Y.
  TITLE     Cathepsin E in neutrophils contributes to the generation of
            neuropathic pain in experimental autoimmune encephalomyelitis
  JOURNAL   Pain 160 (9), 2050-2062 (2019)
   PUBMED   31095099
  REMARK    GeneRIF: Cathepsin-E deficient animals were highly resistant to
            (MOG35-55) induced mechanical allodynia.
REFERENCE   5  (bases 1 to 2120)
  AUTHORS   Moreira,J., Saraiva,M. and Saraiva,M.J.
  TITLE     Downregulated Cathepsin E expression in bone marrow-derived
            macrophages from the pre-clinical familial amyloid polyneuropathy
            model
  JOURNAL   Amyloid 26 (sup1), 63-64 (2019)
   PUBMED   31343320
  REMARK    GeneRIF: Infact, decreased CtsE expression levels in BMDM of
            V30Mmice and their apparent impairment observed to LPSresponse
            could explain the mechanism for lower immunecell chemotaxis and
            impaired macrophage function observedin familial amyloid
            polyneuropathy.
REFERENCE   6  (bases 1 to 2120)
  AUTHORS   Tatnell,P.J., Lees,W.E. and Kay,J.
  TITLE     Cloning, expression and characterisation of murine procathepsin E
  JOURNAL   FEBS Lett 408 (1), 62-66 (1997)
   PUBMED   9180269
REFERENCE   7  (bases 1 to 2120)
  AUTHORS   Hart,M.C., Korshunova,Y.O. and Cooper,J.A.
  TITLE     Mapping of the mouse actin capping protein alpha subunit genes and
            pseudogenes
  JOURNAL   Genomics 39 (3), 264-270 (1997)
   PUBMED   9119363
REFERENCE   8  (bases 1 to 2120)
  AUTHORS   Amano,T., Nakanishi,H., Oka,M. and Yamamoto,K.
  TITLE     Increased expression of cathepsins E and D in reactive microglial
            cells associated with spongiform degeneration in the brain stem of
            senescence-accelerated mouse
  JOURNAL   Exp Neurol 136 (2), 171-182 (1995)
   PUBMED   7498407
REFERENCE   9  (bases 1 to 2120)
  AUTHORS   Bennett,K., Levine,T., Ellis,J.S., Peanasky,R.J., Samloff,I.M.,
            Kay,J. and Chain,B.M.
  TITLE     Antigen processing for presentation by class II major
            histocompatibility complex requires cleavage by cathepsin E
  JOURNAL   Eur J Immunol 22 (6), 1519-1524 (1992)
   PUBMED   1601038
REFERENCE   10 (bases 1 to 2120)
  AUTHORS   Couvreur,J.M., Azuma,T., Miller,D.A., Rocchi,M., Mohandas,T.K.,
            Boudi,F.A. and Taggart,R.T.
  TITLE     Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by
            in situ hybridization and analysis of somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 53 (2-3), 137-139 (1990)
   PUBMED   2369841
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC120217.13, AK145875.1 and
            AC138277.16.
            
            On Jan 30, 2008 this sequence version replaced NM_007799.2.
            
            Summary: This gene encodes a member of the peptidase A1 family of
            aspartate proteases and preproprotein that is proteolytically
            processed to generate a mature protein product. The encoded protein
            may be involved in antigen processing and the maturation of
            secretory proteins. Elevated expression of this gene has been
            observed in neurodegeneration. Homozygous knockout mice for this
            gene exhibit lysosomal storage disorder, impaired autophagy,
            mitochondrial abnormalities, dermatitis, and reduced weight gain in
            an obesity model. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005432.1, AK145875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC120217.13        143223-143369
            148-2082            AK145875.1         5-1939
            2083-2120           AC138277.16        102781-102818       c
FEATURES             Location/Qualifiers
     source          1..2120
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.14 cM"
     gene            1..2120
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /note="cathepsin E"
                     /db_xref="GeneID:13034"
                     /db_xref="MGI:MGI:107361"
     exon            1..244
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /inference="alignment:Splign:2.1.0"
     exon            245..435
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..1558
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /EC_number="3.4.23.34"
                     /codon_start=1
                     /product="cathepsin E preproprotein"
                     /protein_id="NP_031825.2"
                     /db_xref="CCDS:CCDS15271.1"
                     /db_xref="GeneID:13034"
                     /db_xref="MGI:MGI:107361"
                     /translation="MKPLLVLLLLLLLDLAQAQGALHRVPLRRHQSLRKKLRAQGQLS
                     EFWRSHNLDMTRLSESCNVYSSVNEPLINYLDMEYFGTISIGTPPQNFTVIFDTGSSN
                     LWVPSVYCTSPACKAHPVFHPSQSDTYTEVGNHFSIQYGTGSLTGIIGADQVSVEGLT
                     VDGQQFGESVKEPGQTFVNAEFDGILGLGYPSLAAGGVTPVFDNMMAQNLVALPMFSV
                     YLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQAYWQIALDGIQVGDTVMFCSEG
                     CQAIVDTGTSLITGPPDKIKQLQEAIGATPIDGEYAVDCATLDTMPNVTFLINEVSYT
                     LNPTDYILPDLVEGMQFCGSGFQGLDIPPPAGPLWILGDVFIRQFYSVFDRGNNQVGL
                     APAVP"
     exon            436..592
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /inference="alignment:Splign:2.1.0"
     exon            593..710
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /inference="alignment:Splign:2.1.0"
     exon            711..829
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1029
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1152
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1294
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1393
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..2120
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2095..2100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /note="hexamer: CATAAA"
     polyA_site      2116
                     /gene="Ctse"
                     /gene_synonym="A430072O03Rik; C920004C08Rik; CatE; CE"
                     /note="major polyA site"
ORIGIN      
        1 caacttcatt tgttcctcag aactgcagat gccctgtgtg actccagaag cggttagaaa
       61 gatcaggcgt ggttatctcc atttgcagct gaggtggcca agagataaga gttgcttaaa
      121 gtcggagtta gcaaacaaca aaacggggtt tccacacaga gctcagcttc ggagcccaac
      181 ccatccactt actacaagaa aacgaaattc ttgacatttt gggttatatc cggtaacttc
      241 aaagactggg cagggcaggt ctgggcacca ggaagagcca gtgcccctgc cctgtgatca
      301 agaggagaga agggtggaag ggagatcgga gcagagtgag agagaagcta ccccttggac
      361 cacaatgaag cccctccttg tgctgctgct gctgctgctc ctggatctgg ctcaggccca
      421 aggtgctctg cacagagtgc ccctcagaag acatcagtcc cttcggaaga aactacgggc
      481 ccaaggacag ctctcagaat tctggaggtc tcataacttg gacatgaccc gactcagcga
      541 gtcctgtaat gtgtattcga gtgtcaatga acccctcatc aactacctgg atatggaata
      601 ctttggcacc atctccatcg gcaccccgcc gcagaacttc actgtcatct ttgacaccgg
      661 ttcatccaac ctctgggtcc cttctgtgta ctgcaccagc ccagcatgca aggcacaccc
      721 agtattccat ccatcgcagt ccgacacata cacggaggta gggaatcatt tctccatcca
      781 gtatggtacc gggagcctga caggaatcat tggagctgat caagtctctg tggaagggtt
      841 gactgtggat ggccagcagt ttggagaaag tgtcaaggag ccaggccaga cctttgtgaa
      901 tgcagagttt gatgggattc tgggtctggg atacccctca ttggctgctg gaggagtgac
      961 cccagtgttt gacaacatga tggcccagaa ccttgtggct ctgcctatgt tttctgtcta
     1021 cttgagcagt gaccctcaag gtggctcagg cagtgagctg actttcggag gctatgaccc
     1081 ctctcatttc tctgggagcc tcaactggat cccagtcacc aagcaagcct attggcagat
     1141 tgccctggat ggaatccagg tgggagacac tgtgatgttc tgctccgaag gctgccaggc
     1201 catagtggac acagggacct ctctcatcac tggccccccc gacaagatca aacagcttca
     1261 agaggccatt ggggccacac ccattgatgg agaatatgca gtggattgtg ccactctcga
     1321 cacgatgcca aacgttacct tcctcatcaa cgaggtttca tataccctca acccaactga
     1381 ctacatcctg ccggacttgg tggaaggaat gcagttctgt ggcagtggct ttcaaggact
     1441 tgacattcca cctccagctg ggcccctctg gatcctgggg gatgtcttca tccgacagtt
     1501 ctactcagtc tttgaccgtg gaaataacca agtgggattg gcccccgcag ttccctaaag
     1561 agggatgtat gcctacatat ggatgcctga tacccattta acctgttaga tacctttgta
     1621 actatcaaag ccgtcatttc ccatggggtg tagccacccc agagtattca gaccaatcaa
     1681 agcataagag tgcaccccac tcactgcaaa cacacacaca cacacaccac ctctaccatc
     1741 accacgatga aagaagttct gtctatagtc ttcactgctt attgttgact ttctattatg
     1801 gaaatctcta aacatgtaca cagtagacac gatggcaaga taaataccca cacacctctg
     1861 cctcaggtca caacccatcc atgtgtggcc cagactctct atcttccatc cctctggttc
     1921 cacgcctcta gatttggaag cagattctaa gcaccaggtc attttatcta atgtctaaca
     1981 tccttacaaa tcagaattta aatgtctcac cctctcataa atgtggacct gtttttacag
     2041 ttggtttatt tgtatcagga ttaaaaccag atccataact ggacaaaaaa aacccataaa
     2101 ctgatttgat tttaaatatc
//
