LOCUS       NM_009983               1934 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus cathepsin D (Ctsd), mRNA.
ACCESSION   NM_009983
VERSION     NM_009983.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1934)
  AUTHORS   Ruiz-Blazquez,P., Fernandez-Fernandez,M., Pistorio,V.,
            Martinez-Sanchez,C., Costanzo,M., Iruzubieta,P., Zhuravleva,E.,
            Cacho-Pujol,J., Arino,S., Del Castillo-Cruz,A., Nunez,S.,
            Andersen,J.B., Ruoppolo,M., Crespo,J., Garcia-Ruiz,C., Pavone,L.M.,
            Reinheckel,T., Sancho-Bru,P., Coll,M., Fernandez-Checa,J.C. and
            Moles,A.
  TITLE     Cathepsin D is essential for the degradomic shift of macrophages
            required to resolve liver fibrosis
  JOURNAL   Mol Metab 87, 101989 (2024)
   PUBMED   39019115
  REMARK    GeneRIF: Cathepsin D is essential for the degradomic shift of
            macrophages required to resolve liver fibrosis.
REFERENCE   2  (bases 1 to 1934)
  AUTHORS   Ng,E.S.Y., Hu,J., Jiang,Z. and Radu,R.A.
  TITLE     Impaired cathepsin D in retinal pigment epithelium cells mediates
            Stargardt disease pathogenesis
  JOURNAL   FASEB J 38 (11), e23720 (2024)
   PUBMED   38837708
  REMARK    GeneRIF: Impaired cathepsin D in retinal pigment epithelium cells
            mediates Stargardt disease pathogenesis.
REFERENCE   3  (bases 1 to 1934)
  AUTHORS   Terron,H.M., Parikh,S.J., Abdul-Hay,S.O., Sahara,T., Kang,D.,
            Dickson,D.W., Saftig,P., LaFerla,F.M., Lane,S. and Leissring,M.A.
  TITLE     Prominent tauopathy and intracellular beta-amyloid accumulation
            triggered by genetic deletion of cathepsin D: implications for
            Alzheimer disease pathogenesis
  JOURNAL   Alzheimers Res Ther 16 (1), 70 (2024)
   PUBMED   38575959
  REMARK    GeneRIF: Prominent tauopathy and intracellular beta-amyloid
            accumulation triggered by genetic deletion of cathepsin D:
            implications for Alzheimer disease pathogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1934)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1934)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   6  (bases 1 to 1934)
  AUTHORS   Amano,T., Nakanishi,H., Oka,M. and Yamamoto,K.
  TITLE     Increased expression of cathepsins E and D in reactive microglial
            cells associated with spongiform degeneration in the brain stem of
            senescence-accelerated mouse
  JOURNAL   Exp Neurol 136 (2), 171-182 (1995)
   PUBMED   7498407
REFERENCE   7  (bases 1 to 1934)
  AUTHORS   Saftig,P., Hetman,M., Schmahl,W., Weber,K., Heine,L., Mossmann,H.,
            Koster,A., Hess,B., Evers,M., von Figura,K. et al.
  TITLE     Mice deficient for the lysosomal proteinase cathepsin D exhibit
            progressive atrophy of the intestinal mucosa and profound
            destruction of lymphoid cells
  JOURNAL   EMBO J 14 (15), 3599-3608 (1995)
   PUBMED   7641679
REFERENCE   8  (bases 1 to 1934)
  AUTHORS   Yasuda,Y., Nishi,N., Takahashi,J.A., Konishi,H., Ohara,I.,
            Fujita,H., Ohta,M., Itoh,N., Hatanaka,M. and Tanimura,T.
  TITLE     Induction of avascular yolk sac due to reduction of basic
            fibroblast growth factor by retinoic acid in mice
  JOURNAL   Dev Biol 150 (2), 397-413 (1992)
   PUBMED   1372572
REFERENCE   9  (bases 1 to 1934)
  AUTHORS   Diedrich,J.F., Staskus,K.A., Retzel,E.F. and Haase,A.T.
  TITLE     Nucleotide sequence of a cDNA encoding mouse cathepsin D
  JOURNAL   Nucleic Acids Res 18 (23), 7184 (1990)
   PUBMED   2263503
REFERENCE   10 (bases 1 to 1934)
  AUTHORS   Grusby,M.J., Mitchell,S.C. and Glimcher,L.H.
  TITLE     Molecular cloning of mouse cathepsin D
  JOURNAL   Nucleic Acids Res 18 (13), 4008 (1990)
   PUBMED   2374732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X52886.1 and CD741449.1.
            
            On Jun 3, 2018 this sequence version replaced NM_009983.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054758.1, X52886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1911              X52886.1           44-1954
            1912-1934           CD741449.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1934
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 87.93 cM"
     gene            1..1934
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /note="cathepsin D"
                     /db_xref="GeneID:13033"
                     /db_xref="MGI:MGI:88562"
     exon            1..91
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1256
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /EC_number="3.4.23.5"
                     /codon_start=1
                     /product="cathepsin D precursor"
                     /protein_id="NP_034113.1"
                     /db_xref="CCDS:CCDS22029.1"
                     /db_xref="GeneID:13033"
                     /db_xref="MGI:MGI:88562"
                     /translation="MKTPGVLLLILGLLASSSFAIIRIPLRKFTSIRRTMTEVGGSVE
                     DLILKGPITKYSMQSSPKTTEPVSELLKNYLDAQYYGDIGIGTPPQCFTVVFDTGSSN
                     LWVPSIHCKILDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPC
                     KSDQSKARGIKVEKQIFGEATKQPGIVFVAAKFDGILGMGYPHISVNNVLPVFDNLMQ
                     QKLVDKNIFSFYLNRDPEGQPGGELMLGGTDSKYYHGELSYLNVTRKAYWQVHMDQLE
                     VGNELTLCKGGCEAIVDTGTSLLVGPVEEVKELQKAIGAVPLIQGEYMIPCEKVSSLP
                     TVYLKLGGKNYELHPDKYILKVSQGGKTICLSGFMGMDIPPPSGPLWILGDVFIGSYY
                     TVFDRDNNRVGFANAVVL"
     exon            92..251
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /inference="alignment:Splign:2.1.0"
     exon            252..375
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /inference="alignment:Splign:2.1.0"
     exon            376..494
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /inference="alignment:Splign:2.1.0"
     exon            495..721
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /inference="alignment:Splign:2.1.0"
     exon            722..844
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /inference="alignment:Splign:2.1.0"
     exon            845..989
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1088
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1917
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1889..1894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /note="hexamer: AATAAA"
     polyA_site      1911
                     /gene="Ctsd"
                     /gene_synonym="CatD; CD"
                     /note="major polyA site"
ORIGIN      
        1 gctctcttcg ggccgccgcg accatgaaga ctcccggcgt cttgctgctc attctcggcc
       61 tcctggcttc gtcctccttc gcgattatca gaatccctct gcgcaagttc acatctatcc
      121 gtcggactat gacggaggtg ggcggctctg tggaagacct gatcctcaaa ggccccatca
      181 ccaagtactc catgcagtca tcgcctaaga ccacggagcc agtgtcagag ttactcaaaa
      241 actacctgga tgcccagtac tatggcgata tcggcatcgg aaccccgccg cagtgtttca
      301 cagtcgtctt tgatactggc tcctctaacc tgtgggtccc ctccattcat tgcaagatac
      361 ttgacatagc ctgctgggtc caccataagt acaacagtga caagtccagc acctatgtga
      421 agaacggcac gtcctttgac atccactacg gctcaggaag cctctctggg tacctgagcc
      481 aggacactgt atcggttcca tgtaagtctg accagtcaaa ggcaagaggt atcaaggtgg
      541 agaaacagat ctttggagaa gccaccaagc agcctggaat cgtatttgtt gcagccaagt
      601 ttgatggcat cttgggcatg ggctaccctc atatctctgt taacaacgtg cttccggtct
      661 ttgacaacct gatgcaacag aagctggtgg acaagaacat cttctccttc tacctgaaca
      721 gggacccaga agggcaaccc ggaggagaac taatgcttgg tggcactgac tccaagtact
      781 accacgggga gctgtcctac ctgaacgtca ctcgaaaggc ctactggcag gtgcacatgg
      841 accagttgga ggtgggcaat gagctgaccc tgtgcaaggg aggctgtgag gctattgtgg
      901 acacagggac atctcttctg gtggggcctg tggaagaggt gaaggagctg cagaaggcca
      961 tcggggcagt gcctcttatc cagggtgagt atatgattcc ttgtgagaag gtgtccagcc
     1021 tgcccacggt ctacctgaag ctaggaggca aaaactatga actacaccca gacaagtata
     1081 tactcaaggt atcgcagggt ggaaagacaa tctgcctgag tggcttcatg ggaatggaca
     1141 taccccctcc cagtgggccg ctctggatcc tgggcgatgt cttcattggt tcctactaca
     1201 ctgtgtttga cagagacaac aatagggtcg gctttgccaa tgctgtcgta ctctaacttg
     1261 ctccttctcc actgtcaggg aactggatca gagtccagta gaggaagcca gccagcccca
     1321 tccctccacc tgccccactc acacatagtc acactcgctt agtgttgctg gacccttggg
     1381 ggagacctgg ctggagcttg tccagctgtt ctgttctgtg gttcctcacc ctgggttcag
     1441 attgctgccc tctgcctgtc tgaaggaggc caaggcccac ccagtacacg aggctgcctt
     1501 caaaggcccc tactggttta atagctgctg agatggattg tcttgtcctg ccgccctttg
     1561 ctgtgtgggc agtactctga agcaggcaaa tgggtcttag gatccctccc agaaacctgc
     1621 tctgacccag acccatcacc cagcttgggg atggcaccac gttctactgc ccctccaact
     1681 ctggcctggc aaaggcctga aggtgagcag gaaggagcaa gaggacagaa gcaaaactat
     1741 gaacctgggg ggttacctag ggcttgaccc cgccctcctg ggaaggcatg cctcagcctg
     1801 gggtagaggt aggatgactg actggttttg gctggcctct gctgccctca tcctgggcta
     1861 ggcagctggg agccaaagtt gaaatacaaa taaagttgtt ttgggccttg atctctaaaa
     1921 aaaaaaaaaa aaaa
//
